Dong Quai reviews

Dong Quai [Angelica sinensis, Chinese angelica; Angelica acutiloba root (Japanese Dong Quai)]

Dong Quai is a member the celery family of plants. Dong Quai produces white flowers in summers, and it can be
found moist areas. The root of the Dong Quai plant has been used in herbal medicine.

Dong Quai Benefits
Dong Quai is often included in herbal combinations to provide health benefits for abnormal menstruation,
including suppressed menstrual flow, dysmenorrhea (painful menstruation), and uterine bleeding. [6] However, it
may not have any benefits on menopause, or related symptoms such as hot flashes. Further, dong quai does not
produce estrogen-like responses in endometrial thickness or in vaginal maturation and was no more helpful than
placebo in relieving menopausal symptoms. [5] Traditional Chinese medicine employs dong quai in treating both
men and women with high blood pressure or related conditions. [4]

Angelica acutiloba root (Japanese Dong Quai) Benefits on Lipid Profiles
High-fat diet-induced obese rats were treated orally with the Dong Quai root extract once daily for 8 weeks. The
Dong Quai Root Extract (300 mg/kg per day) supplementation significantly lowered body weight gain, visceral fat-
pad weights and plasma lipid levels, as well as the coronary artery risk index and the atherogenic index of HFD-
fed rats. The Dong Quai Root Extract caused dose related reductions in the hepatic triglyceride and cholesterol
contents, as well as lowered hepatic lipid droplet accumulation and epididymal adipocyte size in the HFD-fed rats.

In another study, insulin resistance was induced in rats by feeding a high fructose diet for 6 weeks. Thereafter,
the rats were maintained on the same diet and treated with oral A. acutiloba root extract or pioglitazone once daily
for 8 weeks. A. acutiloba (300 mg/kg/day) displayed similar characteristics to pioglitazone (20 mg/kg/day) in
reducing HOMA-IR and elevating ISIcomp. Elevated glycosylated hemoglobin levels and hyperinsulinemia were
ameliorated by A. acutiloba treatment without hepatotoxic or nephrotoxic effects. A. acutiloba was effective to
improve insulin sensitivity in the animal study. [A2]

Does dong quai benefit people at menopause?
Herbal formulations such as dong quai, ginseng, kava, and dietary soy, among others, do not appear to benefit
patients more than placebo. [A3]

Does dong quai have benefits on people suffered from breast cancer?
Current use of fish oil was associated with reduced risk of breast cancer (HR, 0.68; 95% CI, 0.50-0.92). These
results held for ductal but not lobular cancers. The remaining specialty supplements were not associated with
breast cancer risk: Specifically, use of supplements sometimes taken for menopausal symptoms (black cohosh,
dong quai, soy, or St. John's wort) was not associated with risk. [A4]

Dong Quai Side Effects
Most supplements have side effects, the type and severity of side effects vary from person to person. In general,
supplements side effects include stomach upset, nausea, vomiting, burping, gas, or fever. While, a common dong
quai side effect is the increased sensitivity of skin to sunlight. User should avoid direct exposure to the sun or
other sources of UV light.

Dong quai might act like estrogen. Do not take dong quai if you have hormone-sensitive conditions such as
breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids.  Scientists from Hong Kong
Chinese University found that water extracts of dong quai stimulated the growth of estrogen receptor-positive
(MCF-7) breast cancer cells and augmented the estrogen receptor-negative (BT-20) breast cancer cell
proliferation. [1]

Dong quai may give unpleasant side effects to male users. Dong Quai is a supplement for ladies. In Singapore, a
man was found to develop gynaecomastia (Man Boobs) after ingestion of "Dong Quai" pills. The effect might be
related to the higher levels of phytoestrogen in the pills. [2]

Dong quai may interact with anticoagulants and hormone medications inducing a serious side effect. Examples of
anticoagulant (blood thinners) include
ferverfew, garlic, ginger, ginkgo, ginseng, licorice, Chinese skullcap and
turmeric. Hormone medications include estrogens, progesterones, oral contraceptives, tamoxifen or raloxifene.

NIH has the following comments on phytoestrogens:
Phytoestrogens may serve as chemopreventive agents while at the same time being capable of promoting growth
in estrogen receptor positive cancer cell lines. Furthermore, they may exert their estrogenic influence through
receptor-dependent and/or receptor-independent mechanisms. These findings have led to speculation that
phytoestrogen intake might be ill advised for patients at an increased risk for hormone-dependent cancers,
cancer patients, or cancer survivors. [3]

This might not be a complete list about the product side effects. If you notice any side effects of the product,
please contact your doctor or the manufacturer immediately. You should be able to find the contact information
from the product label, and explain what side effect you have to the manufacturer. In the US you may report side
effects to FDA at 1-800-FDA-1088. In Canada - you may report side effects to Health Canada at 1-866-234-2345.
dong quai abortion
No report about dong quai and abortion is found as of September 6, 2011

dong quai fertility
Dong quai has been claimed for inability to conceive children, however, the support is limited.

REFERENCE: [1] Lau CB et al Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with
breast cancer: is it appropriate?, Menopause. 2005 Nov-Dec;12(6):734-40. Epub 2005 Nov 8. [2] Goh SY et al, Gynaecomastia and
the herbal tonic "Dong Quai". Singapore Med J. 2001 Mar;42(3):115-6. [3] Piersen CE Phytoestrogens in botanical dietary
supplements: implications for cancer. Integr Cancer Ther. 2003 Jun;2(2):120-38. 4. Foster S, Yue CX. Herbal Emissaries.
Rochester, VT: Healing Arts Press, 1992, 65–72. 5. Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in
postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981–6. 6. Qi-bing M, Jing-yi T, Bo C.
Advance in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese danggui). Chin Med J 1991;104:776–81.
[A1] Liu IM, Tzeng TF, Liou SS, Chang CJ. Regulation of Obesity and Lipid Disorders by Extracts from Angelica acutiloba Root in
High-fat Diet-induced Obese Rats. Phytother Res. 2011 Jun 6.
[A2]Liu IM, Tzeng TF, Liou SS, Chang CJ. Angelica acutiloba Root Attenuates Insulin Resistance Induced by High-Fructose Diet in
Rats. Phytother Res. 2011 Feb 9. [A3]Hill DA, Hill SR. Counseling patients about hormone therapy and alternatives for menopausal
symptoms. Am Fam Physician. 2010 Oct 1;82(7):801-7. [A4]Brasky TM, Lampe JW, Potter JD, Patterson RE, White E. Specialty
supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort. Cancer Epidemiol Biomarkers Prev. 2010 Jul;19
Dong quai reviews, dong quai benefits, dong quai side effects
September 06, 2011
dong quai side effects
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