The health benefits of Scopoletin August
2008
2008
MAJOR NUTRIENT
DIET.
SUPPLEMENT
PhytoChemicals
Antioxidants
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Products
Acetyl-L Carnitine
Acidophilus
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Almond
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Astaxanthin,
Astragulus
Artichoke
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black cohosh
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Canola oil
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Ellagic Acid
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Eve. Primrose Oil
Falcarinol
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Galangal
Ghrelin
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Green Tea
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Guar Gum
Guggul
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Hoodia
Hop
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Horsetail
Huperzine A
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Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
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N-Acetylcysteine
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Onion
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Pantethine
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Passion Flower
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Peach
Pepper
Peppermint
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serine
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Royal Jelly
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methionine
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Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Stevia
Valerian
Walnuts
Watermelon
Whey
Wild Yam
Xylitol
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Resource
DIET.
SUPPLEMENT
PhytoChemicals
Antioxidants
A-Z Health Foods,
Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
Aloe vera
Aniseed
Apple
Arnica
Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
black cohosh
Bladderwrack
Blackberry
Black Currant
Blueberry
Bilberry
Bitter Melon
Borage Seed Oil
Boswellia
Broccoli
Bromelain
Brown Seaweed
Brussels Sprout
Butterbur
Burdock
Cabbage
Calcium
Calendula
Canola oil
Cauliflower
Cat's Claw
Cayenne
Celadrin
Celery
Chamomile
Chaparral
Cherry
Chondroitin
Chitosan
Chlorophyll
Chromium
Cinnamon
CLA
Cocoa
Cod Liver Oil
Coenzyme Q
Coffee
Comfrey
Conj. Linoleic Acid
Colostrum
Colloidal Silver
Corn
Cranberry
Creatine
Curcumin
Dandelion
Devil's Claw
DHEA
Dill
Dong Quai
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eucalyptus G.
Eve. Primrose Oil
Falcarinol
Fennel
Fenugreek
Feverfew
Folate
Fish Oil
Flaxseed /Linseed
Garcinia C.
Garlic
Galangal
Ghrelin
Ginger
Ginseng
Ginseng/Ginkgo
Ginkgo Biloba
Glucosamine
Goldenseal
Gotu Kola
GRAPE SEED
EXTRACT
Green Tea
Growth Hormone
Stimulants
Goldenseal
Guar Gum
Guggul
Gymnema
Hawthorn
Hoodia
Hop
Horse Chestnut
Horsetail
Huperzine A
Hyaluronic acid
Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
Maca
Mango
Marshmallow
Melatonin
Milk Thistle
Mistletoe
N-Acetylcysteine
Nattokinase
Nectarines
Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
PEANUT
Peach
Pepper
Peppermint
Persimmons
Phosphatidyl
serine
Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rosemary
Royal Jelly
Rutin
S-adenosyl-L-
methionine
Saffron
Saw Palmetto
Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Stevia
Valerian
Walnuts
Watermelon
Whey
Wild Yam
Xylitol
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Resource
Scopoletin, 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one, a
naturally occurring component in cotton leaf and citrus peel is
a fluorescent substrate for peroxidase which has been used
by many investigators for the determination of hydrogen
peroxide concentration. [1]
Scopoletin is believed to have health benefits of blood
pressure lowering effect. In a study, scopoletin inhibited the
indirect electrical stimulation-evoked contractions of the cat
nictitating membrane ( IN VIVO); and also the contractions of
isolated perfused central ear artery of rabbit, induced by
electrical stimulation or intraluminal noradrenaline
administration. [2] Scopoletin also relaxed the smooth
muscles and inhibited the spasmogenic activities of a wide
variety of agonists on guinea-pig isolated ileum. [2]
Scopoletin may also have benefit on people at risk of certain
types of cancer. Scopoletin inhibited proliferation of certain
cancer cells by inducing apoptosis. [4,5]
Scopoletin was found to inhibit hepatic lipid peroxidation and
increased the activity of antioxidants, superoxide dismutase
and catalase. A few studies suggested that scopoletin might
benefit those at risk of high cholesterol, triglyceride and
glucose levels. [6]
Its major unwanted side effect of scopoletin probably is
increased bleeding time. [3]
[1] Corbett JT. The scopoletin assay for hydrogen peroxide. A review and a better
method. J Biochem Biophys Methods. 1989 Jun;18(4):297-307. [2] Ojewole JA and
Adesina SK, Mechanism of the Hypotensive Effect of Scopoletin Isolated from the Fruit
of Tetrapleura tetraptera. Planta Med. 1983 Sep;49(9):46-50. [3] Obasi SC et al, Effects
of single oral doses of scopoletin and aflatoxin B1 on the clotting time, serum
cholesterol and phospholipid levels of chicks. Indian J Physiol Pharmacol. 1994
Apr;38(2):89-94 [4] Liu XL et al, Effect of scopoletin on PC3 cell proliferation and
apoptosis. Acta Pharmacol Sin. 2001 Oct;22(10):929-33. [5] Manuele MG, et al,
Comparative immunomodulatory effect of scopoletin on tumoral and normal
lymphocytes. Life Sci. 2006 Oct 19;79(21):2043-8. Epub 2006 Jul 6. [6] Panda S, Kar A.
Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin
from Aegle marmelos leaves in hyperthyroid rats. Phytother Res. 2006
Dec;20(12):1103-5. [7] Yang JY, et al, Effect of scopoletin on lipoprotein lipase activity
in 3T3-L1 adipocytes. Int J Mol Med. 2007 Oct;20(4):527-31.
This article can not be used as medical advice. Please, consult with your
medical doctor for any question or before taking any drug products and
supplements. ALL RIGHTS RESERVED zhion 2008
Reference
[1] US Patent Application 20080020078 [2] Yu SG et al, Geraniol, an inhibitor of
mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas
transplanted to rats and mice. J Nutr. 1995 Nov;125(11):2763-7. [3] Burke YD Inhibition
of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids.
1997 Feb;32(2):151-6. [4] Yu SG et al Geraniol, an inhibitor of mevalonate biosynthesis,
suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J
Nutr. 1995 Nov;125(11):2763-7. [5] Carnesecchi S, et al, Geraniol, a component of plant
essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J
Pharmacol Exp Ther. 2001 Jul;298(1):197-200.
naturally occurring component in cotton leaf and citrus peel is
a fluorescent substrate for peroxidase which has been used
by many investigators for the determination of hydrogen
peroxide concentration. [1]
Scopoletin is believed to have health benefits of blood
pressure lowering effect. In a study, scopoletin inhibited the
indirect electrical stimulation-evoked contractions of the cat
nictitating membrane ( IN VIVO); and also the contractions of
isolated perfused central ear artery of rabbit, induced by
electrical stimulation or intraluminal noradrenaline
administration. [2] Scopoletin also relaxed the smooth
muscles and inhibited the spasmogenic activities of a wide
variety of agonists on guinea-pig isolated ileum. [2]
Scopoletin may also have benefit on people at risk of certain
types of cancer. Scopoletin inhibited proliferation of certain
cancer cells by inducing apoptosis. [4,5]
Scopoletin was found to inhibit hepatic lipid peroxidation and
increased the activity of antioxidants, superoxide dismutase
and catalase. A few studies suggested that scopoletin might
benefit those at risk of high cholesterol, triglyceride and
glucose levels. [6]
Its major unwanted side effect of scopoletin probably is
increased bleeding time. [3]
[1] Corbett JT. The scopoletin assay for hydrogen peroxide. A review and a better
method. J Biochem Biophys Methods. 1989 Jun;18(4):297-307. [2] Ojewole JA and
Adesina SK, Mechanism of the Hypotensive Effect of Scopoletin Isolated from the Fruit
of Tetrapleura tetraptera. Planta Med. 1983 Sep;49(9):46-50. [3] Obasi SC et al, Effects
of single oral doses of scopoletin and aflatoxin B1 on the clotting time, serum
cholesterol and phospholipid levels of chicks. Indian J Physiol Pharmacol. 1994
Apr;38(2):89-94 [4] Liu XL et al, Effect of scopoletin on PC3 cell proliferation and
apoptosis. Acta Pharmacol Sin. 2001 Oct;22(10):929-33. [5] Manuele MG, et al,
Comparative immunomodulatory effect of scopoletin on tumoral and normal
lymphocytes. Life Sci. 2006 Oct 19;79(21):2043-8. Epub 2006 Jul 6. [6] Panda S, Kar A.
Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin
from Aegle marmelos leaves in hyperthyroid rats. Phytother Res. 2006
Dec;20(12):1103-5. [7] Yang JY, et al, Effect of scopoletin on lipoprotein lipase activity
in 3T3-L1 adipocytes. Int J Mol Med. 2007 Oct;20(4):527-31.
This article can not be used as medical advice. Please, consult with your
medical doctor for any question or before taking any drug products and
supplements. ALL RIGHTS RESERVED zhion 2008
Reference
[1] US Patent Application 20080020078 [2] Yu SG et al, Geraniol, an inhibitor of
mevalonate biosynthesis, suppresses the growth of hepatomas and melanomas
transplanted to rats and mice. J Nutr. 1995 Nov;125(11):2763-7. [3] Burke YD Inhibition
of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids.
1997 Feb;32(2):151-6. [4] Yu SG et al Geraniol, an inhibitor of mevalonate biosynthesis,
suppresses the growth of hepatomas and melanomas transplanted to rats and mice. J
Nutr. 1995 Nov;125(11):2763-7. [5] Carnesecchi S, et al, Geraniol, a component of plant
essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells. J
Pharmacol Exp Ther. 2001 Jul;298(1):197-200.
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