VITAMIN E MAY UP HEART FAILURE RISK,
RESEARCH FINDS
Zhion, 2008

The safety of high-dose vitamin E supplementation (1,200 IU of vitamin E or 800 mg of D-alpha-tocopherol) in human
or animals have been studied. Morinobu T et al, Osaka Medical College, Japan, assigned high-dose vitamin E to 14
healthy adult male volunteers for 28 days and they found that high doses of vitamin E (800 mg dl alpha-tocopheryl
acetate for 30 days) had no adverse effects in healthy men [1]. Meydani SN et al, US Department of Agriculture, also
found short-term supplementation with 800 mg vitamin E/d has no adverse effect on 32 healthy older adults [2].

The effect of high-dose vitamin E supplement on liver and heard diseases has also been studied. Giakoustidis D et al,
Aristotle University, Greece, assigned high (30 mg/kg body weight for 3 days) or very high (300 mg/kg body weight for
3 days) doses of a-tocopherol to Wistar rats with severe warm hepatic ischemia. They found the protection of
a-tocopherol to the liver parenchyma in the animals via histological examinations [3]. Suzukawa M et al,
National Defense Medical College, Japan, concluded that about 400 IU/day
vitamin E, which increased its levels two-fold and prolonged sufficiently the lag
time before LDL oxidation, might be beneficial in decreasing the individual risk of
coronary heart disease (CHD) in their review article [4]. Mosca L. et al, University
of Michigan, assigned 800 IU of vitamin E, 1,000 mg of vitamin C and 24 mg of
beta-carotene (high dose) daily to patients with cardiovascular disease for 12
weeks and they found that a high dose combination of antioxidant nutrients
reduced the susceptibility of LDL to oxidation in patients with cardiovascular
disease [5].

Out of a sudden, results of a seven-year study demonstrated an increased risk
of heart failure from taking the vitamin E supplement. The study included
approximately 4,000 patients, 55 years of age or older, with vascular disease or
diabetes assigned to 400 IU per day of vitamin E or a placebo. The researchers
found no significant differences between the vitamin E group and the placebo
group in cancer rate, cancer deaths, major cardiovascular events (heart attack,
stroke, or death from cardiovascular causes), or death. But they found the higher
risk of heart failure associated with the vitamin E group [6,7]. The results,
published in the March 16 issue of the Journal of the American Medical
Association [7].

REFERENCES

[1] Morinobu T et al, The safety of high-dose vitamin E supplementation in healthy Japanese male adults, J
Nutr Sci Vitaminol (Tokyo). 2002 Feb;48(1):6-9.
[2] Meydani SN et al, Assessment of the safety of high-dose, short-term supplementation with vitamin E in
healthy older adults, Am J Clin Nutr. 1994 Nov;60(5):704-9.
[3] Giakoustidis D et al, Intramuscular administration of very high dose of alpha-tocopherol protects liver from
severe ischemia/reperfusion injury, World J Surg. 2002 Jul;26(7):872-7. Epub 2002 Apr 18.
[4] Suzukawa M et al, Effect of supplementation with vitamin E on LDL oxidizability and prevention of
atherosclerosis. Biofactors. 1998;7(1-2):51-4.
[5] Mosca L et al, Antioxidant nutrient supplementation reduces the susceptibility of low density lipoprotein to
oxidation in patients with coronary artery disease, J Am Coll Cardiol. 1997 Aug;30(2):392-9.
[6] CARSON, Calif. HOPE-TOO Study on Vitamin E Reveals Unexpected Results Not Found in Previous Large
Trials on Nutrient, PRNewswire, March 16, 2005.
[7] Serena Gordon, HealthDay News , Vitamin E Ups Heart Failure Risk, March 15 2005.


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