coenzyme q10 side effects, coenzyme q10 benefits
coenzyme q10 dosage (CoQ 10; ubiquinone)
What is Coenzyme Q10?
Coenzyme Q10 (or CoQ 10) is a compound that is produced in most animals including human being.
CoQ10 plays an important role in our energy production, such as production of ATP. ATP is used in the
energy transfer between mitochondria and cells. Coenzyme Q10 helps mitochondria to metabolize fats
and carbohydrates. It also helps maintain cell membrane flexibility. Animal studies and clinical trials have
shown that a decrease in Coenzyme Q10 levels is related to a wide variety of diseases. Coenzyme Q10,
an antioxidant or a free radical scavenger, inhibits lipid peroxidation. Lipid peroxidation is a normal aspect
of the aging process however it also implicates certain age-related diseases. Thus, supplementation of
Coenzyme Q10 may have multiple health benefits.
Coenzyme Q10 benefits - anti-aging effects
As we age, our body' Coenzyme Q10 production may decline by as much as eighty percent.
Consequently, some people believe that Coenzyme Q10 may beneficially affect the aging process.
Coenzyme Q10 benefits - Cardiac conditions
In 1957, Dr. Frederick Crane, The University of Wisconsin, discovered Coenzyme Q10. One year later,
Merck scientists identified its structure, and produced Coenzyme Q10 through fermentation. In 1960s,
Japanese used Coenzyme Q10 in cardiac insufficiencies. In 1972, Dr. Folkers and Gian Paolo Littarru
found that people suffered from cardiac insufficiencies had very low levels of CoQ10. Supplementation
increased Coenzyme Q10 levels and positively affected heart health. In 1974, Japanese approved the use
of Coenzyme Q10. And now, Coenzyme Q10 is one of the most widely used products in the Japanese
pharmaceutical industry. 
Russian researchers at Ministry of Health of Russian Federation, Moscow, isolated a rat heart and studied
the changes in myocardium during oxidative stress induced by infusion of hydrogen peroxide in the
coronary vessels. They found that coenzyme Q increases resistance of the myocardium to oxidative
stress in two ways- (1) direct antioxidant protection and (2) protection of antioxidant enzymes. 
Researchers have suggested to use Coenzyme Q10 as a supportive therapy for certain conditions. For
instance, preoperative oral Coenzyme Q10 therapy in patients undergoing cardiac surgery increases
myocardial and cardiac mitochondrial Coenzyme Q10 levels, improves mitochondrial efficiency, and
increases myocardial tolerance to in vitro hypoxia-reoxygenation stress.  Furthermore, Coenzyme Q10
may provide some protection against cardiotoxicity or liver toxicity during cancer treatment 
COENZYME Q10 SIDE EFFECTS
CoQ10 appears to be safe and well-tolerated in most patients. In a study, researchers supplied 150 mg of
coenzyme Q10 to a patient suffered from maternally-inherited diabetes and deafness (MIDD). They
couldn't find any side effects.  In another study, researchers treated a patient with 75 mg of coenzyme
Q10 twice a day for 1 year. They also couldn't find any side effects.  However, high doses of CoQ 10
may cause various unwanted side effects. In a 6-month open-label study, researchers offered 600-1200
mg coenzyme to 10 patients suffered from Huntington's disease daily. Though telephone interview,
researchers assessed the associated adverse events - side effects. Four subjects reported mild side
effects such as headache, hearburn, fatigue and increased involuntary movements. 
 Feigin A et al, Assessment of coenzyme Q10 tolerability in Huntington's disease. Mov Disord. 1996 May;11(3):321-3. 
Salles JE et al, Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10, Diabetes Res Clin Pract.
2005 Oct 24.  Angeli SI et al, Coenzyme Q-10 treatment of patients with a 7445A--->G mitochondrial DNA mutation stops
the progression of hearing loss. Acta Otolaryngol. 2005 May;125(5):510-2.  [angsjoen, Peter H. Introduction To
Coenzyme Q10; , Internet source] [5 ] Lakomkin VL et al, Biochemistry (Mosc). 2005 Jan; 70 (1):79-84]. [6
]J Rosenfeldt F et al, Alfred Hospital, Baker Heart Research Institute , Melbourne, Thorac Cardiovasc
Surg. 2005 Jan;129(1):25-32]  Roffe L et al, University of Southampton, Southampton, J Clin Oncol.
2004 Nov 1;22(21):4418-24]
|Coenzyme Q10 (ubiquinone) is one of the top best sellers in the health supplement market. Almost all
the major health supplement manufacturers or suppliers carry this product. The dose is about 100 mg of
Coenzyme q10 per units. Most manufacturers add vitamin E to Coenzyme q10 products.
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