What is GliSODin?

GliSODin
Prepared on April 7, 2009

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What is Glisodin? What are its potential health benefits?

GliSODin is the combination of superoxide dismutases extracted from
cantaloupe melon and wheat gliadin. A patent application for GliSODin (US
2008/0020071 A1) has been filed to treat alcohol induced hangover,
GliSODin has been trademarked by Paris-based Isocell. In North America PL
Thomas distributes the ingredient. [1] The independent claim for the patent
application is "A composition for protecting against, minimizing effects of, and
hastening recovery from symptoms associated with an alcohol induced
hangover, comprising:superoxide dismutase; andprickly pear cactus."

What I found...
I have reviewed the embodiment of the patent application, the patent
application didn't provide any direct clinical evidence on the how GliSODin
benefits our health (April 2, 2009). The application simply mentions that
superoxide dismutase works by promoting the patient's antioxidant defense
and immune support mechanism. The application also mentions that
superoxide dismutase plays a role in reducing inflammation. My question is:
Is GliSODin as good as other superoxide dismutase (from other sources,
other combinations)?

Researchers from ISOCELL Nutra SAS, France, found animals
supplemented with Glisodin showed a significant elevation in circulated
antioxidant enzymes activities. Hepatocytes isolated from animals
supplemented with Glisodin presented a delayed depolarization response
and an enhanced resistance to oxidative stress-induced apoptosis. [2]
Researchers from Association Nationale de Prevention Médicale , France,
found that supplementation with GliSODin was effective in controlling the
thickness of the carotid artery intima and media layers in a study of 76 adults
aged 30-60. [3]

More studies are needed to support its health benefit-claims.

Reference:

[1] Stephen Daniells, SOD supplement may ease brain impairment: Mouse
study NUTRA ingredients-usa.com 16-Feb-2009. [2] Vouldoukis I, Conti M,
Krauss P, Kamaté C, Blazquez S, Tefit M, Mazier D, Calenda A, Dugas B.
Supplementation with gliadin-combined plant superoxide dismutase extract
promotes antioxidant defences and protects against oxidative stress.
Phytother Res. 2004 Dec;18(12):957-62. [3] Cloarec M, Caillard P, Provost
JC, Dever JM, Elbeze Y, Zamaria N. GliSODin, a vegetal sod with gliadin, as
preventative agent vs. atherosclerosis, as confirmed with carotid
ultrasound-B imaging. Eur Ann Allergy Clin Immunol. 2007 Feb;39(2):45-50.