Yohimbe Side Effects
Yohimbe Side Effects
Yohimbe (Pausinystalia yohimbe), a tree bark, is marketed in a
number of products for body building and "enchanced male
performance." It is believed that yohimbe enhance blood flow into
penis consequently, yohimbe may cause an erection. It was found
that yohimbine, the active ingredient of yohimbe, performed better in
combination of arginine. [16]
One study showed that yohimbine combined with arginine could
increase physical arousal among 23 women with female sexual
arousal disorder. [17]. Yohimbe may also help depression, but more
studies are needed to prove this claim.
Yohimbe side effects are serious and include dizziness, anxiety,
hyperstimulation, nausea, renal failure and seizures. Over-dosage
may cause weakness and nervous stimulation followed by paralysis,
fatigue, stomach disorders, blood pressure alternation and
ultimately death. Currently, a few products containing yohimbe are
under FDA investigation.
Yohimbine, the yohimbe major alkaloid, is a vasodilator to lower
blood pressure. Yohimbine is also a prescription drug in the US.
Yohimbine side effects include anxiety attacks via CNS stimulation.
High dose of yohimbine can cause serious side effects when taken
together with tyramine-containing foods such as liver, cheeses, red
wine or with products containing phenylpropanolamine [1-15].
Yomhimbe should not be taken by pregnant or nursing women, or
those with kidney, liver or blood pressure problems or sexual organ
inflammation. Yomhimbe should not be taken together with tricyclic
antidepressants, phenothiazines, clonidine, other drugs or
supplements for lowering blood pressure.
Self-medication is discouraged because of yohimbeÂ’s side effects.
Yohimbe can produce significant side effects even in a small dose,
especially if taken over a long period of time. Yohimbe side effects
are close to its toxic effects.
Dosage of Yomhimbe
Yohimbe bark is taken in a form standardized to yohimbine content.
The usual dose of yohimbine is 15-30 mg daily. Lower dose of
yohimbe may work even better for some people. Because of its
serious side effects, one should consult doctor before taking this
herb.
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References 1. Charney DS et al. Alpha 2-adrenergic and opiate receptor
blockade. Synergistic effects on anxiety in healthy subjects. Arch Gen
Psychiatry. 1986;43:1037–1041. 2. Charney DS, Heninger GR, Sternberg DE.
Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of
oral yohimbine. Life Sci. 1982;30:2033–2041. 3. Charney DS, Heninger GR,
Redmond DE. Yohimbine induced anxiety and increased noradrenergic
function in humans: effects of diazepam and clonidine. Life Sci. 1983;33:19–
29. 4. Charney DS, Breier A, Jatlow PI, et al. Behavioral, biochemical, and blood
pressure responses to alprazolam in healthy subjects: interactions with
yohimbine. Psychopharmacology. 1986;88:133–140. 5. Charney DS, Price
LH, Heninger GR. Desipramine-yohimbine combination treatment of refractory
depression. Arch Gen Psychiatry. 1986;43:1155–1161. 6. De Smet PA,
Smeets OS. Potential risks of health food products containing yohimbe
extracts. BMJ. 1994;309:958. 7. Grossman E, Rosenthal T, Peleg E, et al. Oral
yohimbine increases blood pressure and sympathetic nervous outflow in
hypertensive patients. J Cardiovasc Pharmacol. 1993;22:22–26. 8. Lacomblez
L, Bensimon G, Isnard F, et al. Effect of yohimbine on blood pressure in
patients with depression and orthostatic hypotension induced by
clomipramine. Clin Pharmacol Ther. 1989;45:241–251. 9. Murburg MM,
Villacres EC, Ko GN, et al. Effects of yohimbine on human sympathetic nervous
system function. J Clin Endocrinol Metab. 1991;73:861–865. 10. Musso NR,
Vergassola C, Pende A. Yohimbine effects on blood pressure and plasma
catecholamines in human hypertension. Am J Hypertens. 1995;8:565–571.
15. Illnesses and Injuries Associated With the Use of Selected Dietary
Supplements. U. S. Food and Drug Administration
Center for Food Safety and Applied Nutrition 1993. 16. Lebret T, Herve JM,
Gorny P, et al. Efficacy and safety of a novel combination of L-arginine
glutamate and yohimbine hydrochloride: a new oral therapy for erectile
dysfunction. Eur Urol. 2002;41:608-613. 17. Meston CM, Worcel M. The effects
of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal
women with sexual arousal disorder. Arch Sex Behav. 2002;31:323-332.
HOME
THIS YOHIMBE SIDE EFFECT ARTICLE IS FOR YOUR
INFORMATION ONLY. PLEASE CONSULT WITH YOUR DOCTOR
FOR ANY QUESTION.
ALL RIGHT RESERVED
Yohimbe (Pausinystalia yohimbe), a tree bark, is marketed in a
number of products for body building and "enchanced male
performance." It is believed that yohimbe enhance blood flow into
penis consequently, yohimbe may cause an erection. It was found
that yohimbine, the active ingredient of yohimbe, performed better in
combination of arginine. [16]
One study showed that yohimbine combined with arginine could
increase physical arousal among 23 women with female sexual
arousal disorder. [17]. Yohimbe may also help depression, but more
studies are needed to prove this claim.
Yohimbe side effects are serious and include dizziness, anxiety,
hyperstimulation, nausea, renal failure and seizures. Over-dosage
may cause weakness and nervous stimulation followed by paralysis,
fatigue, stomach disorders, blood pressure alternation and
ultimately death. Currently, a few products containing yohimbe are
under FDA investigation.
Yohimbine, the yohimbe major alkaloid, is a vasodilator to lower
blood pressure. Yohimbine is also a prescription drug in the US.
Yohimbine side effects include anxiety attacks via CNS stimulation.
High dose of yohimbine can cause serious side effects when taken
together with tyramine-containing foods such as liver, cheeses, red
wine or with products containing phenylpropanolamine [1-15].
Yomhimbe should not be taken by pregnant or nursing women, or
those with kidney, liver or blood pressure problems or sexual organ
inflammation. Yomhimbe should not be taken together with tricyclic
antidepressants, phenothiazines, clonidine, other drugs or
supplements for lowering blood pressure.
Self-medication is discouraged because of yohimbeÂ’s side effects.
Yohimbe can produce significant side effects even in a small dose,
especially if taken over a long period of time. Yohimbe side effects
are close to its toxic effects.
Dosage of Yomhimbe
Yohimbe bark is taken in a form standardized to yohimbine content.
The usual dose of yohimbine is 15-30 mg daily. Lower dose of
yohimbe may work even better for some people. Because of its
serious side effects, one should consult doctor before taking this
herb.
HOME
References 1. Charney DS et al. Alpha 2-adrenergic and opiate receptor
blockade. Synergistic effects on anxiety in healthy subjects. Arch Gen
Psychiatry. 1986;43:1037–1041. 2. Charney DS, Heninger GR, Sternberg DE.
Assessment of alpha 2 adrenergic autoreceptor function in humans: effects of
oral yohimbine. Life Sci. 1982;30:2033–2041. 3. Charney DS, Heninger GR,
Redmond DE. Yohimbine induced anxiety and increased noradrenergic
function in humans: effects of diazepam and clonidine. Life Sci. 1983;33:19–
29. 4. Charney DS, Breier A, Jatlow PI, et al. Behavioral, biochemical, and blood
pressure responses to alprazolam in healthy subjects: interactions with
yohimbine. Psychopharmacology. 1986;88:133–140. 5. Charney DS, Price
LH, Heninger GR. Desipramine-yohimbine combination treatment of refractory
depression. Arch Gen Psychiatry. 1986;43:1155–1161. 6. De Smet PA,
Smeets OS. Potential risks of health food products containing yohimbe
extracts. BMJ. 1994;309:958. 7. Grossman E, Rosenthal T, Peleg E, et al. Oral
yohimbine increases blood pressure and sympathetic nervous outflow in
hypertensive patients. J Cardiovasc Pharmacol. 1993;22:22–26. 8. Lacomblez
L, Bensimon G, Isnard F, et al. Effect of yohimbine on blood pressure in
patients with depression and orthostatic hypotension induced by
clomipramine. Clin Pharmacol Ther. 1989;45:241–251. 9. Murburg MM,
Villacres EC, Ko GN, et al. Effects of yohimbine on human sympathetic nervous
system function. J Clin Endocrinol Metab. 1991;73:861–865. 10. Musso NR,
Vergassola C, Pende A. Yohimbine effects on blood pressure and plasma
catecholamines in human hypertension. Am J Hypertens. 1995;8:565–571.
15. Illnesses and Injuries Associated With the Use of Selected Dietary
Supplements. U. S. Food and Drug Administration
Center for Food Safety and Applied Nutrition 1993. 16. Lebret T, Herve JM,
Gorny P, et al. Efficacy and safety of a novel combination of L-arginine
glutamate and yohimbine hydrochloride: a new oral therapy for erectile
dysfunction. Eur Urol. 2002;41:608-613. 17. Meston CM, Worcel M. The effects
of yohimbine plus L-arginine glutamate on sexual arousal in postmenopausal
women with sexual arousal disorder. Arch Sex Behav. 2002;31:323-332.
HOME
THIS YOHIMBE SIDE EFFECT ARTICLE IS FOR YOUR
INFORMATION ONLY. PLEASE CONSULT WITH YOUR DOCTOR
FOR ANY QUESTION.
ALL RIGHT RESERVED
