Hyaluronic Acid Review
Hyaluronic Acid Reference
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Reference

Cream
[1] Foschi D, et al, Hyaluronic acid prevents oxygen free-radical damage to granulation tissue: a study in rats. Int J
Tissue React. 1990;12(6):333-9. [2] Liguori V, et al, Double-blind, randomized clinical study comparing hyaluronic acid
cream to placebo in patients treated with radiotherapy. Radiother Oncol. 1997 Feb;42(2):155-61. [3] Soldati D, et al,
Mucosal wound healing after nasal surgery. A controlled clinical trial on the efficacy of hyaluronic acid containing cream.
Drugs Exp Clin Res. 1999;25(6):253-61. [4] Trabucchi E, et al, Low molecular weight hyaluronic acid prevents oxygen
free radical damage to granulation tissue during wound healing. Int J Tissue React. 2002;24(2):65-71. [5] Koller J. et al,
Topical treatment of partial thickness burns by silver sulfadiazine plus hyaluronic acid compared to silver sulfadiazine
alone: a double-blind, clinical study. Drugs Exp Clin Res. 2004;30(5-6):183-90. [6] Belloni G, et al, A randomised,
double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair) in the treatment of
mild to moderate atopic dermatitis. Eur J Dermatol. 2005 Jan-Feb;15(1):31-6. [7] Costagliola M et al, Second-degree
burns: a comparative, multicenter, randomized trial of hyaluronic acid plus silver sulfadiazine vs. silver sulfadiazine
alone. Curr Med Res Opin. 2005 Aug;21(8):1235-40. [8] Abramovits W, et al, A multicenter, randomized,
vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild
to moderate atopic dermatitis in adults. J Drugs Dermatol. 2006 Mar;5(3):236-44. [9] Primavera G, et al, A double-blind,
vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in
the management of radiation-induced dermatitis. Cutan Ocul Toxicol. 2006;25(3):165-71. [10] Voinchet V, et al, Efficacy
and safety of hyaluronic acid in the management of acute wounds Am J Clin Dermatol. 2006;7(6):353-7 [11] Lupo ML,
et al, Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation. J
Drugs Dermatol. 2007 Jul;6(7):725-9. [12] Hu X, et al, Study on efficacy and safety of bioactive material--combest in
treating burn, Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Nov;21(11):1216-8
Hyaluronic acid injection
[1] Randelli P, et al, Current practice in shoulder pathology: results of a web-based survey among a community of 1,084
orthopedic surgeons. Knee Surg Sports Traumatol Arthrosc. 2011 Oct 1. [2] Ishikawa T, et al, Therapeutic effect of
hyaluronic acid injection for knee and shoulder joint, Clin Calcium. 2002 Jan;12(1):104-7 [3] Amiel D, et al, Value of
hyaluronic acid in the prevention of contracture formation. Clin Orthop Relat Res. 1985 Jun;(196):306-11. [4] Hönig JF,
et al, Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its
surgical correction. J Craniofac Surg. 2003 Mar;14(2):197-200. [5] Dal Sacco D, et al, Scar sarcoidosis after hyaluronic
acid injection. Int J Dermatol. 2005 May;44(5):411-2. [6] de Oliveira Monteiro E. Hyaluronic acid for restoring earlobe
volume. Skinmed. 2006 Nov-Dec;5(6):293-4. [6] Gensanne D, et al, In vivo visualization of hyaluronic acid injection by
high spatial resolution T2 parametric magnetic resonance images. Skin Res Technol. 2007 Nov;13(4):385-9. [7] Pacifico
MD, Ritz M. Correction of senile drooling using the nasolabial sling. J Plast Reconstr Aesthet Surg. 2010 May;63(5):757-
62. [8] Bannuru RR, et al, Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis--
meta-analysis. Osteoarthritis Cartilage. 2011 Jun;19(6):611-9. [9] Escoda-Francolí J, et al, Scientific evidence on the
usefulness of intraarticular hyaluronic acid injection in the management of temporomandibular dysfunction. Med Oral
Patol Oral Cir Bucal. 2010 Jul 1;15(4):e644-8. [10] Eyigör C, et al, Efficacy of intraarticular hyaluronic acid injection
through a lateral approach under fluoroscopic control for advanced hip osteoarthritis. Agri. 2010 Oct;22(4):139-44. [11]
Berros P. Periorbital contour abnormalities: hollow eye ring management with hyalurostructure. Orbit. 2010 Apr;29(2):
119-25. [12] Basterzi Y, et al, Intraarticular hyaluronic acid injection for the treatment of reducing and nonreducing disc
displacement of the temporomandibular joint. Ann Plast Surg. 2009 Mar;62(3):265-7. [13] Thein R, et al, Intra-articular
injection of hyaluronic acid following arthroscopic partial meniscectomy of the knee. Orthopedics. 2010 Oct 11;33(10):
724. [14] Legović D, et al, Microfracture technique in combination with intraarticular hyaluronic acid injection in articular
cartilage defect regeneration in rabbit model. Coll Antropol. 2009 Jun;33(2):619-23. [15] Birchall D, et al, Clinical
outcomes from a physiotherapist-led intra-articular hyaluronic acid injection clinic. Musculoskeletal Care. 2008 Sep;6(3):
135-49. [16] Salini V, et al, Ultrasound-guided hyaluronic acid injection in carpometacarpal osteoarthritis: short-term
results. Int J Immunopathol Pharmacol. 2009 Apr-Jun;22(2):455-60. [17] Judodihardjo H, Dykes P. Objective and
subjective measurements of cutaneous inflammation after a novel hyaluronic acid injection. Dermatol Surg. 2008 Jun;34
Suppl 1:S110-4. [18] Banh K. Facial Ischemia after Hyaluronic Acid Injection. J Emerg Med. 2011 Sep 27. [19] Dougherty
AL, Rashid RM, Bangert CA. Angioedema-type swelling and herpes simplex virus reactivation following hyaluronic acid
injection for lip augmentation. J Am Acad Dermatol. 2011 Jul;65(1):e21-2.
Benefits
Reference: [1] Moskowitz RW, Hyaluronic acid supplementation, Curr. Rheumatol Rep. 2000 Dec; 2 (6): 466-71]. [2]
Karatosum V et al, Comparison of two hyaluronan drugs in patients with advanced osteoarthritis of the knee. A
prospective, randomized, double-blind study with long term follow-up., Clin Exp Rheumatol. 2005 Mar-Apr;23(2):213-8.]
[3] Intra-articular injections of high-molecular-weight hyaluronic acid have biphasic effects on joint inflammation and
destruction in rat antigen-induced arthritis. Arthritis Res Ther. 2005;7(3):R677-86. Epub 2005 Mar 31][4] Hyaluronic
acid-poly-D-lysine-based three-dimensional hydrogel for traumatic brain injury. Tissue Eng. 2005 Mar-Apr;11(3-4):513-
25.] [5] Brown M et al, Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin., J Eur Acad
Dermatol Venereol. 2005 May;19(3):308-18.] [6] Resource New Device Approval Restylane™ Injectable Gel -
P040024, CDRH Consumer Information, May 9, 2005 [7] Hyaluronic acid for the treatment of knee osteoarthritis: long-
term outcomes from a naturalistic primary care experience. Am J Phys Med Rehabil. 2005 Apr;84(4):278-83; quiz 284,
293.] [8] Multicenter study of hyaluronic acid obtained by biotechnology to evaluate clinical efficacy and safety in knee
osteoarthritis., Int J Clin Pharmacol Res. 2005;25(1):1-7..][9] New Device Approval Restylane™ Injectable Gel -
P040024, CDRH Consumer Information, May 9, 2005] [10] Loai Y et al, Bladder tissue engineering: Tissue regeneration
and neovascularization of HA-VEGF-incorporated bladder acellular constructs in mouse and porcine animal models. J
Biomed Mater Res A. 2010 Sep 15;94(4):1205-15. [11] Yim H and Na K. Polycationic Nanodrug Covered with Hyaluronic
Acid for Treatment of P-Glycoprotein Overexpressing Cancer Cells. Biomacromolecules. 2010 Aug 5. [12] de Brito
Bezerra B, et al. Association of hyaluronic acid with a collagen scaffold may improve bone healing in critical-size bone
defects. Clin. Oral Impl. Res. xx, 2011; 000-000. doi: 10.1111/j.1600-0501.2011.02234.x. [13] Häcker FM, et al,, Eur J
Pediatr Surg. 2011 Jun 17 [14] Modrzyński M. et al, Hyaluronic acid gel in the treatment of empty nose syndrome. Am J
Rhinol Allergy. 2011 Mar;25(2):103-6. [15] Viana GA et al, Treatment of tear trough deformity with hyaluronic acid gel
filler. Arq Bras Oftalmol. 2011 Feb;74(1):44-47.
Side Effects
Reference:  [7] Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary
care experience. Am J Phys Med Rehabil. 2005 Apr;84(4):278-83; quiz 284, 293.] [8] Multicenter study of hyaluronic
acid obtained by biotechnology to evaluate clinical efficacy and safety in knee osteoarthritis., Int J Clin Pharmacol Res.
2005;25(1):1-7..][9] New Device Approval Restylane™ Injectable Gel - P040024, CDRH Consumer Information, May 9,
2005] [15] Viana GA et al, Treatment of tear trough deformity with hyaluronic acid gel filler. Arq Bras Oftalmol. 2011
Feb;74(1):44-47.
Injection
FDA1: D. B. Lyle, An In Vitro Test for Inflammatory Potential of Hyaluronic Acid Preparations A-34 2005 FDA Science
Forum [FDA2] M.D.Luu. et al, Materials Issues in the Post-Market Experience of the Ferric Hyaluronan Adhesion
Prevention Solution (Fe-HA).  P-16 2005 FDA Science Forum
Hyaluronic acid Quick View
Hyaluronic Acid is a polysaccharide composed of alternating molecules of N-acetyl glucosamine and D-glucuronic acid. It can be found within
collagen throughout the body. As the most important space filling substance in the human body. Hyaluronic Acid holds water to keep collagen
hydrated and "youthful". Hyaluronic Acid forms a viscous fluid with exceptional lubricating properties necessary for the vital functions of many
parts of the human body including the skin, heart valves, aqueous/ vitreous humor of the eye and synovial fluid (joint lubricant).
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Different articles have been published on hyaluronic acid, and they are:
Serum:
1. Sasaki Y et al, Quantitative measurement of serum hyaluronic acid molecular weight in rheumatoid arthritis patients
and the role of hyaluronidase. Int J Rheum Dis. 2011 Oct;14(4):313-9. 2. Silva CC, et al, Schistosomiasis mansoni:
ultrasound-evaluated hepatic fibrosis and serum concentrations of hyaluronic acid. Ann Trop Med Parasitol. 2011
Apr;105(3):233-9. [3] Parsian H, et al, Assessment of liver fibrosis development in chronic hepatitis B patients by serum
hyaluronic acid and laminin levels. Acta Clin Croat. 2010 Sep;49(3):257-65. [4] Ruan HL, et al, Significance of elevated
levels of collagen type IV and hyaluronic acid in gastric juice and serum in gastric cancer and precancerous lesion. Dig
Dis Sci. 2011 Jul;56(7):2001-8 [5] Toshima T, et al, New method for assessing liver fibrosis based on acoustic radiation
force impulse: a special reference to the difference between right and left liver. J Gastroenterol. 2011
May;46(5):705-11. [6].Ribé A, Ribé N. Neck skin rejuvenation: histological and clinical changes after combined therapy
with a fractional non-ablative laser and stabilized hyaluronic acid-based gel of non-animal origin. J Cosmet Laser Ther.
2011 Aug;13(4):154-61. [7] Naik MN et al, Nonsurgical management of epiblepharon using hyaluronic acid gel. Ophthal
Plast Reconstr Surg. 2010 May-Jun;26(3):215-7. [8] Turlier V, et al, Assessment of the clinical efficacy of a hyaluronic
acid-based deep wrinkle filler using new instrumental methods. J Cosmet Laser Ther. 2010 Aug;12(4):195-202. [8]
Trookman NS et al, Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J
Clin Aesthet Dermatol. 2009 Mar;2(3):38-43.
Topical Products
[TP-1] Pavicic T et al, Efficacy of cream-based novel formulations of hyaluronic Acid of different molecular weights in
anti-wrinkle treatment. J Drugs Dermatol. 2011 Sep 1;10(9):990-1000. [TP-2] Kapoor P, et al, Topical hyaluronic Acid in
the management of oral ulcers. Indian J Dermatol. 2011 May;56(3):300-2. [TP-3]