What are the health benefits of Royal Jelly? Royal Jelly is extremely nutrient dense.  It contains at least 20 amino
acids, 8 of which are essential and 5 unidentified related compounds. Studies have shown that royal jelly may
provide health benefits on various conditions such as arthritis, cancer, skin conditions, high blood pressure,
infection, inflammation, allergy, fatique and microbial effects.
What are the health benefits of royal jelly?

Royal jelly may offer various health benefits, a few animal and
in-vitro studies suggest.

Royal jelly  shows skin protection in cell studies.
It has been known that royal Jelly promotes collagen
production by skin fibroblasts in the presence of ascorbic
acid-2-O-alpha-glucoside. Fujisaki et al further found that
purified royal jelly was similar to those of
10-hydroxy-2-decenoic acid, which can induce the fibroblast
cells to produce transforming growht fator-beta 1.
Transforming growth factor-beta 1 is an important factor for
collagen production.
Identification of a collagen production-promoting factor from an extract of
royal jelly and its possible mechanism. Koya-Miyata et al, Fujisaki Institute,
Japan, BioSci BioTechnol BioChem, 2004 Apr;68(4):767-73.

Royal jelly may have benefits of blood pressure
lowering.
"Protease N treated royal Jelly and its peptides" can inibit
angiotensin I-converting enzyme (ACE) activity and they can
lower the blood pressure in repeated oral doses on
spontaneously hypertensive rates. Tokunaga's research
group found that the antihypertensive effect of the peptide
mixture could be as high as 38%.
Antihypertensive effect of peptides from royal jelly in spontaneously
hypertensive rats. tokunaga et al, API Company, Japan. Biol Pharm Bull, 2004
Feb;27(2):189-92.

Royal jelly shows anti-inflammatory action in a cell study,

Kohno has examined Royal Jelly's anti-inflammatory actions at
cytokine level using cultures of mouse peritoneal
macrophages. They found that Royal Jelly has
anti-inflammatory actions through inhibiting proinflammatory
cytokine production by activated macrophages.
Royal Jelly inhibits the production of proinflammatory cytokines by activated
macrophages. Kohno et al, Fujisaki Institute, Japan. BioSci BioTechnol
BioChem. 2004 Jan;68(1):138-45.

Royal Jelly may have benefits of DNA Protection
anti-cancer activities, animal study suggest.
Inoue et al studied the effect of dietary Royal Jelly on tissue
DNA oxidative damage and on the life span of C3H/HeJ mice.
They found that the levels of 8-hydroxy-2-deoxyguanosine (a
marker of oxidative stress) was significantly reduced if the
mice were fed with Royal Jelly for 16 weeks. The dietary Royal
Jelly also increased the average life span of C3H/HeJ mice
through the mechanism of reduced oxidative damage.
Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced
DNA damage. Inoue et al, Fujisaki Institute, Japan. Exp Gerontol. 2003
Sep;38(9):965-9.

Binclletto C. et al found royal jelly was able to produce effect
on haematopoiesis of Ehrlich ascites tumor-bearing mice.
Thus, royal jelly prevented the myelosupression in mice. Effects
produced by Royal Jelly on haematopoiesis: relation with host resistance
against Ehrlich ascites tumour challenge. Int Immunopharmacol. 2005 Apr;
5(4):679-88.

Royal jelly has antiallergic effects.
Okamoto's research group has shown that Royal Jelly has
potent exhibit anti-allergic properties in a mouse model of
immediate hypersensivity. In a futher study, they found that a
70 KDa glycoprotein, ie. the major Royal Jelly Protein 3
(MRJP3), could suppress IL-4, IL-2 and IFN-gamma  
production.
Major Royal Jelly Protein 3 modulates immune responses in vitro and in vivo.
Okamto et al. Fujisaki Institute, Japan. Life Sci. 2003 Sep 5;73(16):2029-45.

Royal Jelly may help atopic dermatitis.
Royal Jelly is able to inhibit the production of IL-4, IL-5, IL-10
and antigen-specific interferon-gamma in spleen cells of
ovalbumin(OVA)/Alum-immunized mice. It is also known that
both Th1 and Th2 cytokines play pathogenic roles in the
development of atopic dermatitis. Fujisaki et al found that
Royal Jelly suppresses the development of the lesions,
possibly by a combination of down-regulating TNP-specific
IFN-gamma production and up-regulating iNOS expression.
Oral administration of Royal Jelly inhibits the development of atopic
dermatitis-like skin lesions in NC/Nga mice. Taniguchi et al, Fujisaki Institute,
Japan. Int Immunopharmacol. 2003 Sep;3(9):1313-24.

Royal jelly has anti-fatigue effects.
Kamakura et al forced mice to swim in an adjustable-current
swimming pool. They found that mice fed with a 5 7-kDa
protein extracted from Royal Jelly showed significantly
decreased accumulation of serum lactate and serum ammonia.
This suggests that Royal Jelly can ameliorate the physical
fatigue after exercise.
Antifatique effect of fresh royal jelly in mice. Kamakura et al, Pola Co., Japan.
J Nutr Sci Vitaminol (Tokyo).2001 Dec;47(6):394-401.

Royal jelly has antibacterial effects.
Fontana R. et al at Brazil identified four peptides possessing
anti-microbial properties-Jelleine-I, Jelleine-II, Jelleine-III and
Jelleine-IV from royal jelly. Jelleines; a family of antimicrobial peptides
from the royal jelly of honeybees. Peptides. 2004 Jun;25(6):919-28.

Fujiwara et al found a potent protein against Gram-positive
bacteria in royal jelly. The primary structure of that protein
has 51 residues with three intramolecular disulfide linkages.
Reference. A potent antibacterial protein in royal jelly. Purification and
determination of the primary structure of royalisin. Fujiwara et al. Morinaga
Milk Industry Company LTD. Japan. J Biol Chem. 1990 Jul 5;265(19):11333-7.

Are there any royal jelly side effects?
Royal jelly appears to be safe to bees and human. However,  
there are 9 reports about its side-effects related to asthma or
anaphylaxis, but all happened before 1999. The adverse
reactions in these cases include urticaria, eczema, rhinitis and
acute asthma.  Leung R et al, Royal jelly consumption and hypersensitivity
in the community. Clin Exp Allergy. 1997 Mar;27(3):333-6. [1-9]

There is a also report of a 53 year old woman with abdominal
pain and bloody diarrhoea (haemorrhagic colitis) associated
with royal jelly intake. Case report: haemorrhagic colitis associated with
royal jelly intake. J Gastroenterol hepatol. 1997 Jul, 12(7):495-9.
__________________________________________________
Royal Jelly
Royal Jelly- Royal Jelly is the milky-white gelatinous substance
secreted from the cephalic glands of the worker bees for  the growth
and of the queen bee. Without royal jelly, the queen bee would be no
different from the worker bees including its life span. Chemically, royal
jelly is a water-based emulsion of proteins, sugars, lipids and some
other ingredients. One of the proteins and some lipid components
have been found to against some types of bacteria. While its sugar
composition is very similar to those found in honey-fructose and
glucose. Royal jelly is commonly formulated into capsules, chewable
tablets, elixir and liquid. [pdr health online publication, December 26, 2005]
Fresh Royal Jelly- Some manufacturers sells fresh royal jelly directly
to the consumers, such that the consumers do not need to worry
how long the products have been sitting on a shelf. Usually, they also
ship out fresh bee pollen, propolis and honey products. Usually, the
price for fresh royal jelly is very expensive. Freeze-dried Royal Jelly-
Royal jelly is als widely freeze-dried into powder and then packed into
capsules. Freeze-drying is a process to remove the moisture from the
product,


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                                                       NOTE
The informatiion above is for your reference only. If you have any
questions, you should contact your medical doctor immediately.
ALL RIGHTS RESERVED 2008.

References
royal jelly causes asthma and other diseases
1. Harwood M et al, Asthma following royal jelly, NZ Med J 1996 Aug 23;
109(1028):325.2. Laporte JR et al, Bronchospasm induced by royal jelly,
Allergy 1996 Jun; 51(6):440.3. Thien FC et al, Asthma and anaphylaxis
induced by royal jelly, Clin Exp Allergy. 1996 Feb;26(2):216-22.
4. Peacock S. Respiratory distress and royal jelly, BMJ 1995 Dec.
2;311(7018):1472.5. Leung R et al, Royal jelly-induced asthma and
anaphylaxis: clinical characteristics and immunologic correlations. J. Allergy
Clin. Immunol. 1995 Dec;96)6Pt1)1004-7.6. Roger A et al, Anaphylaxis
caused by royal jelly, Allergol Immunopathol (Madr). 1995
May-Jun;23(3):133-5.7. Bullock RJ et al, Fatal royal jelly-induced asthma, Med
J Aust. 1994 Jan 3, 160(1)44.6. Thien FC et al, Royal Jelly induced asthma,
Med J Aust. 1993 Nov 1, 159(9)639.7. Takahashi M et al, Contact dermatitis
due to honeybee royal jelly, 1983 Nov9(6):452-5.
8.Murakami K. et al, A case of eosinophilic gastroenteritis induced by royal
jelly, Nippon Shokakibyo Gakkai Zasshi. 1994 Sep;91(9):1447-50.
Benfits of Royal Jelly
Benefits and side effects - research finds
updated on Feb 16, 2008    
Dandelion grows
almost everywhere in
the world. In this
picture, a small wild
bee visiting a
dandelion is often
attracted by salty
sweat on hot days.

Photo by Scott Baucer
CDC
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