Systolic blood pressure
High systolic blood pressure treatments and causes.
At middle age or older, some people may notice a gradual rise in their systolic blood pressure.

In the past, we considered diastolic blood pressure as the most important component of blood
pressure and the primary target of antihypertensive therapy. [6] However, studies have shown that
systolic blood pressure is an important indicator for cardiovascular diseases.

Elevated systolic blood pressure results from age-associated vascular stiffening and reduced
compliance that can be revealed and quantified by analysis of arterial pressure waveforms.
Evaluation of pulse wave velocity together with other related measures has shown that arterial
stiffness increases with advancing age and other cardiovascular events such as the metabolic
syndrome, diabetes, obesity, hypercholesterolemia, and elevated C-reactive protein. [1, 2, 5]
Some researchers even consider systolic blood pressure as the most relevant component of blood
pressure for determining risk for cardiovascular and other events in hypertensive patients,
particularly those >50 years of age. While, several studies show that systolic blood pressure is
also associated with renal disease progression. [4]

In fact, systolic blood pressure is more difficult to control than diastolic blood pressure, and most
middle age and older hypertensive patients fail to achieve recommended targets. [1]

Younger persons tend toward isolated diastolic hypertension or combined systolic-diastolic
hypertension, primarily driven by increased peripheral resistance and more effectively treated by
antihypertensive medications; whereas older persons develop isolated systolic hypertension
associated with increased arterial stiffness that appears to be less amenable to current therapies.
Thus, diastolic pressure in hypertensive patients often plateaus as patients reach middle-age and
subsequently declines, whereas systolic pressure consistently rises through the ensuing decades.
[1]

Basile J. from Medical University of South Carolina suggested lifestyle modification, including
weight loss and salt restriction to reduce blood pressure, and may decrease the need for
pharmacologic therapy. He also suggested the initial use of a diuretic-based or calcium channel
blocker-based regimen to improve the outcome for systolic blood pressure of 160 mm Hg or more
and the diastolic blood pressure of les than 90 mm Hg. He also recommended two or more drugs
to achieve the present blood pressure goal of less than140 mm Hg for seniors.

Indapamide SR (a low-dose thiazide-type diuretic) has been shown effective in lowering the
systolic blood pressure. Other medications include thiazide diuretics, calcium channel blockers
and angiotensin-converting enzyme inhibitor. [3]

Treatment of isolated systolic hypertension is associated with a reduction in overall cardiovascular
mortality of 22%, in coronary heart disease mortality of 26%, and in stroke mortality of 33% for
seniors. [8]

Tekturna has approved for high blood pressure.
Seven Reasons to drink green tea

ALL RIGHTS RESERVED ZHION  THIS ARTICLE IS FOR YOUR REFERENCE ONLY. DISCUSS WITH YOUR DOCTOR FOR
DETAILS AND TREATMENTS.

[1] Franklin SS. Systolic blood pressure: it's time to take control. Am J Hypertens. 2004 Dec;17(12 Pt 2):49S-54S. [2] Schiffrin EL.
Vascular stiffening and arterial compliance. Implications for systolic blood pressure. Am J Hypertens. 2004 Dec;17(12 Pt
2):39S-48S. [3] London GM. Efficacy of indapamide 1.5 mg, sustained release, in the lowering of systolic blood pressure. J Hum
Hypertens. 2004 Dec;18 Suppl 2:S9-S14. [4] Mentari E, Rahman M. Blood pressure and progression of chronic kidney disease:
importance of systolic, diastolic, or diurnal variation. Curr Hypertens Rep. 2004 Oct;6(5):400-4. [5] van Trijp MJ, Grobbee DE, Hoes
AW, Bots ML. Prediction of cardiovascular disease on the basis of blood pressure measurements more reliable with systolic than
with diastolic measurement. Ned Tijdschr Geneeskd. 2003 Jul 26;147(30):1456-9. [6] Strandberg TE, Pitkala K. What is the most
important component of blood pressure: systolic, diastolic or pulse pressure? Curr Opin Nephrol Hypertens. 2003 May;12(3):293-7.
[7] Basile J. Hypertension in the elderly: a review of the importance of systolic blood pressure elevation. J Clin Hypertens
(Greenwich). 2002 Mar-Apr;4(2):108-12, 119. [8] Campo C, Segura J, Ruilope LM. Factors influencing the systolic blood pressure
response to drug therapy. J Clin Hypertens (Greenwich). 2002 Jan-Feb;4(1):35-40.
A study of 204 married
people and 99 single men
and women shows that
happy marriage may be a
boon for blood pressure.Of
course, other factors -
including diet, exercise,
smoking, and stress - also
affect blood pressure.
Those factors count for
everyone, single or
married, happy or not.

Happy Marriage, Better Blood
Pressure WebMD Mar 20, 2008
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