Original Article and users' comments
Stevia probably has minimum side effects* [4]. Stevia accounts for about 40% of
the sweetener market in Japan and is widely used in South America. [5] It is
suited for diabetes*. No allergic reactions to it seem to exist. [6]
No significant side effect was observed and no deterioration of the quality of life
was shown in a 3-month, multi-center, randomized, double-blinded, placebo-
controlled study. [9] [*PLEASE READ QA SECTION]
STEVIA TOXICITY
Sekihashi K et al, Safety Research Institute for Chemical Compounds Co., Ltd,
Japan evaluated the genotoxicity of steviol, a metabolite of stevia extract using a
comet assay. They found that steviol did not damage the nuclear DNA of TK6
and WTK1 cells. They also investigated organs of mice body after oral
administration of steviol at 250, 500, 1000, and 2000 mg/kg. They found no
damage with stomach, colon, liver, kidney and testis. They concluded that stevia
extract and steviol did not have DNA-damaging activity in cultured cells and
mouse organs. [23]
HIGH DOSE OF STEVIA CAUSED MALE INFERTILITY IN A RAT STUDY.
A study showed that chronic administration (60 days) of a Stevia rebaudiana
aqueous extract produced a decrease in final weight of testis, seminal vesicle
and cauda epididymidis. In addition, Stevia treatment tended to decrease the
plasma testosterone level, probably by a putative affinity of glycosides of extract
for a certain androgen receptor, and no alteration occurred in luteinizing
hormone level.[24]
POTENTIAL DRUG INTERACTIONS
Stevioside from the leaves of Stevia rebaudiana acts as a typical systemic
vasodilator. [8-14] A 2-year study of 168 patients suffered from hypertension
(aged 20-75) demonstrated that oral stevioside (from Stevia rebaudiana Bertoni)
decreased systolic and diastolic blood pressure without significant adverse
effects [14] Consult your doctor before taking stevia together with other blood-
pressure lowering agents and/or blood-sugar lowering agents.
------------------------------------------------------------------------------------------
COMMENTS FROM READERS [QA]
Diana P. XXX@aol.com Fri 21 Jul 2006
Why does stevia give me a headache?
ZHION SAT 22 Jul 2006
I couldn't find any scientific report directly related the intake of stevia to
heachache. However, some web-articles suggests diziness, headache, muscle
weakness, bloating, nausea, muscle tenderness and kidney toxicity as its side
effects or toxic effects. Some of these side effects are also symptoms of
hypoglycemia. Let us relate the activities of stevia, hypoglycemia and headache
together.
It is known that stevia has anti-hyperglycemic properties. In a study, researchers
recruited 12 patients with Type 2 Diabetes. They found that the intake of
stevioside could reduce the postprandial blood glucose levels. In addition,
stevia also has blood pressure lowering activities. Thus, overdose or excessive
intake of stevia will lead to hypoglycemia and hypotension.
If the blood sugar levels fall below the normal range (70-110 mg/dl), episode of
hypoglycemia may occur. symptoms of mild-moderate hypoglycemia include
nausa, hunger, nervousness, coldness, rapid pulse, numbness, dizziness,
headache, blurred vision, weakness and difficulty walking. While, the basic
symptoms for headache are dizziness, nausea, fainting etc. Thus, it makes
sense that excessive dose of stevia causes headache. However, this is just my
thought, experiment is need to prove this idea. Thanks.
-----------------------------------------------------------------------------------------
XXXXXXX@XXXXXXX.net Mon, 15 Sep 2008 19:36:25 -0700
Hello there. I was so glad to read your article regarding STEVIA side effects. I
have used stevia for many years on a daily basis. I now have severe
hypoglycemia. I am waking up every 2 hours because my blood sugar drops.
But at each meal I have stevia. I had not related it to the stevia because
everything I had read about it said it was o-glycemic index and was even safe for
diabetics. This is probably my answer that I have been looking for almost a
year. Thank you so very much.
ZHION Sept 18, 2008
Thanks for your comment; it's encouraging. My best wishes for your health.
---------------------------------------------------------------------------------------
XXXXXXXX @earthlink.net Mon, 15 Sep 2008 10:25:29 -0400
The information currently provided on the website are not reflective of current
findings.:
http://www.zhion.com/herb/STEVIA_side_effects.html
The current studies are not duplicating the effects with fertility the "Melis MS.
Effects of chronic administration of Stevia rebaudiana on fertility in rats" reported
and is outdated material (1999).
The most current finding:
Rebaudioside A: Two-generation reproductive toxicity study in rats
Leslie L. Curry, Ashley Roberts,and Nigel Brown .......There are other studies as
well... this one the newest on the question.
ZHION Sept 20, 2008
Thanks for your comment; updated. Just curious, are you related to Dr. Curry LL
or The Coca-Cola Company? Thanks again.
----------------------------------------------------------------------------------
XXXX@gmail.com Thu, 25 Sep 2008 11:41:21 -0700
I have been reading everyone post on Stevia. I think it does things on everyone
differently..plus most people will read thing and then write to say they have this
or that happen to them..to make it look like there is a problem with the plant it
self. Over the year on both sides here in Canada as well as the states there has
always been way to find a better ways for sweetener for people that are diabetic.
Like everything ESL when a good thing comes along some one got to complain
and give it a bad name. I'm Diabetic and have been for years and have been
using stevia in my coffee,tea right to eating the leafs from the plant it self. I grow
it every year and have given some to people and they can't believe how good it is
and like it better.
People just don't realize a good thing when they see it. Why can't Canada and
the USA see it that this is good cause if it has been used for thousands of years
do you really think people have stopped using it..and are dieing..it's only a plant.
If I felt it was unsafe I would not be using it or eating it at all. I wish people stop
there complaining or wining about something that is good. I hate all the man
made sweeteners.,they are not safe or good for you. But people want to believe
all these company who make the man made sweeteners are best and better for
you when they are the ones that have all the problems with them. think about it
Aspartame is not good cause they found out if left in the sun it can be danger est
and here is a list of all the sweeteners that are not good for you. I will not stop
useing it as it is the best thing that came into my life since my hubby gave me my
first leaf.
Healthy Sweeteners Sweeteners to Avoid
Stevia * Aspartame (NutraSweet, Equal, Canderel)
Other Low Carb Sweeteners Neotame
Evaporated Cane Juice Sucralose (Splenda, Altern)
Fruit Juice Acesulfame-K (Sunette, Sweet & Safe, Sweet One)
Rice Syrup Cyclamates
Honey Saccharin
Licorice Root (small amounts) Refined Sugar #
Fructooligosaccharides (FOS) High Fructose Sweeteners #
Amasake
Vegetable Glycerin
Sugar Alcohols (xylitol, sorbitol) ^
Maple Syrup (Without Added Sugar)
Barley Malt
Key: * Safe for diabetics / # Can be used in small amounts during transition to
healthy sweeteners / ^ Use only in very small amounts - not for those with bowel
disorders.
My Reply Thu, 25 Sep 2008 12:18:46 -0700 (PDT)
Thank you very much for your input. Your message is very informative. I agree
with you, everybody react differently toward particular supplements and we
should not overdose ourselves. I'll share your message with other readers, as
rule of thumb, I won't post your name and email address in my website........
I wonder why people talk about stevia these days. Recently, I found out that
Coca Cola and Cargill (one of the world's largest providers of food and
agricultural products) have worked together to develop a Stevia-based
sweetener for use as an additive in foods and beverages for years. They
have published a few articles on the safety of using stevia. The FDA now
allows Stevia as a dietary supplement only, not as a food additive. The
companies may be closer to getting the FDA approval they need to use Stevia
in their products. The brand name will be Truvia™.
Coca Cola has already filed 24 patent applications covering Stevia's use in
products ranging from vitamins to cereal. As a result, the world's largest
beverage maker may be seeking to corner the market on the natural
sweetener.
Zhion September 29, 2008.
THIS ARTICLE IS FOR YOUR REFERENCE ONLY. YOU SHOULD CONSULT YOUR DOCTOR
FOR ANY QUESTIONS AND BEFORE TAKING STEVIA. ALL RIGHTS RESERVED 2008
ZHION
HOME
STEVIA REPORT
References
[1] Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs,
and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 478–80.[2] Curi R, Alvarez M,
Bazotte RB, et al. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.
Braz J Med Biol Res 1986;19:771–4. [3] White JR Jr, Kramer J, Campbell RK, Bernstein R.
Oral use of a topical preparation containing an extract of Stevia rebaudiana and the
chrysanthemum flower in the management of hyperglycemia. Diabetes Care 1994;17:940.[4]
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and
Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 478–80. [5] Blumenthal M. FDA
rejects AHPA stevia petition. Whole Foods 1994:Apr;61–4. [6] Geuns JM. Stevioside.
Phytochemistry. 2003 Nov;64(5):913-21. [7] D'Agostino M, De Simone F, Pizza C, Aquino R.
Sterols in Stevia rebaudiana Bertoni. Boll Soc Ital Biol Sper. 1984 Dec 30;60(12):2237-40.
[8] Melis MS Stevioside effect on renal function of normal and hypertensive rats. J
Ethnopharmacol. 1992 Jun;36(3):213-7.[9] Chan P et al A double-blind placebo-controlled
study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin
Pharmacol. 2000 Sep;50(3):215-20.[10] Chan P et al, The effect of stevioside on blood
pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. 1998;63
(19):1679-84. [11] Lee CN et al Inhibitory effect of stevioside on calcium influx to produce
antihypertension. Planta Med. 2001 Dec;67(9):796-9].[12] Hsu YH et al, Antihypertensive
effect of stevioside in different strains of hypertensive rats. Zhonghua Yi Xue Za Zhi (Taipei).
2002 Jan;65(1):1-6. [13]Liu JC et al Mechanism of the antihypertensive effect of stevioside in
anesthetized dogs. Pharmacology. 2003 Jan;67(1):14-20.[14] Hsieh MH et al Efficacy and
tolerability of oral stevioside in patients with mild essential hypertension: a two-year,
randomized, placebo-controlled study. Clin Ther. 2003 Nov;25(11):2797-808.[15] Curi R et
al, Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Braz J Med
Biol Res. 1986;19(6):771-4.[16] Jeppesen PB et al, Stevioside acts directly on pancreatic
beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and
adenosine triphosphate-sensitive K+-channel activity. Metabolism. 2000 Feb;49(2):208-14.
[17] Jeppesen PB et al, Stevioside induces antihyperglycaemic, insulinotropic and
glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats.
Phytomedicine. 2002 Jan;9(1):9-14. 18] Gregersen S, Jeppesen PB, Holst JJ, Hermansen K.
Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004 Jan;53
(1):73-6.[19] Chen TH et al Mechanism of the hypoglycemic effect of stevioside, a glycoside
of Stevia rebaudiana. Planta Med. 2005 Feb;71(2):108-13.[20] Yasukawa K et al Inhibitory
effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-
stage carcinogenesis in mouse skin. Pharm Bull. 2002 Nov;25(11):1488-90.[21] Amaro-Luis
et al Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora.
Ann Pharm Fr. 1997;55(6):262-8[22] Koyama E et al. Absorption and metabolism of
glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food
Chem Toxicol. 2003 Jun;41(6):875-83.
[23] Sekihashi K et al Genotoxicity studies of stevia extract and steviol by the comet assay, J
Toxicol Sci. 2002 Dec;27 Suppl 1:1-8.[24] Melis MS. Effects of chronic administration of
Stevia rebaudiana on fertility in rats. J Ethnopharmacol. 1999 Nov 1;67(2):157-61.
Stevia probably has minimum side effects* [4]. Stevia accounts for about 40% of
the sweetener market in Japan and is widely used in South America. [5] It is
suited for diabetes*. No allergic reactions to it seem to exist. [6]
No significant side effect was observed and no deterioration of the quality of life
was shown in a 3-month, multi-center, randomized, double-blinded, placebo-
controlled study. [9] [*PLEASE READ QA SECTION]
STEVIA TOXICITY
Sekihashi K et al, Safety Research Institute for Chemical Compounds Co., Ltd,
Japan evaluated the genotoxicity of steviol, a metabolite of stevia extract using a
comet assay. They found that steviol did not damage the nuclear DNA of TK6
and WTK1 cells. They also investigated organs of mice body after oral
administration of steviol at 250, 500, 1000, and 2000 mg/kg. They found no
damage with stomach, colon, liver, kidney and testis. They concluded that stevia
extract and steviol did not have DNA-damaging activity in cultured cells and
mouse organs. [23]
HIGH DOSE OF STEVIA CAUSED MALE INFERTILITY IN A RAT STUDY.
A study showed that chronic administration (60 days) of a Stevia rebaudiana
aqueous extract produced a decrease in final weight of testis, seminal vesicle
and cauda epididymidis. In addition, Stevia treatment tended to decrease the
plasma testosterone level, probably by a putative affinity of glycosides of extract
for a certain androgen receptor, and no alteration occurred in luteinizing
hormone level.[24]
POTENTIAL DRUG INTERACTIONS
Stevioside from the leaves of Stevia rebaudiana acts as a typical systemic
vasodilator. [8-14] A 2-year study of 168 patients suffered from hypertension
(aged 20-75) demonstrated that oral stevioside (from Stevia rebaudiana Bertoni)
decreased systolic and diastolic blood pressure without significant adverse
effects [14] Consult your doctor before taking stevia together with other blood-
pressure lowering agents and/or blood-sugar lowering agents.
------------------------------------------------------------------------------------------
COMMENTS FROM READERS [QA]
Diana P. XXX@aol.com Fri 21 Jul 2006
Why does stevia give me a headache?
ZHION SAT 22 Jul 2006
I couldn't find any scientific report directly related the intake of stevia to
heachache. However, some web-articles suggests diziness, headache, muscle
weakness, bloating, nausea, muscle tenderness and kidney toxicity as its side
effects or toxic effects. Some of these side effects are also symptoms of
hypoglycemia. Let us relate the activities of stevia, hypoglycemia and headache
together.
It is known that stevia has anti-hyperglycemic properties. In a study, researchers
recruited 12 patients with Type 2 Diabetes. They found that the intake of
stevioside could reduce the postprandial blood glucose levels. In addition,
stevia also has blood pressure lowering activities. Thus, overdose or excessive
intake of stevia will lead to hypoglycemia and hypotension.
If the blood sugar levels fall below the normal range (70-110 mg/dl), episode of
hypoglycemia may occur. symptoms of mild-moderate hypoglycemia include
nausa, hunger, nervousness, coldness, rapid pulse, numbness, dizziness,
headache, blurred vision, weakness and difficulty walking. While, the basic
symptoms for headache are dizziness, nausea, fainting etc. Thus, it makes
sense that excessive dose of stevia causes headache. However, this is just my
thought, experiment is need to prove this idea. Thanks.
-----------------------------------------------------------------------------------------
XXXXXXX@XXXXXXX.net Mon, 15 Sep 2008 19:36:25 -0700
Hello there. I was so glad to read your article regarding STEVIA side effects. I
have used stevia for many years on a daily basis. I now have severe
hypoglycemia. I am waking up every 2 hours because my blood sugar drops.
But at each meal I have stevia. I had not related it to the stevia because
everything I had read about it said it was o-glycemic index and was even safe for
diabetics. This is probably my answer that I have been looking for almost a
year. Thank you so very much.
ZHION Sept 18, 2008
Thanks for your comment; it's encouraging. My best wishes for your health.
---------------------------------------------------------------------------------------
XXXXXXXX @earthlink.net Mon, 15 Sep 2008 10:25:29 -0400
The information currently provided on the website are not reflective of current
findings.:
http://www.zhion.com/herb/STEVIA_side_effects.html
The current studies are not duplicating the effects with fertility the "Melis MS.
Effects of chronic administration of Stevia rebaudiana on fertility in rats" reported
and is outdated material (1999).
The most current finding:
Rebaudioside A: Two-generation reproductive toxicity study in rats
Leslie L. Curry, Ashley Roberts,and Nigel Brown .......There are other studies as
well... this one the newest on the question.
ZHION Sept 20, 2008
Thanks for your comment; updated. Just curious, are you related to Dr. Curry LL
or The Coca-Cola Company? Thanks again.
----------------------------------------------------------------------------------
XXXX@gmail.com Thu, 25 Sep 2008 11:41:21 -0700
I have been reading everyone post on Stevia. I think it does things on everyone
differently..plus most people will read thing and then write to say they have this
or that happen to them..to make it look like there is a problem with the plant it
self. Over the year on both sides here in Canada as well as the states there has
always been way to find a better ways for sweetener for people that are diabetic.
Like everything ESL when a good thing comes along some one got to complain
and give it a bad name. I'm Diabetic and have been for years and have been
using stevia in my coffee,tea right to eating the leafs from the plant it self. I grow
it every year and have given some to people and they can't believe how good it is
and like it better.
People just don't realize a good thing when they see it. Why can't Canada and
the USA see it that this is good cause if it has been used for thousands of years
do you really think people have stopped using it..and are dieing..it's only a plant.
If I felt it was unsafe I would not be using it or eating it at all. I wish people stop
there complaining or wining about something that is good. I hate all the man
made sweeteners.,they are not safe or good for you. But people want to believe
all these company who make the man made sweeteners are best and better for
you when they are the ones that have all the problems with them. think about it
Aspartame is not good cause they found out if left in the sun it can be danger est
and here is a list of all the sweeteners that are not good for you. I will not stop
useing it as it is the best thing that came into my life since my hubby gave me my
first leaf.
Healthy Sweeteners Sweeteners to Avoid
Stevia * Aspartame (NutraSweet, Equal, Canderel)
Other Low Carb Sweeteners Neotame
Evaporated Cane Juice Sucralose (Splenda, Altern)
Fruit Juice Acesulfame-K (Sunette, Sweet & Safe, Sweet One)
Rice Syrup Cyclamates
Honey Saccharin
Licorice Root (small amounts) Refined Sugar #
Fructooligosaccharides (FOS) High Fructose Sweeteners #
Amasake
Vegetable Glycerin
Sugar Alcohols (xylitol, sorbitol) ^
Maple Syrup (Without Added Sugar)
Barley Malt
Key: * Safe for diabetics / # Can be used in small amounts during transition to
healthy sweeteners / ^ Use only in very small amounts - not for those with bowel
disorders.
My Reply Thu, 25 Sep 2008 12:18:46 -0700 (PDT)
Thank you very much for your input. Your message is very informative. I agree
with you, everybody react differently toward particular supplements and we
should not overdose ourselves. I'll share your message with other readers, as
rule of thumb, I won't post your name and email address in my website........
I wonder why people talk about stevia these days. Recently, I found out that
Coca Cola and Cargill (one of the world's largest providers of food and
agricultural products) have worked together to develop a Stevia-based
sweetener for use as an additive in foods and beverages for years. They
have published a few articles on the safety of using stevia. The FDA now
allows Stevia as a dietary supplement only, not as a food additive. The
companies may be closer to getting the FDA approval they need to use Stevia
in their products. The brand name will be Truvia™.
Coca Cola has already filed 24 patent applications covering Stevia's use in
products ranging from vitamins to cereal. As a result, the world's largest
beverage maker may be seeking to corner the market on the natural
sweetener.
Zhion September 29, 2008.
THIS ARTICLE IS FOR YOUR REFERENCE ONLY. YOU SHOULD CONSULT YOUR DOCTOR
FOR ANY QUESTIONS AND BEFORE TAKING STEVIA. ALL RIGHTS RESERVED 2008
ZHION
HOME
STEVIA REPORT
References
[1] Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs,
and Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 478–80.[2] Curi R, Alvarez M,
Bazotte RB, et al. Effect of Stevia rebaudiana on glucose tolerance in normal adult humans.
Braz J Med Biol Res 1986;19:771–4. [3] White JR Jr, Kramer J, Campbell RK, Bernstein R.
Oral use of a topical preparation containing an extract of Stevia rebaudiana and the
chrysanthemum flower in the management of hyperglycemia. Diabetes Care 1994;17:940.[4]
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Foods, Drugs, and
Cosmetics, 2d ed. New York: John Wiley & Sons, 1996, 478–80. [5] Blumenthal M. FDA
rejects AHPA stevia petition. Whole Foods 1994:Apr;61–4. [6] Geuns JM. Stevioside.
Phytochemistry. 2003 Nov;64(5):913-21. [7] D'Agostino M, De Simone F, Pizza C, Aquino R.
Sterols in Stevia rebaudiana Bertoni. Boll Soc Ital Biol Sper. 1984 Dec 30;60(12):2237-40.
[8] Melis MS Stevioside effect on renal function of normal and hypertensive rats. J
Ethnopharmacol. 1992 Jun;36(3):213-7.[9] Chan P et al A double-blind placebo-controlled
study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin
Pharmacol. 2000 Sep;50(3):215-20.[10] Chan P et al, The effect of stevioside on blood
pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci. 1998;63
(19):1679-84. [11] Lee CN et al Inhibitory effect of stevioside on calcium influx to produce
antihypertension. Planta Med. 2001 Dec;67(9):796-9].[12] Hsu YH et al, Antihypertensive
effect of stevioside in different strains of hypertensive rats. Zhonghua Yi Xue Za Zhi (Taipei).
2002 Jan;65(1):1-6. [13]Liu JC et al Mechanism of the antihypertensive effect of stevioside in
anesthetized dogs. Pharmacology. 2003 Jan;67(1):14-20.[14] Hsieh MH et al Efficacy and
tolerability of oral stevioside in patients with mild essential hypertension: a two-year,
randomized, placebo-controlled study. Clin Ther. 2003 Nov;25(11):2797-808.[15] Curi R et
al, Effect of Stevia rebaudiana on glucose tolerance in normal adult humans. Braz J Med
Biol Res. 1986;19(6):771-4.[16] Jeppesen PB et al, Stevioside acts directly on pancreatic
beta cells to secrete insulin: actions independent of cyclic adenosine monophosphate and
adenosine triphosphate-sensitive K+-channel activity. Metabolism. 2000 Feb;49(2):208-14.
[17] Jeppesen PB et al, Stevioside induces antihyperglycaemic, insulinotropic and
glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats.
Phytomedicine. 2002 Jan;9(1):9-14. 18] Gregersen S, Jeppesen PB, Holst JJ, Hermansen K.
Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism. 2004 Jan;53
(1):73-6.[19] Chen TH et al Mechanism of the hypoglycemic effect of stevioside, a glycoside
of Stevia rebaudiana. Planta Med. 2005 Feb;71(2):108-13.[20] Yasukawa K et al Inhibitory
effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-
stage carcinogenesis in mouse skin. Pharm Bull. 2002 Nov;25(11):1488-90.[21] Amaro-Luis
et al Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora.
Ann Pharm Fr. 1997;55(6):262-8[22] Koyama E et al. Absorption and metabolism of
glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food
Chem Toxicol. 2003 Jun;41(6):875-83.
[23] Sekihashi K et al Genotoxicity studies of stevia extract and steviol by the comet assay, J
Toxicol Sci. 2002 Dec;27 Suppl 1:1-8.[24] Melis MS. Effects of chronic administration of
Stevia rebaudiana on fertility in rats. J Ethnopharmacol. 1999 Nov 1;67(2):157-61.
| STEVIA side effect - research finds Zhion@zhion.com |
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HOME
Herb Side Effect
Resource
Article based on new findings
(WARNING Read the original article and users' comments, and consult with
your doctor before taking any supplements)
The plant, Stevia rebaudiana Bertoni (SrB), has been used for the treatment of
diabetes in traditional medicine. Previously, it was demonstrated that
long-term administration of the glycoside stevioside has insulinotropic,
glucagonostatic, anti-hyperglycemic and blood pressure-lowering effects in
type 2 diabetic animal models. [4] However, Dyrskog SE
[stig.dyrskog@ki.au.dk], Jeppesen PB, Chen J, Christensen LP, Hermansen K
from Aarhus University Hospital DK supplemented male Goto-Kakizaki (GK)
rats with oral rebaudioside A (0.025 g/kg BW/day) for eight weeks, they
observed no effect on blood pressure or weight development. [4] At the same
time, Nikiforov Al and Eapen AK from Toxicology Regulatory Services, Inc.
Virginia, found no toxicity of dietary administration of rebaudioside A in
Sprague-Dawley rats in a 90-day study. [5]
Rebaudioside A and stevioside are steviol glycosides extracted from the plant
Stevia rebaudiana (Bertoni) and are used in several countries as food and
beverage sweeteners. [2,3]
Carakostas MC [mcarakostas@na.ko.com] Curry LL, Boileau AC and Brusick
DJ, from The Coca-Cola Company, concluded that high purity rebaudioside A
(rebiana) produced to food-grade specifications and according to Good
Manufacturing Practices is safe for human consumption under its intended
conditions of use as a general purpose sweetener in their review article. And,
clinical studies provide further evidence that purified rebaudioside A has no
effect on either blood pressure or glucose homeostasis. [2]
Curry LL and Roberts A, from Cargill Inc. MN, [Leslie_Curry@cargill.com]
evaluated the safety issue (or toxicity) of the steriva-derived sweetener,
rebaudioside A (CAS No. 58543-16-1). They administered rebaudioside A at
various dietary concentrations for a few weeks. They found reductions in body
weight gain (especially in high-dose groups) and inconsistent reductions in
serum bile acids and cholesterol. However, all other hepatic function test
results and liver histopathology were within normal limits. Macroscopic and
microscopic examinations of all organs are unremarkable with respect to
treatment-related findings. [1]
Again, Curry LL, Carakostas MC, Boileau AC, Brusick DJ. together with Tarka
SM, Reeves MS, Farmer MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC,
Dicklin MR from Provident Clinical Research (this time), IN, reported
consumption of as much as 1000mg/day of rebaudioside A for 4 weeks
produced no clinically important changes in blood pressure in healthy adults
with normal and low-normal blood pressure. [3]
[1] Curry LL, Roberts A. Subchronic toxicity of rebaudioside A. Food Chem
Toxicol. 2008 Jul;46 Suppl 7:S11-20. Epub 2008 May 16. [2] Carakostas MC,
Curry LL, Boileau AC, Brusick DJ. Overview: the history, technical function and
safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food
and beverages. Food Chem Toxicol. 2008 Jul;46 Suppl 7:S1-S10. Epub 2008
May 16. [3] Maki KC, Curry LL, Carakostas MC, Tarka SM, Reeves MS, Farmer
MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC, Dicklin MR, Boileau AC,
Bisognano JD. The hemodynamic effects of rebaudioside A in healthy adults
with normal and low-normal blood pressure. Food Chem Toxicol. 2008 Jul;46
Suppl 7:S40-6. Epub 2008 May 16. [4] Dyrskog SE [stig.dyrskog@ki.au.dk],
Jeppesen PB, Chen J, Christensen LP, Hermansen K, The diterpene
glycoside, rebaudioside A, does not improve glycemic control or affect blood
pressure after eight weeks treatment in the Goto-Kakizaki rat. Rev Diabet Stud.
2005 Summer;2(2):84-91. Epub 2005 Aug 10. [5] Nikiforov Al and Eapen AK A
90-day oral (dietary) toxicity study of rebaudioside A in Sprague-Dawley rats. Int
J Toxicol. 2008 Jan-Feb;27(1):65-80.
(WARNING Read the original article and users' comments, and consult with
your doctor before taking any supplements)
The plant, Stevia rebaudiana Bertoni (SrB), has been used for the treatment of
diabetes in traditional medicine. Previously, it was demonstrated that
long-term administration of the glycoside stevioside has insulinotropic,
glucagonostatic, anti-hyperglycemic and blood pressure-lowering effects in
type 2 diabetic animal models. [4] However, Dyrskog SE
[stig.dyrskog@ki.au.dk], Jeppesen PB, Chen J, Christensen LP, Hermansen K
from Aarhus University Hospital DK supplemented male Goto-Kakizaki (GK)
rats with oral rebaudioside A (0.025 g/kg BW/day) for eight weeks, they
observed no effect on blood pressure or weight development. [4] At the same
time, Nikiforov Al and Eapen AK from Toxicology Regulatory Services, Inc.
Virginia, found no toxicity of dietary administration of rebaudioside A in
Sprague-Dawley rats in a 90-day study. [5]
Rebaudioside A and stevioside are steviol glycosides extracted from the plant
Stevia rebaudiana (Bertoni) and are used in several countries as food and
beverage sweeteners. [2,3]
Carakostas MC [mcarakostas@na.ko.com] Curry LL, Boileau AC and Brusick
DJ, from The Coca-Cola Company, concluded that high purity rebaudioside A
(rebiana) produced to food-grade specifications and according to Good
Manufacturing Practices is safe for human consumption under its intended
conditions of use as a general purpose sweetener in their review article. And,
clinical studies provide further evidence that purified rebaudioside A has no
effect on either blood pressure or glucose homeostasis. [2]
Curry LL and Roberts A, from Cargill Inc. MN, [Leslie_Curry@cargill.com]
evaluated the safety issue (or toxicity) of the steriva-derived sweetener,
rebaudioside A (CAS No. 58543-16-1). They administered rebaudioside A at
various dietary concentrations for a few weeks. They found reductions in body
weight gain (especially in high-dose groups) and inconsistent reductions in
serum bile acids and cholesterol. However, all other hepatic function test
results and liver histopathology were within normal limits. Macroscopic and
microscopic examinations of all organs are unremarkable with respect to
treatment-related findings. [1]
Again, Curry LL, Carakostas MC, Boileau AC, Brusick DJ. together with Tarka
SM, Reeves MS, Farmer MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC,
Dicklin MR from Provident Clinical Research (this time), IN, reported
consumption of as much as 1000mg/day of rebaudioside A for 4 weeks
produced no clinically important changes in blood pressure in healthy adults
with normal and low-normal blood pressure. [3]
[1] Curry LL, Roberts A. Subchronic toxicity of rebaudioside A. Food Chem
Toxicol. 2008 Jul;46 Suppl 7:S11-20. Epub 2008 May 16. [2] Carakostas MC,
Curry LL, Boileau AC, Brusick DJ. Overview: the history, technical function and
safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food
and beverages. Food Chem Toxicol. 2008 Jul;46 Suppl 7:S1-S10. Epub 2008
May 16. [3] Maki KC, Curry LL, Carakostas MC, Tarka SM, Reeves MS, Farmer
MV, McKenney JM, Toth PD, Schwartz SL, Lubin BC, Dicklin MR, Boileau AC,
Bisognano JD. The hemodynamic effects of rebaudioside A in healthy adults
with normal and low-normal blood pressure. Food Chem Toxicol. 2008 Jul;46
Suppl 7:S40-6. Epub 2008 May 16. [4] Dyrskog SE [stig.dyrskog@ki.au.dk],
Jeppesen PB, Chen J, Christensen LP, Hermansen K, The diterpene
glycoside, rebaudioside A, does not improve glycemic control or affect blood
pressure after eight weeks treatment in the Goto-Kakizaki rat. Rev Diabet Stud.
2005 Summer;2(2):84-91. Epub 2005 Aug 10. [5] Nikiforov Al and Eapen AK A
90-day oral (dietary) toxicity study of rebaudioside A in Sprague-Dawley rats. Int
J Toxicol. 2008 Jan-Feb;27(1):65-80.