ROYAL JELLY: effects on hair growth and fertility
October 1, 2012
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Abstract

Royal jelly is the food for larvae which will develop into queen bees. Royal jelly is secreted from the worker bees'
salivary glands, which contains a mixture of sterols, glycosides, fatty acids, minerals, vitamins and a large
amount of proteins.  The key potential benefits of royal jelly are anti-inflammatory and anti-cancer activities have
been described in
Royal Jelly Side Effects and Benefits - Review. This article gives a general review on its
benefits and side effects but details in its potential benefits on hair and fertility.
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Royal Jelly Composition, Capsule, Health Benefits and Side Effects

Royal Jelly is very nutritious, it is the sole food for the queen bee, contains nucleic acids, ATP, ADP, AMP,
different kinds of minerals, B-vitamins, vitamins A, C, D, E and K. Most commercial Royal Jelly
supplement-products are sold as capsules. For most products, the unit dose is 500 mg of fresh royal jelly or 167
mg of freeze-dried royal jelly. Most products recommended 1-2 unit dose daily. Royal Jelly is also popularly
combined with ginseng.

Royal Jelly may have many health benefits. Royal Jelly shows that royal jelly prolonged the life span of mice.[1]
Royal jelly protein hydrolysate also shows blood pressure lowering effects in spontaneously hypertensive rats.
[2], while a human study shows Royal Jelly supplements lower cholesterol levels. [3] In a study, mice were forced
to swim for 15 min once; then the maximum swimming time to fatigue was measured. The swimming endurance
of the royal jelly group significantly increased compared with others. The royal jelly group showed significantly
decreased accumulation of serum lactate and serum ammonia and decreased depletion of muscle glycogen
after swimming. [4]

Royal Jelly sounds like a good supplements for anti-aging, or those who needs extra strength. However, allergic
reactions to royal jelly have been reported. Asthma, together with anaphylaxis, have been observed in subjects
following ingestion of royal jelly. [5] A 53-year-old woman developed abdominal pain and bloody diarrhoea after
taking of Royal Jelly. [6]

Further royal jelly has blood thinning properties and hence those on blood thinning agents should be cautious.
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Royal jelly fertility treatment

Does royal jelly benefit people on fertility?
Some people try to get pregnant, they may begin with "natural ways" to boost their fertility. Internet marketers
promote royal jelly supplement as an aid for couples to achieve pregnancy. An
internet writer suggests that
royal jelly increases libido, supports egg and sperm health. There are 303,000 results for a search of
keyword-combination of "
royal jelly fertility" but there are only 5 in Pubmed. Pubmed is a search engine for
scientific reports.

It has been reported that royalactin, a component of royal jelly, induces queen differentiation in honeybees.
royalactin increased body size and ovary development and shortened developmental time in honeybees. This
compound also has similar effects in the fruitfly. It is believed that royalactin activates p70 S6 kinase, which was
responsible for the increase of body size, increased the activity of mitogen-activated protein kinase, [A1, A2]

It is known that male rabbits under heat stress have fertility issue leading to major production losses. In a study
of male rabbits under heat stress, royal jelly treatments significantly boosted testosterone level, increased
ejaculated volume, increased seminal plasma fructose, improved sperm motility, increase sperm total output,
reduced abnormal sperm and dead sperm compared to the heat stressed control animals. [A3]

These results are exciting, but clinical studies are needed to help us to understand if royal jelly is effective on
human fertility
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Royal Jelly for Hair Benefits

Are there any effects of royal jelly on hair conditions? When I typed "royal jelly hair" in Google search, it shows
2,560,000 results!

Balas Raluca at
Street Articles proposes six benefits of royal jelly on hair - moisturizing, solution for dandruff,
unblocking hair follicles, improving hair thickness, against radicals (anti-oxidation effects), and scalp
rejuvenation. Christina Floyd at
ehow suggests three ingredients of royal jelly may help to prevent hair loss.
Inositol is essental for hair growth, biotin helps produce keratin (for hair and nail growth), folic acid improves skin
regeneration and hair growth. One visitor named Manders left a message at
Amazon.com that she has been
using Royal Jelly for at least 10 years and she still has dark hair.  However, when I checked with
Pubmed on the
keywords "royal jelly hair", I found no items!

According to
Wikipedia, biotin is necessary for cell growth, the production of fatty acids, and the metabolism of
fats and amino acids. It plays a role in the citric acid cycle. Symptoms of biotin deficiency include Hair loss
(alopecia), conjunctivitis and dermatitis. Folic acid itself is not biologically active, but its biological importance is
due to tetrahydrofolate and other derivatives after its conversion to dihydrofolic acid in the liver. The human
body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain
biological reactions. Folic acid is definitely important in aiding rapid cell division and growth. While, inositol
functions as the basis for a number of signaling and secondary messenger molecules for insulin signal
transduction, gene expression, etc. There is insufficient evidence for hair growth. [
WebMD]

Related Article:
Royal Jelly Review - Benefits and Side Effects
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Reference
[1] Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage.
Exp Gerontol. 2003. [2]Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats.
Biol Pharm Bull. 2004. [3] Royal jelly supplementation improves lipoprotein metabolism in humans. J Nutr Sci
Vitaminol. 2007. [4] Anti-fatigue effect of fresh royal jelly in mice., J Nutr Sci Vitaminol 2001. [5] Food-induced
anaphylaxis caused by ingestion of royal jelly. J Dermatol. 2006.[6] Case report: haemorrhagic colitis associated
with royal jelly intake. J Gastroenterol Hepatol. 1997.[7] Royal jelly consumption and hypersensitivity in the
community., Clin Exp Allergy. 1997. [8] Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy. 1996.

[A1] Yamanaka N, O'Connor MB. Apiology: royal secrets in the queen's fat body. Curr Biol. 2011 Jul
12;21(13):R510-2. [A2] Kamakura M. Royalactin induces queen differentiation in honeybees. Nature. 2011 May
26;473(7348):478-83 [A3] Elnagar SA. Royal jelly counteracts bucks' "summer infertility". Anim Reprod Sci. 2010
Aug;121(1-2):174-80.