| Resveratrol Side Effects September 12, 2011 |
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Most supplements have certain benefits and certain side effects. You may already know about the benefits
of resveratrol and this article highlights the potential side effects of resveratrol. We first review the
information about resveratrol side effects circulated over the internet and then we review a few scientific
articles about its side effects.
Resveratrol Side Effects
One top-ranked website in Google says, overdosage of resveratrol may lead to tendinitis pain, but the side
effects vary from person to person depending on the physical attributes of the users. The website further
says resveratrol can work as a blood-thinner. Faulty consumption of resveratrol may lead to insomina, joint
ache, diarrhea, stomach pain, colored urine, flu and acne.
Another top-ranked website in Google says, intake of resveratrol can lead to an increase in blood pressure.
Wait a minute, the previous website says resveratrol is a blood-thinner?? This website further says
resveratrol side effects include a buzzed feeling, insomnia, stomach cramping and diarrhea.
Linus Pauling Institute, Oregan State University says, resveratrol is not known to cause adverse effects in
humans. A single dose up to 5 grams led to no serious side effects. Linus Pauling Institute suggests patents
with hormone-related cancers should avoid resveratrol supplements. It is unclear how the estrogenic
activities affects the cancers.
_______________________________________________________________________
Resveratrol Side Effects - Scientific Articles
1. Hinderance of metal absorption Resveratrol is believed to have at least three potential side effects. 1.
The first potential resveratrol side effect is a speculation based on its anti-cancer mechanism. In a study of
2005, plasmid bluescript SK(+) DNA was treated with increasing concentrations of resveratrol in the
presence and absence of copper ions, transformed into competent DH5alpha cells and sequenced. The
study shows a decrease in the transformation efficiency of the plasmid after resveratrol treatment, and
although all types of mutations were recorded, point mutations (deletions/substitutions) were found to be the
predominant ones. Resveratrol alone resulted in deletion of mainly guanine bases. In the chromatin of
nucleus, copper ions are bound to guanine bases. This study suggests the mobilization of such endogenous
copper by resveratrol resulting in prooxidant DNA cleavage at the site. In various cancer cell lines, the
copper concentration is reported to be elevated and this study may explain the anticancer activity of
resveratrol. [3] In fact, resveratrol is generally considered as a copper chelator. [4-6]. Thus, it is speculated
that oral intake excessive amount of resveratrol orally may hinder the absorption of certain metal ions,
especially copper ion, leading to copper deficiency. Please, note that it is not a direct evidence for such side
effect.
2. High Doses - Delay of Recovery of Gastric Ulcer The second potential resveratrol side effect is
observed from an animal study. Researchers from Dr. B.C. Roy Post Graduate Institute of Basic Medical
Sciences & I.P.G.M.E. & R., India., demonstrated the biphasic activity of resveratrol in indomethacin-induced
gastric ulcerated mice. They observed a beneficial effect of resveratrol at a low dose (2 mg/kg) but
unwanted side effect at a higher dose of resveratrol (10 mg/kg). The lower dose of resveratrol (2 mg /kg)
augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg / kg),
resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis
and angiogenesis. It (high dose) ultimately resulted in delay healing of indomethacin-induced gastric ulcers.
[1, 2]
3. Drug Interaction Hong SP, Chosun University, Korea, found that intake of resveratrol significantly
increased the extent of the absorption (AUC) of diltiazem, except for resveratrol 0.5 mg/kg, in a rat study.
The relative bioavailability of diltiazem in the presence of resveratrol (2.5 and 10 mg/kg) was increased by
1.48- to 1.60-fold! Researchers explained that resveratrol significantly increased the bioavailability of
diltiazem due to the inhibition of both the cytochrome P450 3A4-mediated metabolism and the efflux pump
P-glycoprotein in the intestine and/or liver. [7] This unwanted side effect can be extremely serious for
diltiazem users! It is also speculated that resveratrol may slow down the metabolism of some drugs including
statins, statins, erectile dysfunction meds, calcium channel blockers and some immune-system
suppressants. That could dangerously screw up the doses. [9]
4. Cancinogenic? There's some evidence that resveratrol may activate estrogen receptors on cells,
spelling side effects or trouble for women with a history of estrogen-sensitive tumours (often breast, ovarian
and uterine). [9]
5. Pimples and Infections Finally, Dr. Gerald Weissmann, director of New York University's biotechnology
study center pointed out a possible side effects of resveratrol. In an interview, he said, ""you might get
terrible pimples, infections or worse" Resveratrol may set loose in the body to scavenge toxins also function
to dampen our defenses against some dangerous bacteria." [8] Resveratrol probably may have some other
side effects not reported yet. Please, consult with your doctor before taking any supplements.
Resveratrol Resveratrol Arthritis Resveratrol Cancer Resveratrol Diabetes Resveratrol
Supplements
Reference:
[1] Dey A, Guha P, Chattopadhyay S, Bandyopadhyay SK. Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochem
Biophys Res Commun. 2009 Mar 27;381(1):90-5. Epub 2009 Feb 12. [2] Guha P, Dey A, Sarkar B, Dhyani MV, Chattopadhyay S, Bandyopadhyay
SK. Improved anti-ulcer and anticancer properties of a trans-resveratrol analog in mice. J Pharmacol Exp Ther. 2009 Mar;328(3):829-38. Epub
2008 Dec 9. [3] Ahmad A, Syed FA, Singh S, Hadi SM, Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid
DNA. Toxicol Lett. 2005 Oct 15;159(1):1-12. [4] U.S. Patent Application 20070148689 [5] Cooper, Garth J.S., et al, Preventing and/or treating
cardiovascular disease and/or associated heart failure. U.S. Patent Application 20030203973. [6] Noel, Joseph.; et al, Methods of producing
polyketide synthase mutants and compositions and uses thereof, U.S. Patent Application 20040106175. [7] Hong SP, Choi DH, Choi JS. Effects
of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats. Cardiovasc Ther. 2008
Winter;26(4):269-75. [8] Resveratrol is a supplement, not a drug, Los Angeles Times, July 23, 2009 6:00 AM. [9] THE LIVE-LONGER
SUPPLEMENT: SHOULD YOU BE TAKING IT? Telegraph Journal.com Saturday July 25th, 2009
_______________________________________________________________________________________________________________
of resveratrol and this article highlights the potential side effects of resveratrol. We first review the
information about resveratrol side effects circulated over the internet and then we review a few scientific
articles about its side effects.
Resveratrol Side Effects
One top-ranked website in Google says, overdosage of resveratrol may lead to tendinitis pain, but the side
effects vary from person to person depending on the physical attributes of the users. The website further
says resveratrol can work as a blood-thinner. Faulty consumption of resveratrol may lead to insomina, joint
ache, diarrhea, stomach pain, colored urine, flu and acne.
Another top-ranked website in Google says, intake of resveratrol can lead to an increase in blood pressure.
Wait a minute, the previous website says resveratrol is a blood-thinner?? This website further says
resveratrol side effects include a buzzed feeling, insomnia, stomach cramping and diarrhea.
Linus Pauling Institute, Oregan State University says, resveratrol is not known to cause adverse effects in
humans. A single dose up to 5 grams led to no serious side effects. Linus Pauling Institute suggests patents
with hormone-related cancers should avoid resveratrol supplements. It is unclear how the estrogenic
activities affects the cancers.
_______________________________________________________________________
Resveratrol Side Effects - Scientific Articles
1. Hinderance of metal absorption Resveratrol is believed to have at least three potential side effects. 1.
The first potential resveratrol side effect is a speculation based on its anti-cancer mechanism. In a study of
2005, plasmid bluescript SK(+) DNA was treated with increasing concentrations of resveratrol in the
presence and absence of copper ions, transformed into competent DH5alpha cells and sequenced. The
study shows a decrease in the transformation efficiency of the plasmid after resveratrol treatment, and
although all types of mutations were recorded, point mutations (deletions/substitutions) were found to be the
predominant ones. Resveratrol alone resulted in deletion of mainly guanine bases. In the chromatin of
nucleus, copper ions are bound to guanine bases. This study suggests the mobilization of such endogenous
copper by resveratrol resulting in prooxidant DNA cleavage at the site. In various cancer cell lines, the
copper concentration is reported to be elevated and this study may explain the anticancer activity of
resveratrol. [3] In fact, resveratrol is generally considered as a copper chelator. [4-6]. Thus, it is speculated
that oral intake excessive amount of resveratrol orally may hinder the absorption of certain metal ions,
especially copper ion, leading to copper deficiency. Please, note that it is not a direct evidence for such side
effect.
2. High Doses - Delay of Recovery of Gastric Ulcer The second potential resveratrol side effect is
observed from an animal study. Researchers from Dr. B.C. Roy Post Graduate Institute of Basic Medical
Sciences & I.P.G.M.E. & R., India., demonstrated the biphasic activity of resveratrol in indomethacin-induced
gastric ulcerated mice. They observed a beneficial effect of resveratrol at a low dose (2 mg/kg) but
unwanted side effect at a higher dose of resveratrol (10 mg/kg). The lower dose of resveratrol (2 mg /kg)
augmented eNOS expression without altering COX-1 expression, but, at a higher dose (10 mg / kg),
resveratrol predominantly suppressed COX-1 expression, which significantly reduced both PGE2 synthesis
and angiogenesis. It (high dose) ultimately resulted in delay healing of indomethacin-induced gastric ulcers.
[1, 2]
3. Drug Interaction Hong SP, Chosun University, Korea, found that intake of resveratrol significantly
increased the extent of the absorption (AUC) of diltiazem, except for resveratrol 0.5 mg/kg, in a rat study.
The relative bioavailability of diltiazem in the presence of resveratrol (2.5 and 10 mg/kg) was increased by
1.48- to 1.60-fold! Researchers explained that resveratrol significantly increased the bioavailability of
diltiazem due to the inhibition of both the cytochrome P450 3A4-mediated metabolism and the efflux pump
P-glycoprotein in the intestine and/or liver. [7] This unwanted side effect can be extremely serious for
diltiazem users! It is also speculated that resveratrol may slow down the metabolism of some drugs including
statins, statins, erectile dysfunction meds, calcium channel blockers and some immune-system
suppressants. That could dangerously screw up the doses. [9]
4. Cancinogenic? There's some evidence that resveratrol may activate estrogen receptors on cells,
spelling side effects or trouble for women with a history of estrogen-sensitive tumours (often breast, ovarian
and uterine). [9]
5. Pimples and Infections Finally, Dr. Gerald Weissmann, director of New York University's biotechnology
study center pointed out a possible side effects of resveratrol. In an interview, he said, ""you might get
terrible pimples, infections or worse" Resveratrol may set loose in the body to scavenge toxins also function
to dampen our defenses against some dangerous bacteria." [8] Resveratrol probably may have some other
side effects not reported yet. Please, consult with your doctor before taking any supplements.
Resveratrol Resveratrol Arthritis Resveratrol Cancer Resveratrol Diabetes Resveratrol
Supplements
Reference:
[1] Dey A, Guha P, Chattopadhyay S, Bandyopadhyay SK. Biphasic activity of resveratrol on indomethacin-induced gastric ulcers. Biochem
Biophys Res Commun. 2009 Mar 27;381(1):90-5. Epub 2009 Feb 12. [2] Guha P, Dey A, Sarkar B, Dhyani MV, Chattopadhyay S, Bandyopadhyay
SK. Improved anti-ulcer and anticancer properties of a trans-resveratrol analog in mice. J Pharmacol Exp Ther. 2009 Mar;328(3):829-38. Epub
2008 Dec 9. [3] Ahmad A, Syed FA, Singh S, Hadi SM, Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid
DNA. Toxicol Lett. 2005 Oct 15;159(1):1-12. [4] U.S. Patent Application 20070148689 [5] Cooper, Garth J.S., et al, Preventing and/or treating
cardiovascular disease and/or associated heart failure. U.S. Patent Application 20030203973. [6] Noel, Joseph.; et al, Methods of producing
polyketide synthase mutants and compositions and uses thereof, U.S. Patent Application 20040106175. [7] Hong SP, Choi DH, Choi JS. Effects
of resveratrol on the pharmacokinetics of diltiazem and its major metabolite, desacetyldiltiazem, in rats. Cardiovasc Ther. 2008
Winter;26(4):269-75. [8] Resveratrol is a supplement, not a drug, Los Angeles Times, July 23, 2009 6:00 AM. [9] THE LIVE-LONGER
SUPPLEMENT: SHOULD YOU BE TAKING IT? Telegraph Journal.com Saturday July 25th, 2009
_______________________________________________________________________________________________________________
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This website discusses the benefits and side effects of various supplements, herbs and drug products.
Different people may experience different side effects and benefits of a product. You are encouraged to report
adverse side effects to FDA, its website is www.fda.gov., or report the adverse side effects to the
manufacturer, you should be able to find the contact information on the label.
There are always new information. Please, send me an email (zhion@zhion.com) to correct my mistake(s).
Reasonable care has been taken in preparing this document and the information provided herein is believed
to be accurate. The information is not intended to be a substitute for professional medical advice. It is
important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of a supplement or a drug product. Finally, please, do not transfer the article to other website. Thank
you. ALL RIGHTS RESERVED.
Different people may experience different side effects and benefits of a product. You are encouraged to report
adverse side effects to FDA, its website is www.fda.gov., or report the adverse side effects to the
manufacturer, you should be able to find the contact information on the label.
There are always new information. Please, send me an email (zhion@zhion.com) to correct my mistake(s).
Reasonable care has been taken in preparing this document and the information provided herein is believed
to be accurate. The information is not intended to be a substitute for professional medical advice. It is
important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of a supplement or a drug product. Finally, please, do not transfer the article to other website. Thank
you. ALL RIGHTS RESERVED.