The health benefits of
Ferulic acid


Ferulic acid, together with dihydroferulic acid, is a component of
lignocellulose, allowing the crosslink the lignin and polysaccharides; the
crosslink provides rigidity to the cell walls. [7] Ferulic acid is found in seeds
of plants such as in rice, wheat, and oats, as well as in coffee, apple,
artichoke, peanut, orange and pineapple.



Ferulic acid was found to provide neuroprotection against oxidative
stress-related apoptosis by inhibiting ICAM-1 mRNA expression after
cerebral ischemia/reperfusion injury in rats. [1] In addition, ferulic acid
dose-dependently inhibited beta-amyloid fibrils formation from amyloid
beta-peptide. Thus, ferulic acid may offer benefit people at risk of
Alzheimer's disease. [4]



Ferulic acid significantly inhibited angiotensin II-induced VSMC proliferation
in a dose-dependent manner.  [5] Ferulic acid was also found to have
hypotensive effect in stroke-prone spontaneously hypertensive rats. [2, 7] In
another animal study, ferulic acid was shown to decrease blood glucose
level, plasma total cholesterol and low density lipoptrotein cholesterol
concentration. [3, 6]


[1] Cheng CY et al, Ferulic acid provides neuroprotection against oxidative stress-related apoptosis after
cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain Res. 2008 May
13;1209:136-50. Epub 2008 Mar 18. [2] Ardiansyah et al, Novel effects of a single administration of ferulic
acid on the regulation of blood pressure and the hepatic lipid metabolic profile in stroke-prone spontaneously
hypertensive rats. J Agric Food Chem. 2008 Apr 23;56(8):2825-30. Epub 2008 Mar 18. [3] Jung EH,
Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice. J
Agric Food Chem. 2007 Nov 28;55(24):9800-4. Epub 2007 Nov 1. [4] Ono K, et al,  Ferulic acid destabilizes
preformed beta-amyloid fibrils in vitro. Biochem Biophys Res Commun. 2005 Oct 21;336(2):444-9. [5] Hou YZ,
et al, Ferulic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II. Eur J
Pharmacol. 2004 Sep 19;499(1-2):85-90. [6] Sri Balasubashini M, et al, Protective effects of ferulic acid on
hyperlipidemic diabetic rats. Acta Diabetol. 2003 Sep;40(3):118-22. [8] Suzuki A, et al,  Short- and long-term
effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am J Hypertens. 2002 Apr;15(4 Pt
1):351-7. [7] Mathew S, Abraham TE. Ferulic acid: an antioxidant found naturally in plant cell walls and
feruloyl esterases involved in its release and their applications. Crit Rev Biotechnol. 2004;24(2-3):59-83.

This article can not be used as medical advice. Please, consult with your medical doctor for
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