Rhodiola
rosea (hong jing tian, 紅 景 天), Radix Thodiolae, Flos Thodiolae, Herb Thodiolae Rhodiola Rosea golden root, rose-rootroot,
extract, rhizome benefits, side effects, research findings
. zhion@zhoin.com
rosea (hong jing tian, 紅 景 天), Radix Thodiolae, Flos Thodiolae, Herb Thodiolae Rhodiola Rosea golden root, rose-rootroot,
extract, rhizome benefits, side effects, research findings
. zhion@zhoin.com
| WHAT IS THE USE OF RHODIOLA? Rhodiola (Rhodiola rosea) has been used in traditional medicine as a means to stimulate the nervous system, decrease depression and fatigue for centuries in Eastern Europe and Asia. It is also used to help prevent high altitude sickness. Because of multiple uses, it is also known as "golden root".. |
| Researchers classify Rhodiola as an adaptogen. Basically, adaptogen is an agent increases in power of resistance against multiple stressors and helps the body to reassume homeostasis. To do this, Rhodiola promotes the release of certain neurotransmitters responsible for feelings of well-being, as well as regulating hormone production in response to stress including oxidative damage by free radicals. It also appears to increase the permeability of the blood-brain barrier to neurotransmitter precursors, aiding and even increasing their beneficial effects. In fact, scientists have studied rhodiola extensively in the last few years and they found this herb may have multiple health benefits. |
WHAT ARE THE HEALTH BENEFITS OF RHODIOLA?
Rhodiola Rosea Extract prevents ischemic brain damage development; research finds.
Pogorelyi VE et al, State Pharmaceutical Academy, Russia stated that Rhodiola Rosea extract
could prevent the ischemic brain damage development in their article. They further suggested
that a course administration of the drug in a dose of 700 mg/kg arrested the development of
hyper- and hypoperfusion in cerebral circulation, weakened the postischemic hyperglycemic
reaction, lowered oxygen extraction by cerebral tissues, suppressed lactate acidosis, promoted
pyruvate participation in metabolic processes inhibits edema swelling, prevented the "calcium
paradox" development, and decreaseed manifestations of the lipid peroxidation processes.
[Eksp Klin Farmakol. 2002 Jul-Aug;65(4):19-22].
Rhodiola Rosea works as an adaptogen
Korean and Russian scientists have done a lot of studies to find out how rhodiola benefits on
cognitive functions:
Spasov AA et al, Volgograd Medical Academy, Russia, investigated the stimulating and
normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a
stressful examination period using a double-blind, placebo-controlled pilot study . The students
took the extract and placebo for 20 days during an examination period. They concluded that the
extract gave significant results.[ Phytomedicine. 2000 Apr;7(2):85-9]
Mook-Jung I et al, Ajou University School of Medicine, Korea. tested the constituents of Rhodiola
sacra S. H. Fu and R. sachalinensis A. BOR for their neuroprotective effects. They found that a
few constituents had considerable protective effects against beta-amyloid-induced death of
B103 neuronal cells in vitro. These compounds also showed protective effects against
staurosporine-induced cell death, and two of them protected neurons from H2O2-induced cell
death. They thought that these compounds might protect neurons from beta-amyloid toxicity
based on antiapoptotic and antioxidative activity [Biol Pharm Bull. 2002 Aug;25(8):1101-4
Rhodiolia helps prevent cancer; research finds
Razina TG et al, Russian Academy of Medical Sciences, Russia, inoculated mice with with
metastasing Lewis lung carcinoma. They then found that the extracts of Baikal scullcap
(Scutellaria baikalensis), rhodiola (Rhodiola rosea), common licorice (Glycyrrhiza glabra)
potentiated the antitumor and antimetastatic effects of cyclophosphan (cyclophosphamide)
[Eksp Klin Farmakol. 2000 Sep-Oct;63(5):59-61].
Salikhova RA et al, studied the effect of the Rhodiola rosea extracts on chromosome
aberrations, production of cells with micronuclei and unscheduled DNA synthesis in bone
marrow cells of mice under action of mutagens cyclophosphamide and N-nitroso-N-methylurea
(NMU). They found that Rhodiola rosea extracts reduced significantly the yield of cells with the
chromosome aberrations and micronuclei induced by cyclophosphamide in vivo, inhibited
unscheduled DNA synthesis induced by NMU in vitro. They suggested that Rhodiola rosea
extracts are antimutagens due to ability to raise the efficiency of the intracell DNA repair
mechanisms. [Patol Fiziol Eksp Ter. 1997 Oct-Dec;(4):22-4]
Bocharova OA et al found that oral administration of Rhodiola rosea extract to a small group of
patents (n = 12) with superficial bladder carcinoma (T1G1-2) improved the characteristics of the
urothelial tissue integration, parameters of leukocyte integrins and T-cell immunity. [Urol Nefrol
(Mosk). 1995 Mar-Apr;(2):46-7.]
Rhodiola may benefit people suffered from high altitude sickness.
Rhodiola (Rhodiola rosea) has been used to stimulate the nervous system and fatigue for
centuries in Eastern Europe and Asia. It has been used as remedy for high altitude sickness.
Bock K et al, Katholieke Universiteit Leuven, Belgium investigated the effect of acute and
4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement,
reaction time, and attention in a double blind placebo-controlled randomized study (n= 24). They
fed subjects either with Rhodiola rosea (R, 200-mg Rhodiola rosea extract containing 3%
rosavin + 1% salidroside plus 500 mg starch) or placebo then they assessed their speed of limb
movement, aural and visual reaction time, and the ability to sustain attention. After the study, they
concluded that acute Rhodiola rosea intake can improve endurance exercise capacity in young
healthy volunteers. [Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307]
Abidov M. et al, Russian Academy of Natural Sciences, Moscow, studied the effects of oral
treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots
on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in
rats. Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of
exhaustive swimming in comparison with control rats and rats treated with R. crenullata. R. rosea
extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative
energy processes after intense exercise. [Bull Exp Biol Med. 2003 Dec;136(6):585-7.]
Darbinyan V et al investigated the effect of repeated low-dose treatment with a standardized
extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of
56 young, healthy physicians. They expressed the total mental performance as Fatigue Index.
They tested the complex perceptive and cognitive cerebral functions, such as associative
thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual
perception as to reflect the overall level of mental fatigue. They found that there was a statistically
significant improvement in these tests in the treatment group. They didn't find any side-effect.
They concluded that Rhodiola rosea L could reduce general fatigue under certain stressful
conditions. [Phytomedicine. 2000 Oct;7(5):365-71].
Rhodiola may help under conditions of hypoxia.
Wing SL et al, University of Utah, USA investigated the effects of Rhodiola on hypoxia and
oxidative stress at a simulated altitude of 4600 m, using 15 volunteers (ages 20-33). They
allowed the volunteers to receive 3 separate 60-minute hypoxic exposures by breathing 13.6%
oxygen at an ambient barometric pressure of 633 mm Hg (simulating the partial pressure of
oxygen at 4600 m elevation). Each subject received, in random order, treatments of a 7-day
supply of placebo or Rhodiola rosca. They found hypoxia-induced oxidative stress was
observed in the control group only. Rhodiola rosca appeared not to increase oxidative stress
and may decrease free radical formation after hypoxic exposure compared with the control.
[Wilderness Environ Med. 2003 Spring;14(1):9-16]
Rhodiola may benefit people suffered from certain types of cardiac and glucose-level
conditions.
Maimeskulova LA et al, Siberian Division of the Russian Academy of Medical Sciences,
Russia, repeated prophylactic administration of plant adaptogen preparations based on extracts
from rhodiola, eleutherococcus, leuzea, and ginseng, produced a pronounced antiarrhythmic
effect on the model of adrenal arrhythmia in animals. [Eksp Klin Farmakol. 2000
Jul-Aug;63(4):29-31]
Lishmanov IuB et al, Russia, reported that a course injection of Rhodiola rosea extract for eight
days could increase the resistance of experimental animals to adrenalin- or CaCl2-induced
arrhythmias. They assumed the antiarrhythmic effect of Rhodiola injection course was
associated with the induction of opioid peptides biosynthesis. [Biull Eksp Biol Med. 1993
Aug;116(8):175-6.]
Lishmanov IuB et al stated that a course of oral administration of Rhodiola rosea extract in a
dose of 3.5 mg/kg prevents reperfusion decrease in contraction amplitude of the isolated
perfused rat heart in their article. They also suggested that the Rhodiola rosea extract also
prevents reduction of coronary flow and development of contracture in the postischemic period
and. the protective effect of Rhodiola may probably be connected with increase in the level of
endogenous opioid peptides. [Eksp Klin Farmakol. 1997 May-Jun;60(3):34-6].
Zhang Z, Liu et al, China Academy of Traditional Chinese Medicine, Beijing proved that
Rhodiola Capsules could significantly decrease the oxygen consumption of myocardium and
oxygen consumption index in anesthetic dogs, decrease the coronary artery resistance without
any major effect on the coronary artery blood flow. They also found the capsules also lowered
blood pressure and heart rate. [Zhongguo Zhong Yao Za Zhi. 1998 Feb;23(2):104-6, inside back]
Maslova LV et al studied the effect of course of administration of Rhodiola rosea extract on the
pattern of stress-induced cardiac damage. They used 99mTc-pyrophosphate accumulation in
the heart as the parameter for the progress. They concluded that Rhodiola rosea prevented
stress-induced cardiac damage. Simultaneously, they measured myocardial catecholamines
and cAMP levels and found that the adaptogen prevented lower adrenal catecholamines during
stress. They concluded that the antistressor and cardioprotective effects of Rhodiola rosea are
associated with limited adrenergic effect on the heart. [Eksp Klin Farmakol. 1994
Nov-Dec;57(6):61-3.]
Cheng XJ etal, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province,
China, isolated Rhodiola sachalinensis polysaccharides (RSP) from the root of Rhodiola
sachalinensis and demonstrated that RSP could decrease the levels of blood sugar, liver
glycogen and total blood lipid when injected peritoneally to mice at 50, 100 and 200 mg/kg once
or for 7 successive days. [Zhongguo Zhong Yao Za Zhi. 1993 Sep;18(9):557-9, 575]
Rhodiolae may benefit people under stress.
Rhodiola (Rhodiola rosea) has been used to protect the liver in traditional medicine for years.
Zhu BW et al, Dalian Institute of Light Industry, China, believed that noise is one of the factors
that induces critical stress in animals. They investigated the alleviation of noise-stress-induced
physiological damages by traditional medicine using Rhodiolae radices. They used the contents
of glycogen, lactic acid and cholesterol in the liver of noise-stressed rats as parameters. They
found that noise induced stress in the rats with an evidence that a decrease in contents of these
compounds in the liver. And, Rhodiolae maintained the contents of these compounds in the liver
of the rats [Biosci Biotechnol Biochem. 2003 Sep;67(9):1930-6]
Song EK et al, Wonkwang University, Korea isolated two hepatoprotective phenolic
compounds, kaempferol (2) and salidroside (4), based based on the hepatoprotective activity
against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Their The EC(50)
values of compounds 2 and 4 were 33.5 and 51.3 micro m, respectively. [Phytother Res. 2003
May;17(5):563-5]
Iaremii IN et al, Bukovinian State Medical Academy, Ukraine, studied the effect of a liquid
extract from Rhodiola rosea on the functional state of rat liver with experimental toxic hepatitis.
They found that the extract produced a hepatoprotective effect, as manifested by normalized
activity of aspartate aminotransferase and alkaline phosphatase, normalized content of
medium-molecular-weight peptides, urea, and bilirubin, and reduced activity of alanine
aminotransferase and glutathione-S-transferase in the blood plasma of rats with the toxic
hepatitis model. [Eksp Klin Farmakol. 2002 Nov-Dec;65(6):57-9]
Nan JX et al, Wonkwang University, Korea, induced liver injury of rats repetitive administration of
carbon tetrachloride. This liver damage would elevate levels of hydroxyproline and
malondialdehyde in the liver. They then fed the rats with an aqueous extract from the root of
Rhodiola sachalinensis at doses of 50, 100 or 200 mg/kg throughout the carbon tetrachloride
treatment for 28 days. They found that the extract reduced the levels of hydroxyproline and
malondialdehyde. Immunohistological findings indicated the extracts inhibited hepatic stellate
cell activation, which is a major step for collagen accumulation during liver injury. These data
suggest that Rhodiola sachalinensis extracts protect the liver from repetitive injury induced by
carbon tetrachloride in rats. [J Ethnopharmacol. 2003 Feb;84(2-3):143-8.]
SIDE EFFECTS OF RHODIOLA ROSEA
The use of Rhodiola rosea in recommended doses typically generates no side effects, unlike
traditional stimulants that posses addiction, tolerance and abuse potential, produce a negative
effect on sleep structure, and cause rebound hypersomnolence or "come down" effects. [1]
THIS ARTICLE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTIONS, YOU SHOULD CONSULT WITH YOUR
DOCTOR. NOTE THAT MOST ARE JUST EITHER ANIMAL OR IN VITRO STUDIES, RHODIOLA MAY WORK DIFFERENTLY
IN HUMAN BODY. IN ADDITION SOURCE, PURITY, DOSAGE FORM DESIGN WILL ALSO AFFECT THE RESULTS. ALL
RIGHTS RESERVED 2009 zhion. DO NOT COPY NOR TRANSFER THIS ARTICLE TO OTHER WEBSITES OR OTHER TYPES
OF PUBLICATIONS WITHOUT PERMISSION.
1. A Panossian, H. Wagner Stimulating effect of adaptogens: an overview with particular reference to their efficacy
following single dose administration Phytother Res. 2005 Oct;19(10):819-38.
Rhodiola Rosea Extract prevents ischemic brain damage development; research finds.
Pogorelyi VE et al, State Pharmaceutical Academy, Russia stated that Rhodiola Rosea extract
could prevent the ischemic brain damage development in their article. They further suggested
that a course administration of the drug in a dose of 700 mg/kg arrested the development of
hyper- and hypoperfusion in cerebral circulation, weakened the postischemic hyperglycemic
reaction, lowered oxygen extraction by cerebral tissues, suppressed lactate acidosis, promoted
pyruvate participation in metabolic processes inhibits edema swelling, prevented the "calcium
paradox" development, and decreaseed manifestations of the lipid peroxidation processes.
[Eksp Klin Farmakol. 2002 Jul-Aug;65(4):19-22].
Rhodiola Rosea works as an adaptogen
Korean and Russian scientists have done a lot of studies to find out how rhodiola benefits on
cognitive functions:
Spasov AA et al, Volgograd Medical Academy, Russia, investigated the stimulating and
normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a
stressful examination period using a double-blind, placebo-controlled pilot study . The students
took the extract and placebo for 20 days during an examination period. They concluded that the
extract gave significant results.[ Phytomedicine. 2000 Apr;7(2):85-9]
Mook-Jung I et al, Ajou University School of Medicine, Korea. tested the constituents of Rhodiola
sacra S. H. Fu and R. sachalinensis A. BOR for their neuroprotective effects. They found that a
few constituents had considerable protective effects against beta-amyloid-induced death of
B103 neuronal cells in vitro. These compounds also showed protective effects against
staurosporine-induced cell death, and two of them protected neurons from H2O2-induced cell
death. They thought that these compounds might protect neurons from beta-amyloid toxicity
based on antiapoptotic and antioxidative activity [Biol Pharm Bull. 2002 Aug;25(8):1101-4
Rhodiolia helps prevent cancer; research finds
Razina TG et al, Russian Academy of Medical Sciences, Russia, inoculated mice with with
metastasing Lewis lung carcinoma. They then found that the extracts of Baikal scullcap
(Scutellaria baikalensis), rhodiola (Rhodiola rosea), common licorice (Glycyrrhiza glabra)
potentiated the antitumor and antimetastatic effects of cyclophosphan (cyclophosphamide)
[Eksp Klin Farmakol. 2000 Sep-Oct;63(5):59-61].
Salikhova RA et al, studied the effect of the Rhodiola rosea extracts on chromosome
aberrations, production of cells with micronuclei and unscheduled DNA synthesis in bone
marrow cells of mice under action of mutagens cyclophosphamide and N-nitroso-N-methylurea
(NMU). They found that Rhodiola rosea extracts reduced significantly the yield of cells with the
chromosome aberrations and micronuclei induced by cyclophosphamide in vivo, inhibited
unscheduled DNA synthesis induced by NMU in vitro. They suggested that Rhodiola rosea
extracts are antimutagens due to ability to raise the efficiency of the intracell DNA repair
mechanisms. [Patol Fiziol Eksp Ter. 1997 Oct-Dec;(4):22-4]
Bocharova OA et al found that oral administration of Rhodiola rosea extract to a small group of
patents (n = 12) with superficial bladder carcinoma (T1G1-2) improved the characteristics of the
urothelial tissue integration, parameters of leukocyte integrins and T-cell immunity. [Urol Nefrol
(Mosk). 1995 Mar-Apr;(2):46-7.]
Rhodiola may benefit people suffered from high altitude sickness.
Rhodiola (Rhodiola rosea) has been used to stimulate the nervous system and fatigue for
centuries in Eastern Europe and Asia. It has been used as remedy for high altitude sickness.
Bock K et al, Katholieke Universiteit Leuven, Belgium investigated the effect of acute and
4-week Rhodiola rosea intake on physical capacity, muscle strength, speed of limb movement,
reaction time, and attention in a double blind placebo-controlled randomized study (n= 24). They
fed subjects either with Rhodiola rosea (R, 200-mg Rhodiola rosea extract containing 3%
rosavin + 1% salidroside plus 500 mg starch) or placebo then they assessed their speed of limb
movement, aural and visual reaction time, and the ability to sustain attention. After the study, they
concluded that acute Rhodiola rosea intake can improve endurance exercise capacity in young
healthy volunteers. [Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307]
Abidov M. et al, Russian Academy of Natural Sciences, Moscow, studied the effects of oral
treatment with extracts from Rhodiola rosea (50 mg/kg) and Rhodiola crenulata (50 mg/kg) roots
on the duration of exhaustive swimming and ATP content in mitochondria of skeletal muscles in
rats. Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of
exhaustive swimming in comparison with control rats and rats treated with R. crenullata. R. rosea
extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative
energy processes after intense exercise. [Bull Exp Biol Med. 2003 Dec;136(6):585-7.]
Darbinyan V et al investigated the effect of repeated low-dose treatment with a standardized
extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of
56 young, healthy physicians. They expressed the total mental performance as Fatigue Index.
They tested the complex perceptive and cognitive cerebral functions, such as associative
thinking, short-term memory, calculation and ability of concentration, and speed of audio-visual
perception as to reflect the overall level of mental fatigue. They found that there was a statistically
significant improvement in these tests in the treatment group. They didn't find any side-effect.
They concluded that Rhodiola rosea L could reduce general fatigue under certain stressful
conditions. [Phytomedicine. 2000 Oct;7(5):365-71].
Rhodiola may help under conditions of hypoxia.
Wing SL et al, University of Utah, USA investigated the effects of Rhodiola on hypoxia and
oxidative stress at a simulated altitude of 4600 m, using 15 volunteers (ages 20-33). They
allowed the volunteers to receive 3 separate 60-minute hypoxic exposures by breathing 13.6%
oxygen at an ambient barometric pressure of 633 mm Hg (simulating the partial pressure of
oxygen at 4600 m elevation). Each subject received, in random order, treatments of a 7-day
supply of placebo or Rhodiola rosca. They found hypoxia-induced oxidative stress was
observed in the control group only. Rhodiola rosca appeared not to increase oxidative stress
and may decrease free radical formation after hypoxic exposure compared with the control.
[Wilderness Environ Med. 2003 Spring;14(1):9-16]
Rhodiola may benefit people suffered from certain types of cardiac and glucose-level
conditions.
Maimeskulova LA et al, Siberian Division of the Russian Academy of Medical Sciences,
Russia, repeated prophylactic administration of plant adaptogen preparations based on extracts
from rhodiola, eleutherococcus, leuzea, and ginseng, produced a pronounced antiarrhythmic
effect on the model of adrenal arrhythmia in animals. [Eksp Klin Farmakol. 2000
Jul-Aug;63(4):29-31]
Lishmanov IuB et al, Russia, reported that a course injection of Rhodiola rosea extract for eight
days could increase the resistance of experimental animals to adrenalin- or CaCl2-induced
arrhythmias. They assumed the antiarrhythmic effect of Rhodiola injection course was
associated with the induction of opioid peptides biosynthesis. [Biull Eksp Biol Med. 1993
Aug;116(8):175-6.]
Lishmanov IuB et al stated that a course of oral administration of Rhodiola rosea extract in a
dose of 3.5 mg/kg prevents reperfusion decrease in contraction amplitude of the isolated
perfused rat heart in their article. They also suggested that the Rhodiola rosea extract also
prevents reduction of coronary flow and development of contracture in the postischemic period
and. the protective effect of Rhodiola may probably be connected with increase in the level of
endogenous opioid peptides. [Eksp Klin Farmakol. 1997 May-Jun;60(3):34-6].
Zhang Z, Liu et al, China Academy of Traditional Chinese Medicine, Beijing proved that
Rhodiola Capsules could significantly decrease the oxygen consumption of myocardium and
oxygen consumption index in anesthetic dogs, decrease the coronary artery resistance without
any major effect on the coronary artery blood flow. They also found the capsules also lowered
blood pressure and heart rate. [Zhongguo Zhong Yao Za Zhi. 1998 Feb;23(2):104-6, inside back]
Maslova LV et al studied the effect of course of administration of Rhodiola rosea extract on the
pattern of stress-induced cardiac damage. They used 99mTc-pyrophosphate accumulation in
the heart as the parameter for the progress. They concluded that Rhodiola rosea prevented
stress-induced cardiac damage. Simultaneously, they measured myocardial catecholamines
and cAMP levels and found that the adaptogen prevented lower adrenal catecholamines during
stress. They concluded that the antistressor and cardioprotective effects of Rhodiola rosea are
associated with limited adrenergic effect on the heart. [Eksp Klin Farmakol. 1994
Nov-Dec;57(6):61-3.]
Cheng XJ etal, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province,
China, isolated Rhodiola sachalinensis polysaccharides (RSP) from the root of Rhodiola
sachalinensis and demonstrated that RSP could decrease the levels of blood sugar, liver
glycogen and total blood lipid when injected peritoneally to mice at 50, 100 and 200 mg/kg once
or for 7 successive days. [Zhongguo Zhong Yao Za Zhi. 1993 Sep;18(9):557-9, 575]
Rhodiolae may benefit people under stress.
Rhodiola (Rhodiola rosea) has been used to protect the liver in traditional medicine for years.
Zhu BW et al, Dalian Institute of Light Industry, China, believed that noise is one of the factors
that induces critical stress in animals. They investigated the alleviation of noise-stress-induced
physiological damages by traditional medicine using Rhodiolae radices. They used the contents
of glycogen, lactic acid and cholesterol in the liver of noise-stressed rats as parameters. They
found that noise induced stress in the rats with an evidence that a decrease in contents of these
compounds in the liver. And, Rhodiolae maintained the contents of these compounds in the liver
of the rats [Biosci Biotechnol Biochem. 2003 Sep;67(9):1930-6]
Song EK et al, Wonkwang University, Korea isolated two hepatoprotective phenolic
compounds, kaempferol (2) and salidroside (4), based based on the hepatoprotective activity
against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells. Their The EC(50)
values of compounds 2 and 4 were 33.5 and 51.3 micro m, respectively. [Phytother Res. 2003
May;17(5):563-5]
Iaremii IN et al, Bukovinian State Medical Academy, Ukraine, studied the effect of a liquid
extract from Rhodiola rosea on the functional state of rat liver with experimental toxic hepatitis.
They found that the extract produced a hepatoprotective effect, as manifested by normalized
activity of aspartate aminotransferase and alkaline phosphatase, normalized content of
medium-molecular-weight peptides, urea, and bilirubin, and reduced activity of alanine
aminotransferase and glutathione-S-transferase in the blood plasma of rats with the toxic
hepatitis model. [Eksp Klin Farmakol. 2002 Nov-Dec;65(6):57-9]
Nan JX et al, Wonkwang University, Korea, induced liver injury of rats repetitive administration of
carbon tetrachloride. This liver damage would elevate levels of hydroxyproline and
malondialdehyde in the liver. They then fed the rats with an aqueous extract from the root of
Rhodiola sachalinensis at doses of 50, 100 or 200 mg/kg throughout the carbon tetrachloride
treatment for 28 days. They found that the extract reduced the levels of hydroxyproline and
malondialdehyde. Immunohistological findings indicated the extracts inhibited hepatic stellate
cell activation, which is a major step for collagen accumulation during liver injury. These data
suggest that Rhodiola sachalinensis extracts protect the liver from repetitive injury induced by
carbon tetrachloride in rats. [J Ethnopharmacol. 2003 Feb;84(2-3):143-8.]
SIDE EFFECTS OF RHODIOLA ROSEA
The use of Rhodiola rosea in recommended doses typically generates no side effects, unlike
traditional stimulants that posses addiction, tolerance and abuse potential, produce a negative
effect on sleep structure, and cause rebound hypersomnolence or "come down" effects. [1]
THIS ARTICLE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTIONS, YOU SHOULD CONSULT WITH YOUR
DOCTOR. NOTE THAT MOST ARE JUST EITHER ANIMAL OR IN VITRO STUDIES, RHODIOLA MAY WORK DIFFERENTLY
IN HUMAN BODY. IN ADDITION SOURCE, PURITY, DOSAGE FORM DESIGN WILL ALSO AFFECT THE RESULTS. ALL
RIGHTS RESERVED 2009 zhion. DO NOT COPY NOR TRANSFER THIS ARTICLE TO OTHER WEBSITES OR OTHER TYPES
OF PUBLICATIONS WITHOUT PERMISSION.
1. A Panossian, H. Wagner Stimulating effect of adaptogens: an overview with particular reference to their efficacy
following single dose administration Phytother Res. 2005 Oct;19(10):819-38.
| THE PHENOLIC COMPOUNDS OF RHODIOLA Lee MW et al, Chung Ang University, Korea has furnished six phenolic compounds from Rhodiola sachalinensis root extract (acetone) which exhibited significant scavenging effects against DPPH free radical. They determined these compounds as follows: gallic acid (1), (-)-epigallocatechin 3-O-gallate (2), kaempferol (3), kaempferol 7-O-alpha-L-rhamnopyranosi de (4), herbacetin 7-O-alpha-L-rhamnopyranosi de, (5) and rhodiolinin (6) by physico-chemical and spectral evidences. [Arch Pharm Res. 2000 Oct;23(5):455-8.] |
| "The ingredients of Rodiola effect the central nervous system by increasing the ability to concentrate. They also prevent the heart system from stress and arrhythmias, and posses some antioxidant activity. Rhodiola rosea L. preparations may stop the growth of the malignant tumors and metastases in the liver." Kucinskaite A et al, "Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine" Medicina (Kaunas). 2004;40(7):614-9. [Article in Lithuanian]. |
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