| Osteoarthritis - Cartilage Enzyme Degradation |
Osteoarthritis, a consequence of aging, is a chronic disease of the
joints leading to spurring of bone, pain and decreased mobility and
function. It is also a cartilage damage results from degradation of
macromolecules in cartilage tissue such as aggrecan and type II
collagen. The main symptoms are pain and morning stiffness, which
usually worsens with exercise [3].
According to studies, the destruction appears to be a result of
uncontrolled proteolytic extracellular matrix destruction [1]. The major
components of the cartilage extracellular matrix are aggrecan and
type II collagen. They both are important for the cartilage health.
Aggrecan hydrates the collagen network and provides the cartilage
tissue with its characteristic pressibility and elasticity. It plays
protective role in preventing degradation of collagen fibrils. Aggrecan
and type II collagen molecules cooperatively maintain the cartilage
integrity and function [5].
Scientists have found that several metalloproteases such as
ADAMTS5 (aggrecanase-2), ADAMTS4, MMP-13 and MT4-MMP are
involved in cartilage macromolecule degradation [1,2,4,5]. Inhibition of
their generic expressions or their actions may prevent cartilage
degradation and improve osteoarthritis conditions.
References
[1] Glasson SS et al, Deletion of active ADAMTS5 prevents cartilage degradation
in a murine model of osteoarthritis. Nature. 2005 Mar 31;434(7033):644-8.
[2] Australian Scientists Find Arthritis-Causing Enzyme, Reuters, Mar 31, 2005.
[3] http://www.zhion.com/osteoarthritis_suppl, April 1, 2005
[4] Patwari P et al, Analysis of ADAMTS4 and MT4-MMP indicates that both are
involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis
Cartilage. 2005 Apr;13(4):269-77.
[5] Ishiguro N and Kojima, T, Role of aggrecanase and MMP in cartilage
degradation, Clin Calcium. 2004 Jul;14(7):38-44.
ARTICLES
Health Supplements for Arthritis
Glucosamine and Chondroitin
Hyaluronic acid and MSM
Cat's Claw
Bone Issue in General
joints leading to spurring of bone, pain and decreased mobility and
function. It is also a cartilage damage results from degradation of
macromolecules in cartilage tissue such as aggrecan and type II
collagen. The main symptoms are pain and morning stiffness, which
usually worsens with exercise [3].
According to studies, the destruction appears to be a result of
uncontrolled proteolytic extracellular matrix destruction [1]. The major
components of the cartilage extracellular matrix are aggrecan and
type II collagen. They both are important for the cartilage health.
Aggrecan hydrates the collagen network and provides the cartilage
tissue with its characteristic pressibility and elasticity. It plays
protective role in preventing degradation of collagen fibrils. Aggrecan
and type II collagen molecules cooperatively maintain the cartilage
integrity and function [5].
Scientists have found that several metalloproteases such as
ADAMTS5 (aggrecanase-2), ADAMTS4, MMP-13 and MT4-MMP are
involved in cartilage macromolecule degradation [1,2,4,5]. Inhibition of
their generic expressions or their actions may prevent cartilage
degradation and improve osteoarthritis conditions.
References
[1] Glasson SS et al, Deletion of active ADAMTS5 prevents cartilage degradation
in a murine model of osteoarthritis. Nature. 2005 Mar 31;434(7033):644-8.
[2] Australian Scientists Find Arthritis-Causing Enzyme, Reuters, Mar 31, 2005.
[3] http://www.zhion.com/osteoarthritis_suppl, April 1, 2005
[4] Patwari P et al, Analysis of ADAMTS4 and MT4-MMP indicates that both are
involved in aggrecanolysis in interleukin-1-treated bovine cartilage. Osteoarthritis
Cartilage. 2005 Apr;13(4):269-77.
[5] Ishiguro N and Kojima, T, Role of aggrecanase and MMP in cartilage
degradation, Clin Calcium. 2004 Jul;14(7):38-44.
ARTICLES
Health Supplements for Arthritis
Glucosamine and Chondroitin
Hyaluronic acid and MSM
Cat's Claw
Bone Issue in General
Exercise is good for us.