RESVERATROL dosages zhion@zhion.com     February 17, 2012
Introduction

Yucca schidigera Roezl has been traditionally used to treat a variety of diseases including arthritis and rheumatism,
it was then found that Yucca contains resveratrol. Resveratrol is also found in Veratrum grandiflorum, berries,
peanuts, grapes, red wine and some other plants. Test-tube and animal studies indicate that resveratrol exhibits a
wide range of biological effects, including antiplatelet, anti-inflammatory, anticancer, antimutagenic and antifungal
properties. It could be interesting to estimate what dosage the users need to achieve such benefits. In this article,
we estimate the resveratrol dosage requirement to achieve the relevant therapeutic effects based on 1. resveratrol
concentration in the blood, in an animal study, and 2. the resveratrol doage/body weight ratio used in animal studies.
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1. Estimation of Resveratrol Dosage based on Resveratrol Concentration found in animal studies

Resveratrol (5-35 micromol/l) was found to be able to induce concentration-dependent relaxation of mesenteric
arteries preconstricted with noradrenaline (8 micromol/l) or KCl (125 mmol/l) from both lean and dietary-obese rats.
[d1]

A phase I study of oral resveratrol (single resveratrol dosages of 0.5, 1, 2.5, or 5 g) was conducted by Leicester
University, UK, in 10 healthy volunteers per dose level. Resveratrol and six metabolites were recovered from plasma
and urine. Peak plasma levels of resveratrol at the highest dose were 539 +/- 384 ng/mL (2.4 micromol/L), which
occurred 1.5 h post-dose. Cancer preventive effects of resveratrol in cells in vitro require levels of at least 5
micromol/L. The results suggest that consumption of very high resveratrol dosage (>>5 g daily) is needed to elicit
systemic levels commensurate with cancer preventive efficacy. [c7]
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2. Resveratrol Dose / Body Weight Ration Requirement for Therapeutic Effects

Study 1 Treatment with resveratrol dosage of 10mg/kg orally from week 4 to week 6 significantly attenuated the cold
allodynia and thermal hyperalgesia, suggesting the application of resveratrol in diabetes, especially for diabetic
neuropathy. [d5]

Study 2 Oral resveratrol dosage of 20 mg/kg daily for 4 weeks also remarkably prevented the DMN-induced loss in
body and liver weight, and inhibited the elevation of serum alanine transaminase, aspartate transaminase, alkaline
phosphatase and bilirubin levels. [LP1]

Study 3 Resveratrol Dosage of 20 mg/(kg . d) was adminstrated for 90 days to increase sperm counts. [9]

Study 4 Dosage of (vitamin D+400 mg/kg resveratrol+2,000 mg/kg quercetin+1,040 mg/kg genistein) reduced body
weight gain and the fat pad weights in aged ovariectomized female rats.

Assuming the physiology of the animals used in the study is comparable to human's, for a body weight of 86.6 Kg,
the required reservatrol dosage to achieve the biological effect (in Study 1) is 86.6 X 10 is 866 mg.
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Safety Reveratrol Dosage

For the article Reveratrol Side Effects, we know that high dosages of resveratrol is unsafe. Then, up to what dosage
is safe?

Researchers administered rats dosage of 0, 300, 1000, and 3000 mg trans-resveratrol per kilogram body weight per
day for 4 weeks. Most of the adverse or side events occurred in the rats administered 3000 mg per kilogram body
weight per day. Signs of toxicity included reduced final body weights and food consumption; elevated BUN,
creatinine, alkaline phosphatase, alanine aminotransferase, total bilirubin, and albumin; reduced hemoglobin,
hematocrit, and red cell counts; and increased white cell counts. They also observed renal lesions. No adverse or
side effects were observed at 300 mg resveratrol per kilogram body weight per day in rats. [12] While, another
scientific article suggests resveratrol is safe at doses equivalent to 500 mg/day. [1]

Hormetic response of resveratrol against cardioprotection.
Recently, I have received a comment from a visitor about the hormesis of resveratrol. Hormesis is a dose response
phenomenon characterized by a low dose stimulation, high dose inhibition, resulting in either a J-shaped or an
inverted U-shaped dose response curves. [RD1] Recent studies indicate the hormetic action of resveratrol, in which
resveratrol protects the heart cells at a lower dose while kills them at relatively higher doses. In an animal study,
resveratrol formulation (Longevinex) was tested. A group of rats were fed with three different doses of resveratrol or
Longevinex (dosage 2.5 mg/kg, 25 mg/kg and 100 mg/kg) for up to 30 days, while the control group was only given
placebo. The results showed hormesis for pure resveratrol, which was cardioprotective at lower doses and
detrimental for higher doses, but surprisingly Longevinex did not display such hormetic action. [RD2]

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Resveratrol Dosage in Red Wine and Supplements

One liter of red wine contains only 1.5-3 mg of resveratrol. Consequently, resveratrol supplements are available in
the market. One serving (2 capsules) of Resvinex 500 contains 500 mg of trans-resveratrol, while Puritan's Pride
supplies various types of resveratrol products at range of 50 to 250 mg.


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                                                                               Reference
Different people may experience different side effects and benefits of a product. You are encouraged to report
adverse side effects to FDA, its website is www.fda.gov., or report the adverse side effects to the
manufacturer, you should be able to find the contact information on the label.

There are always new information. Please, send me an email (zhion@zhion.com) to correct my mistake(s).
Reasonable care has been taken in preparing this document and the information provided herein is believed
to be accurate. The information is not intended to be a substitute for professional medical advice. It is
important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of a supplement or a drug product. Finally, please, do not transfer the article to other website. Thank
you. ALL RIGHTS RESERVED.