In vitro Fertilization and Premature Ovarian Failure
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In vitro fertilization (IVF), eggs are surgically removed from the ovary and
mixed with sperm outside the body in a Petri dish to achieve fertilization. After
about 40 hours, the eggs are examined to see if they have become fertilized
by the sperm and are dividing into cells. The fertilized egg (embryo) is then
transferred into the uterus to begin a pregnancy or cryopreserved (frozen) for
future use. In vitro fertilization has received a great deal of media attention
since it was first introduced in 1978, but it actually accounts for less than five
percent of all infertility treatment in the United States. The average cost of an
in vitro fertilization cycle in the United States is about $12,400. [1]
Premature ovarian failure is characterized by secondary oligomenorrhoea
or amenorrhoea and serum follicle stimulating hormone (FSH) levels above
40 IU/l before or at the age of 40. The incidence is 1:1000 below age 30 and
1:100 below age 40. The chance to conceive spontaneously after premature
ovarian failure is about 5-10%. Currently, there is no treatment available to
restore ovarian function and increase the pregnancy rate. In vitro fertilization
using oocyte donation is the only successful fertility treatment option. [2, 3]
REFERENCES:
[1] American Society for Reproductive Medicine, Online-Publication, October
5, 2005. [2] van Kasteren YM, Premature ovarian failure, Ned Tijdschr
Geneeskd. 2000 Nov 4;144(45):2142-6. [3] Letur H et al, Spontaneous
pregnancies and premature menopause, Gynecol Obstet Fertil. 2004
Sep;32(9):748-55.
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