Hedera helix (Hedera helix   var. colchica, chang chun teng長 春 滕)

Hedera helix (Hedera helix   var. colchica, chang chun teng長 春 滕)is a plant well-known as ivy or English
ivy, and a member of the Araliaceae family. [5]

In 1990, French researchers reported the antimutagenic activities of some saponins extracted from
Hedera helix. [1] In 2001, researchers further evaluated the antimutagenic activities of a saponin
compound - alphahederin extracted from Hedera helix. These results demonstrated the antimutagenic
activity of alphahederin withboth desmutagenic and bioantimutagenic mechanisms. [3]

In 1997, Trute A, Gross J, Mutschler E, Nahrstedt A. from Wilhelms-Universität, Münster, Germany,
demonstrated the antispasmodic activities of dry extracts and some saponins and phenolic compounds
from Hedera helix in a test-tube study. [2] In 2003, Hofmann D, Hecker M, and Völp A. from Klinikum der
Johann Wolfgang Goethe-Universität, Germany, concluded ivy leaf extract preparations have somewhat
effects on the respiratory functions of children with chronic bronchial asthma, based from three clinical
trials. [4]

Researchers from Turkey prepared a crude saponin extract and a purified saponin extract. They found the
purified saponin extract is more potent on inflammation in rats. [5, 7] They also found that hederasaponin-
C, -E and -F, may exert their anti-inflammatory effects by blocking bradykinin or other inflammation
mediators. The latter affect may occur via affecting prostaglandin pathways. Regarding the structure
activity relationship,  it is likely that sugars at C3 position and Rha7-Glcl-6Glc moiety at C28 position are
essential for the acute anti-inflammatory effect. [8]

These researchers further isolated alpha-hederin, hederasaponin-C, hederacolchiside-E and
hederacolchiside-F. They found these saponins showed 94, 86, 88 and 75% inhibition on lipid
peroxidation of linoleic acid emulsion. [6]

Reference:

[1] Elias R, De Méo M, Vidal-Ollivier E, Laget M, Balansard G, Dumenil G. Laboratoire de Pharmacognosie, Faculté de Pharmacie, Marseille, France.
Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L. Mutagenesis. 1990 Jul;5(4):327-31. [2]
Trute A, Gross J, Mutschler E, Nahrstedt A. In vitro antispasmodic compounds of the dry extract obtained from Hedera helix. Planta Med. 1997 Apr;63(2):
125-9. [3] Villani P, Orsière T, Sari-Minodier I, Bouvenot G, Botta A. Laboratoire de biogénotoxicologie In Marseille cedex 5 vitro study of the
antimutagenic activity of alphahederin Ann Biol Clin (Paris). 2001 May-Jun;59(3):285-9. [4] Hofmann D, Hecker M, Völp A.Efficacy of dry extract of ivy
leaves in children with bronchial asthma--a review of randomized controlled trials. Phytomedicine. 2003 Mar;10(2-3):213-20. [5] Süleyman H, Mshvildadze
V, Gepdiremen A, Elias R. Atatürk University, Turkey, Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats. Phytomedicine.
2003;10(5):370-4. [6] Gülçin I, Mshvildadze V, Gepdiremen A, Elias R. [igulcin@atauni.edu.tr ] Ataturk University Antioxidant activity of saponins isolated
from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. Planta Med. 2004 Jun;70(6):561-3. [7] Gepdiremen A,
Mshvildadze V, Süleyman H, Elias R. akcahan@atauni.edu.tr Atatürk University Acute and chronic antiinflammatory effects of Hedera colchica in rats. J
Ethnopharmacol. 2004 Sep;94(1):191-5. [8] Gepdiremen A, Mshvildadze V, Süleyman H, Elias R. Acute anti-inflammatory activity of four saponins isolated
from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. Phytomedicine. 2005 Jun;
12(6-7):440-4.
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