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Side Effects, Safety, Benefits, sugar cane, Research study October 22, 2011
Policosanol Dosages in Experiments
The common range of policosanol dosages used in clinical studies is from 5-50 mg. Here is a summary of a few studies:
1. Policosanol was administered at 20 mg/day for 7 days significantly inhibited platelet aggregation, while the low
policosanol dosage (5 mg/day) was ineffective. No adverse-effects were reported. 
2. Researchers applied single doses (5-50 mg) to healthy volunteers. Policosanol administered at 20 mg/day for 7 days
significantly inhibited platelet aggregation. No toxic nor side effects were observed. .
3. Nikitin IuP et al, compared efficacy and tolerance of polycosanol vs besafibrate in 113 patients with
hypercholesterolemia. 59 patients received polycosanol (10 mg/day), 54 patients were given besafibrate (400 mg/day)
for 8 weeks. After 8-week course of treatment, daily 10 mg of policosanol is more effective on cholesterol-lowering.
And, the adverse effects in the group taking policosanol were mild. 
4. Policosanol at a dose of 40 mg/day does not offer significant additional cholesterol-lowering efficacy over the 20
mg/day dose in a 6-month study. 
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Policosanol is a mixture of primary aliphatic alcohols-tetracosanol, hexacosanol, heptacosanol, octacosanol,
nonacosanol, triacontanol, dotriacontanol and tetratriacontanol [Patent 5663156]. The manufacturing method for
policosanol include ethanol extraction and purification. Its melting point is 70-82C. Policosanol is insoluble in water. Most
clinical trials suggest policosanol may decrease cholesterol levels. Policosanol may help prevent atherosclerotic lesions
and cerebral ischemia in Mongolian gerbils.
Early study about policosanol's effect on cholesterol level
In 1984, sugar cane wax was demonstrated to be able to lower lipid in rodents.[2,3] Later, another study demonstrated
that octacosanol (a policosanol) could lower triglyceride and cholesterol contents in the liver. In 1987, a study
demonstrated that high doses of hexacosanol (a policosanol) had cholesterol lowering effects.  Thus, policosanol was
"suspected" to be able to benefit people with a high cholesterol profile.
In 1994, Cuban researchers reported that policosanol inhibited the cholesterol synthesis at early steps of cholesterol
biosynthetic pathway in a study of human lung fibroblasts. They also reported that policosanol lowered the total
cholesterol mainly through a decrease in LDL-C levels in a study of rabbits. They filed the first patent on the policosanol
composition.[6-8] In 1996, the Cuban researchers reported that oral policosanol could inhibit hepatic cholesterol
biosynthesis in rats. Two years later, a group filed a patent on a composition containing policosanol to reduce serum
cholesterol levels. Policosanol reduced cholesterol levels in patients suffered from type II hypercholesterolaemia.
In 2001, the Cuban researchers transferred fibroblast to a lipid-depleted medium to accelerate cholesterol synthesis.
Addition of policosanol retarded the cholesterol synthesis in a dose-dependent manner. 
Benefits, Side Effects, Polycosanol Sugar cane, Policosanol Cholesterol, Dosages Reference