CONJUGATED LINOLEIC ACID
(CLA) weight loss and side effects, benefits; research finds
(CLA) weight loss and side effects, benefits; research finds
| Conjugated linoleic acid (CLA) has rapidly become one of the most talked about weight loss products since its introduction to the public in the late 90s. |
Popular
Supplements
Acetyl-L Carnitine
Acidophilus
Almond
Bladderwrack
Bilberry
Chromium
CLA
Cod Liver Oil
Coenzyme Q
Colostrum
Dandelion
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eve. Primrose Oil
Fish Oil
Flaxseed
Garlic
Ginger
Ginseng
Ginkgo Biloba
Glucosamine
Gotu Kola
Guar Gum
Hyaluronic acid
Lecithin
Lycopene
Milk Thistle
Nattokinase
Passion Flower
Probiotics
Policosanol /
Polycosanol
Pycnogenol
Reishi / Lingzhi
Resveratrol
Rhodiola
Royal Jelly
Stevia
Whey
Xylitol
More Supplements
Supplements
Acetyl-L Carnitine
Acidophilus
Almond
Bladderwrack
Bilberry
Chromium
CLA
Cod Liver Oil
Coenzyme Q
Colostrum
Dandelion
EGCG
Echinacea
Eleuthero
Ellagic Acid
Eve. Primrose Oil
Fish Oil
Flaxseed
Garlic
Ginger
Ginseng
Ginkgo Biloba
Glucosamine
Gotu Kola
Guar Gum
Hyaluronic acid
Lecithin
Lycopene
Milk Thistle
Nattokinase
Passion Flower
Probiotics
Policosanol /
Polycosanol
Pycnogenol
Reishi / Lingzhi
Resveratrol
Rhodiola
Royal Jelly
Stevia
Whey
Xylitol
More Supplements
 |  |  |  |
THIS WEBSITE TALKS ABOUT THE SIDE EFFECTS AND THE POTENTIAL HEALTH BENEFITS OF HERBS, SUPPLEMENTS,
PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES.
ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR
DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2008. DO NOT COPY NOR TRANSFER ARTICLES TO OTHER WEBSITES NOR OTHER
FORMS OF PUBLICATIONS. Privacy Policy. ARTICLE INDEX
PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES.
ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR
DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2008. DO NOT COPY NOR TRANSFER ARTICLES TO OTHER WEBSITES NOR OTHER
FORMS OF PUBLICATIONS. Privacy Policy. ARTICLE INDEX
 | |  | |  | |  | |  | |  | |  |
Conjugated linoleic acid (CLA) is a group of positional and geometric isomers
of linoleic acid (LA, C18:2 cis-9, cis-12).
Conjugated linoleic acid (CLA) is popular in health supplement industry as it
may have benefits of reducing body fat and increasing muscle mass. A few
studies also suggest that conjugated linoleic acid (CLA) may also have
benefits of lowering the risk of atherosclerosis and cancers for some people.
Sources of Conjugated Linoleic Acid (CLA)
Conjugated linoleic acid (CLA) is available in dairy products, beef, poultry,
eggs, and corn oil. Bacteria that live in the intestine of humans can also
convert linoleic acid to conjugated linoleic acid (CLA).
Conjugated Linoleic Acid (CLA) Supplements
The source for some conjugated linoleic acid (CLA) supplements are
safflower oil. Most brands of conjugated linoleic acid (CLA) on the market
today contain 70% conjugated linoleic acid (CLA); with no trans-fats present.
Potential Health Benefits of Conjugated Linoliec Acid – Research
Supports
Atherosclerosis and Cholesterol
A study has shown the anti-atheroslerotic and antioxidant activities of
Conjugated linoleic acid (CLA) via increasing oxidative stability in plasma and
hepatic membrane in the vitamin E-deficient rats [8] Individual conjugated
linoleic acid (CLA) isomers was shown to reduce the development of
atherosclerotic lesion in hamsters. [9] In a cell culture, conjugated linoleic
acid (CLA) reduces apoB100 production and secretion compared to
saturated and polyunsaturated fatty acids, possibly by limiting the availability
of free cholesterol (required for apoB100 production). A reduction in apoB100
production in the body would decrease the levels of VLDL and atherogenic
LDL and thus reduce the risk of developing cardiovascular disease. Some
other studies in animals also showed that conjugated linoleic acid (CLA) may
reduce the risk of atherosclerosis. [15-17]
Cancers
Dietary conjugated linoleic acid CLA was shown to inhibit colon tumor cell
proliferation in vitro and in vivo via the CDK inhibitor p21(CIP1/WAF1). [15]
And, various basic research studies have demonstrated that conjugated
linoleic acid (CLA) might reduce the risk of several types of cancers including
breast, prostate, colorectal, lung, skin, and stomach. [10-13] Scientists have
also investigated on how conjugated linoleic acid (CLA) inhibited cancer cell
growth
extensively. Conjugated linoleic acid CLA may trigger apoptosis in the
estrogen unresponsive MDA-MB-231 human breast cancer cell line via
mechanisms involving above all the mitochondrial pathway. [14]
Immune Function
Conjugated linoleic acid CLA improved performance, lymphocyte proliferation,
and increased the CD8+ lymphocyte population, while reduced the production
of PGE2 and interleukin-lbeta (IL- 1beta). Supplementation of conjugated
linoleic acid; CLA enhanced lymphocyte proliferation function, possibly by
regulating the PGE2 production, and improved growth performance of pigs.
[15]
Diabetes / Glucose Tolerance
Animal research suggests an effect of conjugated linoleic acid (CLA)
supplementation on improving glucose tolerance. [16]
Weight Management
Conjugated linoleic acid (CLA) may benefit people who want weight loss.
Some studies showed that conjugated linoleic acid (CLA) is effective on
reduction of body fat. In one study, conjugated linoleic acid (CLA) significantly
reduced percent body fat, but did not significantly reduce body weight [17] In
another study, supplementation with 4.2 grams of conjugated linoleic acid
(CLA); per day for four weeks produced a reduction in waist size but not
weight loss. [18]
Safflower oil is a common source for conjugated linolieic acid (CLA), but, the
effects of taking conjugated linolieic acid (CLA) and safflower oil on body
mass index (BMI), total and trunk adipose mass, as well as the lean meat
(tissue) can be very different. Norris LE and co-researchers compared the
effects of 2 dietary oils, conjugated linoleic acid (CLA) and safflower oil (SAF),
on body weight and composition in obese postmenopausal women with type-2
diabetes in a 36-week study. They found that supplementation with
conjugated linoleic acid (CLA) reduced body mass index (BMI) (P = 0.0022)
and total adipose mass (P = 0.0187) without altering lean mass. The effect of
CLA in lowering BMI was detected during the last 8 wk of each 16-wk diet
period. In contrast, safflower oil had no effect on BMI or total adipose mass
but reduced trunk adipose mass and increased lean mass. Safflower oil also
significantly lowered fasting glucose and increased adiponectin. [S1]
CONJUGATED LINOLEIC ACID IN MILK
Supplementation of vegetable oils tended to improve milk production of
lactating cows, and the conjugated linoleic acid (CLA) content in milk fat was
significantly increased. Soybean oil seemed to be the optimal source to
increase conjugated linoleic acid (CLA) production. [17]
SIDE EFFECTS AND REFERENCE
of linoleic acid (LA, C18:2 cis-9, cis-12).
Conjugated linoleic acid (CLA) is popular in health supplement industry as it
may have benefits of reducing body fat and increasing muscle mass. A few
studies also suggest that conjugated linoleic acid (CLA) may also have
benefits of lowering the risk of atherosclerosis and cancers for some people.
Sources of Conjugated Linoleic Acid (CLA)
Conjugated linoleic acid (CLA) is available in dairy products, beef, poultry,
eggs, and corn oil. Bacteria that live in the intestine of humans can also
convert linoleic acid to conjugated linoleic acid (CLA).
Conjugated Linoleic Acid (CLA) Supplements
The source for some conjugated linoleic acid (CLA) supplements are
safflower oil. Most brands of conjugated linoleic acid (CLA) on the market
today contain 70% conjugated linoleic acid (CLA); with no trans-fats present.
Potential Health Benefits of Conjugated Linoliec Acid – Research
Supports
Atherosclerosis and Cholesterol
A study has shown the anti-atheroslerotic and antioxidant activities of
Conjugated linoleic acid (CLA) via increasing oxidative stability in plasma and
hepatic membrane in the vitamin E-deficient rats [8] Individual conjugated
linoleic acid (CLA) isomers was shown to reduce the development of
atherosclerotic lesion in hamsters. [9] In a cell culture, conjugated linoleic
acid (CLA) reduces apoB100 production and secretion compared to
saturated and polyunsaturated fatty acids, possibly by limiting the availability
of free cholesterol (required for apoB100 production). A reduction in apoB100
production in the body would decrease the levels of VLDL and atherogenic
LDL and thus reduce the risk of developing cardiovascular disease. Some
other studies in animals also showed that conjugated linoleic acid (CLA) may
reduce the risk of atherosclerosis. [15-17]
Cancers
Dietary conjugated linoleic acid CLA was shown to inhibit colon tumor cell
proliferation in vitro and in vivo via the CDK inhibitor p21(CIP1/WAF1). [15]
And, various basic research studies have demonstrated that conjugated
linoleic acid (CLA) might reduce the risk of several types of cancers including
breast, prostate, colorectal, lung, skin, and stomach. [10-13] Scientists have
also investigated on how conjugated linoleic acid (CLA) inhibited cancer cell
growth
extensively. Conjugated linoleic acid CLA may trigger apoptosis in the
estrogen unresponsive MDA-MB-231 human breast cancer cell line via
mechanisms involving above all the mitochondrial pathway. [14]
Immune Function
Conjugated linoleic acid CLA improved performance, lymphocyte proliferation,
and increased the CD8+ lymphocyte population, while reduced the production
of PGE2 and interleukin-lbeta (IL- 1beta). Supplementation of conjugated
linoleic acid; CLA enhanced lymphocyte proliferation function, possibly by
regulating the PGE2 production, and improved growth performance of pigs.
[15]
Diabetes / Glucose Tolerance
Animal research suggests an effect of conjugated linoleic acid (CLA)
supplementation on improving glucose tolerance. [16]
Weight Management
Conjugated linoleic acid (CLA) may benefit people who want weight loss.
Some studies showed that conjugated linoleic acid (CLA) is effective on
reduction of body fat. In one study, conjugated linoleic acid (CLA) significantly
reduced percent body fat, but did not significantly reduce body weight [17] In
another study, supplementation with 4.2 grams of conjugated linoleic acid
(CLA); per day for four weeks produced a reduction in waist size but not
weight loss. [18]
Safflower oil is a common source for conjugated linolieic acid (CLA), but, the
effects of taking conjugated linolieic acid (CLA) and safflower oil on body
mass index (BMI), total and trunk adipose mass, as well as the lean meat
(tissue) can be very different. Norris LE and co-researchers compared the
effects of 2 dietary oils, conjugated linoleic acid (CLA) and safflower oil (SAF),
on body weight and composition in obese postmenopausal women with type-2
diabetes in a 36-week study. They found that supplementation with
conjugated linoleic acid (CLA) reduced body mass index (BMI) (P = 0.0022)
and total adipose mass (P = 0.0187) without altering lean mass. The effect of
CLA in lowering BMI was detected during the last 8 wk of each 16-wk diet
period. In contrast, safflower oil had no effect on BMI or total adipose mass
but reduced trunk adipose mass and increased lean mass. Safflower oil also
significantly lowered fasting glucose and increased adiponectin. [S1]
CONJUGATED LINOLEIC ACID IN MILK
Supplementation of vegetable oils tended to improve milk production of
lactating cows, and the conjugated linoleic acid (CLA) content in milk fat was
significantly increased. Soybean oil seemed to be the optimal source to
increase conjugated linoleic acid (CLA) production. [17]
SIDE EFFECTS AND REFERENCE
