Compounds in broccoli, cauliflower, and watercress
block lung cancer progression.
FEB, 2008 zhion@zhion.com
block lung cancer progression.
FEB, 2008 zhion@zhion.com
A family of compounds found in cruciferous vegetables,
such as broccoli, cauliflower, and watercress, blocked lung
cancer progression in both animal studies and in tests with
human lung cancer cells.
Chemoprevention is regarded as one of the most promising and
realistic approaches in the prevention of human cancer. Among
naturally occurring products, sulfur-containing compounds,
especially garlic compounds and isothiocyanates, represent two
important and promising chemopreventive families because of
their potent chemopreventive effects in various in vivo and in vitro
models. In recent years, numerous investigations have shown
that sulfur-containing compounds induce apoptosis in multiple cell
lines and experimental animals. [2]
What is Isothiocyanates?
Isothiocyanates are sulfur-containing compounds which are largely
responsible for the typical flavor of cruciferous vegetables. In
animals including humans they are conjugated with glutathione;
the first product of this reaction is a dithiocarbamate, which can
be ultimately metabolized to the corresponding mercapturic acid,
excreted in urine. [1]
What is the benefits of isothiocyanates or veggie diets?
Epidemiological studies on the relationship between cancer risk
with isothiocyanate intake or excretion have shown inverse
associations, mainly with lung cancer. The studies are also
consistent in reporting a gene-environment interaction, with a
stronger protective effect in persons null for the GSTM1 or GSTT1
genotype. [1]
Recent study has shown its benefits on lung cancer.
The study's principal investigator Fung-Lung Chung, Ph.D., say
the results, published in a set of papers in the September 15
issue of Cancer Research, suggest that these chemicals — put
into a veggie pill of sorts — might some day be used to help
current and former smokers ward off development of lung cancer,
the leading cause of cancer death in Americans.
One of the two new studies being reported was the first to test
whether these compounds, derived from naturally occurring
isothiocyanates, could have an impact on the stages of cancer
development specifically after exposure to cancer-causing
elements . To test that, the researchers induced lung tumor
development in experimental mice by exposing them to tobacco
carcinogens, and then they fed one group of mice the veggie
compounds. They found that, indeed, use of the chemicals
resulted in a reduced development of benign (harmless) lung
tumors to malignant tumors, compared to mice that did not
receive the compound.
The second new study looked at the effect of the same compound
on human lung cancer cells, which were forced to grow quickly (as
cancer does) because of insertion of a gene known to be involved
in cell growth and regulation. The laboratory test showed that the
derivative of isothiocyanate significantly pushed the human lung
cells to commit “suicide,” compared to cells that did not have
the gene, suggesting that its use may stop fast growing lung
cancer cells from the outset. This study provides some insight
onto “one of the possible mechanisms of action” by which the
compounds may offer some protection against lung cancer
development, the researchers said.
These studies were continuation of a 20-year research effort by
Chung and his team, much of it conducted while Chung was at the
Institute for Cancer Prevention before moving to Georgetown
University Medical Center. The body of research they have
established on the connection between cruciferous vegetables and
lung cancer is one of the most detailed available.
The study was funded by a grant from the National Institutes of
Health.
REFERENCES
[1] Bianchini F and Vainio H Isothiocyanates in cancer prevention. Drug Metab Rev.
2004 Oct;36(3-4):655-67.[2] Wu X, Kassie F, and Mersch-Sundermann V,
Induction of apoptosis in tumor cells by naturally occurring sulfur-containing
compounds. Mutat Res. 2005 Mar;589(2):81-102. Epub 2005 Jan 4. [3] Laura
Cavender, Compounds Found in Veggies Can Block Lung Cancer Progression in
Experimental Studies, Georgetown University Medical Center , Press Release,
September 15, 2005
such as broccoli, cauliflower, and watercress, blocked lung
cancer progression in both animal studies and in tests with
human lung cancer cells.
Chemoprevention is regarded as one of the most promising and
realistic approaches in the prevention of human cancer. Among
naturally occurring products, sulfur-containing compounds,
especially garlic compounds and isothiocyanates, represent two
important and promising chemopreventive families because of
their potent chemopreventive effects in various in vivo and in vitro
models. In recent years, numerous investigations have shown
that sulfur-containing compounds induce apoptosis in multiple cell
lines and experimental animals. [2]
What is Isothiocyanates?
Isothiocyanates are sulfur-containing compounds which are largely
responsible for the typical flavor of cruciferous vegetables. In
animals including humans they are conjugated with glutathione;
the first product of this reaction is a dithiocarbamate, which can
be ultimately metabolized to the corresponding mercapturic acid,
excreted in urine. [1]
What is the benefits of isothiocyanates or veggie diets?
Epidemiological studies on the relationship between cancer risk
with isothiocyanate intake or excretion have shown inverse
associations, mainly with lung cancer. The studies are also
consistent in reporting a gene-environment interaction, with a
stronger protective effect in persons null for the GSTM1 or GSTT1
genotype. [1]
Recent study has shown its benefits on lung cancer.
The study's principal investigator Fung-Lung Chung, Ph.D., say
the results, published in a set of papers in the September 15
issue of Cancer Research, suggest that these chemicals — put
into a veggie pill of sorts — might some day be used to help
current and former smokers ward off development of lung cancer,
the leading cause of cancer death in Americans.
One of the two new studies being reported was the first to test
whether these compounds, derived from naturally occurring
isothiocyanates, could have an impact on the stages of cancer
development specifically after exposure to cancer-causing
elements . To test that, the researchers induced lung tumor
development in experimental mice by exposing them to tobacco
carcinogens, and then they fed one group of mice the veggie
compounds. They found that, indeed, use of the chemicals
resulted in a reduced development of benign (harmless) lung
tumors to malignant tumors, compared to mice that did not
receive the compound.
The second new study looked at the effect of the same compound
on human lung cancer cells, which were forced to grow quickly (as
cancer does) because of insertion of a gene known to be involved
in cell growth and regulation. The laboratory test showed that the
derivative of isothiocyanate significantly pushed the human lung
cells to commit “suicide,” compared to cells that did not have
the gene, suggesting that its use may stop fast growing lung
cancer cells from the outset. This study provides some insight
onto “one of the possible mechanisms of action” by which the
compounds may offer some protection against lung cancer
development, the researchers said.
These studies were continuation of a 20-year research effort by
Chung and his team, much of it conducted while Chung was at the
Institute for Cancer Prevention before moving to Georgetown
University Medical Center. The body of research they have
established on the connection between cruciferous vegetables and
lung cancer is one of the most detailed available.
The study was funded by a grant from the National Institutes of
Health.
REFERENCES
[1] Bianchini F and Vainio H Isothiocyanates in cancer prevention. Drug Metab Rev.
2004 Oct;36(3-4):655-67.[2] Wu X, Kassie F, and Mersch-Sundermann V,
Induction of apoptosis in tumor cells by naturally occurring sulfur-containing
compounds. Mutat Res. 2005 Mar;589(2):81-102. Epub 2005 Jan 4. [3] Laura
Cavender, Compounds Found in Veggies Can Block Lung Cancer Progression in
Experimental Studies, Georgetown University Medical Center , Press Release,
September 15, 2005
MAJOR NUTRIENT
DIET.
SUPPLEMENT
PhytoChemicals
Antioxidants
A-Z Health Foods,
Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
Aloe vera
Andrographis
Aniseed
Apple
Arnica
Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
Beet
black cohosh
Bladderwrack
Blackberry
Black Currant
Bloodroot
Blueberry
Bilberry
Bitter Melon
Borage Seed Oil
Boswellia
Black Soya Bean
Broccoli
Bromelain
Brown Seaweed
Brussels Sprout
Butein
Butterbur
Burdock
Cabbage
Cactus
Caffeine
Calcium
Calendula
Canola oil
Cauliflower
Cat's Claw
Cayenne
Celadrin
Celery
Chamomile
Chaparral
Cherry
Chokeberry
Chondroitin
Chitosan
Chlorella
Chlorophyll
Chromium
Cinnamon
CLA
Cocoa
Cod Liver Oil
Coenzyme Q
Coffee
Comfrey
Conj. Linoleic Acid
Colostrum
Colloidal Silver
Cordyceps
Corn
Cranberry
Creatine
Curcumin
Damiana
Dandelion
Danggui_Buxue
Devil's Claw
DHEA
Dill
Dong Quai
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eucalyptus G.
Eve. Primrose Oil
Falcarinol
Fennel
Fenugreek
Feverfew
Folate
Fish Oil
Flaxseed Meal
Flaxseed /Linseed
Garcinia C.
Garlic
Galangal
Ghrelin
Ginger
Ginseng
Ginseng/Ginkgo
Ginkgo Biloba
Glucosamine
Goldenseal
Gotu Kola
GRAPE SEED
EXTRACT
Green Coffee Bean
Green Tea
Growth Hormone
Stimulants
Goldenseal
Guar Gum
Guggul
Gymnema
Hawthorn
Hoodia
Hop
Horse Chestnut
Horsetail
Huperzine A
Hyaluronic acid
Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
Maca
Maitake
Mango
Mangosteen
Marshmallow
Melatonin
Milk Thistle
Mistletoe
N-Acetylcysteine
Nattokinase
Nectarines
Octacosanol
Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
PEANUT
Peach
Peony
Pepper
Peppermint
Persimmons
Phellinus linteus
Phosphatidyl
serine
Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Quince
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rhubarb
Rice Bran Oil
Rosemary
Royal Jelly
Rutin
S-adenosyl-L-
methionine
Saffron
Saw Palmetto
Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Soy
Stevia
Valerian
Vitamin D
Vitex
Walnuts
Watermelon
Wheat Grass
Whey
Wild Yam
Witch Hazel
Wormwood
Xylitol
Yarrow
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Blood Pressure
Lowering Herbs
Cholesterol
Lowering Herbs
Supplements for
Cadiovascular
Diseases
Coenzyme Q and
Creatine for
Parkinson's
disease?
DIET.
SUPPLEMENT
PhytoChemicals
Antioxidants
A-Z Health Foods,
Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
Aloe vera
Andrographis
Aniseed
Apple
Arnica
Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
Beet
black cohosh
Bladderwrack
Blackberry
Black Currant
Bloodroot
Blueberry
Bilberry
Bitter Melon
Borage Seed Oil
Boswellia
Black Soya Bean
Broccoli
Bromelain
Brown Seaweed
Brussels Sprout
Butein
Butterbur
Burdock
Cabbage
Cactus
Caffeine
Calcium
Calendula
Canola oil
Cauliflower
Cat's Claw
Cayenne
Celadrin
Celery
Chamomile
Chaparral
Cherry
Chokeberry
Chondroitin
Chitosan
Chlorella
Chlorophyll
Chromium
Cinnamon
CLA
Cocoa
Cod Liver Oil
Coenzyme Q
Coffee
Comfrey
Conj. Linoleic Acid
Colostrum
Colloidal Silver
Cordyceps
Corn
Cranberry
Creatine
Curcumin
Damiana
Dandelion
Danggui_Buxue
Devil's Claw
DHEA
Dill
Dong Quai
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eucalyptus G.
Eve. Primrose Oil
Falcarinol
Fennel
Fenugreek
Feverfew
Folate
Fish Oil
Flaxseed Meal
Flaxseed /Linseed
Garcinia C.
Garlic
Galangal
Ghrelin
Ginger
Ginseng
Ginseng/Ginkgo
Ginkgo Biloba
Glucosamine
Goldenseal
Gotu Kola
GRAPE SEED
EXTRACT
Green Coffee Bean
Green Tea
Growth Hormone
Stimulants
Goldenseal
Guar Gum
Guggul
Gymnema
Hawthorn
Hoodia
Hop
Horse Chestnut
Horsetail
Huperzine A
Hyaluronic acid
Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
Maca
Maitake
Mango
Mangosteen
Marshmallow
Melatonin
Milk Thistle
Mistletoe
N-Acetylcysteine
Nattokinase
Nectarines
Octacosanol
Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
PEANUT
Peach
Peony
Pepper
Peppermint
Persimmons
Phellinus linteus
Phosphatidyl
serine
Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Quince
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rhubarb
Rice Bran Oil
Rosemary
Royal Jelly
Rutin
S-adenosyl-L-
methionine
Saffron
Saw Palmetto
Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Soy
Stevia
Valerian
Vitamin D
Vitex
Walnuts
Watermelon
Wheat Grass
Whey
Wild Yam
Witch Hazel
Wormwood
Xylitol
Yarrow
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Blood Pressure
Lowering Herbs
Cholesterol
Lowering Herbs
Supplements for
Cadiovascular
Diseases
Coenzyme Q and
Creatine for
Parkinson's
disease?