| Phellinus linteus Health Benefits and Side Effects 2007 |
It is known that polysaccharides extracted from the Phellinus linteus
mushroom possess anti-tumor activity. Phellinus linteus mushroom
indirectly augments the host's immune system against cancer cells
and reduced tumor proliferation. [1,2]
Prostate Cancer Cells
Researchers from Harvard Medical School demonstrated that
LNCaP cells expressing the androgen receptor are highly
susceptible to apoptosis in response to treatment with high doses of
Phellinus linteus. They also found that caspase 2 is a key target in
the determination of the susceptibility of prostate cancer cells to
PL-induced apoptosis. [1]
Lung Cancer Cells
Researchers from Boston University School of Medicine reported
that high doses of Phellinus linteus mushroom could make lung
cancer cells to undergo apoptosis in a dose-dependent fashion
while low doses of Phellinus linteus mushroom allows the arrest of
the cell-cycle. Furthermore, the low dose of Phellinus linteus
mushroom was able to synergize with doxorubicin to induce
apoptosis in the lung cancer cells. [2]
A study of rats in Korea showed that pretreatment with mycelial
culture of Phellinus linteus provided protection of the gastric mucosa
from ethanol-induced injury by maintaining the mucus barrier. The
ulcer was induced by ethanol. Pretreatment with mycelial culture of
Phellinus linteus at doses of 20 and 60 mg/kg, led to a significant
decrease of bleeding and ulcer index. [3]
Melanoma Cells
Korean researchers showed that Phellinus linteus significantly
inhibited melanoma cell metastasis in mice. In the study, Phellinus
linteus directly inhibited cancer cell adhesion to and invasion through
the extracellular matrix. [4]
Colon Cancer Cells
Phellinus linteus inhibited the proliferation and colony formation of
SW480 human colon cancer cells. Flow cytometry analysis showed
that Phellinus linteus increased the populations of both apoptotic sub-
G1 and G2/M phase. [6]
Neuroblastoma
Researchers from Korea found that the anti-proliferative and
apoptotic effects of mycelium extracts of Phellinus linteus on
neuroblastoma were associated with a significant induction of the
Bax and cyclin-dependent kinase inhibitor p21. [10]
Anti-inflammatory activities.
Phellinus linteus showd an anti-inflammatory activity via mediation of
HO-1 in an in vitro inflammation model. [5]
Anti-bacterial activities.
Methanol extract and its fractions (CHCl3, n-BuOH and H2O) of the
fruit body of Phellinus linteus mushroom showed antibacterial activity
against methicillin-resistant Staphylococcus aureus. [8]
Antioxidant activities
Hispidin, antioxidant extracted from the mycelial culture broth of
Phellinus linteus, inhibited 22.6 and 56.8% of the super oxide anion
radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5%
of the DPPH radical at 0.1 and 1.0 mM, respectively. [9]
Liver Protection
In a study, an ethyl acetate fraction of mycelial culture of Phellinus
linteus protected hepatocytes from H(2)O(2)- or
galactosamine-induced injury. [7]
COMMENTS
Phellinus linteus may have lots of health benefits, but there are
limited clinical studies. Results of animal models and cell culture may
not be same in human body. In addition, studies on its side effects
are needed.
ALL RIGHTS RESERVED ZHION 2007. DO NOT TAKE ANY SUPPLEMENTS WITHOUT
CONSULTING A DOCTOR. THIS ARTICLE IS FOR YOUR INFORMATION ONLY.
[1] Zhu T, et al, Phellinus linteus activates different pathways to induce apoptosis in prostate cancer
cells. Br J Cancer. 2007 Feb 26;96(4):583-90. Epub 2007 Jan 30. [2] Guo J, et al, Modulation of
lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol Carcinog. 2007 Feb;46(2):144-54.
[3] Lee JH, et al, Effects of mycelial culture of Phellinus linteus on ethanol-induced gastric ulcer in
rats. Phytother Res. 2006 May;20(5):396-402. [4] Han SB, et al, Acidic polysaccharide from
Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. Int
Immunopharmacol. 2006 Apr;6(4):697-702. Epub 2005 Nov 8. [5] Kim BC, et al, Heme oxygenase-1
mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7
macrophages. J Ethnopharmacol. 2006 Jul 19;106(3):364-71. Epub 2006 Feb 20. [6] Li G, et al,
Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in
SW480 human colon cancer cells. Cancer Lett. 2004 Dec 28;216(2):175-81. [7] Kim SH, et al,
Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatotoxins.
J Ethnopharmacol. 2004 Dec;95(2-3):367-72. [8] Hur JM, et al, Antibacterial effect of Phellinus
linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia. 2004 Sep;75(6):603-5. [9]
Park IH, et al, An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch Pharm
Res. 2004 Jun;27(6):615-8. [10] Choi YH, et al, Induction of apoptotic cell death by mycelium
extracts of Phellinus linteus in human neuroblastoma cells. Int J Mol Med. 2004 Aug;14(2):227-32.
mushroom possess anti-tumor activity. Phellinus linteus mushroom
indirectly augments the host's immune system against cancer cells
and reduced tumor proliferation. [1,2]
Prostate Cancer Cells
Researchers from Harvard Medical School demonstrated that
LNCaP cells expressing the androgen receptor are highly
susceptible to apoptosis in response to treatment with high doses of
Phellinus linteus. They also found that caspase 2 is a key target in
the determination of the susceptibility of prostate cancer cells to
PL-induced apoptosis. [1]
Lung Cancer Cells
Researchers from Boston University School of Medicine reported
that high doses of Phellinus linteus mushroom could make lung
cancer cells to undergo apoptosis in a dose-dependent fashion
while low doses of Phellinus linteus mushroom allows the arrest of
the cell-cycle. Furthermore, the low dose of Phellinus linteus
mushroom was able to synergize with doxorubicin to induce
apoptosis in the lung cancer cells. [2]
A study of rats in Korea showed that pretreatment with mycelial
culture of Phellinus linteus provided protection of the gastric mucosa
from ethanol-induced injury by maintaining the mucus barrier. The
ulcer was induced by ethanol. Pretreatment with mycelial culture of
Phellinus linteus at doses of 20 and 60 mg/kg, led to a significant
decrease of bleeding and ulcer index. [3]
Melanoma Cells
Korean researchers showed that Phellinus linteus significantly
inhibited melanoma cell metastasis in mice. In the study, Phellinus
linteus directly inhibited cancer cell adhesion to and invasion through
the extracellular matrix. [4]
Colon Cancer Cells
Phellinus linteus inhibited the proliferation and colony formation of
SW480 human colon cancer cells. Flow cytometry analysis showed
that Phellinus linteus increased the populations of both apoptotic sub-
G1 and G2/M phase. [6]
Neuroblastoma
Researchers from Korea found that the anti-proliferative and
apoptotic effects of mycelium extracts of Phellinus linteus on
neuroblastoma were associated with a significant induction of the
Bax and cyclin-dependent kinase inhibitor p21. [10]
Anti-inflammatory activities.
Phellinus linteus showd an anti-inflammatory activity via mediation of
HO-1 in an in vitro inflammation model. [5]
Anti-bacterial activities.
Methanol extract and its fractions (CHCl3, n-BuOH and H2O) of the
fruit body of Phellinus linteus mushroom showed antibacterial activity
against methicillin-resistant Staphylococcus aureus. [8]
Antioxidant activities
Hispidin, antioxidant extracted from the mycelial culture broth of
Phellinus linteus, inhibited 22.6 and 56.8% of the super oxide anion
radical, 79.4 and 95.3% of the hydroxyl radical, and 28.1 and 85.5%
of the DPPH radical at 0.1 and 1.0 mM, respectively. [9]
Liver Protection
In a study, an ethyl acetate fraction of mycelial culture of Phellinus
linteus protected hepatocytes from H(2)O(2)- or
galactosamine-induced injury. [7]
COMMENTS
Phellinus linteus may have lots of health benefits, but there are
limited clinical studies. Results of animal models and cell culture may
not be same in human body. In addition, studies on its side effects
are needed.
ALL RIGHTS RESERVED ZHION 2007. DO NOT TAKE ANY SUPPLEMENTS WITHOUT
CONSULTING A DOCTOR. THIS ARTICLE IS FOR YOUR INFORMATION ONLY.
[1] Zhu T, et al, Phellinus linteus activates different pathways to induce apoptosis in prostate cancer
cells. Br J Cancer. 2007 Feb 26;96(4):583-90. Epub 2007 Jan 30. [2] Guo J, et al, Modulation of
lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol Carcinog. 2007 Feb;46(2):144-54.
[3] Lee JH, et al, Effects of mycelial culture of Phellinus linteus on ethanol-induced gastric ulcer in
rats. Phytother Res. 2006 May;20(5):396-402. [4] Han SB, et al, Acidic polysaccharide from
Phellinus linteus inhibits melanoma cell metastasis by blocking cell adhesion and invasion. Int
Immunopharmacol. 2006 Apr;6(4):697-702. Epub 2005 Nov 8. [5] Kim BC, et al, Heme oxygenase-1
mediates the anti-inflammatory effect of mushroom Phellinus linteus in LPS-stimulated RAW264.7
macrophages. J Ethnopharmacol. 2006 Jul 19;106(3):364-71. Epub 2006 Feb 20. [6] Li G, et al,
Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in
SW480 human colon cancer cells. Cancer Lett. 2004 Dec 28;216(2):175-81. [7] Kim SH, et al,
Mycelial culture of Phellinus linteus protects primary cultured rat hepatocytes against hepatotoxins.
J Ethnopharmacol. 2004 Dec;95(2-3):367-72. [8] Hur JM, et al, Antibacterial effect of Phellinus
linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia. 2004 Sep;75(6):603-5. [9]
Park IH, et al, An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch Pharm
Res. 2004 Jun;27(6):615-8. [10] Choi YH, et al, Induction of apoptotic cell death by mycelium
extracts of Phellinus linteus in human neuroblastoma cells. Int J Mol Med. 2004 Aug;14(2):227-32.