Policosanol Reference
REFERENCE
. A [1. Aleman CL, et al Carcinogenicity of policosanol in mice: an 18-month study. Food Chem Toxicol. 1995
Jul;33(7):573-8. 2. Aleman CL, Carcinogenicity of policosanol in Sprague Dawley rats: a 24 month study. Teratog
Carcinog Mutagen. 1994;14(5):239-49. 3. A 12-month study of policosanol oral toxicity in Sprague Dawley rats.
Toxicol Lett. 1994 Jan;70(1):77-87.4. Mesa AR et al, Toxicity of policosanol in beagle dogs: one-year study. Toxicol
Lett. 1994 Aug;73(2):81-90. 5. Rodriguez-Echenique C, Effects of policosanol chronically administered in male
monkeys (Macaca arctoides). Food Chem Toxicol. 1994 Jun;32(6):565-75. 6 Rodriguez MD et al, Teratogenic and
reproductive studies of policosanol in the rat and rabbit. Teratog Carcinog Mutagen. 1994;14(3):107-13.] [1]Fraga V
et al, Arch Med Res. 1997 Autumn; 28 (3): 355-60].[2]Fukuda, Effect of sugar cane wax on serum liver lipids on rats;
Chemical Abstracts, 106, 17, 137413p and[3] Sho H. et al, Effects of Okinawan sugar cane wax and fatty alcohols on
serum and liver lipids in the rates, J. Nutri. Vitaminol 30 (6) 553-559.[4]Shimura S. et al, Studies on the effect of
octacosanol on the motor endurance in mice; Nutrition Reports Int. 198736, 1029-1038.[5]Hagiwara Y. Antilipaemic
agents containing hexacosanol used to treat hypertension, arteriosclerosis, diabetes mellitus, heart disease and
obesity 1987. JP A 62 099323.[6] Mixture of higher primary aliphatic alcohols, its obtention from sugar cane wax and
its pharmaceutical uses, patent# 5663156. Patent # 5856316 [7]Biol Res. 1994;27(3-4):199-203] [8]Arruzazabala ML
et al, Cholesterol-lowering effects of policosanol in rabbits. Biol Res. 1994;27(3-4):205-8.[9]Biol Res.
1996;29(2):253-7][10] Composition for reducing serum cholesterol levels, Patents # 5952393 and 6197832. [11]Arch
Med Res. 2001 Jan-Feb;32(1):8-12][12] [Med Hypotheses. 2005;64(3):636-45].[13] Pons P et al, Effects of
successive dose increases of policosanol on the lipid profile of patients with type II hypercholesterolaemia and
tolerability to treatment. Int J Clin Pharmacol Res. 1994;14(1):27-33. [14] Results of the multicenter controlled study of
the hypolipidemic drug polycosanol in Russia Ter Arkh. 2000;72(12):7-10. [15]Gamez R. et Effects of concurrent
therapy with policosanol and omega-3 fatty acids on lipid profile and platelet aggregation in rabbits. Drugs R D.
2005;6(1):11-9. [16] Jacoby D. Drug treatment of intermittent claudication. Drugs. 2004;64(15):1657-70. [17] Castano
G, A double-blind, placebo-controlled study of the effects of policosanol in patients with intermittent claudication
Angiology. 1999 Feb;50(2):123-30. [18]Castano G et al, Effects of policosanol and ticlopidine in patients with
intermittent claudication: a double-blinded pilot comparative study. Angiology. 2004 Jul-Aug;55(4):361-71.[19]
Castano G et al, Effects of policosanol and lovastatin in patients with intermittent claudication: a double-blind
comparative pilot study. Angiology. 2003 Jan;54(1):25-38.[20] Arruzazabala ML et al, Effects of Policosanol on platelet
aggregation in rats. Thromb Res. 1993 Feb 1;69(3):321-7. [21]  Valdes S. Effect of policosanol on platelet
aggregation in healthy volunteers. Int J Clin Pharmacol Res. 1996;16(2-3):67-72.  [22] Arruzazabala ML Comparative
study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy
volunteers. Pharmacol Res. 1997 Oct;36(4):293-7. [23] Arruzazabala ML et al, Effect of policosanol on cerebral
ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2. Prostaglandins Leukot Essent Fatty Acids.
1993 Sep;49(3):695-7. [24] Menendez R et al, Inhibition of rat lipoprotein lipid peroxidation by the oral administration
of D003, a mixture of very long-chain saturated fatty acids. Can J Physiol Pharmacol. 2002 Jan;80(1):13-21.[25] Noa
M et al, Effect of policosanol on lipofundin-induced atherosclerotic lesions in rats, J Pharm Pharmacol. 1995
Apr;47(4):289-91. [26] Octacosanol supplementation increases running endurance time and improves biochemical
parameters after exhaustion in trained rats., J Med Food. 2003 Winter;6(4):345-51. [27] Castano G et al, Concomitant
use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol Res. 2004;24(2-3):65-77. [28]  Noa M et
al, Effect of policosanol on isoprenaline-induced myocardial necrosis in rats. J Pharm Pharmacol. 1994
Apr;46(4):282-5. [29] Carbajal D et al Effect of policosanol on experimental thrombosis models. Prostaglandins Leukot
Essent Fatty Acids. 1994 May;50(5):249-51. [30] Bai S et al  Space Med Med Eng (Beijing). 1997 Dec;10(6):450-2.
[31] Noa M et al, Policosanol prevents bone loss in ovariectomized rats., Drugs Exp Clin Res. 2004;30(3):117-23.[32]
Effect of policosanol on platelet aggregation in healthy volunteers, Int J Clin Pharmacol Res. 1996;16(2-3):67-72.[33]
Fernandez S, A pharmacological surveillance study of the tolerability of policosanol in the elderly population. Am J
Geriatr Pharmacother. 2004 Dec;2(4):219-29. [33] Chen JT et al, Meta-analysis of natural therapies for
hyperlipidemia: plant sterols and stanols versus policosanol. Pharmacotherapy. 2005 Feb;25(2):171-83. [34] A
two-year study on the efficacy and tolerability of policosanol patients with type II hyperlipoproteinaemia, Int J Clin
Pharmacol Res. 1995;15(4):159-65]. [35] Results of the multicenter controlled study of the hypolipidemic drug
polycosanol in Russia Ter Arkh. 2000;72(12):7-10. [36] An ezetimibe-policosanol combination has the potential to be
an OTC agent that could dramatically lower LDL cholesterol without s ide effects. Med Hypotheses.
2005,64(3):636-45. [37] Chen JT et al, Meta-analysis of natural therapies for hyperlipidemia: plant sterols and stanols
versus policosanol. Pharmacotherapy. 2005 Feb;25(2):171-83. [38]  Varady KA Role of policosanols in the prevention
and treatment of cardiovascular disease. Nutr Rev. 2003 Nov;61(11):376-83. [39] Castano G et al, Effects of
policosanol and lovastatin on lipid profile and lipid peroxidation in patients with dyslipidemia associated with type 2
diabetes mellitus. Int J Clin Pharmacol Res. 2002;22(3-4):89-99. [40] Castano G, Comparison of the efficacy, safety
and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II
hypercholesterolemia. Int J Clin Pharmacol Res. 2002;22(2):55-66. [41] McCarty MF. An ezetimibe-policosanol
combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without s ide effects.
Med Hypotheses. 2005;64(3):636-45. [42] Castano G et al Effects of policosanol 20 versus 40 mg/day in the
treatment of patients with type II hypercholesterolemia: a 6-month double-blind study. Int J Clin Pharmacol Res.
2001;21(1):43-57. [43] Lin Y., Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to
mildly elevated cholesterol concentrations. Metabolism. 2004 Oct;53(10):1309-14. [44] Policosanol contents and
compositions of wheat varieties. J Agric Food Chem. 2005 Jul 13;53(14);5583-6. C1 Policosanol S ide Effects
Chinese- school netfirms.com online publication. June 2005 2 C2Femandez L et al. Policosanol;results of a
postmarketing surveillance control on 27,879 patients. Curr Ther Res. 1998;59:717-722. [C3] Arruzazabalab ML.
Effect of policosanol successive dose increases on platelet aggregation in healthy volunteers. Pharmacol Res.
1996;34:181-185, [C4] Arruzazabala ML et al. Comparative study of policosanol, aspirin and the combination therapy
policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res. 1997;36:293-297. [C5] Carbajal D
et al. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy
volunteers. Prostaglandins leukot Essent Fatty Acids 1998;58:61-64. [D1] Thippeswamy G, et al, Octacosanol isolated
from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B
and its DNA binding activity. Eur J Pharmacol. 2008 Jul 7;588(2-3):141-50.
THIS WEBSITE TALKS ABOUT THE SIDE EFFECTS AND THE POTENTIAL HEALTH BENEFITS OF HERBS, SUPPLEMENTS, PHYTONUTRIENTS AND DRUG
PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES. ARTICLES IN THIS WEB SITE IS FOR YOUR
REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2009. DO NOT
COPY NOR TRANSFER ARTICLES TO OTHER WEBSITES NOR OTHER FORMS OF PUBLICATIONS.
Privacy Policy. ARTICLE INDEX/ Science
This website discusses the benefits and side effects of various supplements, herbs and drug products.
Different side effects to FDA, its website is
www.fda.gov., or report the adverse side effects to the
manufacturer, you should be able to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s).
Reasonable care has been taken in preparing this document and the information provided herein is believed
to be accurate. The information is not intended to be a substitute for professional medical advice. It is
important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of a supplement or a drug product. Finally, please, do not transfer the article to other website. Thank
you. ALL RIGHTS RESERVED.
P1. Kassis AN et al, Sugar cane policosanols do not reduce LDL oxidation in hypercholesterolemic individuals., Lipids.
2009 May;44(5):391-6. 2. Murphy KJ, et al, Lack of effect of sugar cane and sunflower seed policosanols on plasma
cholesterol in rabbits. J Am Coll Nutr. 2008 Aug;27(4):476-84. [3] Francini-Pesenti F, et al, Sugar cane policosanol
failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: a double blind, controlled study.
Complement Ther Med. 2008 Apr;16(2):61-5. [4] Kassis AN, et al, Changes in cholesterol kinetics following sugar cane
policosanol supplementation: a randomized control trial. Lipids Health Dis. 2008 Apr 30;7:17 [5] Francini-Pesenti F, et
al, Effect of sugar cane policosanol on lipid profile in primary hypercholesterolemia, Phytother Res. 2008
Mar;22(3):318-22. [6] Dullens SP, et al, Effects of emulsified policosanols with different chain lengths on cholesterol
metabolism in heterozygous LDL receptor-deficient mice. J Lipid Res. 2008 Apr;49(4):790-6.