Linseed Oil Benefit
research finds            May 9, 2008
Linseed oil may prevent heart disease, reduce cholesterol levels,
high blood pressure and slow down atherosclerosis; research finds.
Linseed oil may also be benefitial to bipolar disorder, cancer
prevention or even rheumatoid arthritis. Moreover, more scientific
evidence is needed to support this argument.

Linseed oil is derived from the hard, tiny seeds of the flax plant. Like
fish oil, linseed oil contains an omega-3 fatty acid = alpha-linolenic
acid (ALA). In addition to alpha-linolenic acid, linseed oil also
contains omega-6 fatty acids. Both acids are essential to health. A
typical dosage of flaxseed oil is 1-2 tablespoons.

RESEARCH FINDINGS FOR LINSEED OIL BENEFITS

BRAIN
Phospholipase A2 hydrolyzes fatty acids from membrane
phospholipids: liberated omega-6 PUFAs are metabolized to
prostaglandins with a higher inflammatory potential. Intervention
trials in human subjects show that omega-3 fatty acids have
possible positive effects in the treatment of various psychiatric
disorders.
Haag M. Essential fatty acids and the brain. Can J Psychiatry. 2003
Apr;48(3):195-203

CHOLESTEROL
Alpha-Linolenic acid (linseed oil) significantly decreased hepatic
cholesterol but no effect was observed on heart and kidney
cholesterol levels.
Yang L et al alpha-Linolenic acid but not conjugated linolenic
acid is hypocholesterolaemic in hamsters. : Br J Nutr. 2005 Apr;93 (4):433-8.

CARDIOVASCULAR DISEASE
Alpha-linolenic acid (linseed oil) may reduce cardiovascular risk
through platelet function and inflammation.
Mozaffarian D. Does
alpha-linolenic acid intake reduce the risk of coronary heart disease? A review of the
evidence. Altern Ther Health Med. 2005 May-Jun;11 (3):24-30; quiz 31, 79.

Spray-dried milk formulations supplemented with linseed oil are
probably effective to decrease the risk factors associated with
cardiovascular disease.
Ramaprasad TR et al, Supplementation and delivery of
n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats. Lipids. 2004
Jul;39(7):627-32.

Studies in rats suggest that alpha-linolenic acid (linseed oil) may be
more effective in preventing ventricular fibrillations than
eicosapentaenoic and docosahexaenoic acid.
Ristic-Medic D et al,
Alpha-linolenic acid* and cardiovascular diseases. Med Pregl. 2003;56 Suppl 1:19-25.
*flaxseed oil

Dietary linseed oil exerted antiarrhythmic effects during
ischemia-reperfusion in rabbit hearts, possibly through shortening
of the action potential.
Ander BP et al, Dietary flaxseed protects against ventricular
fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits. J
Nutr. 2004 Dec;134(12):3250-6.

In healthy horses supplemented with linseed oil, platelet
aggregation was not altered.
Hansen RA et al, Effects of dietary flaxseed oil
supplementation on equine plasma fatty acid concentrations and whole blood platelet
aggregation. J Vet Intern Med. 2002 Jul-Aug;16(4):457-63.

BONE HEALTH
Dietary level of alpha-linolenic acid (10% linseed oil) results in
modest improvements in some bone outcomes in a study of mice.
Cohen SL et al, Flaxseed oil and inflammation-associated bone abnormalities in
interleukin-10 knockout mice. J Nutr Biochem. 2005 Jun;16 (6):368-74.

RENAL DISEASE
Linseed oil slowed down early fibrosis progression in renal injury of
mice.
Sankaran D. Modulation of renal injury in pcy mice by dietary fat containing n-3
fatty acids depends on the level and type of fat. Lipids. 2004 Mar;39(3):207-14.


CANCER

BREAST CANCER
MICE Mice were injected with human breast cancer cells and fed
basal diet. Excisions of tumor were performed, when the tumors
reached 110 mm.  Linseed oil supplementation was found to
achieve a greater reduction in lung and total metastases.
Chen J et al
Flaxseed and its components reduce metastasis after surgical excision of solid human
breast tumor in mice. Cancer Lett. 2005 May 2

In a study of mouse, linseed oil combined with melatonin caused a
significant decrease in the number and size of tumors. High doses
of linseed oil could also delay in the growth of mammary cancers.
Rao GN, Effect of melatonin and linolenic acid on mammary cancer in transgenic mice
with c-neu breast cancer oncogene. Breast Cancer Res Treat. 2000 Dec;64(3):287-96.

Supplementation with linseed oil for 13 weeks after carcinogen
administration was found to reduce established mammary cancer
size in rats.
Thompson LU et al, The effect of flaxseed oil may be related to its high
alpha-linolenic acid. Carcinogenesis. 1996 Jun;17(6):1373-6.

HUMAN In a study of 16 premenopausal women, linseed
supplementation was observed to significantly increase the urinary
2:16alpha-OHE1 ratio which indicated flaxseed may be
chemoprotective in premenopausal women.
Haggans CJ The effect of
flaxseed and wheat bran consumption on urinary estrogen metabolites in premenopausal
women. Cancer Epidemiol Biomarkers Prev. 2000 Jul;9(7):719-25.

COLON CANCER
Linseed oil is effective in preventing colon tumor development when
compared with dietary corn oil in rats.
Dwivedi C et al, Chemopreventive
effects of dietary flaxseed oil on colon tumor development. Nutr Cancer. 2005;51(1):52-8.

DIABETES
Linseed oil did not increase the effect of dietary therapy in
correction of glycemia, hypertension and atherogenic lipid levels.

Alekseeva RI et al, Effects of a diet including linseed oil on clinical and metabolic
parameters in patients with type 2 diabetes mellitus. Vopr Pitan. 2000;69(6):32-5.

LIVER CANCER
The PGE2 concentrations were decreased in livers and tumours of
rats fed linseed oil.
Jelinska M., Effects of dietary linseed, evening primrose or fish
oils on fatty acid and prostaglandin E2 contents in the rat livers and
7,12-dimethylbenz[a]anthracene-induced tumours. Biochim Biophys Acta. 2003 Apr
17;1637(3):193-9.

Spontaneous tumorigenesis in the liver of male C3H/He mice bred
for 50 wk was suppressed by being supplied with linseed oil.
Thuy NT
et al, Comparative effect of dietary olive, safflower, and linseed oils* on spontaneous liver
tumorigenesis in C3H/He mice. J Nutr Sci Vitaminol (Tokyo). 2001 Oct;47(5):363-6.

RENAL INJURY
In a study of rats, flaxseed oil feeding produced hepatic and renal
enrichments of n-3 PUFA and an increase in C18:>C18 PUFA
ratios. The linseed oil-based diet was associated with lower mean
cystic. Thus, linseed oil feeding moderates renal injury and the
consumption of linseed oil-based products may provide health
benefit.
Ogborn MR et al, Dietary flax oil reduces renal injury, oxidized LDL content, and
tissue n-6/n-3 FA ratio in experimental polycystic kidney disease. Lipids. 2002
Nov;37(11):1059-65.

UVB-INDUCED SKIN INJURY
Anti-inflammatory activity of dietary linseed oil was demonstrated in
UVB-irradiated hairless mice. UVB-induced prostaglandin E2
(PGE2) production was significantly lower in rats fed an ALA-rich
(linseed oil) diet after UVB irradiation.
Takemura N et al, Dietary, but not
topical, alpha-linolenic acid suppresses UVB-induced skin injury in hairless mice when
compared with linoleic acids. Photochem Photobiol. 2002 Dec;76(6):657-63.

LINSEED OIL SIDE EFEECT

Up to the date this article is prepared, serious linseed oil side
effects have not been reported. Linseed oil appears to be a safe
nutritional supplement when used as recommended. However,
people who are at high risk of cancer should not take linseed oil,
unless they are under physician's advice.

Linseed oil is not safe when it is heated for a long time. The
heated linseed oil side effect include liver enlargement or even liver
damage. The fume from heated flaxseed oil may cause cancer.
While, high dose linseed oil side effects include non-formed feces,
depression, anorexia, mild colic, high serum glucose and bilirubin
levels. [based on animal studies]. Linseed oil side effects, based on
research findings are summarized as follows:

Cooking linseed oil fumes may increase lung cancer risk.
Metayer C. et
al Cooking oil fumes and risk of lung cancer in women in rural Gansu, China. Lung Cancer.
2002 Feb;35(2):111-7.

Horses given large doses of linseed oil had nonformed feces by 24
hours after the first administration of linseed oil in a study. During or
after two weeks flaxseed oil supplementation, some horses also
developed depression, anorexia, mild colic, high serum glucose and
bilirubin levels.
Schumacher J et al, Clinical and clinicopathologic effects of large
doses of raw linseed oil* as compared to mineral oil in healthy horses. J Vet Intern Med.
1997 Sep-Oct;11(5):296-9.*flaxseed oil

Linseed oil turned to be toxic when it was heated at high
temperatures. During gestation and lactation, female rats fed with
heated linseed oil. Newborn rats found dead and their livers were
heavier and higher in lipid content.
Potteau B. Influence of heated linseed oil*
on reproduction in the female rat and on the composition of hepatic lipids in young rats
Ann Nutr Aliment. 1976;30(1):67-88.*flaxseed oil.

THIS ARTICLE IS FOR YOUR REFERENCE ONLY IF YOU HAVE ANY QUESTION
YOU SHOULD CONSULT WITH YOUR DOCTOR IMMEDIATELY.
                                ALL RIGHT RESERVED 2008
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