Cinnamon, an ancient spice, usually is regarded as the bark of the Cinnamomum zeylanicum tree; it is
also called as darchin in India and Iran, canela in Protugal and Spain, cannelle in France and Zimt in
Germany. In the Middle Ages or earlier, cinnamon has already been used as favorite flavor in food,
wines, drinks, perfumes and fragrances. Cinnamon has been believed to benefit diarrhea and other
gastrointestinal problems for years.

Cinnamon health benefits

Benefits of cinnamon: anti-oxidant activities.
Researchers from Brasil demonstrated antioxidant activities of various cinnamon extracts using
b-carotene/linoleic acid system, at 50 degrees C and absorbance reading at 470 nm every 15 min
intervals for 120 min. [11]

cinnamon diabetes
In the early studies, cinnamon has been shown to potentiate the insulin effect through upregulation of the
glucose uptake in cultured adipocytes. [7]

Researchers at Nagoya University, Japan, fed healthy male Wistar rats with a high-fructose diet (HFD) for
three weeks with or with cinnamon extract. They then measured the in vivo glucose utilization by
euglycemic clamp technique. They found that early cinnamon extract administration to HFD-fed rats
would prevent the development of insulin resistance at least in part by enhancing insulin signaling and
possibly via the NO pathway in skeletal muscle. [5]

Researchers in Pakistan divided 60 Type 2 diabetes patients into six groups. Groups 1, 2, and 3
consumed 1, 3, or 6 g of cinnamon daily, and groups 4, 5, and 6 had placebo capsules. The patients
consumed cinnamon for 40 days. They found that all three levels of cinnamon reduced the mean fasting
serum glucose (18-29%) while no significant changes in the placebo groups. [6]

German researchers treated 79 patients diagnosed diabetes mellitus type 2 with either a cinnamon
extract (3 g of cinnamon powder per day) or a placebo capsule three times a day for 4 months in a
double-blind study. They found a moderate beneficial effect of cinnamon extract in reducing fasting
plasma glucose concentrations in diabetic patients with poor glycaemic control. [1]

However, researchers from Netherlands did not found any improvement in glycemic control in patients
with type 2 diabetes by cinnamon supplementation. In their study, they used a less common species of
cinnamon- Cinnamomum cassia, the duration of study was only six weeks and the dose was also low
-(1.5 g/d). [3]

cinnamon cholesterol
Researchers in Pakistan noticed that patients with diabetes type 2 consumed cinnamon for 40 days.
They had reduced mean fasting serum glucose (18-29%), triglyceride (23-30%), LDL cholesterol
(7-27%), and total cholesterol (12-26%) levels. [6]

cinnamon health benefits - blood pressure lowering effects.
In a study of spontaneously hypertensive rats, researchers treated the rats with sucrose and
non-sucrose containing diets together with various amounts of cinnamon, cinnamon extracts, or
chromium. Diets high in sucrose content were associated with insulin resistance and the elevation of
systolic blood pressure. Researchers found that addition to diets of cinnamon (8% w/w) reduced the
systolic blood pressure of rats eating sucrose containing diets to virtually the same levels as
spontaneously hypertensive rats consuming non sucrose containing diets. The addition of cinnamon into
the diet also lowered the systolic blood pressure of spontaneously hypertensive rats consuming a non
sucrose-containing diet. Aqueous extracts of cinnamon also decreased systolic blood pressure and
lowered the circulating levels of fructosamine. [2]

cinnamon health benefits - cutting cancer risks
Schoene NW and coworkers from USDA demonstrated the potential of cinnamon extracts (polymeric
polyphenols) to interact with phosphorylation / dephosphorylation signaling activities to reduce cellular
proliferation (three myeloid cell lines) in tandem with a block at the G2/M phase of the cell cycle. [4]

Cinnamon preparation shows anti-microbial and anti-infection activities.
Cinnamon oil has been shown to have anti-microbial activities against some bacteria and yeasts. [13]

Five patients with HIV infection and oral candidiasis received a commercially available cinnamon
preparation for one week. There of the five patients had improvement of their oral candidiasis. [14]
Does cinnamon have benefits on gastric conditions or related diseases?
Cinnamon extract (from methylene chloride) inhibited H. pylori at concentration range of common
antibiotics. Complete inhibition in vitro was achieved by 50 microg/ml in egg yolk emulsion agar and by 15
microg/ml supplemented brain heart infusion broth. [10]
However, researchers from Bnai Zion Medical Center, Israel, concluded that cinnamon extract, at a
concentration of 80 mg /day as a single agent, is ineffective in eradicating H. pylori from their study of 15
patients. Helicobacter pylori has been associated with the pathogenesis of antral gastritis, duodenal
ulcer, and gastric lymphoma. [9]

SIDE EFFECTS OF CINNAMON AND ITS EXTRACTS
In a study of the effects of cinnamon extract on Helicobacter pylori, the cinnamon extract was well
tolerated, and side effects were minimal. [9]

Oral erythema multiforme induced by cinnamon has been reported. The disease manifested itself as
chronic extensive surface ulcerations and lip swelling. The patient was treated repeatedly with topical and
systemic steroids but responded to them only temporarily. The patient was cured when the offending
agent--cinnamon--was eliminated from her diet. [8] Fourteen cases of cinnamon-induced stomatitis were
also reported. [15]

A case of a 24-year-old woman who developed a squamous cell carcinoma of her tongue following
persistent and prolonged exposure to cinnamon-flavored gum was reported. [12]

Reference

REFERENCES [1] Mang B, et al, Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes
mellitus type 2. Eur J Clin Invest. 2006 May;36(5):340-4. [2] Preuss HG, et al, Whole cinnamon and aqueous
extracts h sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr. 2006
Apr;25(2):144-50. [3] Vanschoonbeek K, et al, Cinnamon supplementation does not improve glycemic control in
postmenopausal type 2 diabetes patients. J Nutr. 2006 Apr;136(4):977-80. [4] Schoene NW, et al, Water-soluble
polymeric polyphenols from cinnamon inhibit proliferation and alter cell cycle distribution patterns of hematologic
tumor cell lines. Cancer Lett. 2005 Dec 8;230(1):134-40. [5] Qin B, et al, Cinnamon extract prevents the insulin
resistance induced by a high-fructose diet. Horm Metab Res. 2004 Feb;36(2):119-25. [6] Khan A, et al, Cinnamon
improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003 Dec;26(12):3215-8. [7] Qin B, et al,
Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin
signaling in rats. Diabetes Res Clin Pract. 2003 Dec;62(3):139-48. [8] Cohen DM, Bhattacharyya I.
Cinnamon-induced oral erythema multiformelike sensitivity reaction. J Am Dent Assoc. 2000 Jul;131(7):929-34. [9]
Nir Y, et al, Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter. 2000 Jun;5(2):94-7.
[10] Tabak M, et al, Cinnamon extracts' inhibitory effect on Helicobacter pylori. J Ethnopharmacol. 1999 Nov
30;67(3):269-77. [11] Mancini-Filho J, et al, Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne)
extracts. Boll Chim Farm. 1998 Dec;137(11):443-7. [12] Westra WH, et al, Squamous cell carcinoma of the tongue
associated with cinnamon gum use: a case report. Head Neck. 1998 Aug;20(5):430-3. [13] Hili P, et al, Antimicrobial
action of essential oils: the effect of dimethylsulphoxide on the activity of cinnamon oil. Lett Appl Microbiol. 1997
Apr;24(4):269-75. [14] Quale JM, et al, In vitro activity of Cinnamomum zeylanicum against azole resistant and
sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med. 1996;24(2):103-9. [15]
Miller RL, et al, Cinnamon-induced stomatitis venenata, Clinical and characteristic histopathologic features. Oral Surg
Oral Med Oral Pathol. 1992 Jun;73(6):708-16.
Cinnamon health benefits
THIS WEBSITE TALKS ABOUT THE SIDE EFFECTS AND THE POTENTIAL HEALTH BENEFITS OF HERBS, SUPPLEMENTS,
PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND
DISEASES. ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD
CONSULT WITH YOUR DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2011. DO NOT COPY NOR TRANSFER ARTICLES
TO OTHER WEBSITES NOR OTHER FORMS OF PUBLICATIONS.
Privacy Policy. ARTICLE INDEX