Lidoderm (Lidocaine Patch) As Effective As
Oral Medication- Celebrex; Research finds
Oral Medication- Celebrex; Research finds
ZHION APRIL 2005
Recent literature and animal research has provided insight to potentially new analgesic targets
for managing osteoarthritis (OA) pain. Primary afferent neurons located in affected joints
express excessive amounts of abnormally functioning sodium (Na) channels on their surface in
response to the inflammatory process. These Na channels may play an integral role in
production of pain and hyperalgesia [3]. Researchers at Endo Pharmaceuticals, Inc. found a
significant improvement for pain intensity, pain relief, and pain interference with quality of life
when lidocaine patch was applied onto the knee directly. The lidocaine patch 5% was generally
well tolerated and no patients discontinued due to treatment-related adverse events.
Recent literature and animal research has provided insight to potentially new analgesic targets
for managing osteoarthritis (OA) pain. Primary afferent neurons located in affected joints
express excessive amounts of abnormally functioning sodium (Na) channels on their surface in
response to the inflammatory process. These Na channels may play an integral role in
production of pain and hyperalgesia [3]. Researchers at Endo Pharmaceuticals, Inc. found a
significant improvement for pain intensity, pain relief, and pain interference with quality of life
when lidocaine patch was applied onto the knee directly. The lidocaine patch 5% was generally
well tolerated and no patients discontinued due to treatment-related adverse events.
Osteoarthritis currently affects 20 million people in the United States [2]. Kivitz A J et al with the
Altoona Arthritis and Osteoporosis Center in Duncansville, Pennsylvania, randomly assigned
143 patients to Lidoderm (ie lidocaine patch) once daily or to take Celebrex. After 12 week of
study, 71 percent of those in the Lidoderm group and 72 percent in the celecoxib group
experienced a 30 percent or greater improvement in average daily pain intensity [1].
REFERENCES
[1] Karla Gale, Lidocaine Patch Curbs Osteoarthritis Pain, Reuters Health, Mon Apr 4, 2005
[2] Pain Patch As Effective As Oral Medication , Sci-Tech Today, United Press International,
April 4, 2005
[3] Galer BS et al, Topical lidocaine patch 5% may target a novel underlying pain mechanism in
osteoarthritis., Curr Med Res Opin. 2004 Sep;20(9):1455-8
Altoona Arthritis and Osteoporosis Center in Duncansville, Pennsylvania, randomly assigned
143 patients to Lidoderm (ie lidocaine patch) once daily or to take Celebrex. After 12 week of
study, 71 percent of those in the Lidoderm group and 72 percent in the celecoxib group
experienced a 30 percent or greater improvement in average daily pain intensity [1].
REFERENCES
[1] Karla Gale, Lidocaine Patch Curbs Osteoarthritis Pain, Reuters Health, Mon Apr 4, 2005
[2] Pain Patch As Effective As Oral Medication , Sci-Tech Today, United Press International,
April 4, 2005
[3] Galer BS et al, Topical lidocaine patch 5% may target a novel underlying pain mechanism in
osteoarthritis., Curr Med Res Opin. 2004 Sep;20(9):1455-8
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1. Benefits of cod liver oil
2. Devil's claw side effects and benefits
3. How does resveratrol benefit animals suffered from arthritis?
4. Shark cartilage side effects and benefits
5. Stinging nettles - health benefits on various conditions such as coughs, tuberculosis &
arthritis.
6. Wheat grass health benefits
7. Fish oil side effects
8. Borage oil may benefit people suffered from rheumatoid arthritis.
9. Rutin may help arthritis.
10. Health benefits of cherry
11. Chestnut side effects and benefits
12. Feverfew, reputed by folklore to be effective in arthritis
13. Hyaluronic acid - a treatment for arthritis?
14. Boswellia Serrata benefits - arthritis and colitis
15. Celery health benefits and nutritional facts
16. How does chondroitin benefit osteoarthritis?
17. Achyranthees bidentata may have anti-inflammatory, anti-arthritis and analgestic effects.
18. Health benefits of Rosmarinic acid
19. Health benefits of Cyanidin
20. Maitake Benefits and Side Effects
21. Capsicum [red chili pepper] benefits and side effects
22. Yucca -Preliminary study shows these saponins may benefit arthritis
23. Fenugreek benefits on arthritis.
24. Hops may have anti-inflammation effects and benefit arthritis.
25. Oldenlandia diffusa may also benefit animals suffered from inflammation and arthritis.
26. Evening primrose oil in rheumatoid arthritis.
27. Health benefits of nobiletin
28. Atractylodes--- Does it have health benefits?
29. Honokiol stabilized the severity of symptomatic collagen-induced arthritis
30. Black cohosh - It may also benefit people suffered from arthritis.
31. Chamomile benefits and side effects
32. Saffron benefits and side effects
33. Burdock has been claimed to benefit in a wide variety of conditions, including arthritis
34. Glucosamine side effects
35. Ashwaganha side effects and its effects on inflammation
36. Watermelon may help...
37. Turmeric side effects
38. Royal jelly
39. Celadrin benefits
40. Does grape seed extract lower bad cholesterol?
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