Obesity, a disease of inflammation; researchers suggest
What is wrong with obesity?
OBESITY MAY RAISE MYELOID LEUKEMIA RISK
Researchers studied a pattern they saw among nearly 41,000 people over eight years, in Victoria, Australia. The
researchers checked the height and weight of these people at the study's start to calculate BMI (body mass index).
They also measured participants' waists and muscle mass and track cases of leukemia and other blood cancers for
about eight years.
Leukemia is divided into two main types-- myeloid and lymphoid. The researchers found only an association between
body size and myeloid leukemia. Overweight and obese people (BMI of 25 or greater) were five times as likely to get
myeloid leukemia as those of smaller BMI. For people with waist sizes over 37 inches, myeloid leukemia risk rose 35%
for every 4 extra inches of waist size. Increased height was not linked to a higher myeloid leukemia risk. Increased
muscle mass was also associated with a higher myeloid leukemia risk.
Sources Increased Body Size Linked to Leukemia, WedMD, August 2, 2005 Myeloid Leukemia Risk Linked to Obesity
HealthDay August 2, 2005
OBESITY IS LINKED TO GASTROESOPHAGEAL REFLUX DISORDER (GERD)
Researchers concluded that excess weight nearly doubled the risk of GERD symptoms such as heartburn, acid
regurgitation, chest pain and difficulty swallowing, based on a meta-analysis of several studies. GERD occurs when
the valve between the stomach and the esophagus fails to close properly. As a result, the contents in the stomach,
including stomach acid, can spill up into the esophagus, leading to erosion of the esophagus or even esophageal
People who were overweight, defined by a body mass index of 25 to 30, were 1.4 times as likely to develop GERD
symptoms, people who were obese were nearly twice as likely to develop symptoms compared to those with a healthy
body weight. While, people with a body mass index greater than 30 were about three times more likely to develop
esophageal cancer than those with a healthy body weight.
There are several explanations for the GERD symptoms and complications: (1) The excessive weight in the abdomen
compresses the stomach and raises the pressure inside, leading to gastric reflux, (2) abdominal obesity contributes
to the release of inflammatory substances. This may raise the risk of GERD (3) Obese people usually eat excessive
amounts of fat and fatty foods, increasing the risk of GERD,.
Reference Got GERD? Weight Loss May Help HealthDay, August 2, 2005
FRUCTOSE SWEETENER INCREASES BODY FAT, RESEARCH FINDS
Consumption of food products containing sucrose and high-fructose may lead to obesity. Sucrose and high-fructose
are commonly used in sweetened foods, carbonated soft drinks, beverages, some juices, corn syrup and cereals. A
widely used sweetener derived from corn, high-fructose corn syrup is similar to sucrose (table sugar) in its
composition, about half glucose and half fructose.
In a study of mice, Dr. Matthias Tsch, University of Cincinnati, used magnetic resonance technology to carefully
monitor body fat in mice. He measured the the average weight of the mice to be 39 grams. After consuming
fructose-sweetened water of a period of pre-determined time, the average weight became 48 grams. This group of
mice had about 90 percent more body fat than the mice that consumed water only.
Sources  New link between soft drinks and weight gain, Medical News Today, Univerity of Cincinnati Jul 31, 2005
Obesity is a disease
Some researchers view obesity as a low-grade systemic inflammatory disease. It is because obese children and
adults have elevated serum levels of C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and leptin. These
chemicals are commonly used as markers for inflammation and they are closely associated with cardiovascular
events [1-4]. Besides, plasma concentrations of all pro-thrombotic factors and plasminogen activator inhibitor-1
(PAI-1) have been shown to be higher in obese patients . This may explain why obesity is linked to coagulation and
fibrinolysis abnormalities as well as increased risk of diabetes, heart disease, and many other chronic diseases.
Recently, Tongjian You and his group at Wake Forest University Baptist Medical Center have examined small
samples of subcutaneous fat from the abdomen and found that the fat tissues actually produce interleukin 6, tumor
necrosis factor alpha and plasminogen activator inhibitor 1. Interleukin 6 and tumor necrosis factor alpha promote
inflammation (as mentioned before), while plasminogen activator inhibitor 1 promotes blood clots. These are also
involved in atherosclerosis, the buildup of fatty deposits in the linings of blood vessels. They also found that higher
levels of the "bad" proteins, interleukin 6 and tumor necrosis factor alpha, were associated with a lower ability to
respond to insulin and use glucose. And, low production of adiponectin in subcutaneous fat is linked with an elevated
risk of heart disease.
Pischon T et al found an inverse-association between physical activity and plasma levels of sTNF-R1, sTNF-R2,
interleukin-6, and C-reactive protein . Thus, frequent physical activity is related to lower systemic inflammation and
improved insulin sensitivity.
Please, remember that the ideal BMI is 25. Being too thin may lead to medical complications such as infertility and
osteoporosis. Steve Bloomfield, the Eating Disorders Association considers anorexia and bulimia as diseases. [A2]
How to loss weight fast
South Beach Diet
1. Kaiser T and Schunker H, Cardiovascular changes in obesity, Herz. 2001 May;26(3):194-201.
2. Pischon T et al, Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers,
Obes Res. 2003 Sep;11(9):1055-64.
3. Das UN , Is obesity an inflammatory condition? Nutrition. 2001 Nov-Dec;17(11-12):953-66.
4. Yudkin JS et al, Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?, Atherosclerosis.
5. De Pergola G et al, Coagulation and fibrinolysis abnormalities in obesity, J Endocrinol Invest. 2002
6. Fat May Promote Inflammation, New Study Suggests, Wake Forest University Baptist Medical Center, Press
Release, March 28, 2005 [A2] British charity issues anorexia Internet warning Reuters Sat Jan 6
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