
Does creatine supplement provide health
benefits?
Researchers from University of Berne, Inselspital,
CH-3010 Berne, Switzerland
Exogenous creatine supplementation has been shown to
reduce neuronal cell loss in experimental paradigms of
acute and chronic neurological diseases. In line with these
findings, first clinical trials have shown beneficial effects of
therapeutic creatine supplementation. Furthermore,
creatine was reported to promote differentiation of
neuronal precursor cells that might be of importance for
improving neuronal cell replacement strategies. Based on
these observations there is growing interest on the effects
and functions of this compound in the central nervous
system. This review gives a short excursion into the basics
of the creatine kinase/phosphocreatine system and aims
at summarizing findings and concepts on the role of
creatine kinase and creatine in the central nervous system
with special emphasis on pathological conditions and the
positive effects of creatine supplementation. [1]
Candow DG, Chilibeck PD. University of Regina,
Saskatchewan, Canada
Sarcopenia, defined as the age-related loss of muscle
mass, is a serious health concern. Contributing factors to
sarcopenia include physical inactivity and undernutrition.
Resistance training has a positive effect on muscle mass
in the elderly. However, muscle loss is still observed in
older adults who perform weight bearing exercise;
suggesting that nutrition is important.
Intake of creatine has the potential to increase muscle
accretion during resistance training, although the
mechanism for its ergogenic effect is unclear. Creatine has
the potential to increase cellular hydration and myogenic
transcription factors and facilitate the up-regulation of
muscle specific-genes such as myosin heavy chain
possibly leading to muscle hypertrophy. [2]
Brosnan JT, Brosnan ME. Memorial University of
Newfoundland, St. John's, Newfoundland, Canada
Creatine synthesis makes major demands on the
metabolism of glycine, arginine, and methionine. Large
doses of creatine monohydrate are widely taken,
particularly by athletes, as an ergogenic supplement;
creatine supplements are also taken by patients suffering
from gyrate atrophy, muscular dystrophy, and
neurodegenerative diseases. Children with inborn errors
of creatine synthesis or transport present with severe
neurological symptoms and a profound depletion of brain
creatine. It is evident that creatine plays a critical, though
underappreciated, role in brain function. [3]
REFERENCES
[1] Functions and effects of creatine in the central nervous
system.Brain Res Bull. 2008 Jul 1;76(4):329-43. Epub
2008 Mar 24
[2] Effect of creatine supplementation during resistance
training on muscle accretion in the elderly. J Nutr Health
Aging. 2007 Mar-Apr;11(2):185-8.
[3] Creatine: endogenous metabolite, dietary, and
therapeutic supplement. Annu Rev Nutr. 2007;27:241-61
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