Lidoderm (Lidocaine Patch) As
Effective As Oral Medication-
Celebrex; Research finds
ZHION APRIL 2005
Recent literature and animal research has provided insight to potentially new analgesic targets for managing
osteoarthritis (OA) pain. Primary afferent neurons located in affected joints express excessive amounts of
abnormally functioning sodium (Na) channels on their surface in response to the inflammatory process. These
Na channels may play an integral role in production of pain and hyperalgesia [3]. Researchers at Endo
Pharmaceuticals, Inc. found a significant improvement for pain intensity, pain relief, and pain interference with
quality of life when lidocaine patch was applied onto the knee directly. The lidocaine patch 5% was generally
well tolerated and no patients discontinued due to treatment-related adverse events.
Osteoarthritis currently affects 20 million people in the United States [2]. Kivitz
A J et al with the Altoona Arthritis and Osteoporosis Center in Duncansville,
Pennsylvania, randomly assigned 143 patients to Lidoderm (ie lidocaine patch)
once daily or to take Celebrex. After 12 week of study, 71 percent of those in the
Lidoderm group and 72 percent in the celecoxib group experienced a 30 percent
or greater improvement in average daily pain intensity [1].
REFERENCES
[1] Karla Gale, Lidocaine Patch Curbs Osteoarthritis Pain, Reuters Health, Mon
Apr 4, 2005
[2] Pain Patch As Effective As Oral Medication , Sci-Tech Today, United Press
International, April 4, 2005
[3] Galer BS et al, Topical lidocaine patch 5% may target a novel underlying pain
mechanism in osteoarthritis., Curr Med Res Opin. 2004 Sep;20(9):1455-8
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