Hyaluronic Acid Serum
November 1, 2011
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Hyaluronic acid serum
Serum is the clear liquid that can be separated from clotted blood, while hyaluronic acid is a glycosaminoglycan and is
essential for protecting the cartilage surface by its physical property. So, to me, hyaluronic acid serum is the
hyaluronic acid concentration in serum. Hyaluronic acid does exist in serum. However, high serum hyaluronic acid
concentration may indicate some kinds of diseases such as rheumatoid arthritis. [1] Hyaluronic acid in serum has
even been suggested as a bio-marker (indicator) for arthritis. [5] Schistosomiasis mansoni is a fibrogenic liver disease
that constitutes a major health problem in north-eastern Brazil. The serum concentrations of hyaluronic acid were
found to be positively correlated with the severity of the periportal fibrosis. [2] Another study also demonstrates that
increase in serum hyaluronic acid concentration above a predictive value (52.0 ng/mL) to be associated with liver
fibrosis. [3] Elevated serum hyaluronic acid concentration is really not a good sign. Collagen type IV and hyaluronic
acid are the major components of basement membrane and extracellular matrix, respectively. Cathepsin D is an
aspartyl lysosomal protease involved in the degradation of the basement membrane and extracellular matrix. A study
of 50 gastric cancer patients shows that the contents of collagen type IV and hyaluronic acid in gastric juice and
hyaluronic acid in serum were significantly higher in patients with gastric cancer than those in patients with
precancerous lesion and control group. [4]

Hyaluronic acid serum as a product
Currently, manufacturers markets use "hyaluronic acid serum" this term as a name for their hyaluronic acid topical

From their compositions, these products are semi-solids, probably gels. The applications of hyaluronic acid gel on
skin issues have been studied extensively. For example, the laser Affirm™ (LA) is a microthermal, non-ablative
fractional laser used for skin rejuvenation. Restylane Vital™ Light (RVL) in the Restylane® Injector, a formulation of
stabilized hyaluronic acid-based gel of non-animal origin, is indicated for rejuvenation of delicate skin. In a study, 9
female patients aged 42-62 years received four treatments, each comprising RVL followed immediately by LA
treatment. Improvements in fine wrinkles, tightness and skin texture were observed. However, an inflammatory
reaction (1000 μm) was seen. [6] A 4-month-old infant with epiblepharon of the right lower eyelid presented with
medial eyelashes touching the corneal surface in primary gaze and resultant punctate epithelial keratopathy.
Hyaluronic acid gel (Juvederm Ultra) 0.2 ml was injected in the suborbicular plane in the valley above the abnormal
skin fold. Immediate out-turning of the eyelid margin was obtained, which 4.5-month follow-up visits with no lash-
corneal touch even in down gaze. [7] Finally, hyaluronic acid gel has also been used as dermal fillers for wrinkles. [8]

In a study, line treatment was formulated with multiple growth factors, antioxidants, and a collagen-building peptide-
ingredients that have been shown to increase collagen levels and provide long-term aesthetic benefits. Hyaluronic
acid filling spheres and a muscle contraction-inhibiting peptide were also included in the formulation. Three-month,
single-center, open-label, clinical study with clinical assessments at Baseline, Minutes (within 15 minutes of initial
application), Month 1, and Month 3. Treatment: Subjects treated periocular and perioral wrinkles twice daily for three
months with the line treatment. Participants: Thirty-seven females, 33 to 45 years of age, with mild-to-moderate, fine
and coarse periocular and perioral wrinkles, were enrolled in the study. Investigator assessments of both periocular
and perioral wrinkles showed statistically significant improvements over Baseline within minutes of initial application;
these positive findings continued to improve through Months 1 and 3.  This study demonstrate that this topical
treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and
coarse wrinkles.[8]
Product Name
Hyaluronic Acid Serum -
1 fl. oz.
De-ionized Water, Aloe Vera Leaf Gel*, Vegetable Glycerin,
Xanthan Gum, Natural Aroma, Sodium Hyaluronate
(Hyaluronic Acid), Green Tea Extract, Algae Extract, Soluble
Collage and Cedar Bark Extract
derma e Hyaluronic Acid
Rehydrating Serum
Water (Purified), Glycerin, Sodium Hyaluronate (Hyaluronic
Acid), Calcium Ascorbate (Ester C), Allantoin (Comfrey Root),
Panthenol, Alanine, Leucine, L-Tyrosine, Dimethicone,
Glycine, Valine, Ammonium Acrylyl Dimethyltaurate / VP
Copolymer, Ceteareth 20, Xanthan Gum, Phenoxyethanol,
Ethylhexl Glycerin, Potassium Sorbate, Natural Fragrance,
Copolyol (Aristoflex)
Reviva Labs
Hyaluronic Acid Serum
Demineralized spring water, glycerine (veg.), hyaluronic acid,
polysorbate 20, hydrolyzed mucopolysaccharides, green tea
extract, hydroxyethylcellulose, simethicone, carmelized sugar,
potassium sorbate, sodium benzoate, citric acid.
Nature's Way
Hydraplenish, Hyaluronic
Acid Serum, Ultra
Potency, 1 fl oz (30 ml)
Sodium hyaluronate, water, SD alcohol 38-B (organic
lavender alcohol)*, althea officinalis (marshmallow) root
extract, chaenomeles japonica (quince) seed extract,
aesculus hippocastanum (horse chestnut) seed extract,
sodium PCA.
Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide and its monomers are N-acetyl glucosamine and D-glucuronic acid. Hyaluronic acid can be found within collagen
throughout the body. As the most important space filling substance in the human body. Hyaluronic Acid holds water to keep collagen hydrated and
"youthful". Hyaluronic Acid forms a viscous fluid with exceptional lubricating properties necessary for the vital functions of many parts of the human
body including the skin, heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the
bodies Hyaluronic Acid. Considering that skin is over 70% water and renews itself more readily than most other bodily tissues. Definitely hyaluronic
Acid may have benefits on skin's structure and daily maintenance.