rosmarinic acid side effects, rosmarinic acid benefits
rosmarinic acid extract                                                 August 17, 2011
What is Rosmarinic acid?

Rosmarinic acid is an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid. Rosmarinic acid can be
found in some higher plants, some fern and hornwort species, species of the Boraginaceae and the
subfamily Nepetoideae of the Lamiaceae.

Rosmarinic acid benefits
Petersen M and Simmond Ms at Philipps-Universität Marburg, Germany, pointed out rosmarinic acid has
antiviral, antibacterial, antiinflammatory and antioxidant. The presence of rosmarinic acid in medicinal
plants, herbs and spices has beneficial and health promoting effects. In plants, rosmarinic acid is supposed
to act as a preformed constitutively accumulated defense compound. [1]

Rosmarinic acid may have neural protection effect; in a vitro study, rosmarinic acid significantly attenuated H
(2)O(2)-induced reactive oxygen species (ROS) generation and apoptotic cell death (human dopaminergic
cell line). [2] In animal studies, rosmarinic acid (from  Perillae Herba) showed an antidepressant-like
property. [3]

Rosmarinic acid benefits - anti-viral and inflammatory effects
Rosmarinic acid showed anti-viral and anti-inflammatory activities; it reduced the mortality of mice infected
with Japanese encephalitis virus. [4]

Rosmarinic acid benefits - on autoimmune arthritis
Rosmarinic acid may benefit people with autoimmune arthritis as it suppressed synovitis in a murine
collagen induced arthritis model. [5]

Rosmarinic acid benefits - skin condition
Atopic dermatitis (AD) is one of the most common skin diseases. Rosmarinic acid at 1 or 5μM was found to
suppress the productions of interferon (IFN)-γ and interleukin (IL)-4 significantly by activated CD4(+) T
cells. Rosmarinic acid suppresses the development of AD-like dermatitis in DNFB-treated NC/Nga mice by
reducing IFN-γ and IL-4 production by activated T cells and total serum IgE levels. [Jang AH et al Int
Immunopharmacol. 2011 Sep;11(9):1271-7]

Rosmarinic acid benefits - anti-cancer effects
Hepatic stellate cells (HSCs), activated during liver injury, are defined as the most important target in the
therapy of hepatic fibrosis. Rosmarinic acid was found to inhibit proliferation and induce apoptosis in HSC-
T6, partly due to the inhibition of phosphorylation in STAT3, which contributed to the reversal of hepatic
fibrosis. [Zhang JJ, et al, Biol Pharm Bull. 2011 Mar;34(3):343-8.]

Rosmarinic acid side effects
No serious rosmarinic acid side effects were reported and extensive blood cell counts and hepatic and
renal function tests showed rosmarinic acid to be a safe, effective. [Life Extension Magazine November
2004]

Reference
[1] Petersen M and Simmond Ms Rosmarinic acid. Phytochemistry. 2003 Jan;62(2):121-5. [2] Lee HJ et al, Rosmarinic acid protects human
dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology. 2008 Sep 4;250(2-3):109-15. Epub 2008 Jul 4. [3] Ito
N et al, Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol
Pharm Bull. 2008 Jul;31(7):1376-80. [4] Antiviral and anti-inflammatory effects of rosmarinic acid in an experimental murine model of
Japanese encephalitis.
Antimicrob Agents Chemother. 2007 Sep;51(9):3367-70. Epub 2007 Jun 18. [5] Youn J et al, Beneficial effects of rosmarinic acid on
suppression of collagen induced arthritis. J Rheumatol. 2003 Jun;30(6):1203-7.

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