|Eleuthero, eleuthero root extract, eleuthero benefits
eleuthero side effects, firstname.lastname@example.org
The use of this popular herb can be traced back over 2,000 years in ancient Chinese medical texts, where it is
indicated for the treatment of a wide variety of ailments. Although it is a cousin of the Panax ginseng family (Korean,
Chinese and American) it’s considered distinctly different. The term panax is derived from the Greek words pan (all)
and akos (cure), which means “cure-all”. In addition to its adaptogenic properties, which seem to stem from its ability to
regulate the activity of the adrenal cortex in response to stress, Eleuthero has some unique benefits. It stimulates the
immune system, especially during times of strenuous physical exertion and stress, and seems especially beneficial for
supporting a healthy mood and mental alertness. Eleuthero is also extremely beneficial as a training aid for athletes.
Today, eleuthero root is marketed as a support for the liver.
Eleutherosides are the active components in Eleuthero.
Eleuthero may benefit people with depression, fatigue or under stress. It also enhances immuno-functions and neuron
ELEUTHERO BENEFITS - ANTIOXIDANT AND ANTI-CANCER ACTIVITIES
Root extracts of Eleuthero, Odaesan, Korea (ethyl acetate and n-butanol fractionations) revealed strong antioxidant
against scavenging on DPPH free radicals. In addition, ethyl acetate fractionation exhibited high anti-lipid peroxidative
activities. They were also active in against seven human cancer cell lines. 
ELEUTHERO BENEFITS - ANTI-INFLAMATORY EFFECTS
Eleuthero root has been used as a tonic and adaptogen to strengthen qi in traditional Korean medicine. The
neuroprotective effects of water extracts of Siberian Ginseng were investigated in transient middle cerebral artery
occlusion (MCAo, 90 min occlusion, 24 h reperfusion) of Sprague-Dawley rats. The infarct volume was significantly
reduced by 36.6% after the peritoneal injection of Eleuthero extracts (100 mg [sol ]kg) compared with the control. In
the immunohistochemical study, Eleutherog extracts markedly inhibited both cyclooxygenase-2 and OX-42 expressions
in the penumbral region at 24 h after MCAo. These results suggest that Eleuthero may have beneficial effect of neuro-
protection by inhibiting inflammation and microglial activation in brain ischaemia. 
ELEUTHERO BENEFITS - ANTI-FATIGUE OR ANTI-STRESS EFFECTS
The eleuthero g cortex has been used extensively in Russia, China, Korea and Japan as an adaptogen. Its benefits
include improvement of non-specific body resistance to stress and fatigue. Researchers compared the effects of the
water extracts (A, B, C, D and E) of five Siberian Ginseng on the swimming time, NK activity and blood corticosterone
level using forced swimming stressed mice. Among five kinds, C, D and E extracts significantly prolonged the swimming
time. C and D extracts inhibited the reduction of NK activity and the corticosterone elevation induced by forced
swimming. The contents of eleutheroside E, isoflaxidin and eleutherosides B plus E were in the order C > D > E > B >
A and C > E > D > A > B extracts, respectively. Therefore, it is suggested that eleutheroside E may be contributed to
the anti-fatigue action, the recovery of the reduction of NK activity and the inhibition of corticosterone elevation
induced by swimming stress. 
However, another study conducted by researchers from University of Iowa was not able to demonstrate the overall anti-
fatigue effects of Eleuthero on subjects compared to the control group. 
The inconsistent results of various studies indicate the impacts of experimental design, dosage forms and the nature
of exercise and stress.
ELEUTHERO BENEFITS - ON HEPATIC FAILURE
Preparations of Eleuthero used in a study were as follows; (i) 70% ethanol extract (ii) water extract (iii) ethanol-soluble
part of the water extract (iv) polysaccharide obtained as an 80% ethanol insoluble of the water extract. Preparations
were given by intraperitoneal (300 mg/kg and 50 mg/kg) or oral (300 mg/kg) injection at 12 hr and 1 hr before a D-
galactosamine/lipopolysaccharide injection. The intraperitoneal injection of water extract and polysaccharide
significantly lowered serum levels of tumour necrosis factor-alpha, aspartate transaminase and alanine transaminase,
improved the histologic changes in liver, inhibited hepatocyte apoptosis confirmed by the terminal deoxynucleotidyl
transferase-mediated dUTP nick end-labeling method and DNA fragmentation assay, and suppressed the lethality
induced by D-galactosamine/lipopolysaccharide. The oral administration of water extract and polysaccharide also
reduced serum aspartate transaminase, alanine transaminase and tumour necrosis factor-alpha levels. In contrast
70% ethanol extract and ethanol-soluble part of the water extract had no protective effect when treated
intraperitoneally or orally. These results indicate Siberian Ginseng stems attenuate fulminant hepatic failure induced
by D-galactosamine/lipopolysaccharide in mice and the protective effect is due to water-soluble polysaccharides in
Siberian Ginseng stems. 
ELEUTHERO BENEFITS - ANTI-COAGULATION
Russian scientist administrated Eleuthero to albino rats (18-20-month age) daily for 30 days They found that the
animal had a better anti-coagulating system or a better protection from thrombogeneration induced with i.v.
administration of tissue thromboplastine. The effect of the adaptogen was more obvious after 60-day treatment. 
ELEUTHERO BENEFITS - ON CONITIVE FUNCTIONS
Acute administration of a liquid Eleuthero extract significantly improves short-term memory in healthy humans. The
expression of this action depends on the daytime and psychophysiological peculiarities of the volunteers.
Administration of the preparation also improved retinal sensitivity. This effect was more pronounced in humans with
weak type of high nervous activity in evening hours. 
ELEUTHERO BENEFITS - ON IMMUNOFUNCTIONS
Scientist also studied the influence of Siberian Ginseng on cellular and humoral immune response in animal models
(Balb/c mice and F1 crossbreeds Balb/cxC3H). The study has shown that Siberian Ginseng has immunomodulatory
properties. It enhanced the cellular response of the mouse immunological system (chemokinetic activity of mice spleen
cells, GvH reaction). They also observed a stimulatory effect of Siberian Ginseng on the humoral response (antibody
In another study, researchers administrated Eleuthero preparations to mice before illness, during illness and a
combination of both. They found an increase of the level of immunoglobulins comprised in the mice's blood serum 
Siberian Ginseng Side Effects
Researchers tested the effect of Eleuthero on 20 seniors with respect to health related quality of life (HRQOL). After 4
week study, they found that patients randomized to Eleuthero had a higher scores in social functioning scales
compared to those received placebo. And, they found no side effects on both groups.  Eleuthero may be safe for
most people at low doses for a short term use. However, side effects may include drowsiness, changes in heart
rhythm, sadness, anxiety, muscle spasms and other side effects. High doses may raise blood pressure. People with
blood pressure over 180/90 should not take Siberian Ginseng.
REFERENCE  Deyama T et al, Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta
Pharmacol Sin. 2001 Dec;22(12):1057-70.  Bu Y et al, Siberian ginseng reduces infarct volume in transient focal
cerebral ischaemia in Sprague-Dawley rats. Phytother Res. 2005 Feb;19(2):167-9. Kimura Y and Sumiyoshi M Effects
of various Eleutherococcus senticosus cortex on swimming time, natural killer activity and corticosterone level in
forced swimming stressed mice. J Ethnopharmacol. 2004 Dec;95(2-3):447-53.  Park EJ et al, Water-soluble
polysaccharide from Eleutherococcus senticosus stems attenuates fulminant hepatic failure induced by D-
galactosamine and lipopolysaccharide in mice. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):298-304.  Cicero AF et
al, Effects of Siberian ginseng (Eleutherococcus senticosus maxim.) on elderly quality of life: a randomized clinical trial. Arch Gerontol
Geriatr Suppl. 2004;(9):69-73.  Bazaz'ian GG et al Effect of Eleutherococcus on the functional status of the anticoagulation system in older animals
Fiziol Zh SSSR Im I M Sechenova. 1987 Oct;73(10):1390-5.  Hartz AJ et al, Randomized controlled trial of Siberian ginseng for chronic fatigue. Psychol
Med. 2004 Jan;34(1):51-61.  Arushanian EB et al, Effect of eleutherococcus on short-term memory and visual perception in healthy humans Eksp Klin
Farmakol. 2003 Sep-Oct;66(5):10-3. Rogala E et al, The influence of Eleuterococcus senticosus on cellular and humoral immunological response of mice.
Pol J Vet Sci. 2003;6(3 Suppl):37-9.  Yu CY et al, Intraspecific relationship analysis by DNA markers and in vitro cytotoxic and antioxidant activity in
Eleutherococcus senticosus. Toxicol In Vitro. 2003 Apr;17(2):229-36.  Drozd J et al, Estimation of humoral activity of Eleutherococcus senticosus.
Acta Pol Pharm. 2002 Sep-Oct;59(5):395-401.
Eleuthero (Eleutherococcus senticosus; formerly labeled as Siberian Ginseng and Acanthopanax senticosus (Wiki) is
a hardy herb indigenous to the Taiga region of the Far East, which includes southeastern Russia, northern China,
Japan and Korea.
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