Hyaluronic acid injection uses, benefits - Reviews
Hyaluronic acid is found in high concentrations in cartilage and synovial fluid, and is an important component of the extracellular matrixes-exerting
joint lubrication and buffering actions thanks to its viscoelastic properties. Hyaluronic acid injection shows benefits to patients suffered from
shoulder, knee and joint osteoarthritis.

Joint stiffness secondary to immobilization was inhibited by intra-articular hyaluronic acid injection in an experimental joint contracture in rabbits. In
1985, hyaluronic acid was reported that it could reduce the measured stiffness in the contracture by approximately 50% as compared to the
contractures of the untreated rabbits. Thus, people wonder if there is also such benefit for human.

Hyaluronic acid has also been reported that it was able to protect against damage to articular cartilage and help to lessen friction between joint
surfaces. Hyaluronic acid is effective for pain relief and for the risk of adhesion, and contractures of joints. The injection of hyaluronic acid is useful
for the treatment of frozen shoulder, osteoarthritis, and rheumatoid arthritis. [2] However, in a study, web-questionnaire was sent to 1000 members
of an international association of surgeons specialized in sports traumatology and knee surgery. 70% of surgeons considered that, among
conservative treatments, hyaluronic acid injection was not an appropriate management for large tendon tears with 70% fatty infiltration of the
infraspinatus tendon and lateral long head of biceps instability. Researchers at Tufts Medical Center reviewed 54 randomized clinical trials of
intra-articular hyaluronic acid Vs placebo on knee osteoarthritis and concluded that intra-articular hyaluronic acid is efficacious by 4 weeks, reaches
its peak effectiveness at 8 weeks and exerts a residual detectable at 24 weeks.

Facial aging, resulting in lower facial ptosis often leads to downward angulation of the oral commissure, which may lead to troublesome angular
chelitis. Treatment involving a combination of hyaluronic acid injection into the marionette lines and botulinum toxin A to the depressor anguli oris
has been successful in a few cases. Hyaluronic acid injection has also been used to restore the earlobe volume for patients seeking a youthful
facial appearance. Hyaluronic acid has also been used for the correction of facial lines. It was believed that hyaluronic acid injection fillers were safe
and had no occurrence of serious side effects. However, side effects of intermittent swelling and severe granulomatous allergic reactions that
evolved into abscesses have been reported. In a rare clinical case, after hyaluronic acid injection in the treatment of nasolabial folds elsewhere, a
54 year old patient developed palpable painful erythematous nodules evolving into abscesses several months after injection. Serious side effects
are uncommon, most patients enjoy the benefits of hyaluronic acid products.

Hyaluronic Acid History
After Solaraze(R) was approved  for the topical treatment of actinic keratoses on October 16, 2000, hyaluronic acid was immediately gotten to be
famous in cosmetic wrinkle removing preparation. Solarze(R) is a drug containing topical gel, it contains 3% diclofenac sodium, benzyl alcohol,
hyaluronate sodium, polyethylene glycol monomethyl ether, and purified water. On the other hand, hyaluronic acid injection preparations have been
shown to benefit patients suffered from knee osteoarthritis. Hyaluronic acid decreases pain and improves conditions such as synovial fluid
viscoelasticity, wrinkle smoothing, cartilage metabolism, and inflammation.

Hyaluronic Acid Chemistry
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid. It can be found within
collagen throughout the body. Hyaluronic Acid holds water to keep collagen hydrated and "youthful". Hyaluronic Acid forms a viscous fluid with
exceptional lubricating properties necessary for the vital functions of many parts of the human body including the skin, heart valves, aqueous/
vitreous humor of the eye and synovial fluid (joint lubricant). The skin contains over 50% of the bodies  Definitely hyaluronic Acid may have benefits
on skin's structure and daily maintenance.

Source of Hyaluronic Acid
Hyaluronic Acid is made by human fibroblast cells. Commercial sources may be from Cocks combs, Chicken cartilage or Microbial fermentation.
Vegetarian source may be made via microbial fermentation.

Hyaluronic acid (hyaluronan or hyaluronate)is synthesized by hyaluronan synthases. These enzymes lengthen hyaluronan by repeatedly adding
glucuronic acid and N-acetylglucosamine to the nascent polysaccharide as it is extruded through the cell membrane into the extracellular space.
The food sources for glucuronic acid are Jerusalem artichokes and some other plants. While,  N-Acetylglucosamine (GlcNAc) is a monosaccharide
that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin. Chitin is present in most fungal cell
walls, insect exoskeletons, the shells of crustaceans and parts of invertebrates. Since most of us do not eat insect nor crab shells, we may simply
obtain hyaluronic acid raw materials (monomers) from the supplement-source for the potential benefits of hyaluronic acid.

Hyaluronic Acid Applications - Mechanism
Our bodies are in a continual state of rebuilding. New skin cells for example replace old ones about every 20 to 30 days. Normally, Hyaluronic Acid
in skin tissue is broken down by hyaluronidase. And, the rate of Hyaluronic Acid degradation can be increased by excess intake of riboflavin (B-2),
ultraviolet radiation exposure or viruses. Any long-term overexposure to any of these may result in premature connective tissue destruction.

Hyaluronic acid is a type of sugar (polysaccharide) that is present in body tissues, such as in skin and cartilage. It is able to combine with water and
swell when in gel form, causing a wrinkle smoothing effect. Sources of hyaluronic acid used in wrinkle fillers can be from bacteria or rooster combs
(avian). In some cases, hyaluronic acid used in wrinkle fillers is chemically modified (crosslinked) to make it last longer in the body. The effects of
this material last approximately 6 – 12 months.

In the past, because of its large molecular weight, the absorption for Hyaluronic Acid in the digestive tract was almost impossible. However, an
enzyme-cleaving technique has been developed to break down Hyaluronic Acid into lower molecular weight polymers. This allows easy absorption of
Hyaluronic Acid when taken orally. Studies have shown that this lighter Hyaluronic Acid might improve wound healing, facial moisture, and benefit
skin smoothness. But its greatest benefit has been seen in joint function. Assuming that 10-150 mg of Hyaluronic Acid is a normally metabolized or
excreted daily with the higher rate of loss in persons over 50, it may make sense for older adults to begin supplementing with 1- 50mg capsule 3
times daily just to maintain equilibrium.
Hyaluronic Acid Reviews
Hyaluronic Acid Benefits, Side Effects , Tablets/Capsules, Serum, Cream and Injection July 25, 2013
Hyaluronic Acid Side Effects, Danger, Risk - Reviews

Hyaluronic Acid Injection Side Effects
While users enjoy the benefits of hyaluronic acid injections, a few of them may also experience the hyaluronic acid side effects. In general, the
side effects are mild-
bruising, redness, swelling, pain, tenderness and itching. For the use in knee osteoarthritis, hyaluronic acid injection is
well-tolerated. Hyaluronic acid side effects mostly limited to local pain and swelling. While, the side effects of hyaluronic acid dermal fillers are mainly
mild inflammations. For special applications of hyaluronic acid get injections, rare side effects such as facial ischemia and herpes simplex virus
reactivation occurred. Hyaluronic acid gel should not be used in patients suffered from severe allergies. In some cases, serious hyaluronic acid side
effects happened for those received more than one injection.

Hyaluronic Acid Topical Products - Creams, Serums - Side Effects
Side effects of hyaluronic acid topic products have not been reported in scientific journals. Technically, users can wipe out the topical product on
the affected site, once they experience discomfort. Thus, the side effects of a hyaluronic acid topical product such as cream or serum are not
serious and long lasting.

Hyaluronic Acid Oral Supplements - Tablet and Capsules - Side Effects
Side effects of oral hyaluronic acid products such as tablets or capsules are not found in scientific journals. Probably, they are well-tolerated, as
hyaluronic acid is a natural polymer.

Up to date, reports of hyaluronic acid side effects are mainly limited to hyaluronic acid injection preparations not its oral preparations such as tablets
and capsules.  
This website discusses the benefits and side effects of various supplements, herbs and drug products. Different people
experience different side effects of hyaluronic acid, you are encouraged to report your experience the side effects of
hyaluronic acid to FDA, its website is
www.fda.gov., or report the adverse side effects to the manufacturer, you should
be able to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s). Reasonable
care has been taken in preparing this document and the information provided herein is believed to be accurate. The
information is not intended to be a substitute for professional medical advice. It is important to seek the advice of a
physician about any medical condition or symptom or the benefits and side effects of a hyaluronic acid products
including tablet, capsule, cream, serum, injection and more. Finally, please, do not transfer the article to other website.
The Uses and Potential Benefits of Hyluronic Acid - Reviews

The major potential benefit of hyluronic acid is its support on osteoarthritis, skin conditions such as actinic keratose,
wrinkles and fold. Hyaluronan preparations have shown to decrease pain but improve the mobility of patients suffered
from knee osteoarthritis. The improvement in the condition is possibly related to alternations in the synovial fluid
viscoelasticity, cartilage metabolism, and inflammation.
High molecular weight hyaluronic acid (Hylan G-F 20) and low
molecular weight hyaluronic acid both benefit patients suffered from knee osteoarthritis.

Skin Care and Wrinkles
Regulatory approval in the USA, Canada and Europe was granted recently for 3% diclofenac in 2.5% hyluronic acid gel,
Solaraze(R), for the topical treatment of actinic keratoses. This injectable
Restylane (hyaluronic acid) gel was approved
on March 25, 2005. It is a transparent hyaluronic acid gel that is injected into facial tissue to smooth wrinkles and folds,
especially around the nose and mouth (nasolabial folds). This hyaluronic acid gel works by temporarily adding volume to
facial tissue to restore a smoother appearance to the face. The effect of this hyaluronic acid gel can last for about 6
months. In a clinical study, most patients needed one injection of this hyaluronic acid gel to achieve the optimal benefits
of wrinkle smoothing; about one-third of patients needed more than one injection of this hyaluronic acid gel to get a
satisfactory result.

Other Potential Uses / Benefits
Endoscopic Hyaluronic Acid/Dextranomer Gel Implantation was found to be effective as first-line treatment of
vesicoureteral reflux in children. Hydrogel made of hyaluronic acid-poly-D lysine was found to be compatible to rat brain
tissue as this hydrogel has an open porous structure and its viscoelastric properties are also similar to the neural
tissue's. 1% hyaluronic acid gel associated with a collagen scaffold was found to benefit new bone formation in
critical-size defects in a rat study.
Hyaluronic acid cream, uses, benefits and Reviews
Hyaluronic acid cream has been applied to atopic dermatitis and wound healing, and it does show benefits in studies.

Atopic Dermatitis
MAS063DP cream containing hyaluronic acid has received marketing authorization in the US and the European Union for
symptom relief of atopic dermatitis (or eczema) and contact dermatitis. A study of radiation dermatitis in patients
receiving radiotherapy for breast cancer also shows the effective benefits of this particular hyaluronic acid cream on for
radiation dermatitis and erythema.

Hyaluronic Acid Cream for Wound Healing
Hyaluronic acid is a key component of the extracellular matrix and is known to be involved in the wound healing process.
It has been shown to improve and accelerate the healing process of chronic wounds. An open-label study shows that
application of hyaluronic acid could also improve the healing progression of acute wounds. Oxygen free-radicals are
known to impair wound healing after ischaemia-reperfusion or polymorphonuclear cell stimulation. Male Sprague-Dawley
rats with open wounds received phenazine methosulfate or zimosan, or had abdominal sepsis to induce oxygen
free-radical generation. Rats received hyaluronic acid cream, hyaluronic acid ethyl ester gel, or placebo treatment.
Hyaluronic acid and its ethyl ester derivative significantly improved the wound healing of rats subjected to an increased
generation of oxygen free-radicals. Thus, hyaluonic acid may benefit people suffered from certain skin conditions.
Hyaluronic Acid Skin Care - Reviews
The mechanism for the hyaluronic acid wrinkler filler is straight forward, and it works very well. Now, the question is how can hyaluronic acid topical
products, such as serum or cream, work? These products are applied to the skin surface only! How does hyaluronic acid benefit people with certain
skin conditions?

The skin barrier, stratum corneum, locates at the outermost layer of the skin. This skin barrier is composed of corneocytes, embedded in organized
complex lipid domains. In the process of epidermal renewal, keratinocytes arrive at the outermost layer of the epidermis, the keratinocytes become
corneocytes, anucleated flattened cells, filled with keratin. This is a water insoluble protein, and contributes the protective function of skin.
Moisturizing of the skin is the first anti-aging skin care. Skin moisturization is essential for its appearance, protection, complexion, softness and the
reinforcement of its barrier properties against hostile environmental factors. The intrinsic water binding capacity of skin is not only due to the
complex natural moisturizing factor present in dead cells, but also to
hyaluronic acid and a regulated water transport within the skin. Thus,
applying hyaluronic acid serum or cream is actually moisturizing the skin. This is how hyaluronic acid benefits our skin.

Oral Hyaluronic Acid Supplements, Tablets, Capsules - Benefits & Uses - Reviews
High molecular weight hyaluronic acid can not be absorbed to our body, only low molecular weight hyaluronic acid can be absorbed. It is not sure if
the absorbed hyaluronic acid is able to diffuse to the joint to relieve the pain or to the skin to remove the wrinkles. However, some articles indicate
the benefits of the oral hyaluronic acid supplements. Because hyaluronic acid is a naturally-occurring chemical in our body, oral hyaluronic acid side
effect is not expected at low doses for healthy adults.
Hyaluronic Acid Injection Side Effects - Reviews of Individual Cases

Most patients do not experience side effects or experience only mild side effects. Serious side effects are very rare but
happen. And mostly, the patients are able to recover within a period of time.

Side Effects: Red knee, hot knee, knee very swollen, knee effusion.

A male patients with a history of osteoarthritis, who experienced knee redness, knee warmth, knee swelling, and knee
effusion after starting synvisc. The patient had a history of previous treatments with synvisc. He received two injections
of synvisc into his knee. At an unspecified time after the patient's second injection of synvisc the injected knee became
"red, hot and very swollen. "  


A female who received an injection of perlane (cross-linked hyaluronic acid dermal filler) and an injection of restylane
(cross-linked hyaluronic acid dermal filler) experienced side effects. Medical history included previous cosmetic surgery
including a face lift, facial peel, tummy tuck, breast reduction and breast lift. Concomitant medications included armour
thyroid for an unknown duration. The patient received a 1 ml injection of perlane and a 2 ml injection of restylane to the
nasolabial fold and the prejowl area. Pre-procedure medications included unspecified general anesthesia. Additional
procedures at the time of implantation included an arm lift and a facial peel. Soon after the procedure, the patient
experienced an inability to move the right side of her face well.

AESTHETIC USE 02/11/2011
Side Effects: Redness. Injection site swelling. Slight itching at injection sites. Tender, erythematous nodules. Allergic
reaction. Burning.

A female injected with prevelle silk. The patient then experienced an allergic reaction. The patient's medical history
included radial keratotomy in 1986, abdominal liposuction and mild depression in 1995, post menopausal in 2003, right
eye ablation to correct vision in 2007, and juvederm (cross-linked hyaluronic acid) to the lips in 1998. Prevelle silk
treatment was injected for crow's feet and the lips for vertical perioral lines only. The patient experienced redness,
swelling, burning, slight itching at the injection sites which was around both eyes at the crow's feet and the vertical
perioral lines around the mouth. The severity of the symptom was

Side Effects: erythema, oedema and pruritus

A female pt was treated with 3 injections of hyalgan in the knee. On an unk date, the pt was treated with hyalgan in the
left shoulder, and she experienced eruption on left ear, erythema, oedema and pruritus. (Note, This side effect is
related to an injection, not an oral dosage form.) Three months earlier, the pt received one injection of hyalgan
20mg/2ml and on the same evening she experienced serum sickness, urticaria, and fever to 39. 5 degrees celsius some
days later. The pt was hospitalized on six days later, for fever to 38. 7 degrees celsius and urticaria without mucous
infringement; she
recovered with corticotherapy. No arthralgia. At the time of the reporting, the pt has recovered.

Hyaluronic acid is a natural compound, its preparations are well-tolerated, and beneficial to patients suffered from
osteoarthritis. However, hyaluronic acid can also be used as a wrinkle remover. Hyaluronic acid can be injected or
applied topically. Oral preparations of hyaluronic acid are also available.

In most cases, its side effects are mild (if happen), and mainly related to the injection preparations. Serious cases also
happened, but they are rare. And mostly, the serious side effects happened after multiple hyaluronic acid injections.
Users must discuss with their medical doctors before receiving such treatment.
In a study, line treatment was formulated with multiple growth factors, antioxidants, and a collagen-building peptide-ingredients that have been
shown to increase collagen levels and provide long-term aesthetic benefits. Hyaluronic acid filling spheres and a muscle contraction-inhibiting
peptide were also included in the formulation.

Subjects treated periocular and perioral wrinkles twice daily for three months with the line treatment showed statistically significant improvements
over baseline within minutes of initial application; these positive findings continued to improve through Months 1 and 3.  This study demonstrate that
this topical treatment was well tolerated and provided both immediate and long-term improvements in the appearance of fine and coarse wrinkles.[8]

Hyaluronic acid gel uses, benefits - Reviews
The applications of hyaluronic acid gel on skin issues have been studied extensively. For example, the laser Affirm™ (LA) is a microthermal, non-
ablative fractional laser used for skin rejuvenation.

Restylane Vital™ Light (RVL) in the Restylane® Injector, a formulation of stabilized hyaluronic acid-based gel of non-animal origin, is indicated for
rejuvenation of delicate skin. In a study, 9 female patients aged 42-62 years received four treatments, each comprising RVL followed immediately by
LA treatment. Improvements in fine wrinkles, tightness and skin texture were observed. An inflammatory reaction also occurred. [6] A 4-month-old
infant with epiblepharon of the right lower eyelid presented with medial eyelashes touching the corneal surface in primary gaze and resultant
punctate epithelial keratopathy. Hyaluronic acid gel (Juvederm Ultra) 0.2 ml was injected in the suborbicular plane in the valley above the abnormal
skin fold. Immediate out-turning of the eyelid margin was obtained, which 4.5-month follow-up visits with no lash-corneal touch even in down gaze.
[7] Finally, hyaluronic acid gel has also been used as dermal fillers for wrinkles. [8]

Hyaluronic acid serum uses, benefits - Reviews
Serum is the clear liquid separated from clotted blood, hyaluronic acid exists in serum. High hyaluronic acid concentration in serum may indicate
some kinds of diseases such as rheumatoid arthritis. [1] Consequently, serum hyaluronic acid has even been suggested as a bio-marker for
arthritis. [5] Schistosomiasis mansoni is a fibrogenic liver disease, in this disease, the serum concentrations of hyaluronic acid were found to be
positively correlated with the severity of the periportal fibrosis. [2] Serum hyaluronic acid concentration above a value of 52.0 ng/mL may indicate
liver fibrosis. [3] Elevated serum hyaluronic acid concentration is really not a good sign. Hyaluronic acid in serum is also significantly higher in
patients with gastric cancer. [4] On the other hand, a few manufacturers markets call their hyaluronic acid topical products as "hyaluronic acid
serum". From their compositions, their products are likely semi-solid.
Product Name
Hyaluronic Acid Serum - 1 fl. oz.
De-ionized Water, Aloe Vera Leaf Gel*, Vegetable Glycerin, Xanthan Gum, Natural
Aroma, Sodium Hyaluronate (Hyaluronic Acid), Green Tea Extract, Algae Extract,
Soluble Collage and Cedar Bark Extract
derma e Hyaluronic Acid Rehydrating Serum
Water (Purified), Glycerin, Sodium Hyaluronate (Hyaluronic Acid), Calcium
Ascorbate (Ester C), Allantoin (Comfrey Root), Panthenol, Alanine, Leucine,
L-Tyrosine, Dimethicone, Glycine, Valine, Ammonium Acrylyl Dimethyltaurate / VP
Copolymer, Ceteareth 20, Xanthan Gum, Phenoxyethanol, Ethylhexl Glycerin,
Potassium Sorbate, Natural Fragrance, Copolyol (Aristoflex)
Hyaluronic Acid Serum
Demineralized spring water, glycerine (veg.), hyaluronic acid, polysorbate 20,
hydrolyzed mucopolysaccharides, green tea extract, hydroxyethylcellulose,
simethicone, carmelized sugar, potassium sorbate, sodium benzoate, citric acid.
Hydraplenish, Hyaluronic Acid Serum, Ultra
Potency, 1 fl oz (30 ml)
Sodium hyaluronate, water, SD alcohol 38-B (organic lavender alcohol)*, althea
officinalis (marshmallow) root extract, chaenomeles japonica (quince) seed extract,
aesculus hippocastanum (horse chestnut) seed extract, sodium PCA.
Amount Per Serving
Vitacost Hyaluronic Acid with BioCell
Collagen II®
BioCell Collagen II 1000 mg (Hydrolyzed Collagen Type II 600 mg, Chondroitin Sulfate
200 mg and Hyaluronic Acid 100 mg)
Nature's Way Hydraplenish® Plus MSM
1. BioCell Collagen II 1000 mg (Hydrolyzed Collagen Type II 600 mg, Chondroitin
Sulfate 200 mg and Hyaluronic Acid 100 mg) 2. MSM (Methylsulfonylmethane) as
OptiMSM® 500 mg
Nature's Way Hydraplenish® Hyaluronic
BioCell Collagen II 1000 mg (Hydrolyzed Collagen Type II 600 mg, Chondroitin Sulfate
200 mg and Hyaluronic Acid 100 mg)
Jarrow Formulas Hyaluronic Acid
Hyaluronic Acid 100 mg
NeoCell Fish Collagen plus HA With
Natural Hyaluronic Acid
Fish Super Collagen™ 2 g, PureHA™ Natural Hyaluronic Acid 20 mg, and a few other
minerals and vitamins.
Lifetime Liquid Hyaluronic Acid Berry
Hyaluronic Acid (hen comb) 100 mg; Sugar (fruit juice concentrate blend) 5 g
Source Naturals Skin Eternal Hyaluronic
BioCell Collagen Yielding 1 g (Hydrolyzed Collagen Type II 600 mg, Chondroitin
Sulfate 200 mg and Hyaluronic Acid 100 mg)
NeoCell Hyaluronic Acid
Hyaluronic Acid 100 mg
Swanson Ultra Hyal-Joint Super Potency
Hyaluronic Acid
Hyaluronic Acid 100 mg; Collagen (from Hyal-Joint®) 25 mg Other Glycosaminoglycans
(from Hyal-Joint®) 17 mg
NOW Foods Hyaluronic Acid with MSM,
Vegetarian Capsules
Sodium from Sodium Hyaluronate 9 mg, Hyaluronic Acid from Sodium Hyaluronate, 100
mg, MSM Methylsulphonylmethane, 900 mg
Veg Hyaluronic Acid MSM/Glucosamine
Glucosamine HCL 500 mg, MSM 333 mg, Hyaluronic Acid 6.75 mg
Botox Vs Hyaluronic acid - Side Effect and Benefit Consideration
Botox is a drug made from a toxin produced by the bacterium Clostridium botulinum. Botox is the same toxin that causes
a life-threatening type of food poisoning called botulism. Doctors use it in small doses to treat facial wrinkles, severe
underarm sweating, and cervical dystonia. In most cases, Botox is safe without serious side effects and users are happy
with this product. However, FDA has received reports of systemic adverse side effects including respiratory compromise
and death following the use of botulinum toxins types A and B for both FDA-approved and unapproved uses. The
reactions reported are suggestive of botulism. The most serious cases of side effects had outcomes that included
hospitalization and death. Thus, some people prefer to have hyaluronic acid injection for treating their wrinkles or