Andrographis uses, warnings, benefits and side effects - Reviews
December 29, 2011 ZHION.COM
Liver
Andrographis may have benefits of liver Protection [8, 31-33] Extracts of Andrographis paniculata have showed
protection on liver from various chemicals such as carbon tetrachloride. [31-33]

Fertility
Andrographis may have effects on fertility, animal studies suggested. Researchers mixed Andrographis Paniculata
powder with animal's food (Rats Pelletts) and fed female mice daily with this preparation for six weeks. None of the
animal were pregnant when mated with the male of proven fertility who did not receive the drug. While, most of the
control were pregnant. [34]

Researchers fed male albino rats with dry leaf of Andrographis Paniculata at a dose level of 20 mg powder per day for
60 days, resulted in cessation of spermatogenesis, degenerative changes in the seminiferous tubules, regression of
Leydig cells and regressive and/or degenerative changes in the epididymis, seminal vesicle, ventral prostate and
coagulating gland. The treatment also resulted in accumulation of glycogen and cholesterol in the testis. [35]

Wound
Andrographis paniculata extracts may have benefits on wound healing. Histologically, wounds dressed with Andrographis
extracts showed markedly less scar width and contained large amounts of fibroblast proliferation in a rat study. More
collagen and less angiogenesis with absence of inflammatory cells were seen for wounds dressed with 10%
Andrographis paniculata compared to the blank placebo. [Al-Bayaty FH et al, Nat Prod Res. 2011 Jan 1:1-7.]
____________________________________________________________________________________________

Adrographis Warnings, Safety Issues, Side Effects
Adverse side-effect-events reported following administration of Andrographis paniculata were generally mild and
infrequent. [1-4] In general, Adrographis side effects may include gastric upset, headache, bitter taste and fatique. Since
it has effects on the liver, high doses of Andrographis paniculata extracts may affect liver functions. To avoid the
potential side effects, users are suggested to have liver function tests periodically for long term uses, and users should
consult with their medical doctors before taking any supplements for medical uses.

Data is insufficient to determine what level is high dose. But it is known that the
dosage of Adrographis depends on the
uses; it may vary from 1.5 mg/Kg to a few hundred mg/Kg (dose/body weight). Users should discuss with their doctors for
the dosages before taking Adrographis extracts or supplements.
__________________________________________________________________________________________________________________________

REFERENCE [1] Coon JT, et al, Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety
and efficacy.Planta Med. 2004 Apr;70(4):293-8. [2] Spasov AA, et al, Comparative controlled study of Andrographis paniculata fixed
combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in
children.Phytother Res. 2004 Jan;18(1):47-53.[3] Amaryan G, Double-blind, placebo-controlled, randomized, pilot clinical trial of
ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra
chinensis Bail. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever.Phytomedicine. 2003 May;10(4):271-85. [4]
Gabrielian ES, et al, A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of
acute upper respiratory tract infections including sinusitis.Phytomedicine. 2002 Oct;9(7):589-97. [5] Thamlikitkul V, et al, Efficacy of
Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai. 1991 Oct;74(10):437-42. [6] Sheeja K, et al, Antioxidant
and anti-inflammatory activities of the plant Andrographis paniculata Nees.Immunopharmacol Immunotoxicol. 2006;28(1):129-40. [7]
Batkhuu J, et al, Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from
Andrographis paniculata.Biol Pharm Bull. 2002 Sep;25(9):1169-74. [8] Trivedi NP, et al, Hepatoprotective and antioxidant property of
Andrographis paniculata (Nees) in BHC induced liver damage in mice.Indian J Exp Biol. 2001 Jan;39(1):41-6. [9] Wang HW, et al, Effects of
Andrographis paniculata component on nitric oxide, endothelin and lipid peroxidation in experimental atherosclerotic rabbits. Zhongguo
Zhong Xi Yi Jie He Za Zhi. 1997 Sep;17(9):547-9. [10] Zhang XF, et al, Antihyperglycaemic and anti-oxidant properties of Andrographis
paniculata in normal and diabetic rats.Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):358-63. [11] Reyes BA, Anti-diabetic potentials of
Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats.J Ethnopharmacol.
2006 Apr 21;105(1-2):196-200. Epub 2005 Nov 18. [12] Zhang XF, Tan BK.Anti-diabetic property of ethanolic extract of Andrographis
paniculata in streptozotocin-diabetic rats. Acta Pharmacol Sin. 2000 Dec;21(12):1157-64. [13] Borhanuddin M, et al, Hypoglycaemic effects
of Andrographis paniculata Nees on non-diabetic rabbits.Bangladesh Med Res Counc Bull. 1994 Apr;20(1):24-6. [14] Zhang XF, Tan
BK.Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmacol Sin. 2000
Dec;21(12):1157-64. [15] Borhanuddin M, et al, Hypoglycaemic effects of Andrographis paniculata Nees on non-diabetic
rabbits.Bangladesh Med Res Counc Bull. 1994 Apr;20(1):24-6. [14] Cheung HY, et al, Andrographolide isolated from Andrographis
paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells.Planta Med. 2005
Dec;71(12):1106-11.[15] Kumar RA, et al, Anticancer and immunostimulatory compounds from Andrographis paniculata.J Ethnopharmacol.
2004 Jun;92(2-3):291-5.[16] Singh RP, et al,Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic
carcinogen metabolizing enzymes and antioxidant status. Phytother Res. 2001 Aug;15(5):382-90. [17] Mandal SC, et al, Studies on
psychopharmacological activity of Andrographis paniculata extract.Phytother Res. 2001 May;15(3):253-6. [18] Singha PK, et al, Antimicrobial
activity of Andrographis paniculata.Fitoterapia. 2003 Dec;74(7-8):692-4.[19] Wiart C, et al, Antiviral properties of ent-labdene diterpenes of
Andrographis paniculata nees, inhibitors of herpes simplex virus type 1.Phytother Res. 2005 Dec;19(12):1069-70. [20] Thamlikitkul V, et al,
Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults. J Med Assoc Thai. 1991 Oct;74(10):437-42. [21]Coon JT, et al,
Andrographis paniculata in the treatment of upper respiratory tract infections: a systematic review of safety and efficacy.Planta Med. 2004
Apr;70(4):293-8. [22] Poolsup N, et al, Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract
infection: systematic review of randomized controlled trials.J Clin Pharm Ther. 2004 Feb;29(1):37-45. [23] Gabrielian ES, et al, A double
blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the treatment of acute upper respiratory tract
infections including sinusitis.Phytomedicine. 2002 Oct;9(7):589-97. [24]Melchior J, Double-blind, placebo-controlled pilot and phase III
study of activity of standardized Andrographis paniculata Herba Nees extract fixed combination (Kan jang) in the treatment of uncomplicated
upper-respiratory tract infection.Phytomedicine. 2000 Oct;7(5):341-50. [25] Caceres DD, et al, Use of visual analogue scale measurements
(VAS) to asses the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A
randomized double blind-placebo study.Phytomedicine. 1999 Oct;6(4):217-23.[26] Kumar RA, et al, Anticancer and immunostimulatory
compounds from Andrographis paniculata.J Ethnopharmacol. 2004 Jun;92(2-3):291-5.[27] Puri A, et al,Immunostimulant agents from
Andrographis paniculata. J Nat Prod. 1993 Jul;56(7):995-9. [28] Zhang CY, Tan BK.Hypotensive activity of aqueous extract of Andrographis
paniculata in rats.Clin Exp Pharmacol Physiol. 1996 Aug;23(8):675-8. [29] Zhao HY, et al, Antithrombotic effects of Andrographis paniculata
nees in preventing myocardial infarction.Chin Med J (Engl). 1991 Sep;104(9):770-5. [30] Zhang YZ, et al, Study of Andrographis paniculata
extracts on antiplatelet aggregation and release reaction and its mechanism, Zhongguo Zhong Xi Yi Jie He Za Zhi. 1994 Jan;14(1):28-30,
34, 5. [31] Handa SS, et al,Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian J
Med Res. 1990 Aug;92:276-83. [32] Rana AC, et al, Hepatoprotective effects of Andrographis paniculata against carbon
tetrachloride-induced liver damage.Arch Pharm Res. 1991 Mar;14(1):93-5. [33] Kapil A, et al, Antihepatotoxic effects of major diterpenoid
constituents of Andrographis paniculata.Biochem Pharmacol. 1993 Jul 6;46(1):182-5. [34] Zoha MS, et al, Antifertility effect of andrographis
paniculata in mice.Bangladesh Med Res Counc Bull. 1989 Jun;15(1):34-7. [35]Akbarsha MA, et al, Antifertility effect of Andrographis
paniculata (Nees) in male albino rat.Indian J Exp Biol. 1990 May;28(5):421-6.
Different people may experience different side effects and benefits of a product. You are encouraged to report adverse side effects of Andrographis
supplement to FDA, its website is
www.fda.gov., or report its side effects to the manufacturer, you should be able to find the contact information on
the label.

There are always new information. Please, send me an email (
zhion@zhion.com) to correct my mistake(s). Reasonable care has been taken in
preparing this document and the information provided herein is believed to be accurate. The information is not intended to be a substitute for
professional medical advice. It is important to seek the advice of a physician about any medical condition or symptom or the benefits and side
effects of Andrographis. Finally, please, do not transfer the article to other website. Thank you. ALL RIGHTS RESERVED.
Andrographis Review
Andrographis [Chiretta, Chuan xin lian, Kalmegh, Kirata] grows in China and India. Its leaves and flowers have been used in herbal medicine for
years. It has been believed that Andrographis may offer health benefits in common cold, immune function, cancer and infections. Andrographolide,
the major constituent of the extract is implicated towards its health claims or benefits.

Andrographis paniculata is an erect annual herb, it is extremely bitter in taste in all parts of the plant body. The plant is known in India as Maha-tita,
i.e. "king of bitters". In Ayurveda, Andrographis paniculata is known as Kalmegh or Kalamegha, meaning "dark cloud". The genus Andrographis
consists of 28 species of small annual shrubs, Only a few species are medicinal, of which Andrographis paniculata is the most popular.
[Wikipedia.com]
___________________________________________________________________________________________________________________
Potential Health Benefits, Uses of Andrographis Paniculata

Inflammation
Andrographis paniculata extracts have antioxidant and anti-inflammatory effects. [6-10] Methanolic extract of
Andrographis paniculata was found to inhibit formation of oxygen derived free radicals such as superoxide, hydroxyl
radicals, lipid peroxidation and nitric oxide in in vitro system. In vivo studies of BALB/c mice, administration of
Andrographis paniculata extract produced complete inhibition of carageenan induced inflammation compared with
controls. Researchers are hoping these activities lead to multiple benefits of Andrographis in health. [6]

Japanese researchers isolated iterpene lactones andrographolide and neoandrographolide from Andrographis
paniculata. They found these compounds suppressed NO production in a concentration-dependent manner in the
concentration range from 0.1 to 100 microM and their IC50 values were 7.9 and 35.5 microM. Neoandrographolide also
suppressed NO production by 35 and 40% when the macrophages were collected after oral administration of
neoandrographolide at doses of 5 and 25 mg/kg/d and LPS stimulated NO production was examined. However,
andrographolide did not reduce NO production on oral administration at the same doses. [7]

Diabetes
Andrographis paniculata may benefit diabetes, animal studies suggest. [10-13] Andrographis paniculata is a popular
herb used by the diabetic patients in Pampanga, Philippines. Researchers from Thomas Jefferson University orally
aministered Andrographis paniculata decoction to alloxan-induced diabetic rats. They found that rats that were treated
with Andrographis paniculata had higher body weight compared with diabetic positive control but exhibited lower body
weight than the non-diabetic control. The blood glucose levels in the Andrographis paniculata treated group was
significantly reduced from day 12 to day 27 compared with diabetic positive control, however, comparable with
non-diabetic control.    

Cancers
Andrographis paniculata extracts show potential benefits in cancers, animal and test-tube studies suggest. [14-16]
Ethanol extract of Andrographis paniculata and andrographolide were found to have significantly growth inhibitory
activities on human acute myeloid leukemic HL-60 cells after 24 h of treatment. Researchers concluded that the extract
and andrographolide induce cell cycle arrest and affect an intrinsic mitochondria-dependent pathway of apoptosis by
regulating the expression of some pro-apoptotic markers in HL-60 cells. [14]

Indian researchers noticed the anti-cancer activities of andrographolide on different types of human cancer cells. [15]

Insommia
Andrographis paniculata may benefit insomnia.The extract exhibited a significant alteration in behaviour pattern and a
reduction in spontaneous motility. The extract also produced a prolongation of the pentobarbitone-induced sleeping time
and lowered the body temperature in different experimental animal models. [17]
Viral Infections
Andrographis paniculata extracts may benefit people suffered from viral infections. [18-25] Aqueous extracts of  Andrographis paniculata showed
significant antimicrobial activity. [18]Andrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide, ent-labdene diterpenes
isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV-1). [19]

In a study of 152 patients with pharyngotonsillitis, researchers found that the effects of high doses of Andrographis paniculata were comparable to
paracetamol on fever and sore throat. [20]

Researchers from the Universities of Exeter and Plymouth, Exeter, UK reviewed five studies and concluded that that Andrographis paniculata is
superior to placebo in alleviating the subjective symptoms of uncomplicated upper respiratory tract infection. There is also preliminary evidence of a
preventative effect. [21]

Immunity
Andrographis paniculata may enhance immunity. Indian researchers noticed three diterpene compounds from Andrographis paniculata had
enhanced proliferation and interleukin-2 (IL-2) induction in human peripheral blood lymphocytes in their study. And, these compounds are
andrographolide, 14-deoxyandrographolide and 14-deoxy-11,12-didehydroandrographolide. [26]

EtOH extract and purified diterpene andrographolides of Andrographis paniculata (Acanthaceae) induced significant stimulation of antibody and
delayed type hypersensitivity (DTH) response to sheep red blood cells (SRBC) in mice. [27]

Cardiovascular system
Andrographis paniculata may have benefits on people at risk of certain cardiovascular issues. Reseachers observed the blood pressure lowering
effects of an aqueous extract of Andrographis paniculata in spontaneously hypertensive rats. They explained that the hypotensive effect of this
extract was probably related to a reduced plasma angiotensin-converting enzyme levels and a reduced level of free radical in the kidneys of the
animals. [28]

A study of 16 dogs shows that Andrographis paniculata impeded aggregation of platelets. Thus, researchers believe that it may help prevent the
formation of thrombi as well as the development of myocardial infarction. [29]

In a study of 63 patients suffered from cardiac and cerebral vascular diseases, researchers supplied the patients with Andrographis paniculata
extracts for one weeks. Researchers noticed that Andrographis paniculata extracts inhibited the releasing of dense and alpha agranules from
platelet. They thought the raise of platelet cAMP level might be the mechanism of antiplatelet effect of Andrographis paniculata. [30]