|NUTRATERIC -An innovative
enteric coating system
Nutrateric is an aqueous enteric coating system designed
specifically to meet the regulatory requirements for dietary
supplement, nutritional and herbal products. It can be applied
to tablets and capsuleseasily using standard processing
equipment with reliable and reproducible enteric protection.
Nutrateric adds value and functionality to nutritional products
with a unique delayed release feature. Delayed release is aimed
to reduce unpleasant flavors and odors and enhance the
stability of natural ingredients in the unfriendly acidic
environment in the stomach and improve product performance.
The Nutrateric coating dispersion is comprised of Surelease�
E-7-19010 supplied as a liquid at 25% solids concentration,
and NS Enteric™ 29Z19241 supplied as a dry powder.
A final dispersion concentration of 10% solids is recommended
for film uniformity.
PREPARATION OF A FILM COATING SYSTEM
CONTAINING SURELEASE AND NS ENTERIC
A. Materials Calculation:
i) Determine total solids required based on target coating
weight and quantity of tablets to be coated.
Quantity Tablets to be coated kg x Target Coating Weight (%)
= Total Required Solids kg (A).
ii) Determine quantity of coating solution needed as a 10%
Total Required Solids kg (A) / 0.10 = Coating Solution kg (B).
iii) Based on 85 : 15 ratio of Surelease: NS Enteric solids,
determine the quantity of each product required.
Total Required Solids kg (A) x 85% = Surelease Solids kg (C).
Total Required Solids kg (A) x 15% = NS Enteric Solids kg
iv) Since Surelease is supplied as a 25% solids dispersion,
determine the quantity needed based on required solids.
Surelease solids kg (C) / 0.25 = Quantity Surelease Dispersion
Required kg (E)
v) Determine quantity water required.
Quantity Surelease Dispersion kg (E) + NS Enteric solids kg
(D) = (F)
Coating Solution kg (B) - (F) = Quantity Water Required (G)
B. Nutrateric Preparation
i) Transfer the necessary quantity of water (G) into a suitable
ii) Stir the water to form a vigorous vortex.
iii) Add NS Enteric (D) and slowly.
iv) Continue to mix for 60 minutes but at lower speeds to insure
v) Gently agitate the Surelease container to ensure complete
dispersion of solids (E). Add this to the breaker and continue
mixing for 10 to 15 minutes.
Vi) Continue to mix the suspension during the coating process.