Scientific Evidence for The Effectiveness of Hyaluronic Acid Topical Products
The hyaluronic acid topical products may be applied for local treatments such as dermatitis, wound healing and
wrinkles. Mostly, hyaluronic acid is blended with other active ingredients in the topical products. Here is a summary of
scientific studies:

Skin Care - Atopic Dermatitis and Wound Healing
MAS063D is a hydrolipidic hyaluronic acid cream that has been developed for the management of atopic dermatitis.
The putative active ingredients of MAS063D are hyaluronic acid, telmesteine, Vitis vinifera, glycyrrhetinic acid. A
five-week study in 30 adult patients with mild to moderate atopic dermatitis showed that MAS063D offered significant
benefits over placebo. MAS063D improved the total body area affected (17.2% --> 13.2%), itch score (2.7 --> 1.3 on a
10-point scale) and EASI score (28.3 --> 24.3) after 22 days treatment compared to baseline. [6] Hyaluronic acid
(hyaluronan) is a key component of the extracellular matrix and is known to be involved in several mechanisms of the
wound healing process. It has been shown to improve and accelerate the healing process of chronic wounds. An
open-label study shows that application of hyaluronic acid could also improve the healing progression of acute wounds.
[10] The following cases are reported in the past few years. Oxygen free-radicals are known to impair wound healing
after ischaemia-reperfusion or polymorphonuclear cell stimulation. Male Sprague-Dawley rats with open wounds
received phenazine methosulfate or zimosan, or had abdominal sepsis to induce oxygen free-radical generation. Rats
received hyaluronic acid cream, hyaluronic acid ethyl ester gel, or placebo treatment. Hyaluronic acid and its ethyl ester
derivative significantly improved the wound healing of rats subjected to an increased generation of oxygen
free-radicals. [1] For details, please, review HYALURONIC ACID CREAM.

Skin Care - Wrinkles and Appearance
Hyaluronic acid injection has also been used to restore the earlobe volume for patients seeking a youthful facial
HYALURONIC ACID INJECTIONS] Can hyaluronic acid topical products have this effect?

A study was conducted to observe the efficacy of topical application of 0.1% hyaluronan (a hyaluronic acid)
formulations of different molecular weights (MW) (50, 130, 300, 800 and 2000 kDa, respectively) in the periocular area
as anti-wrinkle treatment. Seventy-six female subjects between 30 and 60 years of age with clinical signs of periocular
wrinkles applied one of the formulations twice-daily to the area of interest in a randomized fashion for 60 days. Around
the other eye, a vehicle control cream was applied. Measurements of skin hydration and skin elasticity were performed
before treatment, 30 and 60 days thereafter. At similar time points negative replicas were taken and evaluated by
semi-automated morphometry. All hyaluronic acid topical products utilized in this study demonstrated a significant
improvement in skin hydration and overall elasticity values (R2) when compared to placebo. Measurements of wrinkle
depth using mean roughness (Ra) and maximum roughness (Rz) values revealed significant improvement in the 130
and the 50 kDa HA group after 60 days of treatment compared to placebo-treated area. Conclusion: Topical application
of all 0.1% hyaluronic acid formulations used in this study led to significant improvement in skin hydration and elasticity.
Application of low-molecular-weight (LMW) HA was associated with significant reduction of wrinkle depth, which may be
due to better penetration abilities of LMW hyaluronic acid. This is a recent study reported by Pavicic T and other
scientists at Evonik Goldschmidt GmbH, Germany in September of 2011. [TP-1]

Oral Ulcers
The use of topical Hyaluronic acid in the treatment of oral ulcers has been recently reported. [TP-2]
Hyaluronic Acid Topical Products - Wrinkles
November 09, 2011    
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accurate. The information is not intended to be a substitute for professional medical advice. It is important to seek
the advice of a physician about any medical condition or symptom or the benefits and side effects of a supplement
or a drug product. Finally, please, do not transfer the article to other website. Thank you. ALL RIGHTS RESERVED.
Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide, and N-acetyl glucosamine and D-glucuronic acid are the repeating units of this polymer.Hyaluronic acid is
considered as the most important space filling substance in the human body. Hyaluronic Acid holds water to keep collagen hydrated and "youthful".
Hyaluronic Acid forms a viscous fluid with exceptional lubricating properties necessary for the vital functions of many parts of the human body
including the skin, heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the bodies
Hyaluronic Acid. Considering that skin is over 70% water and renews itself more readily than most other bodily tissues. Definitely hyaluronic Acid
may have benefits on skin's structure and daily maintenance. An enzyme-cleaving technique has been developed to break down Hyaluronic Acid
into lower molecular weight polymers. This allows easy absorption of Hyaluronic Acid when taken orally. Then, how does the hyaluronic acid work as
a topical product?