Nelarabine (compound 506U78) is the
water-soluble, 6-methoxy analog of
9-beta-D-ara-G. Nelarabine is readily converted
to ara-G by endogenous adenosine deaminase.
The half-life of nelarabine is approximately 15
minutes compared with 2-4 hours for ara-G.
The clearance of ara-G is higher in children
than in adults (0.312 vs 0.213 L x h(-1) x kg(-1)).
Severe myelosuppression was not
consistently observed. Major responses were
seen in patients with T-cell malignancies.
Patients who responded had significantly
higher intracellular ara-GTP concentrations
compared with those who did not respond.
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