ENTERYX AN ALTERNATIVE TO PRILOSEC, PREVACID, PEPCID, TAGAMET OR ZANTAC
ENTERYX Zhion August 8, 2005
Many people can get relief from have gastroesophageal reflux disease (GERD) symptoms by changing their diet, life-style and/or using drugs. Drugs commonly used to manage GERD symptoms include proton pump inhibitors (PPIs), such as PrilosecÂ® and PrevacidÂ®, H2 receptor antagonists, such as PepcidÂ®, TagametÂ® and ZantacÂ®, and common antacids, such as MaaloxÂ® or MylantaÂ®. In the past, when the drugs became ineffective, anti-reflux surgery was almost the only alternative treatment for GERD symptoms.
On April 22, 2003, Enteryx Procedure Kit (Manufacturer: Enteric Medical Technologies, Inc.) was approved by FDA to treat GERD symptoms. The Enteryx procedure became another alternative treatment to long-term drug use or anti- reflux surgery for GERD. Enteryx is a permanently implanted device but the Enteryx procedure is a minimally invasive treatment option, performed on an outpatient basis. Enteryx is a liquid polymeric material that is injected into the muscle of the lower esophageal sphincter (LES), through an endoscope (a tube used to look at the esophagus and stomach). After the injection, the solvent separates away, leaving Enteryx to solidify into a spongy material, i.e. a permanent implant in the sphincter muscle. Enteryx is intended to reduce the symptoms of GERD by helping the LES keep stomach fluids and acids from backing up into the esophagus. It does not affect the stomachÂ’s ability to produce acid or other digestive fluids. The Enteryx device kit comes with an injection catheter, syringes, and needles are also contained within the device kit.
Enteryx device is used in patients who have persistent symptoms of gastroesophageal reflux disease (GERD) with regular use of PPI medications. If these conditions apply, and your symptoms have responded well to one of the medications, then you may be a candidate for Enteryx. However, you should avoid Enteryx, if you have distended veins in the esophagus, portal hypertension or chronic liver disease.
Enteryx procedure is simple. After the patient has received the sedation, the doctor will place an endoscope down into the patentÂ’s esophagus. The endoscope allows the doctor to see the lining of esophagus and stomach. The doctor will then find the place for injection. The doctor will insert a small tube (catheter) with a needle on its end through the endoscope to the place where the injection is needed. The doctor injects Enteryx material through the catheter and needle. The doctor will use a fluoroscope to check where the Enteryx is injected. The procedure typically takes less than one hour. After the procedure is completed, the patient will be monitored in a recovery room. The patient usually can go home on the same day. However, the patient needs to arrange for someone to drive him home.
In a study, most patients had at least one side effect of the treatment. In a study, about 90% had chest pain below the breastbone after the procedure. However, half of these cases, the pain disappeared in a week. Most patients needed pain medications to treat their pain. Specifically, about 20% had a hard time to swallow after the procedure. This could persist several days or longer. About 10% had fevers right after the procedure. About 10% had sore throats after the procedure and this condition persisted for a week. About 6-7% had more gas including bloating, belching and flatulence after the procedure. Other side effects include nausea, garlic body-odor, bleeding, ulceration, erosion, perforation, fistula and mediastinitis. After the procedure, after 67% of the patients was no longer taking any of the PPI drugs.
Reference www.bostonscientific.com/patient-education August 8, 2005
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