| RESVERATROL Side Effects updated on July 26, 2009 |
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other website or blog.
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What are the potential side effects of resveratrol?
Resveratrol is believed to have at least two potential side effects. The first
potential side effect is a speculation based on its anti-cancer mechanism. In
a study of 2005, plasmid bluescript SK(+) DNA was treated with increasing
concentrations of resveratrol in the presence and absence of copper ions,
transformed into competent DH5alpha cells and sequenced. The study
shows a decrease in the transformation efficiency of the plasmid after
resveratrol treatment, and although all types of mutations were recorded,
point mutations (deletions/substitutions) were found to be the predominant
ones. Resveratrol alone resulted in deletion of mainly guanine bases. In the
chromatin of nucleus, copper ions are bound to guanine bases. This study
suggests the mobilization of such endogenous copper by resveratrol
resulting in prooxidant DNA cleavage at the site. In various cancer cell lines,
the copper concentration is reported to be elevated and this study may
explain the anticancer activity of resveratrol. [3] In fact, resveratrol is
generally considered as a copper chelator. [4-6]. Thus, it is speculated
that oral intake excessive amount of resveratrol orally may hinder
the absorption of certain metal ions, especially copper ion, leading
to copper deficiency. Please, note that there is no direct evidence for
such side effects.
The second potential side effect is observed from an animal study.
Researchers from Dr. B.C. Roy Post Graduate Institute of Basic Medical
Sciences & I.P.G.M.E. & R., India., demonstrated the biphasic activity of
resveratrol in indomethacin-induced gastric ulcerated mice. They observed
a beneficial effect of resveratrol at a low dose (2 mg/kg) but unwanted side
effect at a higher dose of resveratrol (10 mg/kg). The lower dose of
resveratrol (2 mg /kg) augmented eNOS expression without altering COX-1
expression, but, at a higher dose (10 mg / kg), resveratrol predominantly
suppressed COX-1 expression, which significantly reduced both PGE2
synthesis and angiogenesis. It ultimately resulted in delay healing of
indomethacin-induced gastric ulcers. [1, 2]
Hong SP, Chosun University, Korea, found that intake of resveratrol
significantly increased the extent of the absorption (AUC) of diltiazem,
except for resveratrol 0.5 mg/kg, in a rat study. The relative bioavailability of
diltiazem in the presence of resveratrol (2.5 and 10 mg/kg) was increased
by 1.48- to 1.60-fold! Researchers explained that resveratrol
significantly increased the bioavailability of diltiazem due to the
inhibition of both the cytochrome P450 3A4-mediated metabolism and the
efflux pump P-glycoprotein in the intestine and/or liver. [7] This unwanted
side effect can be extremely serious for diltiazem users!
It is also speculated that resveratrol may slow down the metabolism of some
drugs including statins, statins, erectile dysfunction meds, calcium channel
blockers and some immune-system suppressants. That could dangerously
screw up the doses. And there's some evidence that resveratrol may
activate estrogen receptors on cells, spelling side effects or trouble for
women with a history of estrogen-sensitive tumours (often breast, ovarian
and uterine). [9]
Finally, Dr. Gerald Weissmann, director of New York University's
biotechnology study center pointed out a possible side effects of
resveratrol. In an interview, he said, ""you might get terrible pimples,
infections or worse" Resveratrol may set loose in the body to scavenge
toxins also function to dampen our defenses against some dangerous
bacteria." [8] Resveratrol probably may have some other side effects not
reported yet. Please, consult with your doctor before taking any
supplements.
Resveratrol
Reference:
[1] Dey A, Guha P, Chattopadhyay S, Bandyopadhyay SK. Biphasic activity of resveratrol on
indomethacin-induced gastric ulcers. Biochem Biophys Res Commun. 2009 Mar 27;381(1):90-5.
Epub 2009 Feb 12. [2] Guha P, Dey A, Sarkar B, Dhyani MV, Chattopadhyay S, Bandyopadhyay SK.
Improved anti-ulcer and anticancer properties of a trans-resveratrol analog in mice. J Pharmacol Exp
Ther. 2009 Mar;328(3):829-38. Epub 2008 Dec 9. [3] Ahmad A, Syed FA, Singh S, Hadi SM,
Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA.
Toxicol Lett. 2005 Oct 15;159(1):1-12. [4] U.S. Patent Application 20070148689 [5] Cooper, Garth
J.S., et al, Preventing and/or treating cardiovascular disease and/or associated heart failure. U.S.
Patent Application 20030203973. [6] Noel, Joseph.; et al, Methods of producing polyketide synthase
mutants and compositions and uses thereof, U.S. Patent Application 20040106175. [7] Hong SP,
Choi DH, Choi JS. Effects of resveratrol on the pharmacokinetics of diltiazem and its major
metabolite, desacetyldiltiazem, in rats. Cardiovasc Ther. 2008 Winter;26(4):269-75. [8] Resveratrol is
a supplement, not a drug, Los Angeles Times, July 23, 2009 6:00 AM. [9] THE LIVE-LONGER
SUPPLEMENT: SHOULD YOU BE TAKING IT? Telegraph Journal.com Saturday July 25th, 2009
Resveratrol is believed to have at least two potential side effects. The first
potential side effect is a speculation based on its anti-cancer mechanism. In
a study of 2005, plasmid bluescript SK(+) DNA was treated with increasing
concentrations of resveratrol in the presence and absence of copper ions,
transformed into competent DH5alpha cells and sequenced. The study
shows a decrease in the transformation efficiency of the plasmid after
resveratrol treatment, and although all types of mutations were recorded,
point mutations (deletions/substitutions) were found to be the predominant
ones. Resveratrol alone resulted in deletion of mainly guanine bases. In the
chromatin of nucleus, copper ions are bound to guanine bases. This study
suggests the mobilization of such endogenous copper by resveratrol
resulting in prooxidant DNA cleavage at the site. In various cancer cell lines,
the copper concentration is reported to be elevated and this study may
explain the anticancer activity of resveratrol. [3] In fact, resveratrol is
generally considered as a copper chelator. [4-6]. Thus, it is speculated
that oral intake excessive amount of resveratrol orally may hinder
the absorption of certain metal ions, especially copper ion, leading
to copper deficiency. Please, note that there is no direct evidence for
such side effects.
The second potential side effect is observed from an animal study.
Researchers from Dr. B.C. Roy Post Graduate Institute of Basic Medical
Sciences & I.P.G.M.E. & R., India., demonstrated the biphasic activity of
resveratrol in indomethacin-induced gastric ulcerated mice. They observed
a beneficial effect of resveratrol at a low dose (2 mg/kg) but unwanted side
effect at a higher dose of resveratrol (10 mg/kg). The lower dose of
resveratrol (2 mg /kg) augmented eNOS expression without altering COX-1
expression, but, at a higher dose (10 mg / kg), resveratrol predominantly
suppressed COX-1 expression, which significantly reduced both PGE2
synthesis and angiogenesis. It ultimately resulted in delay healing of
indomethacin-induced gastric ulcers. [1, 2]
Hong SP, Chosun University, Korea, found that intake of resveratrol
significantly increased the extent of the absorption (AUC) of diltiazem,
except for resveratrol 0.5 mg/kg, in a rat study. The relative bioavailability of
diltiazem in the presence of resveratrol (2.5 and 10 mg/kg) was increased
by 1.48- to 1.60-fold! Researchers explained that resveratrol
significantly increased the bioavailability of diltiazem due to the
inhibition of both the cytochrome P450 3A4-mediated metabolism and the
efflux pump P-glycoprotein in the intestine and/or liver. [7] This unwanted
side effect can be extremely serious for diltiazem users!
It is also speculated that resveratrol may slow down the metabolism of some
drugs including statins, statins, erectile dysfunction meds, calcium channel
blockers and some immune-system suppressants. That could dangerously
screw up the doses. And there's some evidence that resveratrol may
activate estrogen receptors on cells, spelling side effects or trouble for
women with a history of estrogen-sensitive tumours (often breast, ovarian
and uterine). [9]
Finally, Dr. Gerald Weissmann, director of New York University's
biotechnology study center pointed out a possible side effects of
resveratrol. In an interview, he said, ""you might get terrible pimples,
infections or worse" Resveratrol may set loose in the body to scavenge
toxins also function to dampen our defenses against some dangerous
bacteria." [8] Resveratrol probably may have some other side effects not
reported yet. Please, consult with your doctor before taking any
supplements.
Resveratrol
Reference:
[1] Dey A, Guha P, Chattopadhyay S, Bandyopadhyay SK. Biphasic activity of resveratrol on
indomethacin-induced gastric ulcers. Biochem Biophys Res Commun. 2009 Mar 27;381(1):90-5.
Epub 2009 Feb 12. [2] Guha P, Dey A, Sarkar B, Dhyani MV, Chattopadhyay S, Bandyopadhyay SK.
Improved anti-ulcer and anticancer properties of a trans-resveratrol analog in mice. J Pharmacol Exp
Ther. 2009 Mar;328(3):829-38. Epub 2008 Dec 9. [3] Ahmad A, Syed FA, Singh S, Hadi SM,
Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA.
Toxicol Lett. 2005 Oct 15;159(1):1-12. [4] U.S. Patent Application 20070148689 [5] Cooper, Garth
J.S., et al, Preventing and/or treating cardiovascular disease and/or associated heart failure. U.S.
Patent Application 20030203973. [6] Noel, Joseph.; et al, Methods of producing polyketide synthase
mutants and compositions and uses thereof, U.S. Patent Application 20040106175. [7] Hong SP,
Choi DH, Choi JS. Effects of resveratrol on the pharmacokinetics of diltiazem and its major
metabolite, desacetyldiltiazem, in rats. Cardiovasc Ther. 2008 Winter;26(4):269-75. [8] Resveratrol is
a supplement, not a drug, Los Angeles Times, July 23, 2009 6:00 AM. [9] THE LIVE-LONGER
SUPPLEMENT: SHOULD YOU BE TAKING IT? Telegraph Journal.com Saturday July 25th, 2009
