Butein benefits
updated on Feb 7, 2008
updated on Feb 7, 2008
Butein (3,4,2',4'-tetrahydroxychalone), a plant polyphenol, is a
major biologically active component of the stems of Rhus
verniciflua Stokes. It has long been used as a food additive and as
an herbal medicine throughout Asia.
Recent studies have demonstrated its potential health benefits on
various conditions.
Butein is a strong antioxidant
Butein inhibited iron-induced lipid peroxidation in rat brain
homogenate in a concentration-dependent manner with an IC50,
3.3+/-0.4 microM. It was as potent as alpha-tocopherol in reducing
the stable free radical diphenyl-2-picrylhydrazyl (DPPH) with an
IC0.200, 9.2+/-1.8 microM. Butein was also found to inhibite
copper-catalyzed oxidation of human low-density lipoprotein
(LDL). Spectral analysis revealed that butein was a chelator of
ferrous and copper ions. [8]
Breast Cancer
Estrogen has long been associated with the initiation and
promotion of breast cancer. Inhibiting estrogen synthesis can be
effective in the prevention and treatment of the disease. Some
studies have shown the potential benefits of butin on cancer
prevention. Researchers from Hong Kong found butin as a strong
inhibitor among for aromastse with K(i) value of 0.32 microM. In a
cell proliferation study, the cell number increased by treatment of
10 nM-testosterone was significantly reduced by 5 microM butein.
[1]
Lee SH from Wonkwang University, Korea, demonstrated the
benefits of butein on liver fibrosis induced by carbon tetrachloride
(CCl4) in rats. The results suggest the potential use of butein to
serve as an antifibrogenic agent by inhibition of collagen
accumulation and lipid peroxidation, and by down-regulation of the
expression of both alpha1(I) collagen and TIMP-1 mRNA. [4]
Fibroblasts are believed to play an important role in promoting the
growth of breast cancer cells. Researchers from UC Irvine
demonstrated that butein was able to inhibit the clonogenic growth
of small numbers of UACC-812 breast cancer cells co-cultured
with fibroblasts in vitro. [2]
Colon Cancer
Butein also exhibited degrees of inhibition on the cell proliferation
of human colon adenocarcinoma cell line 220.1. Butein (the most
potent chalcone) at 2 microM concentration inhibited the
incorporation of 14C-labelled thymidine, uridine and leucine into
the colon cancer cells whilst 5-fluorouracil (5-FU, a
chemotherapeutic drug) at 50 microM concentration could
significantly inhibit only the uridine incorporation. [3]
Blood Pressure Lowering Effects
Butein, isolated from Dalbergia odorifera T. Chen, is found to be a
cAMP-specific phosphodiesterase inhibitor. It caused
endothelium-dependent relaxation of rat aorta precontracted with
phenylephrine. Its vasorelaxant effect depended on the
endothelium and was mediated by endothelium-derived relaxing
factor (EDRF). [6] Intravenous injection of butein was found to
lower the arterial blood pressure of anesthetized rats in a
dose-dependent manner. Introduction of butein into the rats
significantly inhibited the plasma ACE activities in a
dose-dependent manner. Prior exposure of endothelium-intact
aortic rings to butein was also found to attenuate angiotensin
I-induced contraction. [5]
Liver Protection
Hepatic stellate cells play a key role in the pathogenesis of hepatic
fibrosis. An in vitro study demonstrated the inhibitory effect of
butein on the activation and proliferation of rat primary cultured
hepatic stellate cells. Butein is a potent inhibitor of rat stellate cell
transformation. [7]
ALL RIGHTS RESERVED ZHION 2007 This article is for your reference only. Side
Effects / toxicity of butein has not been studied. Discuss with your doctor for
details or if you have any question.
REFERENCE [1] Wang Y, et al, The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing
aromatase. Life Sci. 2005 May 20;77(1):39-51. [2] Samoszuk M, Tan J, Chorn G. The chalcone butein from Rhus verniciflua Stokes
inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Altern Med. 2005 Mar 9;5:5. [3]
Yit CC, Das NP. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 1994 Jul 15;82(1):65-72. [4]
Lee SH, The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med. 2003 Nov;69(11):990-4 [5] Kang DG, et al,
Hypotensive effect of butein via the inhibition of angiotensin converting enzyme. Biol Pharm Bull. 2003 Sep;26(9):1345-7. [6] Yu SM, et al,
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor. Eur J Pharmacol. 1995
Jun 23;280(1):69-77. [7] Woo SW, et al, Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. J
Pharm Pharmacol. 2003 Mar;55(3):347-52. [8] Cheng ZJ, et al, Antioxidant properties of butein isolated from Dalbergia odorifera.
Biochim Biophys Acta. 1998 Jun 15;1392(2-3):291-9.
major biologically active component of the stems of Rhus
verniciflua Stokes. It has long been used as a food additive and as
an herbal medicine throughout Asia.
Recent studies have demonstrated its potential health benefits on
various conditions.
Butein is a strong antioxidant
Butein inhibited iron-induced lipid peroxidation in rat brain
homogenate in a concentration-dependent manner with an IC50,
3.3+/-0.4 microM. It was as potent as alpha-tocopherol in reducing
the stable free radical diphenyl-2-picrylhydrazyl (DPPH) with an
IC0.200, 9.2+/-1.8 microM. Butein was also found to inhibite
copper-catalyzed oxidation of human low-density lipoprotein
(LDL). Spectral analysis revealed that butein was a chelator of
ferrous and copper ions. [8]
Breast Cancer
Estrogen has long been associated with the initiation and
promotion of breast cancer. Inhibiting estrogen synthesis can be
effective in the prevention and treatment of the disease. Some
studies have shown the potential benefits of butin on cancer
prevention. Researchers from Hong Kong found butin as a strong
inhibitor among for aromastse with K(i) value of 0.32 microM. In a
cell proliferation study, the cell number increased by treatment of
10 nM-testosterone was significantly reduced by 5 microM butein.
[1]
Lee SH from Wonkwang University, Korea, demonstrated the
benefits of butein on liver fibrosis induced by carbon tetrachloride
(CCl4) in rats. The results suggest the potential use of butein to
serve as an antifibrogenic agent by inhibition of collagen
accumulation and lipid peroxidation, and by down-regulation of the
expression of both alpha1(I) collagen and TIMP-1 mRNA. [4]
Fibroblasts are believed to play an important role in promoting the
growth of breast cancer cells. Researchers from UC Irvine
demonstrated that butein was able to inhibit the clonogenic growth
of small numbers of UACC-812 breast cancer cells co-cultured
with fibroblasts in vitro. [2]
Colon Cancer
Butein also exhibited degrees of inhibition on the cell proliferation
of human colon adenocarcinoma cell line 220.1. Butein (the most
potent chalcone) at 2 microM concentration inhibited the
incorporation of 14C-labelled thymidine, uridine and leucine into
the colon cancer cells whilst 5-fluorouracil (5-FU, a
chemotherapeutic drug) at 50 microM concentration could
significantly inhibit only the uridine incorporation. [3]
Blood Pressure Lowering Effects
Butein, isolated from Dalbergia odorifera T. Chen, is found to be a
cAMP-specific phosphodiesterase inhibitor. It caused
endothelium-dependent relaxation of rat aorta precontracted with
phenylephrine. Its vasorelaxant effect depended on the
endothelium and was mediated by endothelium-derived relaxing
factor (EDRF). [6] Intravenous injection of butein was found to
lower the arterial blood pressure of anesthetized rats in a
dose-dependent manner. Introduction of butein into the rats
significantly inhibited the plasma ACE activities in a
dose-dependent manner. Prior exposure of endothelium-intact
aortic rings to butein was also found to attenuate angiotensin
I-induced contraction. [5]
Liver Protection
Hepatic stellate cells play a key role in the pathogenesis of hepatic
fibrosis. An in vitro study demonstrated the inhibitory effect of
butein on the activation and proliferation of rat primary cultured
hepatic stellate cells. Butein is a potent inhibitor of rat stellate cell
transformation. [7]
ALL RIGHTS RESERVED ZHION 2007 This article is for your reference only. Side
Effects / toxicity of butein has not been studied. Discuss with your doctor for
details or if you have any question.
REFERENCE [1] Wang Y, et al, The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing
aromatase. Life Sci. 2005 May 20;77(1):39-51. [2] Samoszuk M, Tan J, Chorn G. The chalcone butein from Rhus verniciflua Stokes
inhibits clonogenic growth of human breast cancer cells co-cultured with fibroblasts. BMC Complement Altern Med. 2005 Mar 9;5:5. [3]
Yit CC, Das NP. Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett. 1994 Jul 15;82(1):65-72. [4]
Lee SH, The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med. 2003 Nov;69(11):990-4 [5] Kang DG, et al,
Hypotensive effect of butein via the inhibition of angiotensin converting enzyme. Biol Pharm Bull. 2003 Sep;26(9):1345-7. [6] Yu SM, et al,
Endothelium-dependent relaxation of rat aorta by butein, a novel cyclic AMP-specific phosphodiesterase inhibitor. Eur J Pharmacol. 1995
Jun 23;280(1):69-77. [7] Woo SW, et al, Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. J
Pharm Pharmacol. 2003 Mar;55(3):347-52. [8] Cheng ZJ, et al, Antioxidant properties of butein isolated from Dalbergia odorifera.
Biochim Biophys Acta. 1998 Jun 15;1392(2-3):291-9.
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SUPPLEMENT
PhytoChemicals
Antioxidants
A-Z Health Foods,
Products
Acetyl-L Carnitine
Acidophilus
Alfalfa
Almond
Aloe vera
Andrographis
Aniseed
Apple
Arnica
Ashwagandha
Asian Pears
Asparagus
Astaxanthin,
Astragulus
Artichoke
Avena sativa
Avocados
Barley
Banana
Basil
Beet
black cohosh
Bladderwrack
Blackberry
Black Currant
Bloodroot
Blueberry
Bilberry
Bitter Melon
Borage Seed Oil
Boswellia
Black Soya Bean
Broccoli
Bromelain
Brown Seaweed
Brussels Sprout
Butterbur
Burdock
Cabbage
Cactus
Caffeine
Calcium
Calendula
Canola oil
Cauliflower
Cat's Claw
Cayenne
Celadrin
Celery
Chamomile
Chaparral
Cherry
Chokeberry
Chondroitin
Chitosan
Chlorophyll
Chromium
Cinnamon
CLA
Cocoa
Cod Liver Oil
Coenzyme Q
Coffee
Comfrey
Conj. Linoleic Acid
Colostrum
Colloidal Silver
Cordyceps
Corn
Cranberry
Creatine
Curcumin
Damiana
Dandelion
Danggui_Buxue
Devil's Claw
DHEA
Dill
Dong Quai
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eucalyptus G.
Eve. Primrose Oil
Falcarinol
Fennel
Fenugreek
Feverfew
Folate
Fish Oil
Flaxseed Meal
Flaxseed /Linseed
Garcinia C.
Garlic
Galangal
Ghrelin
Ginger
Ginseng
Ginseng/Ginkgo
Ginkgo Biloba
Glucosamine
Goldenseal
Gotu Kola
GRAPE SEED
EXTRACT
Green Coffee Bean
Green Tea
Growth Hormone
Stimulants
Goldenseal
Guar Gum
Guggul
Gymnema
Hawthorn
Hoodia
Hop
Horse Chestnut
Horsetail
Huperzine A
Hyaluronic acid
Isothiocyanates
Kava Kava
Kelp
L-arginine
Lavender
Lecithin
Lemon balm
Licorice
Lingonberry
Lutein
Lycopene
Maca
Maitake
Mango
Mangosteen
Marshmallow
Melatonin
Milk Thistle
Mistletoe
N-Acetylcysteine
Nattokinase
Nectarines
Octacosanol
Olive Oil
Omegic Fatty
Acids
Onion
Orange
Oregon Grape
Pantethine
Papaya
Passion Flower
PEANUT
Peach
Peony
Pepper
Peppermint
Persimmons
Phellinus linteus
Phosphatidyl
serine
Phyllanthus
Potato
Plum
Pomegranate
Probiotics
Policosanol /
Polycosanol
Propolis
Pumpkin
Pycnogenol
Pyruvate
Quercetin
Quince
Radish
Red Clover
Red Yeast Rice
Reishi / Lingzhi
Resveratrol
Rhodiola
Rhubarb
Rice Bran Oil
Rosemary
Royal Jelly
Rutin
S-adenosyl-L-
methionine
Saffron
Saw Palmetto
Schisandra
Selenium
Spinach
Spirulina
Squash
Stinging Nettle
St John Wort
Strawberry
Sweet Potatoes
Taxifolin
Tea Tree Oil
Turmeric [Curry]
Tyrosine
Shark Cartilage
Soy
Stevia
Valerian
Vitamin D
Vitex
Walnuts
Watermelon
Whey
Wild Yam
Witch Hazel
Wormwood
Xylitol
Yarrow
Yohimbe
Yucca
5-Hydroxytrpto
phan
Food Industry
Organic Label
HOME
Herb Side Effect
Blood Pressure
Lowering Herbs
Cholesterol
Lowering Herbs
Supplements for
Cadiovascular
Diseases
Coenzyme Q and
Creatine for
Parkinson's
disease?