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Policosanol
Side Effects, Safety, Benefits, sugar cane, Research study    October 22, 2011
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Policosanol Dosage

Policosanol Dosages in Experiments
The common range of policosanol dosages used in clinical studies is from 5-50 mg. Here is a summary of a few studies:

1. Policosanol was administered at 20 mg/day for 7 days significantly inhibited platelet aggregation, while the low
policosanol dosage (5 mg/day) was ineffective. No adverse-effects were reported. [21]

2. Researchers applied single doses (5-50 mg) to healthy volunteers. Policosanol administered at 20 mg/day for 7 days
significantly inhibited platelet aggregation. No toxic nor side effects were observed. .[32]

3. Nikitin IuP et al, compared efficacy and tolerance of polycosanol vs besafibrate in 113 patients with
hypercholesterolemia. 59 patients received polycosanol (10 mg/day), 54 patients were given besafibrate (400 mg/day)
for 8 weeks. After 8-week course of treatment, daily 10 mg of policosanol is more effective on cholesterol-lowering.
And,  the adverse effects in the group taking policosanol were mild. [35]

4. Policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20
mg/day dose in a 6-month study. [42]
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Reference
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POLICOSANOL
Policosanol is a mixture of primary aliphatic alcohols-tetracosanol, hexacosanol, heptacosanol, octacosanol,
nonacosanol, triacontanol, dotriacontanol and tetratriacontanol [Patent 5663156]. The manufacturing method for
policosanol include ethanol extraction and purification. Its melting point is 70-82C. Policosanol is insoluble in water. Most
clinical trials suggest policosanol may decrease cholesterol levels. Policosanol may help prevent atherosclerotic lesions
and cerebral ischemia in Mongolian gerbils.[1]

Early study about policosanol's effect on cholesterol level
In 1984, sugar cane wax was demonstrated to be able to lower lipid in rodents.[2,3] Later, another study demonstrated
that octacosanol (a policosanol) could lower triglyceride and cholesterol contents in the liver.[4] In 1987, a study
demonstrated that high doses of hexacosanol (a policosanol) had cholesterol lowering effects. [5] Thus, policosanol was
"suspected" to be able to benefit people with a high cholesterol profile.

In 1994, Cuban researchers reported that policosanol inhibited the cholesterol synthesis at early steps of cholesterol
biosynthetic pathway in a study of human lung fibroblasts. They also reported that policosanol lowered the total
cholesterol mainly through a decrease in LDL-C levels in a study of rabbits. They filed the first patent on the policosanol
composition.[6-8] In 1996, the Cuban researchers reported that oral policosanol could inhibit hepatic cholesterol
biosynthesis in rats.[9] Two years later, a group filed a patent on a composition containing policosanol to reduce serum
cholesterol levels.[10] Policosanol reduced cholesterol levels in patients suffered from type II hypercholesterolaemia.
[13]

Mechanism
In 2001, the Cuban researchers transferred fibroblast to a lipid-depleted medium to accelerate cholesterol synthesis.
Addition of policosanol retarded the cholesterol synthesis in a dose-dependent manner. [11]
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Benefits, Side Effects, Polycosanol Sugar cane, Policosanol Cholesterol, Dosages  Reference