VITAMIN E MAY UP HEART FAILURE RISK,
RESEARCH FINDS
Zhion, 2008
The safety of high-dose vitamin E supplementation (1,200 IU of vitamin E or 800 mg of D-alpha-tocopherol) in human
or animals have been studied. Morinobu T et al, Osaka Medical College, Japan, assigned high-dose vitamin E to 14
healthy adult male volunteers for 28 days and they found that high doses of vitamin E (800 mg dl alpha-tocopheryl
acetate for 30 days) had no adverse effects in healthy men [1]. Meydani SN et al, US Department of Agriculture, also
found short-term supplementation with 800 mg vitamin E/d has no adverse effect on 32 healthy older adults [2].
The effect of high-dose vitamin E supplement on liver and heard diseases has also been studied. Giakoustidis D et al,
Aristotle University, Greece, assigned high (30 mg/kg body weight for 3 days) or very high (300 mg/kg body weight for
3 days) doses of a-tocopherol to Wistar rats with severe warm hepatic ischemia. They found the protection of
a-tocopherol to the liver parenchyma in the animals via histological examinations [3]. Suzukawa M et al,
RESEARCH FINDS
Zhion, 2008
The safety of high-dose vitamin E supplementation (1,200 IU of vitamin E or 800 mg of D-alpha-tocopherol) in human
or animals have been studied. Morinobu T et al, Osaka Medical College, Japan, assigned high-dose vitamin E to 14
healthy adult male volunteers for 28 days and they found that high doses of vitamin E (800 mg dl alpha-tocopheryl
acetate for 30 days) had no adverse effects in healthy men [1]. Meydani SN et al, US Department of Agriculture, also
found short-term supplementation with 800 mg vitamin E/d has no adverse effect on 32 healthy older adults [2].
The effect of high-dose vitamin E supplement on liver and heard diseases has also been studied. Giakoustidis D et al,
Aristotle University, Greece, assigned high (30 mg/kg body weight for 3 days) or very high (300 mg/kg body weight for
3 days) doses of a-tocopherol to Wistar rats with severe warm hepatic ischemia. They found the protection of
a-tocopherol to the liver parenchyma in the animals via histological examinations [3]. Suzukawa M et al,
National Defense Medical College, Japan, concluded that about 400 IU/day vitamin E,
which increased its levels two-fold and prolonged sufficiently the lag time before LDL
oxidation, might be beneficial in decreasing the individual risk of coronary heart
disease (CHD) in their review article [4]. Mosca L. et al, University of Michigan,
assigned 800 IU of vitamin E, 1,000 mg of vitamin C and 24 mg of beta-carotene (high
dose) daily to patients with cardiovascular disease for 12 weeks and they found that a
high dose combination of antioxidant nutrients reduced the susceptibility of LDL to
oxidation in patients with cardiovascular disease [5].
Out of a sudden, results of a seven-year study demonstrated an increased risk of
heart failure from taking the vitamin E supplement. The study included approximately
4,000 patients, 55 years of age or older, with vascular disease or diabetes assigned to
400 IU per day of vitamin E or a placebo. The researchers found no significant
differences between the vitamin E group and the placebo group in cancer rate, cancer
deaths, major cardiovascular events (heart attack, stroke, or death from cardiovascular
causes), or death. But they found the higher risk of heart failure associated with the
vitamin E group [6,7]. The results, published in the March 16 issue of the Journal of the
American Medical Association [7].
REFERENCES
[1] Morinobu T et al, The safety of high-dose vitamin E supplementation in healthy Japanese male adults, J Nutr Sci
Vitaminol (Tokyo). 2002 Feb;48(1):6-9.
[2] Meydani SN et al, Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy
older adults, Am J Clin Nutr. 1994 Nov;60(5):704-9.
[3] Giakoustidis D et al, Intramuscular administration of very high dose of alpha-tocopherol protects liver from severe
ischemia/reperfusion injury, World J Surg. 2002 Jul;26(7):872-7. Epub 2002 Apr 18.
[4] Suzukawa M et al, Effect of supplementation with vitamin E on LDL oxidizability and prevention of
atherosclerosis. Biofactors. 1998;7(1-2):51-4.
[5] Mosca L et al, Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to
oxidation in patients with coronary artery disease, J Am Coll Cardiol. 1997 Aug;30(2):392-9.
[6] CARSON, Calif. HOPE-TOO Study on Vitamin E Reveals Unexpected Results Not Found in Previous Large Trials
on Nutrient, PRNewswire, March 16, 2005.
[7] Serena Gordon, HealthDay News , Vitamin E Ups Heart Failure Risk, March 15 2005.
MORE ARTICLE
which increased its levels two-fold and prolonged sufficiently the lag time before LDL
oxidation, might be beneficial in decreasing the individual risk of coronary heart
disease (CHD) in their review article [4]. Mosca L. et al, University of Michigan,
assigned 800 IU of vitamin E, 1,000 mg of vitamin C and 24 mg of beta-carotene (high
dose) daily to patients with cardiovascular disease for 12 weeks and they found that a
high dose combination of antioxidant nutrients reduced the susceptibility of LDL to
oxidation in patients with cardiovascular disease [5].
Out of a sudden, results of a seven-year study demonstrated an increased risk of
heart failure from taking the vitamin E supplement. The study included approximately
4,000 patients, 55 years of age or older, with vascular disease or diabetes assigned to
400 IU per day of vitamin E or a placebo. The researchers found no significant
differences between the vitamin E group and the placebo group in cancer rate, cancer
deaths, major cardiovascular events (heart attack, stroke, or death from cardiovascular
causes), or death. But they found the higher risk of heart failure associated with the
vitamin E group [6,7]. The results, published in the March 16 issue of the Journal of the
American Medical Association [7].
REFERENCES
[1] Morinobu T et al, The safety of high-dose vitamin E supplementation in healthy Japanese male adults, J Nutr Sci
Vitaminol (Tokyo). 2002 Feb;48(1):6-9.
[2] Meydani SN et al, Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy
older adults, Am J Clin Nutr. 1994 Nov;60(5):704-9.
[3] Giakoustidis D et al, Intramuscular administration of very high dose of alpha-tocopherol protects liver from severe
ischemia/reperfusion injury, World J Surg. 2002 Jul;26(7):872-7. Epub 2002 Apr 18.
[4] Suzukawa M et al, Effect of supplementation with vitamin E on LDL oxidizability and prevention of
atherosclerosis. Biofactors. 1998;7(1-2):51-4.
[5] Mosca L et al, Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to
oxidation in patients with coronary artery disease, J Am Coll Cardiol. 1997 Aug;30(2):392-9.
[6] CARSON, Calif. HOPE-TOO Study on Vitamin E Reveals Unexpected Results Not Found in Previous Large Trials
on Nutrient, PRNewswire, March 16, 2005.
[7] Serena Gordon, HealthDay News , Vitamin E Ups Heart Failure Risk, March 15 2005.
MORE ARTICLE
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PHYTONUTRIENTS AND DRUG PRODUCTS. THIS WEBSITE ALSO TALKS ABOUT SOME POPULAR HEALTH ISSUES AND
DISEASES. ARTICLES IN THIS WEB SITE IS FOR YOUR REFERENCE ONLY. IF YOU HAVE ANY QUESTION, YOU SHOULD
CONSULT WITH YOUR DOCTOR IMMEDIATELY. ALL RIGHTS RESERVED 2008. DO NOT COPY NOR TRANSFER ARTICLES TO
OTHER WEBSITES NOR OTHER FORMS OF PUBLICATIONS. Privacy Policy. ARTICLE INDEX/ Science
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