Diabetes increases the risk of hepatocellular carcinoma

Diabetes increases the risk of
hepatocellular carcinoma
last updated April 19, 2007

Diabetes increases the risk of hepatocellular
carcinoma
Diabetes is associated with a two-to-three-fold
increase in the risk of liver cancer
(hepatocellular carcinoma; HCC), regardless
of the presence of other major risk factors
-Hashem El-Serag, Houston Veteran Affairs
Medical Center, Texas.

Dr. El-Serag and his group used the
Surveillance Epidemiology and End-Results
Program (SEER)-Medicare linked database to
identify patients aged 65 years and older
diagnosed with HCC and randomly selected
non-cancer controls between 1994 and 1999.
They searched inpatient and outpatient claims
files for diagnostic codes indicative of
diabetes, hepatitis C virus (HCV), hepatitis B
virus (HBV), alcoholic liver disease, and
haemochromatosis. In multiple logistic
regression analyses, they found that diabetes
was associated with a threefold increase in the
risk of HCC. In a subset of patients without
major risk factors, the adjusted odds ratio for
diabetes declined but remained significant
(diabetics have higher odds of getting the
disease). In addition, they detected a
significant positive interaction between HCV
and diabetes. [Gut. 2005 Apr;54(4):533-9].

Case reports have shown progression of
nonalcoholic fatty liver disease to cirrhosis and
hepatocellular carcinoma. And, both obesity
and diabetes are frequently associated with
nonalcoholic fatty liver disease [Caldwell SH et
al, Obesity and hepatocellular carcinoma,
Gastroenterology. 2004 Nov;127(5 Suppl
1):S97-103]

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