INTRODUCTION Over 40 million Americans suffer from pain and loss of mobility due to osteoarthritis.
Osteoarthritis is an end stage of arthritis, in which the cartilage that makes up bone joints is destroyed,
allowing two bones to rub against each other. It is extremely painful.
GLUCOSAMINE Glucosamine is a natural compound found in high concentrations in joint cartilage. This
joint cartilage functions as a protective tissue allowing the joints to function as they should. However, as
we get older, this cartilage gets thinner. In some cases, osteoarthritis occurs. Glucosamine sulfate along
with chondroitin sulfate are always the product of choice to take for joint problem. It has been thought
that glucosamine is a key factor to healing and regrowth of this tissue. Glucosamine can be derived from
shrimp, oyster, plant life and crab shells.
Glucosamine- benefits in Osteoarthritis Management
A dosage of 1.5 gram of glucosamine daily for 2-4 weeks is just as effective as low doses of NSAIDs in
alleviating pain; research finds. [1]
Another study shows a great decrease in symptom severity after 4-6 weeks oral or intramuscular
administration of glucosamine.[2]
Injection of glucosamine, chondroitin sulfate, dextose and DMSO may help chronic intractable low back
pain. [3]
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Glucosamine Side Effects, Safety and Toxicity
The LD50 of oral glucosamine in animals is about 8000 mg/kg with no side nor adverse effects at 2700
mg/kg for 12 months.
Anderson JW and his co-workers at University of Kentucky reviewed clinical trial data for 3063 human
subjects and found that there were no side nor adverse effects of oral glucosamine administration on
blood, urine or fecal parameters. They concluded that glucosamine is safe under current conditions and
does not affect glucose metabolism. [4]
Oral glucosamine supplementation has limited side effects on patients suffered from type 2 diabetes
mellitus as it does not result in clinically significant alterations in glucose metabolism in these patients. [5]
Most glucosamine is derived from shellfish. You may develop allergy as a glucosamine side effect for oral
glucosamine supplementation, if you are allegic to shellfish.
ASTHMA - one of the glucosamine side effects? Tallia AF and Cardone DA, University of Medicine
and Dentistry of New Jersey searched literature from 1980 to 2002 using ther terms "glucosamine,"
"chondroitin sulfate,"...combined with "asthma". A case of asthma exacerbated by the use of a
glucosamine-chondroitin supplements for osteoarthritis was described. [6]
Reference
[1] Glucosamine and chondroitin sulfate as a possible treatment for osteoarthritis, Ned Tijdschr
Geneeskd. 2002 Sep 28;146(39):1819-23. [2] Glucosamine: a review of its use in the managment of
osteoarthritis. Drug Aging. 2003;20(14):1041-60. [3] Biochmical injection treatment for discogenic low
back pain: a pilot study. Spine J. 2003May-Jun; 3(3):220-6. [4] Anderson JW et al, Glucosamine effects
in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy.
Food Chem Toxicol. 2005 Feb;43(2):187-201. [5] Scroggie DA et al, The effect of glucosamine-
chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus:
a placebo-controlled, double-blinded, randomized clinical trials. Arch Intern Med. 2003 Jul 14; 163(13):
1587-90. [6] Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam
Pract. 2002 Nov-Dec; 15(6):481-4.
Does chondroitin sulfate affect the absorption of glucosamine?
Osteoarthritis is an end stage of arthritis, in which the cartilage that makes up bone joints is destroyed,
allowing two bones to rub against each other. It is extremely painful.
GLUCOSAMINE Glucosamine is a natural compound found in high concentrations in joint cartilage. This
joint cartilage functions as a protective tissue allowing the joints to function as they should. However, as
we get older, this cartilage gets thinner. In some cases, osteoarthritis occurs. Glucosamine sulfate along
with chondroitin sulfate are always the product of choice to take for joint problem. It has been thought
that glucosamine is a key factor to healing and regrowth of this tissue. Glucosamine can be derived from
shrimp, oyster, plant life and crab shells.
Glucosamine- benefits in Osteoarthritis Management
A dosage of 1.5 gram of glucosamine daily for 2-4 weeks is just as effective as low doses of NSAIDs in
alleviating pain; research finds. [1]
Another study shows a great decrease in symptom severity after 4-6 weeks oral or intramuscular
administration of glucosamine.[2]
Injection of glucosamine, chondroitin sulfate, dextose and DMSO may help chronic intractable low back
pain. [3]
____________________________________________________
Glucosamine Side Effects, Safety and Toxicity
The LD50 of oral glucosamine in animals is about 8000 mg/kg with no side nor adverse effects at 2700
mg/kg for 12 months.
Anderson JW and his co-workers at University of Kentucky reviewed clinical trial data for 3063 human
subjects and found that there were no side nor adverse effects of oral glucosamine administration on
blood, urine or fecal parameters. They concluded that glucosamine is safe under current conditions and
does not affect glucose metabolism. [4]
Oral glucosamine supplementation has limited side effects on patients suffered from type 2 diabetes
mellitus as it does not result in clinically significant alterations in glucose metabolism in these patients. [5]
Most glucosamine is derived from shellfish. You may develop allergy as a glucosamine side effect for oral
glucosamine supplementation, if you are allegic to shellfish.
ASTHMA - one of the glucosamine side effects? Tallia AF and Cardone DA, University of Medicine
and Dentistry of New Jersey searched literature from 1980 to 2002 using ther terms "glucosamine,"
"chondroitin sulfate,"...combined with "asthma". A case of asthma exacerbated by the use of a
glucosamine-chondroitin supplements for osteoarthritis was described. [6]
Reference
[1] Glucosamine and chondroitin sulfate as a possible treatment for osteoarthritis, Ned Tijdschr
Geneeskd. 2002 Sep 28;146(39):1819-23. [2] Glucosamine: a review of its use in the managment of
osteoarthritis. Drug Aging. 2003;20(14):1041-60. [3] Biochmical injection treatment for discogenic low
back pain: a pilot study. Spine J. 2003May-Jun; 3(3):220-6. [4] Anderson JW et al, Glucosamine effects
in humans: a review of effects on glucose metabolism, side effects, safety considerations and efficacy.
Food Chem Toxicol. 2005 Feb;43(2):187-201. [5] Scroggie DA et al, The effect of glucosamine-
chondroitin supplementation on glycosylated hemoglobin levels in patients with type 2 diabetes mellitus:
a placebo-controlled, double-blinded, randomized clinical trials. Arch Intern Med. 2003 Jul 14; 163(13):
1587-90. [6] Asthma exacerbation associated with glucosamine-chondroitin supplement. J Am Board Fam
Pract. 2002 Nov-Dec; 15(6):481-4.
Does chondroitin sulfate affect the absorption of glucosamine?
Glucosamine Side effects
and benefits
and benefits
| Glucosamine is a popular supplement for joint health. Howvever, its side effect is a concern. This article summarizes recent research findings related to glucosamine side effects. |
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THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND DISEASES. ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU
HAVE ANY QUESTION, YOU SHOULD CONSULT WITH YOUR DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2009. DO NOT COPY NOR TRANSFER ARTICLES TO
OTHER WEBSITES NOR OTHER FORMS OF PUBLICATIONS. Privacy Policy. ARTICLE INDEX/ Science
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