| RESVERATROL BENEFITS AND SIDE EFFECTS |
Resveratrol is a polyphenol compound that may have health benefits
on various chronic diseases. [1] It exhibits a wide range of biological
effects, including antiplatelet, anti-inflammatory, anticancer,
antimutagenic and antifungal properties. [4] This compound is also
believed responsible for some of the beneficial effects of moderate red
wine drinking on the cardiovascular system. One liter of red wine
contains 1.5-3 mg of resveratrol. Resveratrol also exists in grapes.
Resveratrol is considered as a dietary phytoalexin. Phyto comes from
the word phyton which means a plant, while alexin means to defend.
Phytoalexin means plant antibiotic produced by a plant in response to
the entry of a disease-producing substance. [8]
RESEARCH FINDINGS
CANCER
Resveratrol has been shown to inhibit cancer initiation and promotion
[2] It acts as a selective estrogen receptor modulator (SERM) and
regulates proteins involved in DNA synthesis and cell cycle.
Resveratrol also affects the activity of transcriptional factors involved
in proliferation and stress responses, such as NF-kB, AP1 and Egr1. [3]
GASTRIC ADENOCARCINOMA Researchers from researchers at Cook
County Hospital found that gastric adenocarcinoma cells respond to
resveratrol treatment with suppression of DNA synthesis, activation of
nitric oxide synthase, induction of apoptosis and inhibition of total PKC
and PKC alpha activity. [6]
CARDIOVASCULAR DISEASES
Resveratrol is a phytoestrogen, potent antioxidant, reactive oxygen
species scavenger and metal chelators. [4] Thus, it may have benefits
of protection of the cardiovascular system against ischemic-
reperfusion injury; it may also protect and maintain the intact
endothelium, exhibits antiatherosclerotic properties inhibits the LDL
oxidation, suppress the platelet aggregation and exhibits estrogen
like action. [4, 7]
PANCREATITIS
Because microcirculation occlusion and cytokines over-production is
involved in many diseases such as acute pancreatitis, resveratrol as a
platelet and cytokines inhibitor may have benefits on acute
pancreatitis. [5]
LIVER TRANSPLANT
Resveratrol has been shown to have an immuno-suppressive property
as well as protective effect on hepatocytes under allograft rejection in
a study of Wistar rats. [11]
KIDNEY DISEASES
Resveratrol (RSV) has been shown to reduce ischemia-reperfusion
(I/R) injury of rat kidney both by antioxidant and anti-inflammatory
mechanisms. [10]
SPERM PRODUCTION
In a study, researchers administered 20 mg/(kg . d) of trans-
resveratrol for 90 days. Compared to a control group, the diameter of
the seminiferous tubules was significantly reduced from 437.5 +/- 0.1
mum in the controls to 310.9 +/- 0.1 mum. This decrease was
accompanied by a significant increase in tubular density. Sperm counts
were significantly greater in the resveratrol-treated rats than in the
control group, but sperm quality did not differ. [9]
OTHER IMPORTANT ISSUES
Resveratrol is a potent antioxidant, oxidation may occur during the
manufacturing process or/and storage of the finished products. It has
long been thought that resveratrol supplements were not very
effective in comparison with wine. Recently, some manufacturers have
developed a technique to solve the stability issues of resveratrol
supplements during manufacturing and storage. [1]
DOSE Resveratrol has been used safely in studies at doses equivalent
to 500 mg./day. [1]
TOXICITY / SIDE EFFECTS
Researchers administered rats 0, 300, 1000, and 3000 mg trans-
resveratrol per kilogram body weight per day for 4 weeks. Most of the
adverse or side events occurred in the rats administered 3000 mg per
kilogram body weight per day. Signs of toxicity included reduced final
body weights and food consumption; elevated BUN, creatinine,
alkaline phosphatase, alanine aminotransferase, total bilirubin, and
albumin; reduced hemoglobin, hematocrit, and red cell counts; and
increased white cell counts. They also observed renal lesions. No
adverse or side effects were observed at 300 mg resveratrol per
kilogram body weight per day in rats. [12]
Click: More information on resveratrol
THIS ARTICLE IS FOR YOUR INFORMATION ONLY. IF YOU HAVE ANY
QUESTION, YOU SHOULD CONSULT WITH YOUR DOCTOR. DO NOT COPY NOR
TRANSFER THE CONTENT TO OTHER WEBSITE. ALL RIGHT RESERVED 2008
zhion.
References
[1] Neil E Levin et al, Pomeratrol™ Fact Sheet, NowFoods Online Publication,
September 20, 2005 [2] Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF,
Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural
product derived from grapes. Science 1997;275:218-20 [3] Signorelli P and
Ghidoni R Resveratrol as an anticancer nutrient: molecular basis, open
questions and promises. J Nutr Biochem. 2005 Aug;16(8):449-66. [4] Olas B,
Wachowicz B. Resveratrol, a phenolic antioxidant with effects on blood platelet
functions. Platelets. 2005 Aug;16(5):251-60. [5] Ma ZH, Ma QY. Resveratrol: a
medical drug for acute pancreatitis. World J Gastroenterol. 2005 Jun 7;11(21):
3171-4. [6] Atten MJ, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O.,
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce
apoptosis in gastric cancer cells. Invest New Drugs. 2005 Mar;23(2):111-9. [7]
Dong HH Ren HL New progression in the study of protective properties of
resveratrol in anticardiovascular disease. Bratisl Lek Listy. 2004;105(5-6):225-
9. [8] Phytoalexin, Medfriendly.com Online Publication, September 20, 2005.
[9] Juan ME et al, trans-Resveratrol, a natural antioxidant from grapes,
increases sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60. [10]
Bertelli AA et al, Resveratrol, a component of wine and grapes, in the
prevention of kidney disease. Ann N Y Acad Sci. 2002 May;957:230-8. [11] Wu
SL et al, Resveratrol prolongs allograft survival after liver transplantation in
rats. World J Gastroenterol. 2005 Aug 14;11(30):4745-9. [12] Crowell JA et al,
Resveratrol-associated renal toxicity. Toxicol Sci. 2004 Dec;82(2):614-9. Epub
2004 Aug 25.
on various chronic diseases. [1] It exhibits a wide range of biological
effects, including antiplatelet, anti-inflammatory, anticancer,
antimutagenic and antifungal properties. [4] This compound is also
believed responsible for some of the beneficial effects of moderate red
wine drinking on the cardiovascular system. One liter of red wine
contains 1.5-3 mg of resveratrol. Resveratrol also exists in grapes.
Resveratrol is considered as a dietary phytoalexin. Phyto comes from
the word phyton which means a plant, while alexin means to defend.
Phytoalexin means plant antibiotic produced by a plant in response to
the entry of a disease-producing substance. [8]
RESEARCH FINDINGS
CANCER
Resveratrol has been shown to inhibit cancer initiation and promotion
[2] It acts as a selective estrogen receptor modulator (SERM) and
regulates proteins involved in DNA synthesis and cell cycle.
Resveratrol also affects the activity of transcriptional factors involved
in proliferation and stress responses, such as NF-kB, AP1 and Egr1. [3]
GASTRIC ADENOCARCINOMA Researchers from researchers at Cook
County Hospital found that gastric adenocarcinoma cells respond to
resveratrol treatment with suppression of DNA synthesis, activation of
nitric oxide synthase, induction of apoptosis and inhibition of total PKC
and PKC alpha activity. [6]
CARDIOVASCULAR DISEASES
Resveratrol is a phytoestrogen, potent antioxidant, reactive oxygen
species scavenger and metal chelators. [4] Thus, it may have benefits
of protection of the cardiovascular system against ischemic-
reperfusion injury; it may also protect and maintain the intact
endothelium, exhibits antiatherosclerotic properties inhibits the LDL
oxidation, suppress the platelet aggregation and exhibits estrogen
like action. [4, 7]
PANCREATITIS
Because microcirculation occlusion and cytokines over-production is
involved in many diseases such as acute pancreatitis, resveratrol as a
platelet and cytokines inhibitor may have benefits on acute
pancreatitis. [5]
LIVER TRANSPLANT
Resveratrol has been shown to have an immuno-suppressive property
as well as protective effect on hepatocytes under allograft rejection in
a study of Wistar rats. [11]
KIDNEY DISEASES
Resveratrol (RSV) has been shown to reduce ischemia-reperfusion
(I/R) injury of rat kidney both by antioxidant and anti-inflammatory
mechanisms. [10]
SPERM PRODUCTION
In a study, researchers administered 20 mg/(kg . d) of trans-
resveratrol for 90 days. Compared to a control group, the diameter of
the seminiferous tubules was significantly reduced from 437.5 +/- 0.1
mum in the controls to 310.9 +/- 0.1 mum. This decrease was
accompanied by a significant increase in tubular density. Sperm counts
were significantly greater in the resveratrol-treated rats than in the
control group, but sperm quality did not differ. [9]
OTHER IMPORTANT ISSUES
Resveratrol is a potent antioxidant, oxidation may occur during the
manufacturing process or/and storage of the finished products. It has
long been thought that resveratrol supplements were not very
effective in comparison with wine. Recently, some manufacturers have
developed a technique to solve the stability issues of resveratrol
supplements during manufacturing and storage. [1]
DOSE Resveratrol has been used safely in studies at doses equivalent
to 500 mg./day. [1]
TOXICITY / SIDE EFFECTS
Researchers administered rats 0, 300, 1000, and 3000 mg trans-
resveratrol per kilogram body weight per day for 4 weeks. Most of the
adverse or side events occurred in the rats administered 3000 mg per
kilogram body weight per day. Signs of toxicity included reduced final
body weights and food consumption; elevated BUN, creatinine,
alkaline phosphatase, alanine aminotransferase, total bilirubin, and
albumin; reduced hemoglobin, hematocrit, and red cell counts; and
increased white cell counts. They also observed renal lesions. No
adverse or side effects were observed at 300 mg resveratrol per
kilogram body weight per day in rats. [12]
Click: More information on resveratrol
THIS ARTICLE IS FOR YOUR INFORMATION ONLY. IF YOU HAVE ANY
QUESTION, YOU SHOULD CONSULT WITH YOUR DOCTOR. DO NOT COPY NOR
TRANSFER THE CONTENT TO OTHER WEBSITE. ALL RIGHT RESERVED 2008
zhion.
References
[1] Neil E Levin et al, Pomeratrol™ Fact Sheet, NowFoods Online Publication,
September 20, 2005 [2] Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF,
Beecher CW, et al. Cancer chemopreventive activity of resveratrol, a natural
product derived from grapes. Science 1997;275:218-20 [3] Signorelli P and
Ghidoni R Resveratrol as an anticancer nutrient: molecular basis, open
questions and promises. J Nutr Biochem. 2005 Aug;16(8):449-66. [4] Olas B,
Wachowicz B. Resveratrol, a phenolic antioxidant with effects on blood platelet
functions. Platelets. 2005 Aug;16(5):251-60. [5] Ma ZH, Ma QY. Resveratrol: a
medical drug for acute pancreatitis. World J Gastroenterol. 2005 Jun 7;11(21):
3171-4. [6] Atten MJ, Godoy-Romero E, Attar BM, Milson T, Zopel M, Holian O.,
Resveratrol regulates cellular PKC alpha and delta to inhibit growth and induce
apoptosis in gastric cancer cells. Invest New Drugs. 2005 Mar;23(2):111-9. [7]
Dong HH Ren HL New progression in the study of protective properties of
resveratrol in anticardiovascular disease. Bratisl Lek Listy. 2004;105(5-6):225-
9. [8] Phytoalexin, Medfriendly.com Online Publication, September 20, 2005.
[9] Juan ME et al, trans-Resveratrol, a natural antioxidant from grapes,
increases sperm output in healthy rats. J Nutr. 2005 Apr;135(4):757-60. [10]
Bertelli AA et al, Resveratrol, a component of wine and grapes, in the
prevention of kidney disease. Ann N Y Acad Sci. 2002 May;957:230-8. [11] Wu
SL et al, Resveratrol prolongs allograft survival after liver transplantation in
rats. World J Gastroenterol. 2005 Aug 14;11(30):4745-9. [12] Crowell JA et al,
Resveratrol-associated renal toxicity. Toxicol Sci. 2004 Dec;82(2):614-9. Epub
2004 Aug 25.
| Resveratrol is a polyphenol compound that may have health benefits on various chronic diseases. [1] |
MAJOR NUTRIENT
DIET.
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PhytoChemicals
Antioxidants
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Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
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Apple
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Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
Beet
black cohosh
Bladderwrack
Blackberry
Black Currant
Bloodroot
Blueberry
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Garcinia C.
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Kava Kava
Kelp
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Lavender
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Lemon balm
Licorice
Lingonberry
Lutein
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Maca
Maitake
Mango
Mangosteen
Marshmallow
Melatonin
Milk Thistle
Mistletoe
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Nattokinase
Nectarines
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Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
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Peony
Pepper
Peppermint
Persimmons
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Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Quince
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rhubarb
Rice Bran Oil
Rosemary
Royal Jelly
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methionine
Saffron
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Schisandra
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Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
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Soy
Stevia
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Vitex
Walnuts
Watermelon
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Wild Yam
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DIET.
SUPPLEMENT
PhytoChemicals
Antioxidants
A-Z Health Foods,
Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
Aloe vera
Andrographis
Aniseed
Apple
Arnica
Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
Beet
black cohosh
Bladderwrack
Blackberry
Black Currant
Bloodroot
Blueberry
Bilberry
Bitter Melon
Borage Seed Oil
Boswellia
Black Soya Bean
Broccoli
Bromelain
Brown Seaweed
Brussels Sprout
Butein
Butterbur
Burdock
Cabbage
Cactus
Caffeine
Calcium
Calendula
Canola oil
Cauliflower
Cat's Claw
Cayenne
Celadrin
Celery
Chamomile
Chaparral
Cherry
Chokeberry
Chondroitin
Chitosan
Chlorella
Chlorophyll
Chromium
Cinnamon
CLA
Cocoa
Cod Liver Oil
Coenzyme Q
Coffee
Comfrey
Conj. Linoleic Acid
Colostrum
Colloidal Silver
Cordyceps
Corn
Cranberry
Creatine
Curcumin
Damiana
Dandelion
Danggui_Buxue
Devil's Claw
DHEA
Dill
Dong Quai
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eucalyptus G.
Eve. Primrose Oil
Falcarinol
Fennel
Fenugreek
Feverfew
Folate
Fish Oil
Flaxseed Meal
Flaxseed /Linseed
Garcinia C.
Garlic
Galangal
Ghrelin
Ginger
Ginseng
Ginseng/Ginkgo
Ginkgo Biloba
Glucosamine
Goldenseal
Gotu Kola
GRAPE SEED
EXTRACT
Green Coffee Bean
Green Tea
Growth Hormone
Stimulants
Goldenseal
Guar Gum
Guggul
Gymnema
Hawthorn
Hoodia
Hop
Horse Chestnut
Horsetail
Huperzine A
Hyaluronic acid
Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
Maca
Maitake
Mango
Mangosteen
Marshmallow
Melatonin
Milk Thistle
Mistletoe
N-Acetylcysteine
Nattokinase
Nectarines
Octacosanol
Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
PEANUT
Peach
Peony
Pepper
Peppermint
Persimmons
Phellinus linteus
Phosphatidyl
serine
Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Quince
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rhubarb
Rice Bran Oil
Rosemary
Royal Jelly
Rutin
S-adenosyl-L-
methionine
Saffron
Saw Palmetto
Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Soy
Stevia
Valerian
Vitamin D
Vitex
Walnuts
Watermelon
Wheat Grass
Whey
Wild Yam
Witch Hazel
Wormwood
Xylitol
Yarrow
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Blood Pressure
Lowering Herbs
Cholesterol
Lowering Herbs
Supplements for
Cadiovascular
Diseases
Coenzyme Q and
Creatine for
Parkinson's
disease?