Yucca schidigera Roezl. (Agavaceae) has been traditionally used to treat a
variety of diseases including arthritis and rheumatism. Resveratrol, one of the key
ingredients in Yucca, is believed to contribute a part of the health benefits of
Yucca. [3] In this article, we are going to review the mechanism to cure arthritis
and a few studies suggesting that resveratrol may benefit those at risk of
rheumatic arthritis and related diseases.
Researchers from University of Cincinnati explained the way to cure arthritis.
Arthritis, an inflammation of the joints, is usually a chronic disease that results
from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and
interleukin-1beta) and pro-inflammatory enzymes that mediate the production of
prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase),
together with the expression of adhesion molecules and matrix
metalloproteinases, and hyperproliferation of synovial fibroblasts. All of these
factors are regulated by the activation of the transcription factor nuclear factor-
kappaB. Thus, agents that suppress the expression of tumor necrosis factor-
alpha, interleukin-1beta, cyclooxygenase-2, lipooxygenase, matrix
metalloproteinases or adhesion molecules, or suppress the activation of NF-
kappaB, all have potential for the treatment of arthritis. [6]
COX-1 and COX-2
Oxidative stress is related to a number of autoimmune diseases, including cancer
and rheumatoid arthritis. The main source of pathologic “reactive oxygen species”
are the activated polymorphonuclear leukocytes. Resveratrol was found to inhibit
isolated polymorphonuclear leukocytes in a dose dependent manner. [2]
Researchers from Ludwig-Maximilians-University Munich demonstrated that
resveratrol inhibited the expression of VEGF, MMP-3, MMP-9 and COX-2 in
human articularchondrocytes stimulated with the pro-inflammatory cytokine IL-
1beta. Furthermore, they demonstrated resveratrol suppressed apoptosis and
inflammatory signaling through its actions on the NF-kappaB pathway in human
chondrocytes. [4] Researchers from University of Graz, Australia, also showed
that resveratrol possessed COX-1 inhibition, COX-2 inhibitory potential and an
LTB 4 formation inhibitory activity in an in vitro study. [3]
Anabolic Mediator
Researches from Rush University Medical Center found resveratrol is a potent
anabolic mediator of bovine intervertebral disc cartilage homeostasis from a vitro
study, revealing its potential as a unique biologic treatment to slow the
progression of intervertebral disc degeneration. [1]
IL-1beta
The inflammatory process plays a pivotal role during the pathogenesis of
osteoarthritis, dominated by catabolic processes initiated by pro-inflammatory
cytokines such as IL-1beta. Researchers from Ludwig-Maximilians-University
Munich found resveratrol reversed significantly IL-1beta-reduced cell proliferation
and blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta
synthesis in chondrocytes. Furthermore, resveratrol was able to inhibit the IL-
1beta-induced degradation of mitochondria and apoptosis in chondrocytes in a
time-dependent manner. They also found that resveratrol was able to reverse the
IL-1beta-induced up-regulation of reactive oxygen species (ROS) in
chondrocytes. [5]
Macrophage Migration Inhibitory Factor
Molnar V and Garai J. from University of Pécs, Hungary, considered the cytokine
macrophage migration inhibitory factor as a crucial factor in the pathogenesis of
rheumatoid arthritis. They found resveratrol was a potent inhibitor as the
antipyretic-analgetic drug acetaminophen. [7]
Nuclear factor kappa B (NF-kappaB) / Animal Study
Nuclear factor kappa B (NF-kappaB), is a pivotal transcription factor involved
inthe activation of the TNF-alpha and IL-1beta genes. Activation of NF-kappaB
insynovial cells is a feature seen in arthritis patients. Resveratrol is potent and
specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation.
Researchers from Inönü University Medical Faculty, Turkey, found intra-articular
injections of resveratrol on cartilage and synovium could significantly decreased
cartilage destruction in an experimental rabbit inflammatory arthritic model. [8]
Health benefits and side effects of resveratrol
Resveratrol Side Effects
Resveratrol Cream
Resveratrol Cancer
Resveratrol Diabetes
Does grape seed extract lower bad cholesterol?
Reference:
[1] Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, Park D, Im HJ. The
action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc.
Spine. 2008 Nov 15;33(24):2586-95. [2] Perecko T, Jancinova V, Drabikova K,
Nosal R, Harmatha J. Structure-efficiency relationship in derivatives of stilbene.
Comparison of resveratrol, pinosylvin and pterostilbene. Neuro Endocrinol Lett.
2008 Oct;29(5):802-5. [3]: Wenzig EM, Oleszek W, Stochmal A, Kunert O, Bauer
R. Influence of phenolic constituents from Yucca schidigera bark on arachidonate
metabolism in vitro.J Agric Food Chem. 2008 Oct 8;56(19):8885-90. Epub 2008
Sep 9. [4] Shakibaei M, Csaki C, Nebrich S, Mobasheri A. Resveratrol suppresses
interleukin-1beta-induced inflammatory signaling and apoptosis in human
articular chondrocytes: potential for use as a novel nutraceutical for the treatment
of osteoarthritis. Biochem Pharmacol. 2008 Dec 1;76(11):1426-39. Epub 2008
Jun 3. [5] Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. Regulation of
inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem
Pharmacol. 2008 Feb 1;75(3):677-87. Epub 2007 Sep 18. [6] Khanna D, Sethi G,
Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.
Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol.
2007 Jun;7(3):344-51. Epub 2007 May 1. [7] Molnar V, Garai J. Plant-derived anti-
inflammatory compounds affect MIF tautomerase activity. Int Immunopharmacol.
2005 May;5(5):849-56. Epub 2005 Jan 27. [8] Elmali N, Baysal O, Harma A,
Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation.
2007 Apr;30(1-2):1-6.-----
variety of diseases including arthritis and rheumatism. Resveratrol, one of the key
ingredients in Yucca, is believed to contribute a part of the health benefits of
Yucca. [3] In this article, we are going to review the mechanism to cure arthritis
and a few studies suggesting that resveratrol may benefit those at risk of
rheumatic arthritis and related diseases.
Researchers from University of Cincinnati explained the way to cure arthritis.
Arthritis, an inflammation of the joints, is usually a chronic disease that results
from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and
interleukin-1beta) and pro-inflammatory enzymes that mediate the production of
prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase),
together with the expression of adhesion molecules and matrix
metalloproteinases, and hyperproliferation of synovial fibroblasts. All of these
factors are regulated by the activation of the transcription factor nuclear factor-
kappaB. Thus, agents that suppress the expression of tumor necrosis factor-
alpha, interleukin-1beta, cyclooxygenase-2, lipooxygenase, matrix
metalloproteinases or adhesion molecules, or suppress the activation of NF-
kappaB, all have potential for the treatment of arthritis. [6]
COX-1 and COX-2
Oxidative stress is related to a number of autoimmune diseases, including cancer
and rheumatoid arthritis. The main source of pathologic “reactive oxygen species”
are the activated polymorphonuclear leukocytes. Resveratrol was found to inhibit
isolated polymorphonuclear leukocytes in a dose dependent manner. [2]
Researchers from Ludwig-Maximilians-University Munich demonstrated that
resveratrol inhibited the expression of VEGF, MMP-3, MMP-9 and COX-2 in
human articularchondrocytes stimulated with the pro-inflammatory cytokine IL-
1beta. Furthermore, they demonstrated resveratrol suppressed apoptosis and
inflammatory signaling through its actions on the NF-kappaB pathway in human
chondrocytes. [4] Researchers from University of Graz, Australia, also showed
that resveratrol possessed COX-1 inhibition, COX-2 inhibitory potential and an
LTB 4 formation inhibitory activity in an in vitro study. [3]
Anabolic Mediator
Researches from Rush University Medical Center found resveratrol is a potent
anabolic mediator of bovine intervertebral disc cartilage homeostasis from a vitro
study, revealing its potential as a unique biologic treatment to slow the
progression of intervertebral disc degeneration. [1]
IL-1beta
The inflammatory process plays a pivotal role during the pathogenesis of
osteoarthritis, dominated by catabolic processes initiated by pro-inflammatory
cytokines such as IL-1beta. Researchers from Ludwig-Maximilians-University
Munich found resveratrol reversed significantly IL-1beta-reduced cell proliferation
and blocked IL-1beta-stimulated cell membrane bound- and mature IL-1beta
synthesis in chondrocytes. Furthermore, resveratrol was able to inhibit the IL-
1beta-induced degradation of mitochondria and apoptosis in chondrocytes in a
time-dependent manner. They also found that resveratrol was able to reverse the
IL-1beta-induced up-regulation of reactive oxygen species (ROS) in
chondrocytes. [5]
Macrophage Migration Inhibitory Factor
Molnar V and Garai J. from University of Pécs, Hungary, considered the cytokine
macrophage migration inhibitory factor as a crucial factor in the pathogenesis of
rheumatoid arthritis. They found resveratrol was a potent inhibitor as the
antipyretic-analgetic drug acetaminophen. [7]
Nuclear factor kappa B (NF-kappaB) / Animal Study
Nuclear factor kappa B (NF-kappaB), is a pivotal transcription factor involved
inthe activation of the TNF-alpha and IL-1beta genes. Activation of NF-kappaB
insynovial cells is a feature seen in arthritis patients. Resveratrol is potent and
specific inhibitor of TNF-alpha and IL-1beta induced NF-kappaB activation.
Researchers from Inönü University Medical Faculty, Turkey, found intra-articular
injections of resveratrol on cartilage and synovium could significantly decreased
cartilage destruction in an experimental rabbit inflammatory arthritic model. [8]
Health benefits and side effects of resveratrol
Resveratrol Side Effects
Resveratrol Cream
Resveratrol Cancer
Resveratrol Diabetes
Does grape seed extract lower bad cholesterol?
Reference:
[1] Li X, Phillips FM, An HS, Ellman M, Thonar EJ, Wu W, Park D, Im HJ. The
action of resveratrol, a phytoestrogen found in grapes, on the intervertebral disc.
Spine. 2008 Nov 15;33(24):2586-95. [2] Perecko T, Jancinova V, Drabikova K,
Nosal R, Harmatha J. Structure-efficiency relationship in derivatives of stilbene.
Comparison of resveratrol, pinosylvin and pterostilbene. Neuro Endocrinol Lett.
2008 Oct;29(5):802-5. [3]: Wenzig EM, Oleszek W, Stochmal A, Kunert O, Bauer
R. Influence of phenolic constituents from Yucca schidigera bark on arachidonate
metabolism in vitro.J Agric Food Chem. 2008 Oct 8;56(19):8885-90. Epub 2008
Sep 9. [4] Shakibaei M, Csaki C, Nebrich S, Mobasheri A. Resveratrol suppresses
interleukin-1beta-induced inflammatory signaling and apoptosis in human
articular chondrocytes: potential for use as a novel nutraceutical for the treatment
of osteoarthritis. Biochem Pharmacol. 2008 Dec 1;76(11):1426-39. Epub 2008
Jun 3. [5] Csaki C, Keshishzadeh N, Fischer K, Shakibaei M. Regulation of
inflammation signalling by resveratrol in human chondrocytes in vitro. Biochem
Pharmacol. 2008 Feb 1;75(3):677-87. Epub 2007 Sep 18. [6] Khanna D, Sethi G,
Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.
Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol.
2007 Jun;7(3):344-51. Epub 2007 May 1. [7] Molnar V, Garai J. Plant-derived anti-
inflammatory compounds affect MIF tautomerase activity. Int Immunopharmacol.
2005 May;5(5):849-56. Epub 2005 Jan 27. [8] Elmali N, Baysal O, Harma A,
Esenkaya I, Mizrak B. Effects of resveratrol in inflammatory arthritis. Inflammation.
2007 Apr;30(1-2):1-6.-----
| RESVERATROL arthritis |
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Discuss with your doctor before taking any alternative medicine. This article is for
reference only, it is not a medical advice. All rights reserved. Do not copy this article to
other website or blog.
reference only, it is not a medical advice. All rights reserved. Do not copy this article to
other website or blog.
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