|Grape seed benefits, grape seed extract benefits
September 22, 2011
|Grape Seed Extract,
Muskat [Vitis vinifera L and V. coignetia. Family:Vitaceae]
Grape seed extract is rich in flavonoids, these phytochemicals have antioxidant properties. Antioxidants are believed
to be able to prevent and control numerous ailments by safeguarding cells against the ravages of unstable oxygen
molecules, i.e. the free radicals. The antioxidative activities of grape seed extracts are found to be much stronger
than vitamin C and vitamin E and may involve radical scavenging, quenching, and enzyme-inhibiting actions. 
The most valuable flavonoids in grape seed extract are procyanidolic oligomers (also known as proanthocyanidins).
Beyond their antioxidant powers, proanthocyanidins may also help atherosclerosis, gastric ulcer, large bowel cancer,
cataracts and diabetes.  Thus, grape seed extracts are believed to benefit people with heart disease and cancer.
Grape Seed Extract Benefits
Grape seed extracts benefits - bone formation
A high-calcium diet combined with grape seed proanthocyanidins extract supplement is more effective in reversing
mandibular condyle bone debility in rats. 
Grape seed extracts have anti-stress and anti-oxdation activities.
In a study of rats, grape seed extract showed antistress (adaptogenic), antioxidant and nootropic activities.  Activin,
a grape seed-derived proanthocyanidin extract, was shown to reduce the inflammatory response and the oxidative
stress developed in systemic sclerosis patients 
Grape seed extracts have anti-cancer activities and protect chromosome.
Researchers at University of Alabama at Birmingham found that grape seed extract was chemo-preventive from their
studies using animal model of breast cancer. However, diet had a strong impact to the grape seed extract's
chemopreventive activity. 
Japanese researchers found that grape seed extract could prevented H(2)O(2)-induced chromosomal damage in a
dose proportional fashion.  Llopiz N from Spain showed that procyanidins of grape seed extract were more
effective than the corresponding individual monomers, catechin and epicatechin, to prevent DNA lesions in
hepatocytes (liver cells). 
Researchers at University of Colorado Health Sciences Center (UC), Denver, found a strong synergistic effect of
grape seed extract and doxorubicin for breast cancer treatment, independent of estrogen receptor status of the
cancer cell. 
They also found the anti-angiogenic potential of grape seed extract possesses an anti-angiogenic potential was
associated with its antiproliferative, proapoptotic and inhibition of MMP-2 secretion in endothelial cells. 
Grape seed extract was shown to against prostate cancer.
Same group from UC also found that grape seed extract possessed in vivo anticancer efficacy against
hormone-refractory human prostate cancer, which was associated with grape seed extract 's antiproliferative,
proapoptotic and antiangiogenic activities together with up regulation of insulin-like growth factor binding protein. 
They also found that grape seed extract could induce apoptotic death of human prostate carcinoma DU145 cells via
mitochondrial damage and cytochrome c release in cytosol resulting in PARP cleavage. 
Grape seed extract was shown to against breast cancer.
Eng ET et al at Beckman Research Institute of the City of Hope, CA, found that procyanidin B dimers in red wine and
grape seed could be used as chemopreventive agents against breast cancer by suppressing in situ estrogen
Grape seed extract benefits - prevention of atherosclerosis.
Researchers from Japan found that proanthocyanidin (grape seed extract) was able to inhibit thrombus formation in
the carotid artery. The anti-thrombotic effect of proanthocyanidin may be due to a direct inhibitory effect on platelets.
 While, scientists at Universite Montpellier II, France, found commercial grape extracts prevented the development
of aortic atherosclerosis by 68% (EGS), 63% (EGT), and 34% (GSE). 
Grape seed extracts benefits - diabetes, obesity and high cholesterol profiles?
Grape seed extract- procyanidins was found to have antihyperglycemic effect in a study of diabetic rat. And, the way
that procyanidin (grape seed extract ) affects the activities of insulin-sensitive cell lines was very similar to insulin's. 
In a study, grape seed extract rich in bioactive phytochemicals showed inhibitory activity on the fat-metabolizing
enzymes pancreatic lipase and lipoprotein lipase, suggesting that grape seed extract might be useful as a treatment
to limit dietary fat absorption and the accumulation of fat in adipose tissue. 
But, the evidence is insufficient. Vigna GB et al, found that their polyphenolic extract of grapes had no obvious
modification of total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C) and LDL-C in
their study of heavy smokers. 
Grape seed extracts - wound healing and cataract formation
Khanna S and his group at The Ohio State University Medical Center, Columbus, demonstrated that grape seed
proanthycyanidin extract alone was able to drive vascular endothelial growth factor. Topical application of grape seed
proanthycyanidin extract accelerated wound contraction and closure. Grape seed proanthycyanidin extract treatment
was associated with a more well-defined hyperproliferative epithelial region, higher cell density, enhanced deposition
of connective tissue, and improved histological architecture. 
Japanese researchers found that grape seed extract procyanidins and their antioxidative metabolites (especially the
higher molecular weight procyanidins in the grape seed extract) prevented the progression of cataract formation by
their antioxidative action. 
GRAPE SEED EXTRACT SIDE EFFECTS
Grape seeds appear to be safe, as they are one of the popular supplements in the market. In a few studies, limited
grape seed extract side effects were demonstrated. [20-23] However, high-doses of grape seed extract may reduce
serum iron levels. 
Grape seed extract - bad cholesterol
Grape seed side effects
Grape Seed Oil Benefits and Side Effects
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