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Acidophilus is lactic acid-producing bacteria. In
general, lactobacillus acidophilus is considered to
possess health-promoting attributes. It passes
through the intestine benefiting host's physiology.
Lactobacillus acidophilus is widely used as live
supplement. The potential benefits of lactobacillus
acidophilus in fermented dairy products are
dependent on their survival during manufacture and
storage. Lactobacillus acidophilus is increasingly
used in food and pharmaceutical applications to
balance disturbed intestinal microflora and related
dysfunction of the human gastrointestinal tract.
Lactobacillus acidophilus has been reported to
provide excellent therapeutic benefits. [1]
HOW DOES LACTOBACILLUS ACIDOPHILUS
BENEFIT OUR BODY HEALTH?
1.INFECTION PREVENTION
Lactobacillus acidophilus may have importance in the
prevention and adjuvant therapy of new-born and
childhood enteritis, certain inflammations and
antibiotic associated diarrhoea. Administration of
lactobacillus acidophilus creates eubiosis between
the human organism and the world of bacteria
assuring normal physiologic functions for the
well-being of the organism. [2,3]
Lactobacillus acidophilus adheres to Caco-2 and
mucus-secreting HT-29 cell culture systems,
produces antimicrobial compounds, and is amenable
to genetic manipulation and directed DNA
introduction. Lactobacillus acidophilus survives
gastrointestinal tract transit in both healthy and
diseased populations.
A blend of probiotic strains containing lactobacillus
acidophilus decreased the incidence of pediatric
diarrhea. Lactobacillus acidophilus led to a significant
decrease in levels of toxic amines in the blood of
dialysis patients with small bowel bacterial
overgrowth. At adequate daily feeding levels,
Lactobacillus acidophilus may facilitate lactose
digestion in lactose-intolerant subjects. Further
validation of the probiotic properties of NCFM in
humans and clarification of its mechanisms of
probiotic action are needed to better understand the
role this strain might play in promoting human health.
[4]
The biological activity of lactobacillus acidophilus is
due in part to their ability to attach to enterocytes. This
inhibits the binding of enteric pathogens by a process
of competitive exclusion, i.e. competition for nutrients
and adhesion sites. [3] Attachment of lactobacillus
acidophilus to cell surface receptors of enterocytes
also initiates signalling events that result in the
synthesis of cytokines. Lactobacillus acidophilus also
exerts an influence on commensal micro-organisms
by the production of organic acids (e.g.lactic acids),
hydrogen peroxide, antibiotic-like compounds and
bacteriocins. These substances inhibit growth of
pathogens and also alter the ecological balance of
enteric commensals. [1]
Irritable Bowel Syndrome Although the cause of
irritable bowel syndrome is not known, one possibility
is a disturbance in healthy intestinal bacteria. Based
on this theory, Lactobacillus acidophilus have been
tried as a treatment for IBS. Benefits were seen in
three other small double-blind trials as well, using
Lactobacillus acidophilus. [5]
CANCER RISK LOWERING
Production of butyric acid lactobacillus acidophilus
affects the turnover of enterocytes and neutralizes the
activity of dietary carcinogens, such as nitrosamines,
that are generated by the metabolic activity of
commensal bacteria in subjects consuming a
high-protein diet. Therefore, inclusion of lactobacillus
acidophilus in fermented dairy products enhances
their value as better therapeutic functional foods. [1] A
study has shown that lactobacillus acidophilus
inhibited aberrant crypt formation in mutagenized rats,
indicative of activity that could decrease the risk of
colon cancer. [4]
CHOLESTEROL LOWERING
Lactobacillus acidophilus may be able to inhibit
3-hydroxy-3-methylglutaryl CoA reductase (an enzyme
for cholesterol biosynthesis) and promote the
excretion of dietary cholesterol in feces. Thus,
lactobacillus acidophilus has the benefit for high
cholesterol [3]
IMMUNE RESPONSE
One study found that Lactobacillus acidophilus may
improve the immune response to vaccinations. 6
Sources and Commercial Supplements
Dairy products such as yogurt and kefir are good
sources of acidophilus. Supplements are widely
available in powder, liquid, capsule, or tablet form.
Grocery stores and natural food stores both carry milk
that contains live acidophilus. Dosages of acidophilus
are expressed in billions of organisms. A typical daily
dose should supply about 3 to 5 billion live organisms.
Acidophilus 4X6 Powder, Now, has 4 billion potency
(2 billion lactobacillus acidophilus) and 6 probiotic
strains per serving (1/4 teaspoon; 700 mg).
Acidophilus 2 Billion, Now, has 2 billion potency (2
billion lactobacillus acidophilus) per serving (1/2
teaspoon; 1 g). Mega Acidophilus, Natural Factors,
has 6 billion active cells (5.7 billion of L. rhamnosus
and L. acidophilus) and 200 mg of
fructooligosaccharides (FOS) per serving. Most
acidophilus products require refrigerated for
maintaining the potency. The shelf-life is about 1-2
years.
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[1] Kailasapathy K et al Survival and therapeutic potential of probiotic
organisms with reference to Lactobacillus acidophilus and Bifidobacterium
spp. Immunol Cell Biol. 2000 Feb;78(1):80-8. [2] Halmy C et al, The role of
Lactobacillus acidophilus in the prevention and adjuvant therapy of certain
infectious diseases Orv Hetil. 1998 Sep 27;139(39):2313-8. [3] Mital BK et al,
Anticarcinogenic, hypocholesterolemic, and antagonistic activities of
Lactobacillus acidophilus. Crit Rev Microbiol. 1995;21(3):175-214. [4] Sanders
ME et al, Invited review: the scientific basis of Lactobacillus acidophilus
NCFM functionality as a probiotic. J Dairy Sci. 2001 Feb;84(2):319-31. 5.
Halpern GM, Prindiville T, Blankenberg M, et al. Treatment of irritable bowel
syndrome with Lacteol Fort: a randomized, double-blind, cross-over trial. Am J
Gastroenterol. 1996;91:1579–1585. 6. de Vrese M, Rautenberg P, Laue
C, et al. Probiotic bacteria stimulate virus-specific neutralizing antibodies
following a booster polio vaccination. Eur J Nutr. 2004 Dec 1 [Epub ahead of
print].