Turmeric benefits, Turmeric side effects
September 15, 2011
Turmeric Health Benefits

Cancer
Turmeric may benefit people at risk of various types of cancers, there are many "basic" studies supporting this claim. As
early as in 1985, turmeric demonstrated its anti-cancer activity in tissue cultures and in mice. [3] In the study, turmeric
extract was cytotoxic to lymphocytes and Dalton's lymphoma cells.

Curcumin of turmeric was found to inhibit NF-kappaB. NF-kappaB is a protein which helps cancer cells to survive once
they start to grow. People with the early signs of oesophagus cancer could be advised to eat more turmeric-laced foods
in a bid to beat the killer disease. [11, 12, 19]

BREAST CANCER Turmeric curcumin induces apoptosis in breast cancer cells by regulation of multiple signaling
pathways, indicating its potential use for prevention and treatment of cancer. [21]

Dypepsia
Dypepsia is a condition that the person experiences a variety of digestive problems such as stomach discomfort, gas,
bloating, belching, appetite loss, and nausea for unknown medical cause. Turmeric was shown to be able to benefit
patients by reducing dyspepsia symptoms in a clinical trial. [8,9]

Excitotoxicity
In a study, A 24 h-treatment with turmeric curcumin reduced N-methyl-D: -aspartate (NMDA)-mediated excitotoxic cell
damage. The protective benefit was believed to be associated with decrease of NMDA receptor-mediated Ca(2+) and
reduction in the level of phosphorylated NR1 subunit of the NMDA receptor. [22]

Hypertension
Turmeric was found to have hypotensive and protective beneficial effect on the endothelium in spontaneously
hypertensive rats [23] Thus, turmeric may have benefits of blood pressure lowering.

Ulcer
Turmeric does not appear to have benefits on treating ulcers [6,7].

Liver disease
Curcumin or turmeric might help protect the liver from damage but there are also reports that turmeric extracts may
damage the liver at high doses. [13-18].

Dosage
Turmeric extract is often taken in a form of capsule having curcumin content of 400 to 600 mg.
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TURMERIC SIDE EFFECTS
FDA considers that turmeric may be safely used for the coloring of foods generally, in amounts consistent with good
GMP practice. [20] Further, turmeric has been used in food products for many years, standard doses of turmeric or
curcumin should be safe to a healthy users. [1,4, 10] Turmeric side effects, if any, should be mild and limited.

However, high doses of curcumin may increase the risk of ulcers. [5] People with liver disease should avoid turmeric, as
turmeric may offer unpleasant side effect - toxicity to the liver. [32, 33]. Further, turmeric / curcumin may also offer
adverse side effects to people suffered from gallbladder disease, as turmeric stimulates gallbladder.
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REFERENCES
1. Ammon HPT, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991;57:1–7. 2. Sreejayan N, Rao MNA. Free radical scavenging
activity of curcuminoids. Arzneimittelforschung. 1996;46:169–171.  3 Kuttan P Potential anticancer activity of turmeric (Curcuma longa).
Cancer Lett. 1985 Nov;29(2):197-202. 4. Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-
inflammatory agent. J Pharm Pharmacol. 1973;25:447–452. 5. Gupta B, Kulshrestha VK, Srivastava RK, et al. Mechanisms of curcumin
induced gastric ulcer in rats. Indian J Med Res. 1980;71:806–814. 6. Van Dau N, Ngoc Ham N, Huy Khac D, et al. The effects of a
traditional drug, turmeric (Curcuma longa), and placebo on the healing of duodenal ulcer. Phytomedicine. 1998;5:29–34.  7. Kositchaiwat
C, Kositchaiwat S, Havanondha J. Curcuma longa Linn. in the treatment of gastric ulcer comparison to liquid antacid: a controlled clinical
trial. J Med Assoc Thai. 1993;76:601–605. 8. Rasyid A, Lelo A. The effect of curcumin and placebo on human gall-bladder function: an
ultrasound study. Aliment Pharmacol Ther. 1999;13:245–249. 9. Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, et al.
Randomized double blind study of Curcuma domestica Val. for dyspepsia. J Med Assoc Thai. 1989;72:613–620. 10 Shankar TNB,
Shantha NV, Ramesh HP, et al. Toxicity studies on turmeric (Cucurma longa): acute toxicity studies in rats, guinea pigs and monkeys.
Indian J Exp Biol. 1980;18:73–75. 11 Afaq F, Adhami VM, Ahmad N, et al. Botanical antioxidants for chemoprevention of
photocarcinogenesis. Front Biosci. 2002;7:d784-92.  12 Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of
angiogenesis. Mol Med. 1998;4:376-383.  13 Chuang S, Cheng A, Lin J, Kuo M. Inhibition by curcumin of diethylnitrosamine-induced
hepatic hyperplasia, inflammation, cellular gene products and cell-cycle related proteins in rats. Food Chem Toxicol. 2000;38(11):991-995.  
14 Deshpande UR, Gadre SG, Raste AS, et al. Protective effect of turmeric (Curcuma longa L) extract on carbon tetrachloride-induced liver
damage in rats. Indian J Exp Biol. 1998;36:573-577.  15 Song EK, Cho H, Kim JS, et al. Diarylheptanoids with free radical scavenging and
hepatoprotective activity in vitro from Curcuma longa. Planta Med. 2001;67:876-877 16 Venkatesan N. Pulmonary protective effects of
curcumin against paraquat toxicity. Life Sci. 2000;66:PL21-28. 17 Deshpande S, et al. Subchronic oral toxicity of turmeric and ethanolic
turmeric extract in female mice and rats. Toxicology Letters. 1998;95:183-193.  18 Kandarkar SV, Sawant SS, Ingle AD, et al. Subchronic
oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies. Indian J Exp Biol. 1998 Jul;36(7):675-679.  19 Curry can
help cure cancer icWales Aug 9 2005, Spice's role in cancer fight probed, Daily Mail, 11:44am 9th August 2005 20 TITLE 21--FOOD AND
DRUGS CHAPTER I--FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICE PART 73--LISTING OF
COLOR ADDITIVES EXEMPT FROM CERTIFICATION--Table of Contents Subpart A--Foods Sec. 73.600  Turmeric. FDA Publication August
18, 2005. 21. Ramachandran C, Expression profiles of apoptotic genes induced by curcumin in human breast cancer and mammary
epithelial cell lines. Anticancer Res. 2005 Sep-Oct;25(5):3293-302. 22. Matteucci A, Curcumin treatment protects rat retinal neurons against
excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca(2+) increase. Exp Brain Res. 2005 Aug 3;:1-8 23. Goto H, Effect of
curcuma herbs [Turmeric] on vasomotion and hemorheology in spontaneously hypertensive rat. A1 Mythri RB et al, Curcumin: A Potential
Neuroprotective Agent in Parkinson's Disease. Curr Pharm Des. 2012 Jan 1
This website discusses the benefits and side effects of various supplements, herbs and drug products.
Different people may experience different side effects and benefits of a product. You are encouraged to
report adverse side effects to FDA, its website is
www.fda.gov., or report the adverse side effects to the
manufacturer, you should be able to find the contact information on the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my
mistake(s). Reasonable care has been taken in preparing this document and the information provided
herein is believed to be accurate. The information is not intended to be a substitute for professional
medical advice. It is important to seek the advice of a physician about any medical condition or symptom
or the benefits and side effects of a supplement or a drug product. Finally, please, do not transfer the
article to other website.
Privacy Policy. ARTICLE INDEX ALL RIGHTS RESERVED.
Introduction
Parkinson's disease (PD) is an neurodegenerative disease clinically characterized as a movement disorder. The motor symptoms in PD arise due to
selective degeneration of dopaminergic neurons in the substantia nigra of the ventral midbrain thereby depleting the dopamine levels in the striatum.
Most of the current pharmacotherapeutic approaches in PD are aimed at replenishing the striatal dopamine. Although these drugs provide
symptomatic relief during early PD, many patients develop motor complications with long-term treatment. Curcumin is a polyphenol and an active
component of turmeric (Curcuma longa), a dietary spice used in Indian cuisine and medicine. Curcumin exhibits antioxidant, anti-inflammatory and
anti-cancer activities, crosses the blood-brain barrier and is neuroprotective in neurological disorders. Several studies in different experimental
models of PD strongly support the clinical application of curcumin in PD. [A1] This article discusses the potential health benefits of turmeric in various
aspects.

Turmeric and Turmeric Uses - Reviews
Turmeric is a perennial plant. It can be found in SouthEast Asia. Tumeric is one of the key ingredients in curry. Recently, a scientist found that
turmeric may have anti-cancer properties, this adds one more point to turmeric potential benefits. Turmeric has a unique odor and a bitter taste and
it colors the saliva yellow. Turmeric contains gum, starch, calcium, fiber and curcumin (the colorant and also the active ingredient) [1,2]. Curcumin
was found to have anti-inflammatory and antioxidant properties. Boiling alcohol is usually  used to extract this chemical. Traditionally, tumeric was
used to treat jaundice, gallstones, indigestion, gas, worms, menstruation problems and arthritis. It was applied in the form of a paste to aid healing of
cuts and grazes. However, most of these uses are in lack of scientific support.

In food industry, turmeric is used to manufacture curry powders pickles, and mustard. Turmeric tincture is used as yellow coloring agent for paper
and other products. Today, turmeric is still used as a food preservative and colorant for food products.
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This web side discusses the side effects and benefits of herbs, supplements and drug products. You are encouraged
to report adverse the side effects of turmeric you experienced to FDA, its website is
www.fda.gov., or report the
adverse side effects to the manufacturer, you should be able to find the contact information on the label.

There are always new information on turmeric uses or supplements. Please, send me an email (
zhion@zhion.com) to
correct my mistake(s). Reasonable care has been taken in preparing this document and the information provided
herein is believed to be accurate. The information is not intended to be a substitute for professional medical advice. It
is important to seek the advice of a physician about any medical condition or symptom or the benefits and side effects
of turmeric. Finally, please, do not transfer the article to other website.
Privacy Policy. ARTICLE INDEX. ALL RIGHTS
RESERVED.