Reishi mushroom benefits, reishi benefits, reishi side effects
September 09, 2011
Reishi Mushroom Review
Reishi [Lingzhi, Ganoderma lucidum] mushroom is a popular supplement with an impressive array of reputed health
benefits.  Reishi mushroom has gain a superior reputation among all herbs in Asia. It has been described as a magical
herbal medicine from the Mysterious East. Reishi mushroom is the highest grade of mushroom in the world of fungi.
Some herbalists call reishi mushroom as "The King of All Herbs" or "The Miraculous King of Herbs. Reishi mushroom is
also called as Lingzhi in China, Reishi in Japan and Youngchi in Korea.

Reishi mushrooms grow wild on decaying logs and tree stumps in the coastal provinces of China. Reishi mushroom
grows in six different colors, but the red reishi is the popular.  Reishi has been shown to have benefits on variuos
conditions such as general fatigue and weakness, asthma, insomnia, and cough for thousand years. Reishi's Chinese
name ling zhi means the herb of spiritual potency.  Reishi contains sterols, coumarin, mannitol, polysaccharides, and
triterpenoids [ganoderic acids].

Reishi mushroom benefits with scientific evidence

Reishi Benefits - Antioxidative activities
Reishi mushroom extract demonstrated anti-oxidative activities against heart toxicity in mice in a dose-dependent
manner [1] .

Reishi Benefits - Immunocompetence
Reishi mushroom was safe to horses with respect to the CBC and blood biochemistry data after the reishi dosing.
Reishi mushroom increased the percentage of CD5+, CD4+ and CD8+ T-lymphocytes and the amount of specific
antibody production in horses. [2] A fraction (F3) of a reishi polysaccharide extract was shown to activate the
expression of IL-1, IL-6, IL-12, IFN-gamma, TNF-alpha, GM-CSF, G-CSF and M-CSF. [3]

Reishi Benefits - Blood pressure, LDL and Coronary artery disease
Ganoderic acids (of reishi mushroom) may lower blood pressure and LDL (the bad cholesterol}. These specific
triterpenoids may also help reduce blood platelets from sticking together -an important factor in lowering the risk for
coronary artery disease. Two controlled clinical trials have shown that reishi mushroom could lower high blood pressure
significantly .  [Note. The people with hypertension in the second study had previously not responded to medications,
though these were continued during the study.] [4-6]

Reishi Benefits - Altitude sickness and Hepatitis B
Reishi mushroom may have some efficacy in treating altitude sickness and chronic hepatitis B. [7]  

Reishi Benefits - Glomerulosclerosis
Reishi mushroom may suppress endothelial cell cytotoxicity and proteinuria in 14 patients of glomerulosclerosis. [8]

Reishi Benefits - Diabetes Mellitus
Reishi may have some benefits for people suffered from diabetes mellitus. [9] Zhang HN and Lin ZB, Peking University,
Beijing, investigated the hypoglycemic effect of reishi mushroom polysaccharides in the normal fasted mice and the
possible mechanism. They found that reishi mushroom extract could lower the glucose level in a dose-dependent
manner however the reishi extract had no effect on islets insulin content. [10]

Reishi Benefits - Cancer
Reishi mushroom has been shown to have potiential benefits on the treatment or prevention of certain cancers.  
Reshishi mushroom has demonstrated anticancer activities in experiments with cancer cells. [11]

A Japanese research group extracted triterpene acid, lucidenic acid P (1a), and two triterpene acid methyl esters,
methyl lucidenates P (1b) and Q (2b) from the fruiting body of the reishi mushroom. All of the compounds from reishi
extracted showed potent inhibitory effects on Epstein-Barr virus early antigen induction (96-100% inhibition at 1 x 10(3)
mol ratio/TPA). [12]

Colon cancer Hong KJ et al, Texas Tech University, found that reishi mushroom extract causes no cytotoxicity in human
colon carcinoma HT-29 cells at doses less than 10000 microg/ml. Increasing concentrations of reishi extract reduced
prostaglandin E2 production, but increased nitric oxide production. Together with other data, reishi extract has been
shown to have pro-apoptotic and anti-inflammatory functions, as well as inhibitory effects on cytokine expression during
early inflammation in colonic carcinoma cells. [13]

Breast Cancer Reishi mushroom (ganoderma lucidum) inhibited proliferation of breast cancer MDA-MB-231 cells by
downregulating Akt/NF-kappaB signaling. [14]

Prostate Cancer Reishi mushroom inhibits cell proliferation in a dose- and time-dependent manner by the
down-regulation of expression of cyclin B and Cdc2 and by the up-regulation of p21 expression for the human prostate
caner cells PC-3. The reishi inhibition of the cancer cell growth was also demonstrated by cell cycle arrest at G2/M
phase. [15]

Reishi Benefits - Ulcer
New Zealead researchers observed the anti-ulcer activities of reishi mushroom on the rat. They extracted the
water-soluble polysaccharide from reishi mushroom (ganoderma lucidum) and inhibited the indomethacin-induced
gastric mucosal lesions successfully in rats with the reishi extracts. [16]

Reishi can be taken either as 1.5 grams per day of the crude dried mushroom, 1-1.5 grams per day in powdered

Reishi mushroom side effects include dizziness, dry mouth and throat, nosebleeds, and abdominal upset. If you
experience any side effects of reishi mushroom, you must stop using it and inform your doctor immediately. For details,
please, click [
Reishi Side Effects]
Reference [1] Wong KL et al Antioxidant activity of ganoderma lucidum (reishi) in acute ethanol-induced heart toxicity. Phytother Res. 2004
Dec;18(12):1024-6.] [2] [Lai SW et al, Influence of ganoderma lucidum on blood biochemistry and immunocompetence in horses. Am J
Chin Med. 2004;32(6):931-40.] [3] Chen HS et al, Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum
(Reishi) polysaccharides. Bioorg Med Chem. 2004 Nov 1;12(21):5595-601] [4] Kammatsuse K, Kajiware N, Hayashi K. Studies on
Ganoderma lucidum: I. Efficacy against hypertension and side effects. Yakugaku Zasshi 1985;105:531–3. [5] Jin H, Zhang G, Cao X, et
al. Treatment of hypertension by ling zhi combined with hypotensor and its effects on arterial, arteriolar and capillary pressure and
microcirculation. In: [6] Nimmi H, Xiu RJ, Sawada T, Zheng C. (eds). Microcirculatory Approach to Asian Traditional Medicine. New York:
Elsevier Science, 1996, 131–8.] [7] [Hobbs C. Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107] [8] Futrakul N et
al, Ganoderma lucidum suppresses endothelial cell cytotoxicity and proteinuria in persistent proteinuric focal segmental
glomerulosclerosis (FSGS) nephrosis, Clin Hemorheol Microcirc. 2004;31(4):267-72. [9] [Jones K. Reishi mushroom: Ancient medicine
in modern times. Alt Compl Ther 1998;4:256–66 [review].] [10] Zhang HN et al, Hypoglycemic effect of Ganoderma lucidum
polysaccharides, Acta Pharmacol Sin. 2004 Feb;25(2):191-5] [11] [Sliva D, Methodist Research Institute, IN, Ganoderma Lucidum (Reishi)
in cancer treatment, Integr Cancer Ther. 2003 Dec;2(4):358-64.] [12] Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids
from the fungus Ganoderma lucidum (reishi) and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2003 Dec;66(12):
1582-5] [13]  [Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells.
Phytother Res. 2004 Sep;18(9):768-70.] [14] Jiang J et al,Ganoderma lucidum suppresses growth of breast cancer cells through the
inhibition of Akt/NF-kappaB signaling. Nutr Cancer. 2004;49(2):209-16.] [15] [Jiang J et al, Ganoderma lucidum inhibits proliferation and
induces apoptosis in human prostate cancer cells PC-3, Int J Oncol. 2004 May;24(5):1093-9] [16]  [Gao Y et al, Ganoderma lucidum
polysaccharide fractions accelerate healing of acetic acid0induced ulcers in rates. J Med Food. 2004 Winter;7(4):417-21] [17] Hobbs C.
Medicinal Mushrooms. Santa Cruz, CA: Botanica Press, 1995, 96–107]
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