The health benefits of Beta-Cryptoxanthin
Beta-Cryptoxanthin is a major source of vitamin A, often second only to
beta-carotene, and is present in fruits such as oranges, tangerines, and
papayas. [1] Beta-Cryptoxanthin is believed to have health benefits on people
at risk of certain chronic diseases.
Researchers found high dose of beta-cryptoxanthin reduced the colon cancer
incidence in a study of F344 rats. [2] In addition, several observational
epidemiologic studies suggest that beta-cryptoxanthin could potentially act as
a chemopreventive agent against lung cancer. [5] Miyazawa K and co-workers
at Kanazawa Medical University, Ishikawa, Japan showed dose of 25 ppm of
beta-cryptoxanthin significantly lowered the occurrence of bladder carcinoma
in a mice model. [6]
Researchers from Japan found oral administration of beta-crytoxanthin
prevented bone loss in streptozotocin-diabetic and ovariectomized rats. The
administration of beta-cryptoxanthin to normal rats for 14 days caused a
significant increase in calcium content, alkaline phosphatase activity, and
DNA content in the femoral-diaphyseal and -metaphyseal tissues. [3,4]
Reference [1] Wingerath T, Stahl W, Sies H. beta-Cryptoxanthin selectively increases in human
chylomicrons upon ingestion of tangerine concentrate rich in beta-cryptoxanthin esters. Arch
Biochem Biophys. 1995 Dec 20;324(2):385-90. [2] Narisawa T, et al, Chemoprevention by the
oxygenated carotenoid beta-cryptoxanthin of N-methylnitrosourea-induced colon carcinogenesis in
F344 rats. Jpn J Cancer Res. 1999 Oct;90(10):1061-5. [3] Uchiyama S, Yamaguchi M. Oral
administration of beta-cryptoxanthin prevents bone loss in streptozotocin-diabetic rats in vivo. Biol
Pharm Bull. 2005 Sep;28(9):1766-9. [4] Uchiyama S, Yamaguchi M. Oral administration of
beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med. 2006 Jan;17(1):15-20.
[5] Lian F, et al, Beta-cryptoxanthin suppresses the growth of immortalized human bronchial
epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta
expression. Int J Cancer. 2006 Nov 1;119(9):2084-9. [6] Miyazawa K et al, Dietary beta-cryptoxanthin
inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR
mice. Oncol Rep. 2007 Feb;17(2):297-304.
This article can not be used as medical advice. Please, consult with your medical doctor for
any question or before taking any drug products and supplements. ALL RIGHTS RESERVED
zhion 2011
beta-carotene, and is present in fruits such as oranges, tangerines, and
papayas. [1] Beta-Cryptoxanthin is believed to have health benefits on people
at risk of certain chronic diseases.
Researchers found high dose of beta-cryptoxanthin reduced the colon cancer
incidence in a study of F344 rats. [2] In addition, several observational
epidemiologic studies suggest that beta-cryptoxanthin could potentially act as
a chemopreventive agent against lung cancer. [5] Miyazawa K and co-workers
at Kanazawa Medical University, Ishikawa, Japan showed dose of 25 ppm of
beta-cryptoxanthin significantly lowered the occurrence of bladder carcinoma
in a mice model. [6]
Researchers from Japan found oral administration of beta-crytoxanthin
prevented bone loss in streptozotocin-diabetic and ovariectomized rats. The
administration of beta-cryptoxanthin to normal rats for 14 days caused a
significant increase in calcium content, alkaline phosphatase activity, and
DNA content in the femoral-diaphyseal and -metaphyseal tissues. [3,4]
Reference [1] Wingerath T, Stahl W, Sies H. beta-Cryptoxanthin selectively increases in human
chylomicrons upon ingestion of tangerine concentrate rich in beta-cryptoxanthin esters. Arch
Biochem Biophys. 1995 Dec 20;324(2):385-90. [2] Narisawa T, et al, Chemoprevention by the
oxygenated carotenoid beta-cryptoxanthin of N-methylnitrosourea-induced colon carcinogenesis in
F344 rats. Jpn J Cancer Res. 1999 Oct;90(10):1061-5. [3] Uchiyama S, Yamaguchi M. Oral
administration of beta-cryptoxanthin prevents bone loss in streptozotocin-diabetic rats in vivo. Biol
Pharm Bull. 2005 Sep;28(9):1766-9. [4] Uchiyama S, Yamaguchi M. Oral administration of
beta-cryptoxanthin prevents bone loss in ovariectomized rats. Int J Mol Med. 2006 Jan;17(1):15-20.
[5] Lian F, et al, Beta-cryptoxanthin suppresses the growth of immortalized human bronchial
epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta
expression. Int J Cancer. 2006 Nov 1;119(9):2084-9. [6] Miyazawa K et al, Dietary beta-cryptoxanthin
inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR
mice. Oncol Rep. 2007 Feb;17(2):297-304.
This article can not be used as medical advice. Please, consult with your medical doctor for
any question or before taking any drug products and supplements. ALL RIGHTS RESERVED
zhion 2011
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