The health benefits of
Kaempferol


According to Wikipedia, kaempferol, a natural flavonoid, can be found
mainly in tea, broccoli, ginkgo[1], Delphinium, Witch-hatzel, grapefruit. It is a
yellow crystal. It is believed that kaempferol is what gives the flowers of
Acacia decurrens and Acacia longifolia their color. It has a melting point of
276-278C and it is slightly soluble in water.

Kaempferol is a strong antioxidant and helps to prevent oxidative damage
of our cells, lipids and DNA. Keampferol seems to prevent arteriosclerosis
by inhibiting the oxidation of low density lipoprotein and the formation of
platelets in the blood. Current evidences indicate that kaempferol not only
protect LDL from oxidation but also prevent atherogenesis through
suppressing macrophage uptake of oxLDL. [3]

Study showed kaempferol may have health benefit on people at risk of
cancer. Zhang Y and co-workers at Baylor College of Medicine
demonstrated its anti-cancer activities against pancreatic cancer cell lines
MIA PaCa-2 and Panc-1 in a recent study. Upon the treatment with 70
microm kaempferol for 4 days, MIA PaCa-2 cell proliferation was
significantly inhibited by 79% and 45.7%. The treatment with kaempferol
significantly inhibited Panc-1 cell proliferation. Furthermore, kaempferol had
significantly less cytotoxicity than 5-fluorouracil in normal human pancreatic
ductal epithelial cells. [1] Vivek Sharma and co-workers at National Brain
Research Center, India, found that kaempferol induced apoptosis in glioma
cells by elevating intracellular oxidative stress. Kaempferol also potentiated
the toxic effect of chemotherapeutic agent doxorubicin by amplifying ROS
toxicity and decreasing the efflux of doxorubicin. [2] Leung HW and
co-workers found kaempferol could induce human lung non-small carcinoma
cells H460 cell apoptosis.[5]

Kaempferol has anti-inflammatory activities and it may help protect certain
types of brain damage such as ischemic stroke. [4, 3]




[1] Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer
cells. J Surg Res. 2008 Jul;148(1):17-23. Epub 2008 Mar 26. [2] Vivek Sharma et al, Kaempferol induces
apoptosis in glioblastoma cells through oxidative stressMolecular Cancer Therapeutics 6, 2544-2553,
September 1, 2007. [3]Tu Yu Antiatherogenic effects of kaempferol and rhamnocitrin J Agric Food Chem.
2007 Nov 28;55(24):9969-76. Epub 2007 Nov 1. [3] Lopez-Sanchez C et al, Blood micromolar concentrations
of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain. Brain Res. 2007
Nov 28;1182:123-37. Epub 2007 Sep 21. [4] Hämäläinen M,Anti-inflammatory effects of flavonoids: genistein,
kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappaB activations, whereas flavone,
isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappaB activation along with their inhibitory effect
on iNOS expression and NO production in activated macrophages. Mediators Inflamm. 2007;2007:45673. [5]
Leung HW et al, Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an
induction of antioxidant enzymes. Food Chem Toxicol. 2007 Oct;45(10):2005-13. Epub 2007 May 18.

This article can not be used as medical advice. Please, consult with your medical doctor for
any question or before taking any drug products and supplements. ALL RIGHTS RESERVED