Health EQ: Androstadienone,
Sweat, Smell and Sex
Popular Health Issues-Facts and Prevention
Claire Wyart from the University of California at
Berkeley reported that people secrete a scent that
influences the hormones of the opposite sex.
Androstadienone found in male sweat, saliva and
semen affected women's mood, sexual and
physiological arousal and brain activation. [2]
Delta 4,16-androstadien-3-one (androstadienone)
alters cerebral glucose utilization both in subcortical
regions and in areas of the neocortex not exclusively
associated with olfaction. [3]

Researchers found that smell of androstadienone shot
up cortisol levels within 15 minutes and stayed elevated
for up to an hour in the study of 48 female
undergraduates at Berkeley. In general, cortisol helps
maintain proper arousal and sense of well-being,
respond to stress and other functions. [2]
In fact, researchers have found that for both men and
women odors influence mood, which in turn influences
pain unpleasantness perception. Some studies showed
that the steroid androstadienone modulates mood
differently in men and women, improving mood in
women and worsening it or leaving it unchanged in men.
In the absence of pain, androstadienone improved
mood only in women, while the pleasant odorants
improved mood for both sex. [1]

Interestingly, Villemure C and Bushnell MC from McGill
Centre for Research on Pain found the presence of
androstadienone increased perceived pain intensity
especially in women, suggesting an effect of
androstadienone on pain perception, independent of
mood changes. [1]


[1] Villemure C, Bushnell MC. The effects of the steroid
androstadienone and pleasant odorants on the mood and pain
perception of men and women. Eur J Pain. 2007 Feb;11(2):181-91.
Epub 2006 Mar 20. [2] Will Dunham For women, nothing's like the
smell of men's sweat HealthDay Wed Feb 7, 2007 5:36 PM ET [3]
Jacob S, et al, Neuroreport. 2001 Aug 8;12(11):2391-4. Sustained
human chemosignal unconsciously alters brain function.
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